The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Therapeutic Uses of Inorganic Nitrite and Nitrate: From the Past to the Future
Open accessAbstract
Potential carcinogenic effects, blue baby syndrome, and occasional intoxications caused by nitrite, as well as the suspected health risks related to fertilizer overuse, contributed to the negative image that inorganic nitrite and nitrate have had for decades. Recent experimental studies related to the molecular interaction between nitrite and heme proteins in blood and tissues, the potential role of nitrite in hypoxic vasodilatation, and an unexpected protective action of nitrite against ischemia/reperfusion injury, however, paint a different picture and have led to a renewed interest in the physiological and pharmacological properties of nitrite and nitrate. The range of effects reported suggests that these simple oxyanions of nitrogen have a much richer profile of biological actions than hitherto assumed, and several efforts are currently underway to investigate possible beneficial effects in the clinical arena. We provide here a brief historical account of the medical uses of nitrite and nitrate over the centuries that may serve as a basis for a careful reassessment of the health implications of their exposure and intake and may inform investigations into their therapeutic potential in the future.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is little doubt that the nitrite/sulfide interaction is of some biological relevance as nitrite is the most potent remedy known against sulfide poisoning [25].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [25]
In the citing paper
“This nitrate-nitrite-NO cycle offers a conceptually attractive explanation for the blood pressure lowering and cardioprotective effects of diets rich in nitrate and may provide the molecular basis for past and future therapeutic uses of nitrite/nitrate [20,25], although definitive chemical evidence for the significance of this pathway under physiological conditions is still lacking.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [25]
In the citing paper
“There is little doubt that the nitrite/sulfide interaction is of some biological relevance as nitrite is the most potent remedy known against sulfide poisoning [25].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [25]
In the citing paper
“This nitrate-nitrite-NO cycle offers a conceptually attractive explanation for the blood pressure lowering and cardioprotective effects of diets rich in nitrate and may provide the molecular basis for past and future therapeutic uses of nitrite/nitrate [20,25], although definitive chemical evidence for the significance of this pathway under physiological conditions is still lacking.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 1×
“More recently, the ease with which nitrate is reduced to nitrite and nitrite converted into NO has occasioned interest in the role of plasma nitrite in vascular smooth muscle relaxation and the control of blood pressure and flow(8), and possible therapeutic uses of nitrite.(9,10) Subsequent animal experimental studies…”
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate
Marletta, M. A., Yoon, P. S., Iyengar, R., Leaf, C. D., & Wishnok, J. S. (1988) · Biochemistry · doi:10.1021/bi00424a003 · Cited by 1,601
The New Encyclopaedia Britannica
Goetz, P. W. (1991) · Cited by 1,592
The Production of Malignant Primary Hepatic Tumours in the Rat by Feeding Dimethylnitrosamine
Magee, P. N., & Barnes, J. M. (1956) · British Journal of Cancer · doi:10.1038/bjc.1956.15 · Cited by 900
Enzyme-independent formation of nitric oxide in biological tissues
Zweier, J. L., Wang, P., Samouilov, A., & Kuppusamy, P. (1995) · Nature Medicine · doi:10.1038/nm0895-804 · Cited by 788
Nitrate, bacteria and human health
Lundberg, J. O., Weitzberg, E., Cole, J. A., & Benjamin, N. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro929 · Cited by 739
Duncan, C., Dougall, H., Johnston, P., Green, S., Brogan, R., Leifert, C., Smith, L., Golden, M., & Benjamin, N. (1995) · Nature Medicine · doi:10.1038/nm0695-546 · Cited by 734
Green, L. C., Ruiz de Luzuriaga, K., Wagner, D. A., Rand, W., Istfan, N., Young, V. R., & Tannenbaum, S. R. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.12.7764 · Cited by 665
Furchgott, R. F., & Bhadrakom, S. (1953) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)05163-8 · Cited by 655
Effects of dietary nitrate on oxygen cost during exercise
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637
Webb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608
Effects of Dietary Nitrate on Blood Pressure in Healthy Volunteers
Larsen, F. J., Ekblom, B., Sahlin, K., Lundberg, J. O., & Weitzberg, E. (2006) · New England Journal of Medicine · doi:10.1056/nejmc062800 · Cited by 587
Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585
Self-citationNitrate Synthesis in the Germfree and Conventional Rat
Green, L. C., Tannenbaum, S. R., & Goldman, P. (1981) · Science · doi:10.1126/science.6451927 · Cited by 559
Shiva, S., Sack, M. N., Greer, J. J., Duranski, M., Ringwood, L. A., Burwell, L., Wang, X., MacArthur, P. H., Shoja, A., Raghavachari, N., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070198 · Cited by 555
Identification of the enzymatic mechanism of nitroglycerin bioactivation
Chen, Z., Zhang, J., & Stamler, J. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122225199 · Cited by 545
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
Bryan, N. S., Fernandez, B. O., Bauer, S. M., Garcia-Saura, M. F., Milsom, A. B., Rassaf, T., Maloney, R. E., Bharti, A., Rodriguez, J., & Feelisch, M. (2005) · Nature Chemical Biology · doi:10.1038/nchembio734 · Cited by 518
Self-citationGladwin, M. T., Shelhamer, J. H., Schechter, A. N., Pease-Fye, M. E., Waclawiw, M. A., Panza, J. A., Ognibene, F. P., & Cannon, R. O. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.21.11482 · Cited by 441
ON THE USE OF NITRITE OF AMYL IN ANGINA PECTORIS.
Brunton, T. L. (1867) · The Lancet · doi:10.1016/s0140-6736(02)51392-1 · Cited by 410
Cytochrome and cytochrome oxidase
Keilin, D., Hartree, E. F., & Hartree, E. F. (1939) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1939.0016 · Cited by 404
Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans
ERZURUM, S. C., Ghosh, S., Janocha, A. J., Xu, W., Bauer, S. M., Bryan, N. S., Tejero, J., Hemann, C. F., Hille, R., Stuehr, D. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707462104 · Cited by 369
Self-citationAli, M. Y., Ping, C. Y., Mok, Y.-Y. P., Ling, L. H., Whiteman, M., Bhatia, M., & Moore, P. K. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706906 · Cited by 353
Nitrite‐derived nitric oxide: a possible mediator of ‘acidic–metabolic’ vasodilation
Modin, A., Björne, H., Herulf, M., Alving, K., Weitzberg, E., & Lundberg, J. O. N. (2001) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2001.00771.x · Cited by 346
Dejam, A., Hunter, C. J., Tremonti, C., Pluta, R. M., Hon, Y. Y., Grimes, G., Partovi, K., Pelletier, M. M., Oldfield, E. H., Cannon, R. O., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.712133 · Cited by 334
NITRO-GLYCERINE AS A REMEDY FOR ANGINA PECTORIS.
Murrell, W. (1879) · The Lancet · doi:10.1016/s0140-6736(02)46032-1 · Cited by 293
The History of Cell Respiration and Cytochrome
Keilin, D. (1966) · Medical Entomology and Zoology · Cited by 287
Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator
Hunter, C. J., Dejam, A., Blood, A. B., Shields, H., Kim-Shapiro, D. B., Machado, R. F., Tarekegn, S., Mulla, N., Hopper, A. O., Schechter, A. N., et al. (2004) · Nature Medicine · doi:10.1038/nm1109 · Cited by 281
Nitrosation, diazotisation, and deamination
Ridd, J. H. (1961) · Quarterly Reviews Chemical Society · doi:10.1039/qr9611500418 · Cited by 261
An S -nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate
Angelo, M., Singel, D. J., & Stamler, J. S. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600942103 · Cited by 233
Nitrosation Reactions and the Chemistry of Nitric Oxide
(2004) · Elsevier eBooks · doi:10.1016/b978-0-444-51721-0.x5000-2 · Cited by 229
NITRO-GLYCERINE AS A REMEDY FOR ANGINA PECTORIS.
Murrell, W. (1879) · The Lancet · doi:10.1016/s0140-6736(02)42573-1 · Cited by 219
Yoon, S. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci24684 · Cited by 212
NITRITE AND THIOSULFATE THERAPY IN CYANIDE POISONING
Chen, K. K. (1952) · JAMA · doi:10.1001/jama.1952.02930190015004 · Cited by 203
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics
DEZFULIAN, C., RAAT, N., SHIVA, S., & GLADWIN, M. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.05.001 · Cited by 198
Cardioprotective effects of vegetables: is nitrate the answer?
Lundberg, J. O., Feelisch, M., Björne, H., Jansson, E. Å., & Weitzberg, E. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.01.013 · Cited by 185
Self-citationThe Dispensatory of the United States of America.
Wood, H. C., Griffith, I., Anderson, J. F., Youngken, H. W., & Lawall, C. H. (1894) · JAMA · doi:10.1001/jama.1894.02420920037018 · Cited by 175
Nitric Oxide Is Generated on the Skin Surface by Reduction of Sweat Nitrate
Weller, R., Pattullo, S., Smith, L. M., Golden, M., Ormerod, A. D., & Benjamin, N. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12363167 · Cited by 174
Evaluation of the Magnitude and Rate of Nitric Oxide Production from Nitrite in Biological Systems
Samouilov, A., Kuppusamy, P., & Zweier, J. L. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0785 · Cited by 170
Smith, R. P., & Gosselin, R. E. (1979) · Journal of Occupational and Environmental Medicine · doi:10.1097/00043764-197902000-00008 · Cited by 162
Dietary nitrate increases gastric mucosal blood flow and mucosal defense
Petersson, J., Phillipson, M., Jansson, E. Å., Patzak, A., Lundberg, J. O., & Holm, L. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00435.2006 · Cited by 161
Nitrate and man: toxic, harmless or beneficial?
(2001) · CABI Publishing eBooks · doi:10.1079/9780851995663.0000 · Cited by 142
THE ORIGIN OF THE NITRATES IN THE URINE
Mitchell, H. H., Shonle, H. A., & Grindley, H. S. (1916) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)87531-7 · Cited by 142
Evidence that ingested nitrate and nitrite are beneficial to health
Archer, D. L. (2002) · Journal of Food Protection · doi:10.4315/0362-028x-65.5.872 · Cited by 135
Antimicrobial effect of acidified nitrite on dermatophyte fungi candida and bacterial skin pathogens
Weller, R., Price, R. J., Ormerod, A. D., Benjamin, N., & Leifert, C. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01291.x · Cited by 134
Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn
Moya, M. P., Gow, A. J., Califf, R. M., Goldberg, R. N., & Stamler, J. S. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09385-6 · Cited by 123
Dalsgaard, T., Simonsen, U., & Fago, A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01298.2006 · Cited by 110
Nitrogen Fixation, 3rd Edition
Jenkins, M. B. (2000) · Journal of Environmental Quality · doi:10.2134/jeq2000.00472425002900060047x · Cited by 107
Tucker, A., Pearson, R., Cooke, E., & Benjamin, N. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04095-7 · Cited by 104
van Grinsven, H. J. M., Ward, M. H., Benjamin, N., & de Kok, T. M. C. M. (2006) · Environmental Health · doi:10.1186/1476-069x-5-26 · Cited by 101
Richardson, G., Hicks, S. L., O'Byrne, S., Frost, M. T., Moore, K., Benjamin, N., & McKnight, G. M. (2002) · Nitric Oxide · doi:10.1016/s1089-8603(02)00010-1 · Cited by 101
Janero, D. R., Bryan, N. S., Saijo, F., DHAWAN, V. M., Schwalb, D. J., Warren, M. C., & Feelisch, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406075101 · Cited by 85
Self-citationTreatment of Common Acute Poisonings
(1968) · Archives of Disease in Childhood · doi:10.1136/adc.43.230.504 · Cited by 83
Stine, R. J., SLOSBERG, B., & BEACHAM, B. E. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-85-6-756 · Cited by 80
The effects of topical treatment with acidified nitrite on wound healing in normal and diabetic mice
Weller, R., & Finnen, M. J. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.04.002 · Cited by 80
Metabolic Adaptation During a Sequence of No-Flow and Low-Flow Ischemia
Ferrari, R., Cargnoni, A., Bernocchi, P., Pasini, E., Curello, S., Ceconi, C., & Ruigrok, T. J. C. (1996) · Circulation · doi:10.1161/01.cir.94.10.2587 · Cited by 76
Nitrite, a naturally occurring precursor of nitric oxide that acts like a ‘prodrug’
Suschek, C. V., SCHEWE, T., Sies, H., & Kröncke, K. (2006) · Biological Chemistry · doi:10.1515/bc.2006.065 · Cited by 72
Management of Acute Sulfide Poisoning
Smith, R. P., Kruszyna, R., & Kruszyna, H. G. (1976) · Archives of Environmental Health An International Journal · doi:10.1080/00039896.1976.10667212 · Cited by 66
Wound licking and nitric oxide
Benjamin, N., Pattullo, S., Weller, R., Smith, L. M., & Ormerod, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(05)63002-4 · Cited by 50
Nitrite as an antidote for acute hydrogen sulfide intoxication?
Beck, J. F., BRADBURY, C. M., CONNORS, A. J., & Donini, J. C. (1981) · American Industrial Hygiene Association Journal · doi:10.1080/15298668191420738 · Cited by 48
Formation of nitric oxide from nitrous acid in ischemic tissue and skin
Butler, A. R., & Ridd, J. H. (2004) · Nitric Oxide · doi:10.1016/j.niox.2004.01.004 · Cited by 45
Self-citationCYANIDE INHIBITION AS A MEANS OF ELUCIDATING THE MECHANISMS OF CELLULAR RESPIRATION
Commoner, B. (1940) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.1940.tb00753.x · Cited by 44
Cullen, C., & Lo, V. (2004) · Routledge eBooks · doi:10.4324/9780203482247 · Cited by 44
Nitroglycerin: a homeopathic remedy.
Fye, W. B. (1986) · Circulation · doi:10.1161/01.cir.73.1.21 · Cited by 41
Antihypertensive effect of oral nitrite uptake in the spontaneously hypertensive rat.
Beier, S., Hg, C., Loeffler, K., Schumacher, E., & Thöni, H. (1995) · PubMed · Cited by 40
Lethality of cyanide in the absence of inhibition of liver cytochrome oxidase
Isom, G. E., & Way, J. L. (1976) · Biochemical Pharmacology · doi:10.1016/0006-2952(76)90397-x · Cited by 40
THE NATIONAL STANDARD DISPENSATORY
HARE, H. A., Caspari, C. E., & Rusby, H. H. (1906) · The American Journal of the Medical Sciences · doi:10.1097/00000441-190606000-00015 · Cited by 39
THE ACTION AND EXCRETION OF NITRATES
Keith, N. M. (1930) · Archives of Internal Medicine · doi:10.1001/archinte.1930.00140170058007 · Cited by 39
Debus, A. G. (1964) · Isis · doi:10.1086/349794 · Cited by 34
Medieval Chinese Medicine: The Dunhuang Medical Manuscripts
Cullen, C., & Lo, V. (2004) · Medical Entomology and Zoology · Cited by 31
Treatment of Cyanide Poisoning
Vick, J. A., & Froehlich, H. L. (1991) · Military Medicine · doi:10.1093/milmed/156.7.330 · Cited by 27
Williams, D. L. H. (2004) · Elsevier eBooks · doi:10.1016/b978-044451721-0/50007-4 · Cited by 25
Ueber Metadiamidobenzol als Reagens auf salpetrige Säure
Grieß, P. (1878) · Berichte der deutschen chemischen Gesellschaft · doi:10.1002/cber.187801101168 · Cited by 23
The toxicology of silver nitrate.
Humphreys, S. D. M., & Routledge, P. A. (1999) · PubMed · Cited by 23
History of the treatment of chronic bronchitis
Ziment, I. (2009) · Respiration · doi:10.1159/000195969 · Cited by 21
TRANSIENT METHEMOGLOBINEMIA DUE TO AMMONIUM NITRATE
TARR, L. (1933) · Archives of Internal Medicine · doi:10.1001/archinte.1933.00150200041004 · Cited by 18
Barnum, D. W. (2003) · Journal of Chemical Education · doi:10.1021/ed080p1393 · Cited by 17
Chemical synthesis and microvascular effects of new nitric oxide donors in humans
Khan, F., Pearson, R. J., NEWTON, D. J., Belch, J. J. F., & Butler, A. R. (2003) · Clinical Science · doi:10.1042/cs20030144 · Cited by 16
Self-citationAn Early Mediaeval Chinese Alchemical Text on Aqueous Solutions
T'ien-Ch'in, T., Ping-Yü, H., & Needham, J. (1959) · Ambix · doi:10.1179/amb.1959.7.3.121 · Cited by 16
TOXIC EFFECTS FROM BISMUTH SUBNITRATE
BECK, E. G. (1909) · JAMA · doi:10.1001/jama.1909.25420270014001e · Cited by 14
Addiscott, T. M., & Benjamin, N. (2000) · Rothamsted Repository (Rothamsted Repository) · Cited by 12
The adjuvant action of the lactate ion on the vaso‐dilator effect of sodium nitrite
Densham, B. (1927) · The Journal of Physiology · doi:10.1113/jphysiol.1927.sp002393 · Cited by 11
Materia medica, pharmacy, pharmacology and therapeutics
Hale-White, W. (2010) · University of Michigan Library Repository · Cited by 10
Renal Excretion of Nitrate and Its Effect on Excretion of Sodium and Chloride
Greene, I., & Hiatt, E. P. (1954) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1954.180.1.179 · Cited by 10
The Pharmacology of the Nitrites and Nitro-Glycerine.
Atkinson, G. A. (1888) · PubMed · Cited by 9
[ON THE ANTAGONISTIC ALTERATION OF ACUTE H2S POISONING IN MICE WITH METHEMOGLOBIN-FORMING AGENTS].
Scheler, W., & Kabisch, R. (1963) · PubMed · Cited by 7
Comparison of the Diuretic Effects of Nitrate Salts With Other Diuretic Agents
Hiatt, E. P. (1957) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1957.189.1.173 · Cited by 6
ON NITRITE OF SODIUM AS A TOXIC AGENT.
Ringer, S., & Murrell, W. (1883) · The Lancet · doi:10.1016/s0140-6736(02)23900-8 · Cited by 5
textbook of materia medica and therapeutics
Blumgaten, A. S. (1934) · AJN American Journal of Nursing · doi:10.1097/00000446-193411000-00053 · Cited by 5
Sons, E. R. S. (2010) · Medical Entomology and Zoology · Cited by 3
Granville, A. B. (1820) · New England Journal of Medicine · doi:10.1056/nejm182004010090214 · Cited by 3
Taylor, H. (1877) · BMJ · doi:10.1136/bmj.2.884.832 · Cited by 2
Materia Medica, Pharmacology, and Therapeutics; Inorganic Substances
Phillips, C. D. F. (1895) · The American Journal of the Medical Sciences · doi:10.1097/00000441-189505000-00009 · Cited by 1
On the Duration of the Action of Medicines
Leech, D. J. (1885) · BMJ · doi:10.1136/bmj.2.1300.1005 · Cited by 1
(1997) · The Lancet · doi:10.1016/s0140-6736(05)63003-6 · Cited by 1
Research works printed but not linked: 21
- Cruickshank J, Moyes JM. The presence and significance of nitrites in urine. BMJ. 1914; 2: 712–713.
- Péligot E. Sur l’acide hypoazotique et sur l’acide azoteux. Ann Chim Phys. 1841; 2: 58–68.
- 10.1161/circ.73.1.2866851 · DOI
- Harrington M. Hypotensive Drugs. London UK: Pergamon Press; 1956.
- Fant K. Alfred Nobel: En Biografi. Stockholm Sweden: Norstedts Förlag; 1991: 302.
- Reichert ET, Mitchell SW. On the physiological action of potassium nitrite. Am J Med Sci. 1880; 156: 158–180.
- Hay M. Nitrite of sodium in the treatment of angina pectoris. Practitioner. 1883; 30: 170–194.
- Deusch G, Liepelt A. Die Hautkapillaren beim arteriellen Hochdruck und ihre Beeinflussung durch Nitrite. Deutsches Arch Klin Med. 1928; 160: 207–211.
- 10.1161/circ.94.10.2587 · DOI
- Magendie F. Sur l’emploi de l’acide prussique dans le traitement de plusieurs maladies de poitrine, et particulièrement dans la phtisie pulmonaire. Ann Chim Phys. 1817; 6: 347–360.
- Hug E. Accion del nitrite de sodio del hiposulfate de sodio en el tratamiento de la intoxication provocada por el ciannuro de potassio en al conejo. Rev Soc Argent Biol. 1932; 3: 270–276.
- Viana C, Cagnoli H, Cendan J. L’action du nitrite de sodium dans l’intoxication par les cyanures. C R Seances Soc Biol Fil. 1934; 115: 1649–1651.
- Baskin SI, Froehlich HL, Groff WA. The dissociation of reversal of cyanide (CN) toxicity and methemoglobin formation by nitrite (N) in the isolated heart. Fed Proc. 1986; 45: 196. Abstract.
- Law WT. Sodium nitrite in the treatment of epilepsy. Practitioner. 1882; 28: 420–424.
- Pietsch G. Dissertation sur la Generation du Nitre. Berlin Germany: Chez Haude et Spener; 1746.
- Postgate J. Nitrogen Fixation. 3rd ed. Cambridge UK: CUP; 1998.
- Pearse F. The treatment of paroxysmal nerve disorders. Practitioner. 1891; 46: 29–32.
- Encyclopædia Britannica. Vol. XXIV 11th ed. Cambridge UK: CUP; 1911: 94.
- Oza TM. Thermal decomposition of sodium and potassium nitrites. J Indian Chem Soc. 1945; 22: 173–180.
- Cahn A. Die Magenverdauung im Chlorhunger. Ztschr F Physiol Chem. 1886; 10: 522–535.
- Eustermann GB, Keith NM. Transient methemoglobinemia following administration of ammonium nitrate. Med Clin North Am. 1929; 12: 1489–1496.
Cited by
Sorted by citations
Graves, D. B. (2012) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/45/26/263001 · Cited by 1,534
Food sources of nitrates and nitrites: The physiologic context for potential health benefits
Hord, N. G., Tang, Y., & Bryan, N. S. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27131 · Cited by 1,069
Hofmeister Phenomena: An Update on Ion Specificity in Biology
Nostro, P. L., & Ninham, B. W. (2012) · Chemical Reviews · doi:10.1021/cr200271j · Cited by 1,026
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
Lee, R. J., Xiong, G., Kofonow, J. M., Chen, B., Lysenko, A., Jiang, P., Abraham, V., Doghramji, L. J., Adappa, N. D., Palmer, J. N., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64240 · Cited by 542
Experimental evidence for the functional relevance of anion–π interactions
Dawson, R. E., Hennig, A., Weimann, D. P., Emery, D., Ravikumar, V., Montenegro, J., Takeuchi, T., Gabutti, S., Mayor, M., Mareda, J., et al. (2010) · Nature Chemistry · doi:10.1038/nchem.657 · Cited by 476
Metadata
- Authors
- Butler, A. R., & Feelisch, M.
- Affiliations
- University of St Andrews (GB)
- ORCID
- Feelisch, Martin
- Venue
- Circulation
- Published
- 2008-04-22
- Volume
- 117
- Issue
- 16
- Pages
- 2151-2159
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2026713650
- Cited by
- 184
- References
- 96
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 12 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 6 · 2017: 10 · 2016: 13 · 2015: 18 · 2014: 17 · 2013: 10 · 2012: 15
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- inorganic nitrite, inorganic nitrate, therapeutic applications, heme proteins, ischemia-reperfusion injury, blue baby syndrome, nitrite toxicity, fertilizer overuse
- MeSH terms
- Cardiovascular Diseases, Humans, Nitrates, Nitrites, History, 15th Century, History, 16th Century, History, 17th Century, History, 18th Century, History, 19th Century, History, 20th Century, History, Ancient, History, Medieval
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
