Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 1,846

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Vitamin D Deficiency and Risk of Cardiovascular Disease

Wang, Thomas J., Pencina, Michael J., Booth, Sarah L., Jacques, Paul F., Ingelsson, Erik, Lanier, Katherine, Benjamin, Emelia J., D’Agostino, Ralph B., Wolf, Myles, Vasan, Ramachandran S.·2008·Circulation
DOI 10.1161/circulationaha.107.706127
Open this paper in CoChat — free account

Abstract

Background— Vitamin D receptors have a broad tissue distribution that includes vascular smooth muscle, endothelium, and cardiomyocytes. A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking. Methods and Results— We studied 1739 Framingham Offspring Study participants (mean age 59 years; 55% women; all white) without prior cardiovascular disease. Vitamin D status was assessed by measuring 25-dihydroxyvitamin D (25-OH D) levels. Prespecified thresholds were used to characterize varying degrees of 25-OH D deficiency (<15 ng/mL, <10 ng/mL). Multivariable Cox regression models were adjusted for conventional risk factors. Overall, 28% of individuals had levels <15 ng/mL, and 9% had levels <10 ng/mL. During a mean follow-up of 5.4 years, 120 individuals developed a first cardiovascular event. Individuals with 25-OH D <15 ng/mL had a multivariable-adjusted hazard ratio of 1.62 (95% confidence interval 1.11 to 2.36, P =0.01) for incident cardiovascular events compared with those with 25-OH D ≥15 ng/mL. This effect was evident in participants with hypertension (hazard ratio 2.13, 95% confidence interval 1.30 to 3.48) but not in those without hypertension (hazard ratio 1.04, 95% confidence interval 0.55 to 1.96). There was a graded increase in cardiovascular risk across categories of 25-OH D, with multivariable-adjusted hazard ratios of 1.53 (95% confidence interval 1.00 to 2.36) for levels 10 to <15 ng/mL and 1.80 (95% confidence interval 1.05 to 3.08) for levels <10 ng/mL ( P for linear trend=0.01). Further adjustment for C-reactive protein, physical activity, or vitamin use did not affect the findings. Conclusions— Vitamin D deficiency is associated with incident cardiovascular disease. Further clinical and experimental studies may be warranted to determine whether correction of vitamin D deficiency could contribute to the prevention of cardiovascular disease.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/circulationaha.107.706127

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 55

  1. 10.4065/81.3.353 · DOI · Paper page
  2. Malabanan A, Veronikis IE, Holick MF. Redefining vitamin D insufficiency. Lancet. 1998; 351: 805–806.
  3. 10.1007/s001980050030 · DOI · Paper page
  4. 10.1093/ajcn/76.1.187 · DOI · Paper page
  5. 10.1079/BJN20051544 · DOI · Paper page
  6. 10.1007/BF02555253 · DOI
  7. 10.1161/01.cir.0000160353.27927.70 · DOI · Paper page
  8. 10.1172/JCI114097 · DOI · Paper page
  9. 10.1016/S0021-9258(17)45460-3 · DOI
  10. 10.1152/ajpheart.1997.272.4.H1751 · DOI
  11. 10.1172/JCI113004 · DOI · Paper page
  12. Wu J, Garami M, Cao L, Li Q, Gardner DG. 1,25(OH)2D3 suppresses expression and secretion of atrial natriuretic peptide from cardiac myocytes. Am J Physiol. 1995; 268 (pt 1): E1108–E1113.
  13. 10.1152/ajpendo.00224.2004 · DOI · Paper page
  14. 10.7326/0003-4819-105-5-649 · DOI · Paper page
  15. 10.1161/hyp.30.5.1289 · DOI
  16. 10.1016/0895-7061(95)00154-H · DOI · Paper page
  17. 10.1161/circ.96.6.1755 · DOI
  18. 10.1161/circ.96.5.1477 · DOI
  19. 10.1093/ije/19.3.559 · DOI · Paper page
  20. 10.1161/01.str.0000195184.24297.c1 · DOI · Paper page
  21. 10.1016/S0735-1097(02)02624-4 · DOI · Paper page
  22. 10.1093/qjmed/89.8.579 · DOI
  23. 10.1016/0021-9681(79)90044-4 · DOI
  24. 10.1161/hyp.30.2.150 · DOI
  25. 10.1016/S0140-6736(89)91634-6 · DOI
  26. 10.1093/oxfordjournals.aje.a112813 · DOI · Paper page
  27. 10.2337/diacare.20.7.1183 · DOI · Paper page
  28. 10.1001/archinte.1979.03630450011006 · DOI · Paper page
  29. 10.1016/0002-8703(86)90022-0 · DOI
  30. 10.1093/biomet/80.3.557 · DOI · Paper page
  31. 10.1056/NEJM199803193381201 · DOI · Paper page
  32. 10.2337/diacare.27.12.2813 · DOI · Paper page
  33. 10.1002/art.21601 · DOI
  34. 10.1093/ajcn/66.4.929 · DOI · Paper page
  35. 10.1177/096228029500400302 · DOI · Paper page
  36. 10.1093/ajcn/84.1.18 · DOI · Paper page
  37. 10.2337/diacare.29.03.06.dc05-2148 · DOI · Paper page
  38. 10.1038/sj.ki.5002451 · DOI · Paper page
  39. 10.1681/ASN.V133621 · DOI · Paper page
  40. 10.1172/JCI115213 · DOI
  41. 10.1074/jbc.M404865200 · DOI · Paper page
  42. 10.1016/S0006-291X(02)02254-4 · DOI
  43. Schluter KD, Piper HM. Trophic effects of catecholamines and parathyroid hormone on adult ventricular cardiomyocytes. Am J Physiol. 1992; 263: H1739–H1746.
  44. 10.1159/000069761 · DOI
  45. Amann K, Tornig J, Flechtenmacher C, Nabokov A, Mall G, Ritz E. Blood-pressure-independent wall thickening of intramyocardial arterioles in experimental uraemia: evidence for a permissive action of PTH. Nephrol Dial Transplant. 1995; 10: 2043–2048.
  46. 10.1161/01.str.0000078371.00577.76 · DOI
  47. 10.1161/hypertensionaha.107.087288 · DOI · Paper page
  48. Achinger SG, Ayus JC. The role of vitamin D in left ventricular hypertrophy and cardiac function. Kidney Int Suppl. 2005: S37–S42.
  49. 10.1093/ajh/2.1.20 · DOI
  50. Pfeifer M, Begerow B, Minne HW, Nachtigall D, Hansen C. Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. J Clin Endocrinol Metab. 2001; 86: 1633–1637.
  51. 10.1016/S0272-6386(99)70260-X · DOI · Paper page
  52. 10.1093/ajcn/83.4.754 · DOI · Paper page
  53. 10.1161/circulationaha.106.673491 · DOI · Paper page
  54. 10.1161/circulationaha.106.686238 · DOI
  55. 10.1056/NEJMoa055218 · DOI · Paper page

Cited by

See all 1,846

Metadata

Authors
Wang, T. J., Pencina, M. J., Booth, S. L., Jacques, P. F., Ingelsson, E., Lanier, K., Benjamin, E. J., D’Agostino, R. B., Wolf, M., & Vasan, R. S.
Affiliations
From the Framingham Heart Study, Framingham, Mass (T.J.W., M.J.P., E.I., K.L., E.J.B., R.B.D., R.S.V.); Cardiology Division (T.J.W.) and Renal Division (M.W.), Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass; Statistics and Consulting Unit, Department of Mathematics (M.J.P., R.B.D.), Boston University, Boston, Mass; Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging (S.L.B., P.F.J.), Tufts University, Boston, Mass; and...
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2008-01-29
Volume
117
Issue
4
Pages
503-511
ISSN
  • 0009-7322
  • 1524-4539
DOI
10.1161/circulationaha.107.706127
Cited by
1,846
References
9
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.