The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Therapeutic Uses of Inorganic Nitrite and Nitrate: From the Past to the Future
Open accessAbstract
Potential carcinogenic effects, blue baby syndrome, and occasional intoxications caused by nitrite, as well as the suspected health risks related to fertilizer overuse, contributed to the negative image that inorganic nitrite and nitrate have had for decades. Recent experimental studies related to the molecular interaction between nitrite and heme proteins in blood and tissues, the potential role of nitrite in hypoxic vasodilatation, and an unexpected protective action of nitrite against ischemia/reperfusion injury, however, paint a different picture and have led to a renewed interest in the physiological and pharmacological properties of nitrite and nitrate. The range of effects reported suggests that these simple oxyanions of nitrogen have a much richer profile of biological actions than hitherto assumed, and several efforts are currently underway to investigate possible beneficial effects in the clinical arena. We provide here a brief historical account of the medical uses of nitrite and nitrate over the centuries that may serve as a basis for a careful reassessment of the health implications of their exposure and intake and may inform investigations into their therapeutic potential in the future.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is little doubt that the nitrite/sulfide interaction is of some biological relevance as nitrite is the most potent remedy known against sulfide poisoning [25].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [25]
In the citing paper
“This nitrate-nitrite-NO cycle offers a conceptually attractive explanation for the blood pressure lowering and cardioprotective effects of diets rich in nitrate and may provide the molecular basis for past and future therapeutic uses of nitrite/nitrate [20,25], although definitive chemical evidence for the significance of this pathway under physiological conditions is still lacking.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [25]
In the citing paper
“There is little doubt that the nitrite/sulfide interaction is of some biological relevance as nitrite is the most potent remedy known against sulfide poisoning [25].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [25]
In the citing paper
“This nitrate-nitrite-NO cycle offers a conceptually attractive explanation for the blood pressure lowering and cardioprotective effects of diets rich in nitrate and may provide the molecular basis for past and future therapeutic uses of nitrite/nitrate [20,25], although definitive chemical evidence for the significance of this pathway under physiological conditions is still lacking.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 1×
“More recently, the ease with which nitrate is reduced to nitrite and nitrite converted into NO has occasioned interest in the role of plasma nitrite in vascular smooth muscle relaxation and the control of blood pressure and flow(8), and possible therapeutic uses of nitrite.(9,10) Subsequent animal experimental studies…”
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate
Marletta, M. A., Yoon, P. S., Iyengar, R., Leaf, C. D., & Wishnok, J. S. (1988) · Biochemistry · doi:10.1021/bi00424a003 · Cited by 1,601
The New Encyclopaedia Britannica
Goetz, P. W. (1991) · Cited by 1,592
The Production of Malignant Primary Hepatic Tumours in the Rat by Feeding Dimethylnitrosamine
Magee, P. N., & Barnes, J. M. (1956) · British Journal of Cancer · doi:10.1038/bjc.1956.15 · Cited by 900
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788
Nitrate, bacteria and human health
Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739
Duncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M., & Benjamin, N. (1995) · Nature Medicine · doi:10.1038/nm0695-546 · Cited by 734
Green, L. C., Ruiz de Luzuriaga, K., Wagner, D. A., Rand, W., Istfan, N., Young, V. R., & Tannenbaum, S. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.12.7764 · Cited by 665
Research works printed but not linked: 21
- Cruickshank J, Moyes JM. The presence and significance of nitrites in urine. BMJ. 1914; 2: 712–713.
- Péligot E. Sur l’acide hypoazotique et sur l’acide azoteux. Ann Chim Phys. 1841; 2: 58–68.
- 10.1161/circ.73.1.2866851 · DOI
- Harrington M. Hypotensive Drugs. London UK: Pergamon Press; 1956.
- Fant K. Alfred Nobel: En Biografi. Stockholm Sweden: Norstedts Förlag; 1991: 302.
- Reichert ET, Mitchell SW. On the physiological action of potassium nitrite. Am J Med Sci. 1880; 156: 158–180.
- Hay M. Nitrite of sodium in the treatment of angina pectoris. Practitioner. 1883; 30: 170–194.
- Deusch G, Liepelt A. Die Hautkapillaren beim arteriellen Hochdruck und ihre Beeinflussung durch Nitrite. Deutsches Arch Klin Med. 1928; 160: 207–211.
- 10.1161/circ.94.10.2587 · DOI
- Magendie F. Sur l’emploi de l’acide prussique dans le traitement de plusieurs maladies de poitrine, et particulièrement dans la phtisie pulmonaire. Ann Chim Phys. 1817; 6: 347–360.
- Hug E. Accion del nitrite de sodio del hiposulfate de sodio en el tratamiento de la intoxication provocada por el ciannuro de potassio en al conejo. Rev Soc Argent Biol. 1932; 3: 270–276.
- Viana C, Cagnoli H, Cendan J. L’action du nitrite de sodium dans l’intoxication par les cyanures. C R Seances Soc Biol Fil. 1934; 115: 1649–1651.
- Baskin SI, Froehlich HL, Groff WA. The dissociation of reversal of cyanide (CN) toxicity and methemoglobin formation by nitrite (N) in the isolated heart. Fed Proc. 1986; 45: 196. Abstract.
- Law WT. Sodium nitrite in the treatment of epilepsy. Practitioner. 1882; 28: 420–424.
- Pietsch G. Dissertation sur la Generation du Nitre. Berlin Germany: Chez Haude et Spener; 1746.
- Postgate J. Nitrogen Fixation. 3rd ed. Cambridge UK: CUP; 1998.
- Pearse F. The treatment of paroxysmal nerve disorders. Practitioner. 1891; 46: 29–32.
- Encyclopædia Britannica. Vol. XXIV 11th ed. Cambridge UK: CUP; 1911: 94.
- Oza TM. Thermal decomposition of sodium and potassium nitrites. J Indian Chem Soc. 1945; 22: 173–180.
- Cahn A. Die Magenverdauung im Chlorhunger. Ztschr F Physiol Chem. 1886; 10: 522–535.
- Eustermann GB, Keith NM. Transient methemoglobinemia following administration of ammonium nitrate. Med Clin North Am. 1929; 12: 1489–1496.
Cited by
Sorted by citations
Graves, D. B. (2012) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/45/26/263001 · Cited by 1,534
Food sources of nitrates and nitrites: The physiologic context for potential health benefits
Hord, N. G., Tang, Y., & Bryan, N. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27131 · Cited by 1,069
Hofmeister Phenomena: An Update on Ion Specificity in Biology
Nostro, P. L., & Ninham, B. W. (2012) · Chemical Reviews · doi:10.1021/cr200271j · Cited by 1,026
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
Lee, R. J., Xiong, G., Kofonow, J. M., Chen, B., Lysenko, A., Jiang, P., Abraham, V., Doghramji, L. J., Adappa, N. D., Palmer, J. N., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64240 · Cited by 542
Experimental evidence for the functional relevance of anion–π interactions
Dawson, R. E., Hennig, A., Weimann, D. P., Emery, D., Ravikumar, V., Montenegro, J., Takeuchi, T., Gabutti, S., Mayor, M., Mareda, J., et al. (2010) · Nature Chemistry · doi:10.1038/nchem.657 · Cited by 476
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435
Self-citationMaia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401
Lidder, S., & Webb, A. J. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04420.x · Cited by 360
Roles of dietary inorganic nitrate in cardiovascular health and disease
Lundberg, J. O., Carlström, M., Larsen, F. J., & Weitzberg, E. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq325 · Cited by 355
Oehmigen, K., Winter, J., Hähnel, M., Wilke, C., Brandenburg, R., Weltmann, K., & von Woedtke, T. (2011) · Plasma Processes and Polymers · doi:10.1002/ppap.201000099 · Cited by 291
Carlström, M., Persson, A. E. G., Larsson, E., Hezel, M., Scheffer, P. G., Teerlink, T., Weitzberg, E., & Lundberg, J. O. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq366 · Cited by 261
Kapil, V., Khambata, R. S., Jones, D. A., Rathod, K., Primus, C., Massimo, G., Fukuto, J. M., & Ahluwalia, A. (2020) · Pharmacological Reviews · doi:10.1124/pr.120.019240 · Cited by 248
Bahadoran, Z., Mirmiran, P., Jeddi, S., Azizi, F., Ghasemi, A., & Hadaegh, F. (2016) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2016.06.006 · Cited by 228
The superoxide radical switch in the biology of nitric oxide and peroxynitrite
Piacenza, L., Zeida, A., Trujillo, M., & Radí, R. (2022) · Physiological Reviews · doi:10.1152/physrev.00005.2022 · Cited by 214
Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases
Omar, S. A., Webb, A. J., Lundberg, J. O., & Weitzberg, E. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12441 · Cited by 175
Daiber, A., & Münzel, T. F. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6376 · Cited by 173
Hoon, M. W., Johnson, N. A., Chapman, P., & Burke, L. M. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.5.522 · Cited by 166
Generation of HNO and HSNO from Nitrite by Heme‐Iron‐Catalyzed Metabolism with H2S
Miljkovic, J. L., Kenkel, I., Ivanović‐Burmazović, I., & Filipovic, M. R. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201305669 · Cited by 148
Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care
Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145
Beetroot supplementation lowers daily systolic blood pressure in older, overweight subjects
Jajja, A., Sutyarjoko, A., Lara, J., Rennie, K., Brandt, K., Qadir, O., & Siervo, M. (2014) · Nutrition Research · doi:10.1016/j.nutres.2014.09.007 · Cited by 138
Cui, W.-L., Wang, M., Yang, Y.-H., Wang, J.-Y., Zhu, X., Zhang, H., & Ji, X. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214848 · Cited by 134
The Key Role of Nitric Oxide in Hypoxia: Hypoxic Vasodilation and Energy Supply–Demand Matching
Umbrello, M., Dyson, A., Feelisch, M., & Singer, M. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4979 · Cited by 138
Self-citationThe role of nitrogen oxides in human adaptation to hypoxia
Levett, D. Z. H., Fernandez, B. O., Riley, H. L., Martín, D., Mitchell, K., Leckstrom, C. A., İnce, C., Whipp, B. J., Mythen, M. G., Montgomery, H., et al. (2011) · Scientific Reports · doi:10.1038/srep00109 · Cited by 125
Self-citationNitrite Reduction and Cardiovascular Protection
Omar, S. A., & Webb, A. J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.012 · Cited by 121
The Role of Nitrate in Human Health
Bryan, N. S., & van Grinsven, H. J. M. (2013) · Advances in agronomy · doi:10.1016/b978-0-12-407247-3.00003-2 · Cited by 126
Nitrates and Nitrites in the Treatment of Ischemic Cardiac Disease
Nossaman, V. E., Nossaman, B. D., & Kadowitz, P. J. (2010) · Cardiology in Review · doi:10.1097/crd.0b013e3181c8e14a · Cited by 120
On the chemical biology of the nitrite/sulfide interaction
Cortese-Krott, M. M., Fernandez, B. O., Kelm, M., Butler, A. R., & Feelisch, M. (2015) · Nitric Oxide · doi:10.1016/j.niox.2014.12.009 · Cited by 115
Self-citationInorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113
“The medicinal use of nitrates is also evident from documents dating around 800 AD demonstrating that potassium nitrate was used by the Chinese medicinally to relieve “acute heart pains, and cold in the hands and feet” [8].”
BackgroundIs sunlight good for our heart?
Feelisch, M., Kolb-Bachofen, V., Liu, D., Lundberg, J. O., Revelo, L. P., Suschek, C. V., & Weller, R. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq069 · Cited by 113
Self-citationInorganic nitrate and nitrite and control of blood pressure
Gilchrist, M., Shore, A. C., & Benjamin, N. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq309 · Cited by 113
A comparison of organic and inorganic nitrates/nitrites
Omar, S. A., Artime, E., & Webb, A. J. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.008 · Cited by 106
Dietary Nitrates, Nitrites, and Cardiovascular Disease
Hord, N. G. (2011) · Current Atherosclerosis Reports · doi:10.1007/s11883-011-0209-9 · Cited by 97
Zhu, S.-G., Kukreja, R. C., Das, A., Chen, Q., Lesnefsky, E. J., & Xi, L. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.024 · Cited by 96
Nitrate in foods: harmful or healthy?
Katan, M. B. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28014 · Cited by 95
Ahluwalia, A., Gladwin, M., Coleman, G. D., Hord, N., Howard, G., Kim‐Shapiro, D. B., Lajous, M., Larsen, F. J., Lefer, D. J., McClure, L. A., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003402 · Cited by 92
The prince and the pauper. A tale of anticancer targeted agents
Dueñas‐González, A., García‐López, P., Herrera, L. A., Medina‐Franco, J. L., González‐Fierro, A., & Candelaria, M. (2008) · Molecular Cancer · doi:10.1186/1476-4598-7-82 · Cited by 94
Regulation of mitochondrial function and energetics by reactive nitrogen oxides
Larsen, F. J., Schiffer, T. A., Weitzberg, E., & Lundberg, J. O. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.580 · Cited by 87
Saying NO to H2S: A Story of HNO, HSNO, and SSNO–
Ivanović‐Burmazović, I., & Filipović, M. R. (2019) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.8b02592 · Cited by 88
Münzel, T. F., & Daiber, A. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.11.003 · Cited by 86
Nitrite reduction by molybdoenzymes: a new class of nitric oxide-forming nitrite reductases
Maia, L. B., & Moura, J. J. G. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-014-1234-2 · Cited by 88
Thangamuthu, M., Manickam, P., Balamurugan, M., Bhargava, K., Sethy, N. K., & Karunakaran, C. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.08.036 · Cited by 80
Ingram, T. E., Fraser, A. G., Bleasdale, R. A., Ellins, E. A., Margulescu, A. D., Halcox, J. P., & James, P. E. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.03.050 · Cited by 69
Inorganic nitrite supplementation for healthy arterial aging
Sindler, A. L., DeVan, A. E., Fleenor, B. S., & Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01100.2013 · Cited by 68
Sensing of electrolytes in urine using a miniaturized paper-based device
Ghaderinezhad, F., Koydemir, H. C., Tseng, D. K., Karinca, D., Liang, K., Özcan, A., & Taşoğlu, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-70456-6 · Cited by 64
Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation
Bailey, J., Feelisch, M., Horowitz, J. D., Frenneaux, M. P., & Madhani, M. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.06.009 · Cited by 61
Self-citationVitturi, D. A., & Patel, R. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.037 · Cited by 59
Khatri, J., Mills, C. E., Maskell, P., Odongerel, C., & Webb, A. J. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12913 · Cited by 60
Novena, L. M., Kumar, S. S., & Athimoolam, S. (2016) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2016.03.014 · Cited by 58
Nitrites and nitrates in the human diet: Carcinogens or beneficial hypotensive agents?
Butler, A. R. (2014) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2014.09.040 · Cited by 55
Self-citationSaijo, F., Milsom, A. B., Bryan, N. S., Bauer, S. M., Vowinkel, T., Ivanovic, M., Andry, C., Granger, D. N., Rodriguez, J., & Feelisch, M. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.11.009 · Cited by 51
Self-citationRenal carbonic anhydrases are involved in the reabsorption of endogenous nitrite
Chobanyan-Jürgens, K., Schwarz, A., Böhmer, A., Beckmann, B., Gutzki, F., Michaelsen, J. T., Stichtenoth, D. O., & Tsikas, D. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.01.005 · Cited by 50
Schneider, C., Gebhardt, L., Arndt, S., Karrer, S., Zimmermann, J. L., Fischer, M. J. M., & Bosserhoff, A. (2019) · Cancers · doi:10.3390/cancers11050671 · Cited by 49
Does dietary nitrate say NO to cardiovascular ageing? Current evidence and implications for research
Siervo, M., Scialò, F., Shannon, O. M., Stephan, B. C. M., & Ashor, A. W. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118000058 · Cited by 49
An improved mass spectrometry-based measurement of NO metabolites in biological fluids
Yang, X., Bondonno, C. P., Indrawan, A. P., Hodgson, J. M., & Croft, K. D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.12.002 · Cited by 46
Nitrite and myocardial ischaemia reperfusion injury. Where are we now?
Griffiths, K., Lee, J. J., Frenneaux, M. P., Feelisch, M., & Madhani, M. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107819 · Cited by 46
Self-citationInorganic Nitrite Supplementation Improves Endothelial Function With Aging
Rossman, M. J., Gioscia‐Ryan, R. A., Santos‐Parker, J. R., Ziemba, B. P., Lubieniecki, K. L., Johnson, L. C., Poliektov, N. E., Bispham, N. Z., Woodward, K. A., Nagy, E., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.16175 · Cited by 46
Applications of Sodium Nitrite in Organic Synthesis
Mukhopadhyay, S., & Batra, S. (2019) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201900951 · Cited by 45
Lippi, L., Uberti, F., Folli, A., Turco, A., Curci, C., D’Abrosca, F., Alessandro de, S. I. R. E., & Invernizzi, M. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02203-y · Cited by 43
Strianese, M., Milione, S., Bertolasi, V., & Pellecchia, C. (2013) · Inorganic Chemistry · doi:10.1021/ic401055k · Cited by 43
A “green” diet-based approach to cardiovascular health? Is inorganic nitrate the answer?
Rathod, K. S., Velmurugan, S., & Ahluwalia, A. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500313 · Cited by 42
Plasma-Liquid Interactions: Chemistry and Antimicrobial Effects
von Woedtke, T., Oehmigen, K., Brandenburg, R., Hoder, T., Wilke, C., Hähnel, M., & Weltmann, K. (2011) · NATO science for peace and security series. A, Chemistry and biology · doi:10.1007/978-94-007-2852-3_6 · Cited by 43
de Angelis, C. D., Oliveira‐Paula, G. H., Pinheiro, L. C., Crevelin, E. J., Portella, R. L., de Moraes, L. A. B., & Tanus-Santos, J. E. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.003 · Cited by 38
The Top 5 Can’t-Miss Sport Supplements
António, J., Pereira, F., Curtis, J., Rojas, J., & Evans, C. (2024) · Nutrients · doi:10.3390/nu16193247 · Cited by 46
Potential Therapeutic Strategies for Hypertension‐Exacerbated Cardiotoxicity of Anticancer Drugs
Kuriakose, R. K., Kukreja, R. C., & Xi, L. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8139861 · Cited by 38
Jin, C. W., Du, S., Zhang, Y. S., Tang, C., & Lin, X. (2009) · Annals of Applied Biology · doi:10.1111/j.1744-7348.2009.00327.x · Cited by 37
Chaudhari, S. S., Kim, M., Lei, S., Razvi, F., Alqarzaee, A. A., Hutfless, E. H., Powers, R., Zimmerman, M. C., Fey, P. D., & Thomas, V. C. (2017) · mBio · doi:10.1128/mbio.00887-17 · Cited by 37
Sodium nitrite potentiates renal oxidative stress and injury in hemoglobin exposed guinea pigs
Baek, J. H., Zhang, X., Williams, M. C., Hicks, W. A., Buehler, P. W., & D’Agnillo, F. (2015) · Toxicology · doi:10.1016/j.tox.2015.04.007 · Cited by 35
Investigations on the role of hemoglobin in sulfide metabolism by intact human red blood cells
Bianco, C. L., Savitsky, A., Feelisch, M., & Cortese-Krott, M. M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.045 · Cited by 35
Self-citationPlasma‐activated chemical solutions and their bactericidal effects
Li, Y., Nie, L., Liu, D., Kim, S. J., & Lu, X. (2022) · Plasma Processes and Polymers · doi:10.1002/ppap.202100248 · Cited by 35
Campus PlasmaMed—From Basic Research to Clinical Proof
Weltmann, K.-D., & von Woedtke, T. (2011) · IEEE Transactions on Plasma Science · doi:10.1109/tps.2011.2112674 · Cited by 32
Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction
Rodriguez, C., Vitturi, D. A., He, J., Vandromme, M., Brandon, A., Hutchings, A., Rue, L. W., Kerby, J. D., & Patel, R. P. (2009) · Biochemical Journal · doi:10.1042/bj20090735 · Cited by 31
Organic Nitrates and Nitrate Tolerance—State of the Art and Future Developments
Daiber, A., Münzel, T. F., & Gori, T. (2010) · Advances in pharmacology · doi:10.1016/b978-0-12-385061-4.00007-6 · Cited by 31
Evaluation of Nitrite in Ready-Made Soups
Erkekoğlu, P., Si̇pahi̇, H., & Baydar, T. (2008) · Food Analytical Methods · doi:10.1007/s12161-008-9045-0 · Cited by 29
Soliman, M. M., Aldhahrani, A., & Metwally, M. M. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-85264-9 · Cited by 28
Quantitative aspects of nitric oxide production from nitrate and nitrite
Ghasemi, A. (2022) · EXCLI journal · doi:10.17179/excli2022-4727 · Cited by 30
Inorganic Nitrate in Angina Study: A Randomized Double‐Blind Placebo‐Controlled Trial
Schwarz, K., Singh, S., Parasuraman, S. K., Rudd, A. E., Shepstone, L., Feelisch, M., Minnion, M., Ahmad, S., Madhani, M., Horowitz, J. D., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.006478 · Cited by 27
Self-citationThe potential of aldehyde dehydrogenase 2 as a therapeutic target in cardiovascular disease
Münzel, T. F., & Daiber, A. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2018.1439922 · Cited by 27
The Nitrate–Nitrite–Nitric Oxide Pathway in Mammals
Lundberg, J. O., Weitzberg, E., Shiva, S., & Gladwin, M. T. (2011) · Humana Press eBooks · doi:10.1007/978-1-60761-616-0_3 · Cited by 26
Cui, H., Feng, Y., Shu, C., Yuan, R., Bu, L., Jia, M., & Pang, B. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01605 · Cited by 26
Sacchi, P., Loconte, L., Macetti, G., Rizzato, S., & Presti, L. L. (2019) · Crystal Growth & Design · doi:10.1021/acs.cgd.8b01794 · Cited by 25
Hydration properties determining the reactivity of nitrite in aqueous solution
Vchirawongkwin, S., Kritayakornupong, C., Tongraar, A., & Vchirawongkwin, V. (2014) · Dalton Transactions · doi:10.1039/c4dt00273c · Cited by 23
Yue, Q., Sun, L., Shen, T., Gu, X., Zhang, S., & Liu, J. (2013) · Journal of Fluorescence · doi:10.1007/s10895-013-1265-z · Cited by 22
Santos, O. M. M., Silva, D. M., Martins, F. T., Legendre, A. O., Azarias, L. C., Rosa, I. M. L., Neves, P. P., Araújo, M. B., & Doriguetto, A. C. (2014) · Crystal Growth & Design · doi:10.1021/cg500877z · Cited by 22
Portella, R. D. L., Bickta, J., & Shiva, S. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6260 · Cited by 21
Mental retardation in Down syndrome: Two ways to treat
Kamoun, P. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109289 · Cited by 21
Natural Product Nitric Oxide Chemistry: New Activity of Old Medicines
Jiang, H., Torregrossa, A. C., Parthasarathy, D. K., & Bryan, N. (2012) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2012/873210 · Cited by 24
Cortese-Krott, M. M. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8171 · Cited by 20
Bice, J. S., Burley, D. S., & Baxter, G. F. (2014) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248413518971 · Cited by 22
Sodium nitrite-induced hematological and hemorheological changes in rats
Gluhcheva, Y., Ivanov, I. P., Petrova, E., Павлова, Е. А., & Владов, И. (2012) · Cited by 20
Sulfate, nitrate and blood pressure – An EPIC interaction between sulfur and nitrogen
Kuhnle, G., Luben, R., Khaw, K., & Feelisch, M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.06.006 · Cited by 20
Self-citationHord, N. G., & Conley, M. N. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_12 · Cited by 20
Hidaka, M., Gotoh, A., Shimizu, T., Minamisawa, K., Imamura, H., & Uchida, T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.687632 · Cited by 20
Pinheiro, L. C., Ferreira, G. C., de Angelis, C. D., Toledo, J. C., & Tanus-Santos, J. E. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.03.006 · Cited by 20
Oxygen tension, H2S, and NO bioavailability: is there an interaction?
Kolluru, G. K., Prasai, P. K., Kaskas, A. M., Letchuman, V., & Pattillo, C. B. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00365.2015 · Cited by 19
Hanff, E., Böhmer, A., Jordan, J., & Tsikas, D. (2014) · Journal of Chromatography B · doi:10.1016/j.jchromb.2014.08.041 · Cited by 17
Ralt, D. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2009.03.049 · Cited by 17
Hyperpolarized [15N]nitrate as a potential long lived hyperpolarized contrast agent for MRI
Gamliel, A., Uppala, S., Sapir, G., Harris, T., Nardi‐Schreiber, A., Shaul, D., Sosna, J., Gomori, J. M., & Katz‐Brull, R. (2019) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2019.01.001 · Cited by 16
Naturally cured meats: Quality, safety, and chemistry
Sullivan, G. A. (2011) · Iowa State University Digital Repository (Iowa State University) · doi:10.31274/etd-180810-2479 · Cited by 16
Soliman, M. M., Aldhahrani, A., El-Shazly, S. A., Shukry, M., & Abouzed, T. K. (2021) · Biological Trace Element Research · doi:10.1007/s12011-021-02613-5 · Cited by 15
Cooperative Interactions Between NO and H 2 S: Chemistry, Biology, Physiology, Pathophysiology
Kevil, C. G., Cortese-Krott, M. M., Nagy, P., Papapetropoulos, A., Feelisch, M., & Szabó, C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804273-1.00005-3 · Cited by 16
Self-citation
Metadata
- Authors
- Butler, A. R., & Feelisch, M.
- Affiliations
- University of St Andrews (GB)
- ORCID
- Feelisch, Martin
- Venue
- Circulation
- Published
- 2008-04-22
- Volume
- 117
- Issue
- 16
- Pages
- 2151-2159
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2026713650
- Cited by
- 184
- References
- 96
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 12 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 6 · 2017: 10 · 2016: 13 · 2015: 18 · 2014: 17 · 2013: 10 · 2012: 15
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- inorganic nitrite, inorganic nitrate, therapeutic applications, heme proteins, ischemia-reperfusion injury, blue baby syndrome, nitrite toxicity, fertilizer overuse
- MeSH terms
- Cardiovascular Diseases, Humans, Nitrates, Nitrites, History, 15th Century, History, 16th Century, History, 17th Century, History, 18th Century, History, 19th Century, History, 20th Century, History, Ancient, History, Medieval
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
