The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Fibroblast Growth Factor-23 and Incident Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis (MESA) and the Cardiovascular Health Study (CHS)
Open accessAbstract
Background—: Fibroblast growth factor-23 (FGF-23) is a hormone that promotes urinary phosphate excretion and regulates vitamin D metabolism. Circulating FGF-23 concentrations increase markedly in chronic kidney disease and are associated with increased risk of clinical cardiovascular events. FGF-23 may promote atrial fibrillation (AF) by inducing left ventricular hypertrophy and diastolic and left atrial dysfunction. Methods and Results—: We tested the associations of circulating FGF-23 concentration with incident AF among 6398 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) and 1350 participants in the Cardiovascular Health Study (CHS), all free of clinical cardiovascular disease at baseline. Over a median of 7.7 and 8.0 years of follow-up, we observed 291 and 229 incident AF events in MESA and CHS, respectively. In multivariable Cox proportional hazards models, each 2-fold-higher FGF-23 concentration was associated with a 41% higher risk of incident AF in MESA (hazard ratio, 1.41; 95% confidence interval, 1.13–1.76; P =0.003) and a 30% higher risk of incident AF in CHS (hazard ratio, 1.30; 95% confidence interval, 1.05–1.61; P =0.016) after adjustment for potential confounding characteristics, including kidney disease. Serum phosphate concentration was significantly associated with incident AF in MESA (hazard ratio, 1.15 per 0.5 mg/dL; 95% confidence interval, 1.02–1.31; P =0.023) but not CHS. In MESA, an association of low estimated glomerular filtration rate with incident AF was partially attenuated by adjustment for FGF-23. Conclusion—: Higher circulating FGF-23 concentration is associated with incident AF and may, in part, explain the link between chronic kidney disease and AF.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The link between female sex and stroke might vary across populations and age groups.75–84”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [84]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multiple Imputation for Nonresponse in Surveys
Rubin, D. B. (1987) · Wiley Series in Probability and Statistics · doi:10.1002/9780470316696 · Cited by 20,701
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782
Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318
Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Devereux, R. B., Alonso, D. R., Lutas, E. M., Gottlieb, G. J., Campo, E., Sachs, I., & Reichek, N. (1986) · The American Journal of Cardiology · doi:10.1016/0002-9149(86)90771-x · Cited by 6,226
Go, A. S., Hylek, E. M., Phillips, K. A., Chang, Y., Henault, L. E., Selby, J. V., & Singer, D. E. (2001) · JAMA · doi:10.1001/jama.285.18.2370 · Cited by 6,205
Estimating glomerular filtration rate from serum creatinine and cystatin C
Inker, L. A., Schmid, C. H., Tighiouart, H., Eckfeldt, J. H., Feldman, H. I., Greene, T., Kusek, J. W., Manzi, J., Van Lente, F., Zhang, Y. L., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1114248 · Cited by 4,102
Multi-Ethnic Study of Atherosclerosis: Objectives and Design
Bild, D. E. (2002) · American Journal of Epidemiology · doi:10.1093/aje/kwf113 · Cited by 3,942
The Cardiovascular Health Study: design and rationale.
Fried, L. P., Borhani, N. O., Enright, P., Furberg, C. D., Gardin, J. M., Kronmal, R. A., Kuller, L. H., Manolio, T. A., Mittelmark, M. B., Newman, A., et al. (1991) · Annals of Epidemiology · doi:10.1016/1047-2797(91)90005-w · Cited by 3,652
FGF23 induces left ventricular hypertrophy
Faul, C., Amaral, A. P., Oskouei, B., Hu, M.-C., Sloan, A., Isakova, T., Gutiérrez, O. M., Aguillon-Prada, R., Lincoln, J., Hare, J. M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46122 · Cited by 2,027
Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study
Heeringa, J., van der Kuip, D. A. M., Hofman, A., Kors, J. A., van Herpen, G., Stricker, B. H. C., Stijnen, T., Lip, G. Y. H., & Witteman, J. C. M. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi825 · Cited by 1,939
Inflammation as a risk factor for atrial fibrillation
Aviles, R. J., Martin, D. O., Apperson-Hansen, C., Houghtaling, P. L., Rautaharju, P., Kronmal, R. A., Tracy, R. P., Van Wagoner, D. R., Psaty, B. M., Lauer, M. S., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103131.70301.4f · Cited by 1,425
Cystatin C and the Risk of Death and Cardiovascular Events among Elderly Persons
Shlipak, M. G., Sarnak, M. J., Katz, R., Fried, L. F., Seliger, S. L., Newman, A. B., Siscovick, D. S., & Stehman‐Breen, C. O. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043161 · Cited by 1,241
Self-citationAbhayaratna, W. P., Seward, J. B., Appleton, C. P., Douglas, P. S., Oh, J. K., Tajik, A. J., & Tsang, T. S. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.02.048 · Cited by 1,075
Schnabel, R. B., SULLIVAN, L. M., Levy, D. A., Pencina, M. J., Massaro, J. M., D’Agostino, R. B., Newton‐Cheh, C., Yamamoto, J. F., Magnani, J. W., Tadros, T. M., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60443-8 · Cited by 1,038
Gutiérrez, O. M., Isakova, T., Rhee, E. P., Shah, A., Holmes, J., Collerone, G., Diaeresis]ppner, H. J., & Wolf, M. S. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005010052 · Cited by 920
Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease
Gutiérrez, O. M., Januzzi, J. L., Isakova, T., Laliberte, K. A., Smith, K., Collerone, G., Sarwar, A., Hoffmann, U., Coglianese, E. E., Christenson, R. H., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.844506 · Cited by 843
The Relationship of Left Ventricular Mass and Geometry to Incident Cardiovascular Events
Bluemke, D. A., Kronmal, R. A., Lima, J. A. C., Liu, K., Olson, J., Burke, G. L., & Folsom, A. R. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.09.014 · Cited by 813
Kim, M. H., Johnston, S. S., Chu, B. C., Dalal, M. R., & Schulman, K. L. (2011) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.110.958165 · Cited by 798
Larsson, T., Nisbeth, U. L. F., Ljunggren, Ö., Jüppner, H., & Jonsson, K. B. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00328.x · Cited by 689
Cost of an emerging epidemic: an economic analysis of atrial fibrillation in the UK
Stewart, S., Murphy, N., Walker, A., McGuire, A., & McMurray, J. J. V. (2004) · Heart · doi:10.1136/hrt.2002.008748 · Cited by 590
Vitamin D Therapy and Cardiac Structure and Function in Patients With Chronic Kidney Disease
Thadhani, R., Appelbaum, E. A., Pritchett, Y., Chang, Y., Wenger, J., Tamez, H. E., Bhan, I., Agarwal, R., Zoccali, C., Wanner, C., et al. (2012) · JAMA · doi:10.1001/jama.2012.120 · Cited by 572
Is atrial fibrillation an inflammatory disorder?
Boos, C. J., Anderson, R. A., & Lip, G. Y. H. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi645 · Cited by 552
Chronic Kidney Disease Is Associated With the Incidence of Atrial Fibrillation
Alonso, Á., Norby, F. L., Matsushita, K., Loehr, L. R., Agarwal, S. K., Chen, L. Y., Soliman, E. Z., Astor, B. C., & Coresh, J. (2011) · Circulation · doi:10.1161/circulationaha.111.020982 · Cited by 549
Role of Inflammation in Initiation and Perpetuation of Atrial Fibrillation
Issac, T. T., Dokainish, H., & Lakkis, N. M. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.06.054 · Cited by 525
Wattigney, W. A., Mensah, G. A., & Croft, J. B. (2003) · Circulation · doi:10.1161/01.cir.0000083722.42033.0a · Cited by 505
Parker, B. D., Schurgers, L. J., Brandenburg, V. M., Christenson, R. H., Vermeer, C., Ketteler, M., Shlipak, M. G., Whooley, M. A., & Ix, J. H. (2010) · Annals of Internal Medicine · doi:10.7326/0003-4819-152-10-201005180-00004 · Cited by 463
Self-citationFGF-23 Associates with Death, Cardiovascular Events, and Initiation of Chronic Dialysis
Kendrick, J., Cheung, A. K., Kaufman, J. S., Greene, T., Roberts, W. L., Smits, G., & Chonchol, M. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010121224 · Cited by 452
Self-citationPokushalov, E. A., Romanov, A. B., CORBUCCI, G., Николаевич, А. С., Викторовна, Б. В., Туров, А. Н., Shirokova, N., Karaskov, A. M., Mittal, S., & Steinberg, J. S. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.05.036 · Cited by 437
Circulating fibroblast growth factor-23 is associated with vascular dysfunction in the community
Mirza, M. A. I., Larsson, A. O., Lind, L., & Larsson, T. E. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.01.001 · Cited by 389
Ix, J. H., Katz, R., Kestenbaum, B. R., de Boer, I. H., Chonchol, M., Mukamal, K. J., Rifkin, D. E., Siscovick, D. S., Sarnak, M. J., & Shlipak, M. G. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.03.040 · Cited by 326
Self-citationShigematsu, T., Kazama, J. J., Yamashita, T., Fukumoto, S., Hosoya, T., Gejyo, F., & Fukagawa, M. (2004) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2004.04.029 · Cited by 325
Rising Rates of Hospital Admissions for Atrial Fibrillation
Friberg, J., Buch, P., Scharling, H., Gadsbøll, N., & Jensen, G. B. (2003) · Epidemiology · doi:10.1097/01.ede.0000091649.26364.c0 · Cited by 284
Bansal, N., Fan, D., Hsu, C., Ordoñez, J. D., Marcus, G. M., & Go, A. S. (2012) · Circulation · doi:10.1161/circulationaha.112.123992 · Cited by 259
on behalf of the European Uremic Toxin (EUTox) Work Group, Desjardins, L., Liabeuf, S., Renard, C., Lenglet, A., Lemke, H., Choukroun, G. J., Drüeke, T. B., & Massy, Z. A. (2011) · Osteoporosis International · doi:10.1007/s00198-011-1838-0 · Cited by 219
Gardin, J. M., Wong, N. D., Bommer, W. J., Klopfenstein, H. S., Smith, V. E., Tabatznik, B., Siscovick, D. S., Lobodzinski, S. M., Anton‐Culver, H., & Manolio, T. A. (1992) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(14)80105-3 · Cited by 211
Self-citationLow Serum Magnesium and the Development of Atrial Fibrillation in the Community
Khan, A. M., Lubitz, S. A., SULLIVAN, L. M., Sun, F. X., Levy, D. A., Vasan, R. S., Magnani, J. W., Ellinor, P. T., Benjamin, E. J., & Wang, T. J. (2012) · Circulation · doi:10.1161/circulationaha.111.082511 · Cited by 208
Seiler, S., Reichart, B., Roth, D., Seibert, E., Fliser, D., & Heine, G. H. (2010) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfq309 · Cited by 204
Diastolic Dysfunction and Risk of Atrial Fibrillation
Rosenberg, M. A., & Manning, W. J. (2012) · Circulation · doi:10.1161/circulationaha.112.113233 · Cited by 202
FGF-23 and vascular dysfunction in patients with stage 3 and 4 chronic kidney disease
Yılmaz, M. İ., Sönmez, A., Sağlam, M., Yaman, H., Kılıç, S., Demirkaya, E., Eyileten, T., Çağlar, K., Oğuz, Y., Vural, A., et al. (2010) · Kidney International · doi:10.1038/ki.2010.194 · Cited by 163
Stewart, S. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2511 · Cited by 163
Fibroblast Growth Factor-23 and Cardiovascular Disease in the General Population
Kestenbaum, B. R., Sachs, M. C., Hoofnagle, A. N., Siscovick, D. S., Ix, J. H., Robinson‐Cohen, C., Lima, J. A. C., Polak, J. F., Blondon, M., RUZINSKI, J. T., et al. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000952 · Cited by 154
Self-citationSachs, M. C., Shoben, A. B., Levin, G. P., Robinson‐Cohen, C., Hoofnagle, A. N., Swords-Jenny, N., Ix, J. H., Budoff, M. J., Lutsey, P. L., Siscovick, D. S., et al. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.054502 · Cited by 153
Self-citationSeiler, S., Cremers, B., Rebling, N. M., Hornof, F., Jeken, J., Kersting, S., Steimle, C., Ege, P., Fehrenz, M., Rogacev, K. S., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr215 · Cited by 145
Association of Serum Phosphate Levels With Aortic Valve Sclerosis and Annular Calcification
Linefsky, J. P., O’Brien, K. D., Katz, R., de Boer, I. H., Barasch, E., Jenny, N. S., Siscovick, D. S., & Kestenbaum, B. R. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.11.073 · Cited by 141
Self-citationTamez, H. E., Zoccali, C., Packham, D., Wenger, J., Bhan, I., Appelbaum, E. A., Pritchett, Y., Chang, Y., Agarwal, R., Wanner, C., et al. (2012) · American Heart Journal · doi:10.1016/j.ahj.2012.09.018 · Cited by 122
Elevated FGF 23 and phosphorus are associated with coronary calcification in hemodialysis patients
Srivaths, P. R., Goldstein, S. L., Silverstein, D. M., Krishnamurthy, R., & Brewer, E. D. (2011) · Pediatric Nephrology · doi:10.1007/s00467-011-1822-0 · Cited by 88
Manghat, P., Fraser, W. D., Wierzbicki, A. S., Fogelman, I., Goldsmith, D. J. A., & Hampson, G. (2009) · Osteoporosis International · doi:10.1007/s00198-009-1142-4 · Cited by 84
Jovanovich, A. J., Ix, J. H., Gottdiener, J. S., McFann, K., Katz, R., Kestenbaum, B. R., de Boer, I. H., Sarnak, M. J., Shlipak, M. G., Mukamal, K. J., et al. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.09.002 · Cited by 83
Self-citationRenal Function After Catheter Ablation of Atrial Fibrillation
Takahashi, Y., Takahashi, A., Kuwahara, T., Okubo, K., Fujino, T., Takagi, K., Nakashima, E., Kamiishi, T., Hikita, H., Hirao, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.047266 · Cited by 79
Parathyroid hormone and arterial dysfunction in the m ulti‐ e thnic s tudy of a therosclerosis
Bosworth, C., Sachs, M. C., Duprez, D. A., Hoofnagle, A. N., Ix, J. H., Jacobs, D. R., Peralta, C. A., Siscovick, D. S., Kestenbaum, B. R., & de Boer, I. H. (2013) · Clinical Endocrinology · doi:10.1111/cen.12163 · Cited by 75
Self-citationNorby, F. L., Agarwal, S. K., Grams, M. E., Loehr, L. R., Soliman, E. Z., Lutsey, P. L., Chen, L. Y., Huxley, R., & Alonso, Á. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.11.045 · Cited by 41
A Bias-Corrected Net Reclassification Improvement for Clinical Subgroups
Paynter, N. P., & Cook, N. R. (2012) · Medical Decision Making · doi:10.1177/0272989x12461856 · Cited by 39
Elevation of Parathyroid Hormone Levels in Atrial Fibrillation
Rienstra, M., Lubitz, S. A., Zhang, M. L., Cooper, R. R., & Ellinor, P. T. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.01.041 · Cited by 24
Flagged first, then by citations
Cited by
Sorted by citations
Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis
Ko, D., Rahman, F., Schnabel, R. B., Yin, X., Benjamin, E. J., & Christophersen, I. E. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.45 · Cited by 353
Roles of FGF Signals in Heart Development, Health, and Disease
Itoh, N., Ohta, H., Nakayama, Y., & Konishi, M. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00110 · Cited by 152
Role of Vitamin D in Cardiovascular Diseases
Rai, V., & Agrawal, D. K. (2017) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.07.009 · Cited by 147
FGF23 and klotho at the intersection of kidney and cardiovascular disease
Edmonston, D. L., Grabner, A., & Wolf, M. S. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00903-0 · Cited by 147
Chua, W., Purmah, Y., Cardoso, V. R., Gkoutos, G. V., Tull, S. P., Neculau, G., Thomas, M. R., Kotecha, D., Lip, G. Y. H., Kirchhof, P. F., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy815 · Cited by 140
Metadata
- Authors
- Mathew, J. S., Sachs, M. C., Katz, R., Patton, K. K., Heckbert, S. R., Hoofnagle, A. N., Alonso, A., Chonchol, M., Deo, R., Ix, J. H., Siscovick, D. S., Kestenbaum, B., & de Boer, I. H.
- Affiliations
- University of Minnesota (US)
- From the Division of Cardiology (J.S.M., K.K.P.), Division of Nephrology and Kidney Research Institute (J.S.M., M.C.S., R.K., B.K., I.H.d.B.), Cardiovascular Health Research Unit, Departments of Medicine and Epidemiology (S.R.H., D.S.S.), Department of Epidemiology (S.R.H., B.K., I.H.d.B.), and Department of Laboratory Medicine (A.N.H.), University of Washington, Seattle; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis (A.A.); Division of...
- ORCID
- Venue
- Circulation
- Published
- 2014-07-22
- Volume
- 130
- Issue
- 4
- Pages
- 298-307
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- PMC
- PMC4108550
- OpenAlex
- W2114238925
- Cited by
- 153
- References
- 54
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 8 · 2023: 11 · 2022: 16 · 2021: 18 · 2020: 11 · 2019: 7 · 2018: 18 · 2017: 12 · 2016: 19 · 2015: 12 · 2014: 5
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc085082-026, n01hc085081-021, n01hc085079-024, n01hc085083-027, n01hc085080-026, n01hc095169-003, n01hc085086-022, n01hc55222-0-0-0, n01hc95159-40-0-1)
- National Institute on Aging (R56AG023629, AG023629, R01AG023629)
- National Heart, Lung, and Blood Institute (N01 HC085086, R01HL096875, N01-HC095169, N01 HC085079, N01 HC085083, N01 HC085080, N01-HC-095159, R01HL102214, N01HC085082, N01 HC055222, N01 HC085081, R01HL080295)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK035816)
- National Center for Research Resources (UL1RR024156, UL1RR025005)
- Topics
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- fibroblast growth factor 23, atrial fibrillation, chronic kidney disease, serum phosphorus, vitamin D metabolism, left atrial dysfunction, left ventricular hypertrophy, estimated glomerular filtration rate, cardiovascular risk factors
- MeSH terms
- Fibroblast Growth Factor-23, Aged, Aged, 80 and over, Atrial Fibrillation, Ethnicity, Female, Follow-Up Studies, Glomerular Filtration Rate, Heart Failure, Humans, Male, Middle Aged, Phosphates, Risk Factors, United States, Vitamin D, Comorbidity, Proportional Hazards Models, Hypertrophy, Left Ventricular, Ventricular Dysfunction, Left, Ventricular Remodeling, Renal Insufficiency, Chronic, Fibroblast Growth Factor 3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
