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Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe −/− Mice
Abstract
Background—: Altered composition of the gut microbiota is involved in both the onset and progression of obesity and diabetes mellitus. However, the link between gut microbiota and obesity-related cardiovascular complications has not been explored. The present study was designed to investigate the role of Akkermansia muciniphila , a mucin-degrading bacterium with beneficial effects on metabolism, in the pathogenesis of atherosclerosis in apolipoprotein E–deficient ( Apoe −/− ) mice. Methods and Results—: Apoe −/− mice on normal chow diet or a Western diet were treated with A muciniphila by daily oral gavage for 8 weeks, followed by histological evaluations of atherosclerotic lesion in aorta. Real-time polymerase chain reaction analysis demonstrated that the fecal abundance of A muciniphila was significantly reduced by Western diet. Replenishment with A muciniphila reversed Western diet–induced exacerbation of atherosclerotic lesion formation without affecting hypercholesterolemia. A muciniphila prevented Western diet–induced inflammation in both the circulation and local atherosclerotic lesion, as evidenced by reduced macrophage infiltration and expression of proinflammatory cytokines and chemokines. These changes were accompanied by a marked attenuation in metabolic endotoxemia. A muciniphila –mediated reduction in circulating endotoxin level could be attributed to the induction of intestinal expression of the tight junction proteins (zona occuldens protein-1 and occludin), thereby reversing Western diet–induced increases in gut permeability. Long-term infusion of endotoxin to Apoe −/− mice reversed the protective effect of A muciniphila against atherosclerosis. Conclusion—: A muciniphila attenuates atherosclerotic lesions by ameliorating metabolic endotoxemia-induced inflammation through restoration of the gut barrier.
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TL;DR
In Apoe−/− mice, Western diet reduced gut *Akkermansia muciniphila* and exacerbated atherosclerosis; daily oral live *A. muciniphila* reduced lesion area and size by 31% and 48%, respectively, without changing hypercholesterolemia. The protection was linked to restored gut barrier, lower endotoxemia, and reduced local/systemic inflammation, and was reversed by long-term lipopolysaccharide infusion.
Key findings
- Western diet reduced fecal *A. muciniphila*; live *A. muciniphila* (5×10⁹ cfu daily) reduced Western diet-induced lesion area by 31% and lesion size by 48%, whereas heat-killed bacteria had no effect.
- *A. muciniphila* reduced macrophage infiltration and expression of ICAM-1, MCP-1, F4/80, and TNFα in lesions/aorta, and lowered circulating MCP-1, IL-1β, and sTNFR II; it did not affect adiponectin.
- *A. muciniphila* lowered lipopolysaccharide levels in mesenteric adipose tissue and serum, reduced gut permeability, increased ileal occludin and ZO-1, and partially restored inner mucin layer thickness.
- Long-term lipopolysaccharide infusion (250 µg/kg/day) restored serum lipopolysaccharide and reversed *A. muciniphila*’s protection against lesion area/size and inflammation.
Methods
- Eight-week-old male Apoe−/− mice were fed normal chow or Western diet for 8 weeks; Western diet groups received daily oral gavage of live *A. muciniphila* (5×10⁹ cfu in 200 µL PBS), heat-killed *A. muciniphila*, or PBS. A separate group received lipopolysaccharide via osmotic pumps at 250 µg/kg/day for the last 4 weeks.
- Lesion area/size were assessed by Oil Red O and hematoxylin and eosin staining with ImageJ; inflammation by immunofluorescence/immunohistochemistry and real-time PCR; gut permeability by FITC-dextran; lipopolysaccharide by LAL assay; Caco-2 cell experiments and denaturing gradient gel electrophoresis were also used.
- Sample sizes were n=8–10 for main groups and n=5–7 for lipopolysaccharide infusion groups; statistics used one-way ANOVA with Tukey or Games-Howell post hoc tests, Kruskal-Wallis, or unpaired t tests.
Limitations
- Stated: how gut-residing *A. muciniphila* increases tight junction protein expression remains to be determined.
- Evident: all experiments are in male Apoe−/− mice; no human clinical outcomes or human atherosclerosis endpoints are reported.
- Evident: the study tests one bacterial species under specific diets, with modest sample sizes (n=5–10 per group), and some mechanistic data are in online-only supplements.
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In the paper
“These changes were accompanied by a marked attenuation in metabolic endotoxemia.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
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In the paper
“muciniphila did not have a significant effect on either macrophage accumulation or expression of MCP-1, ICAM-1 and TNFα in the local aortic tissues (Figure 2A-2D and 3A-3D).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Ameliorated Both Aortic and Systemic Inflammation in Western Diet-Fed Apoe -/-Mice
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In the paper
“Our results showed that Western diet-induced aggravation of atherosclerotic lesion was accompanied by a marked reduction of A muciniphila”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Lipopolysaccharide infusion also augmented the number of infiltrated macrophages and the expression of the inflammatory molecules MCP-1 and ICAM-1 in the atherosclerotic lesions of mice treated with A muciniphila (Figure 6A-6C).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Chronic Infusion of Lipopolysaccharide Abolished the Protective Effect of A muciniphila Against Western Diet-Induced Atherosclerosis in Apoe -/-Mice
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In the paper
“whereas restoration of A muciniphila by daily oral gavage substantially reduced atherosclerotic lesions in Apoe -/-mice.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
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In the paper
“However, treatment with propionate or butyrate in Caco-2 cells failed to increase the expression of either occludin or ZO-1 (Figure IVC and IVD in the online-only Data Supplement).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Decreased Intestinal Permeability and Reduced the Penetration of Gut-Derived Lipopolysaccharide Into Circulation in Western Diet-Fed Apoe -/-Mice
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“the fecal amounts of this bacteria were comparable between wild-type and Apoe -/-mice fed a normal chow diet (7.31±0.51versus 7.04±0.69log10 bacteria/g feces in wild-type versus Apoe -/-)”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Oral Gavage With A muciniphila Protected Against Western Diet-Induced Atherosclerotic Lesion Formation in Apoe -/-Mice
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In the paper
“Notably, this increased level of lipopolysaccharide was able to reverse the protective effect of A muciniphila treatment against atherosclerosis, as demonstrated by increased lesion area (Figure 5B and 5D) and size (Figure 5C and 5E) in Apoe -/-mice compared with the A muciniphila-treated mice without infusion of lipopolysaccharide.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Chronic Infusion of Lipopolysaccharide Abolished the Protective Effect of A muciniphila Against Western Diet-Induced Atherosclerosis in Apoe -/-Mice
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In the paper
“Likewise, treatment with A muciniphila inhibited the Western diet-induced protein expression of ICAM-1 and MCP-1”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Ameliorated Both Aortic and Systemic Inflammation in Western Diet-Fed Apoe -/-Mice
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Treatment with the inoculating medium of A muciniphila culture (100 μL/mL) in Caco-2 cells, a human intestine epithelial cell line, significantly upregulated the expression of occludin and ZO-1 compared with those treated with the plain inoculating medium.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Decreased Intestinal Permeability and Reduced the Penetration of Gut-Derived Lipopolysaccharide Into Circulation in Western Diet-Fed Apoe -/-Mice
plaindirect- Asserted: passes — The authors put it forward as true.
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- It may state two separate claims as one. 36
- Probably not a substantial claim. 32
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Western diet-fed Apoe -/-mice showed a significant decrease in the inner mucin layer thickness of ileum, and A muciniphila treatment partially restored the thickness of this layer (Figure III in the online-only Data Supplement).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Decreased Intestinal Permeability and Reduced the Penetration of Gut-Derived Lipopolysaccharide Into Circulation in Western Diet-Fed Apoe -/-Mice
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“However, the daily oral gavage with A muciniphila did not affect the overall pattern of gut microbiota and abundance of the above-mentioned bacterial species (Figure IA-IF in the online-only Data Supplement).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Oral Gavage With A muciniphila Protected Against Western Diet-Induced Atherosclerotic Lesion Formation in Apoe -/-Mice
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“the expression of the epithelial tight junction protein occludin was significantly reduced by Western diet feeding but was upregulated by treatment with live A muciniphila (Figure 4B, 4D, and 4F).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Decreased Intestinal Permeability and Reduced the Penetration of Gut-Derived Lipopolysaccharide Into Circulation in Western Diet-Fed Apoe -/-Mice
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“This pattern change was characterized by increased amounts of Proteobacteria and Firmicutes and a decreased quantity of Bacteroidetes, Fusobacteria, and Tenericutes (Figure IB-IF in the online-only Data Supplement)”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Oral Gavage With A muciniphila Protected Against Western Diet-Induced Atherosclerotic Lesion Formation in Apoe -/-Mice
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“In our atherogenic Apoe -/-model, there was no obvious change in food intake after A muciniphila treatment (Figure IG in the online-only Data Supplement), although there was a slight decrease in body weight and fat mass (Figure IH-IJ in the online-only Data Supplement).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Treatment With A muciniphila Did Not Alter Lipid Metabolism in Apoe -/-Mice
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The serum levels of these 2 proinflammatory factors were significantly increased in Western diet-fed Apoe -/- mice compared with the mice on normal chow diet, whereas these Western diet-induced elevations were obviously diminished by daily oral gavage with A muciniphila but not the heat-killed bacteria (Figure 3E and 3F).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Ameliorated Both Aortic and Systemic Inflammation in Western Diet-Fed Apoe -/-Mice
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“The Western diet resulted in a 3.7fold increase in lesion area and a 2.9-fold increase in lesion size in Apoe -/-mice compared with normal chow diet (Figure 1D and 1E).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Oral Gavage With A muciniphila Protected Against Western Diet-Induced Atherosclerotic Lesion Formation in Apoe -/-Mice
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Treatment with A muciniphila substantially reduced the lesion area and size by 31% and 48%, respectively, in Apoe -/-mice fed a Western diet (Figure 1D and 1E).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Oral Gavage With A muciniphila Protected Against Western Diet-Induced Atherosclerotic Lesion Formation in Apoe -/-Mice
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“A muciniphila prevented Western diet-induced inflammation in both the circulation and local atherosclerotic lesion, as evidenced by reduced macrophage infiltration and expression of proinflammatory cytokines and chemokines.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“The in vivo gut permeability, as determined by oral administration of fluorescent labeled dextran (DX-4000-FITC) followed by measurement of its circulating concentration, was significantly higher in Western diet-fed Apoe -/-mice compared with the normal chow dietfed controls, whereas the Western diet-induced increase of gut permeability was largely blocked by the treatment with live A muciniphila”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Decreased Intestinal Permeability and Reduced the Penetration of Gut-Derived Lipopolysaccharide Into Circulation in Western Diet-Fed Apoe -/-Mice
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“In Apoe -/-mice on normal chow diet, treatment with A muciniphila has no obvious effect on gut permeability (Figure VA in the online-only Data Supplement), circulating levels of inflammatory markers (MCP-1, IL-1β, and sTNFR II; Figure VB-VD in the online-only Data Supplement), and atherosclerotic plaque formation (Figure VE and VF in the online-only Data Supplement)”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Decreased Intestinal Permeability and Reduced the Penetration of Gut-Derived Lipopolysaccharide Into Circulation in Western Diet-Fed Apoe -/-Mice
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“The number of macrophages in atherosclerotic lesions increased after Western diet feeding, and daily oral gavage with A muciniphila significantly reduced the amount, as shown by immunofluorescent staining of the macrophage marker monocytes/macrophages antigen (Figure 2A and 2D).”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Ameliorated Both Aortic and Systemic Inflammation in Western Diet-Fed Apoe -/-Mice
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In the paper
“Replenishment with A muciniphila reversed Western diet-induced exacerbation of atherosclerotic lesion formation without affecting hypercholesterolemia.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
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In the paper
“In contrast, A muciniphila had no effect on the Western diet-induced hypercholesterolemia and alterations in other metabolic profiles”
- Also stated in: § CLINICAL PERSPECTIVE · plain
“the daily oral gavage with A muciniphila did not alter serum levels of total cholesterol, total triglyceride, low-density lipoprotein, and high-density lipoprotein”
- Also stated in: § CLINICAL PERSPECTIVE · plain
“A muciniphila treatment did not significantly affect fasting blood glucose level or glucose tolerance in Apoe -/-mice”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
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In the paper
“The present study demonstrates that the Western diet-induced deterioration of atherosclerosis in Apoe -/-mice is associated with an increased level of Firmicutes, a decreased amount of Bacteroidetes, and especially a marked reduction in A muciniphila in the gut.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
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In the paper
“treatment with A muciniphila substantially reduced the expression of several chemokines and the adhesion molecules MCP-1, TNFα, and ICAM-1, along with lower aortic infiltration of macrophages and diminished atherosclerotic lesion in Apoe -/-mice.”
- Also stated in: § CLINICAL PERSPECTIVE · plain
“Local inflammation in aortic arch was reduced in Apoe -/-mice after oral gavage with Akkermansia muciniphila.”
- Also stated in: § CLINICAL PERSPECTIVE · plain
“Apoe -/-mice treated with Akkermansia muciniphila showed amelioration in both aortic expression and systemic levels of inflammatory molecules.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
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In the paper
“Bacterial DNA has been detected in atherosclerotic lesions, and the pyrosequencing result reveals that the bacteria in lesions are derived from gut and oral cavity, 13”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
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- Not checked yetcites [13] source
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In the paper
“supplementation with one of the species in this phylum, Faecalibacterium prausnitzii, improves the survival rate of chemical-induced colitis in animals.5”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [5] source
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In the paper
“Chlamydia pneumonia is present in atherosclerotic lesions of patients with previous exposure, and infection with this bacterium exacerbates atherosclerosis in animals.11,12”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [11]
- Not checked yetcites [12]
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In the paper
“supplementation with butyric acid improves the metabolic profiles in a dietary obese murine model.8”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [8]
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“higher proportions of Firmicutes and lower levels of Bacteroidetes have been observed in obese individuals, and dietary intervention or bariatric surgery reverses these changes.6”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [6] source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“A lower proportion of butyrate-producing bacteria have been found in individuals with autoimmune diabetes mellitus compared with healthy control subjects, 7”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [7]
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Bacterial infection has been proposed as one of the triggers of inflammation in atherosclerosis.11,12”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [11]
- Not checked yetcites [12]
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“decreased diversity within the phylum of Firmicutes in the gut microbiota is commonly found in patients with Crohn disease, 4”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [4]
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Altered composition and function of gut microbiota have been linked to a number of chronic diseases, including colon cancer, irritated bowel syndrome, colitis, obesity, and diabetes mellitus.3”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [3] source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Atherosclerosis, the main contributor to cardiovascular mortality, is a chronic inflammatory disease.10”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [10] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“A smaller amount of A muciniphila in the gut has been observed in obese children and pregnant women.22,23”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [22] source
- Not checked yetcites [23]
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“It accounts for ≈1% to 3% of the microbial community in healthy subjects, and its abundance is inversely correlated with body weight in mice and humans.20,21”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Akkermansia muciniphila, a mucin-degrading bacterium belonging to the generum of Verrucomicrobia, has recently emerged as an important component of the gut microbial ecosystem.19”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
What the sources say
- Not checked yetcites [19]
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“In mice fed a high-fat diet, A muciniphila given by daily oral gavage reverses fat mass gain, adipose tissue inflammation, and insulin resistance, 21,24”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“a metabolomics analysis shows that metabolism of dietary phosphatidylcholine by gut microbiota produces proatherogenic trimethylamine-N-oxide, which can accelerate atherosclerosis in mice.17,18”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“suggesting that the amount of intestinal A muciniphila under normal diet is sufficient to maintain the integrity of the gut barrier, thereby preventing endotoxinemiainduced systemic inflammation and atherosclerosis.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Decreased Intestinal Permeability and Reduced the Penetration of Gut-Derived Lipopolysaccharide Into Circulation in Western Diet-Fed Apoe -/-Mice
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Gut permeability is regulated by the mucus layer and tight junctions of the intestine.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“suggesting that A muciniphila blocked lipopolysaccharide penetration by preserving the gut barrier.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > A muciniphila Decreased Intestinal Permeability and Reduced the Penetration of Gut-Derived Lipopolysaccharide Into Circulation in Western Diet-Fed Apoe -/-Mice
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Gut permeability is regulated by the mucus layer and tight junctions of the intestine.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“All the animal experiments were approved by the Committee on the Use of Live Animals for Teaching and Research of the University of Hong Kong.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Animal Model
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Metabolic endotoxemia, defined as a 2-to 3-fold elevation of the circulating endotoxin/lipopolysaccharide level, has been proposed as an initiating factor of obesity-related cardiometabolic dysfunction.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [9] source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Bacterial DNA from the gut microbiota has been detected in human atherosclerotic plaques.13”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [13] source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Inflammation and hypercholesterolemia are the 2 key etiological factors for atherosclerosis.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Data are presented as mean±SEM; n=5 to 7.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
plainn = 5- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“the primary control of the gut barrier relies on an intact epithelium where tight junctions sealing the space between individual epithelial cells maintain the epithelial integrity.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [50]
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Loss of occludin leads to an increase in gut permeability, whereas deficiency of ZO-1 can interrupt the assembly of tight junction by inhibiting the recruitment of other components.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [50]
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“Notably, supplementation with prebiotics causes a >100-fold enrichment in gut A muciniphila.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [21] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Our findings raise the possibility of targeting individual species of the gut microbiota for the treatment of atherosclerosis.”
- Also stated in: § Discussion · hedged
“suggesting that therapeutic interventions targeting this single genus/species in gut microbiota may represent a promising strategy for the treatment and prevention of both metabolic and cardiovascular disorders.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Data availability
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence.
- Also stated in: § Discussion · hedged
None of the sources cited for this claim have been checked yet.
In the paper
“Several recent studies have identified trimethylamine N-oxide, a metabolite of the gut microbiota, as an independent risk factor for cardiovascular disease.17,18,34”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“indicating that the antiatherogenic effect of A muciniphila is mediated by limiting the lipopolysaccharide level in the bloodstream and ameliorating metabolic endotoxemia.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Toll-like receptor 4 is expressed in various vascular cells, including endothelial cells, focal leukocytes, and macrophages.
- Rests on an assumption: Activation of Toll-like receptor 4 by lipopolysaccharide stimulates release of proinflammatory molecules from vascular cells and inhibits cholesterol efflux from macrophages, facilitating foam cell formation.
- Rests on an assumption: Lipopolysaccharide-induced inflammatory cytokines in perivascular adipose tissue can act in a paracrine manner to exacerbate vascular inflammation and atherosclerosis.
None of the sources cited for this claim have been checked yet.
In the paper
“A clinical study revealed that subclinical endotoxemia is a strong risk factor for carotid atherosclerosis and that weekly injection of lipopolysaccharide worsens the formation of atherosclerosis in animal models.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [41] source
- Not checked yetcites [42]
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The Western diet-induced atherosclerosis is caused partly by a reduction of A muciniphila in gut, resulting in compromised gut barrier and increased endotoxemia, which in turn exacerbate vascular inflammation.”
- Also stated in: § CLINICAL PERSPECTIVE · plain
“The antiatherogenic effect of A muciniphila was attributed to its ability to reduce aortic and systemic inflammation by protecting the integrity of gut barrier, thereby leading to alleviation of endotoxemia.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Data availability
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Rests on an assumption: Toll-like receptor 4 is expressed in various vascular cells, including endothelial cells, focal leukocytes, and macrophages.
- Rests on an assumption: Activation of Toll-like receptor 4 by lipopolysaccharide stimulates release of proinflammatory molecules from vascular cells and inhibits cholesterol efflux from macrophages, facilitating foam cell formation.
- Rests on an assumption: Lipopolysaccharide-induced inflammatory cytokines in perivascular adipose tissue can act in a paracrine manner to exacerbate vascular inflammation and atherosclerosis.
- Rests on an assumption: Whether altered gut microbiota contributes to the pathogenesis of atherosclerosis remains unknown.
- Rests on an assumption: Hypercholesterolemia and chronic inflammation are the 2 important risk factors for atherosclerosis, which is a major cause of fatal cardiovascular complications.
- Rests on an assumption: Although cholesterol-lowering drugs can effectively reduce the incidence of atherosclerosis, anti-inflammatory therapies against this disease have had limited success, partly because of the lack of understanding of etiological factors that trigger vascular inflammation.
- Rests on an assumption: Previous clinical studies have reported a close association of bacterial infection and endotoxemia with cardiovascular diseases.
- Also stated in: § CLINICAL PERSPECTIVE · plain
In the paper
“lower diversity and abundance of gut microbiota is associated with certain diseases.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [35]
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“Notably, all these models showed a reduction of lesion area and lesional lipid content without any significant alteration of plasma cholesterol levels, which is similar to our findings of A muciniphila treatment.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [46]
- Not checked yetcites [47]
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Current therapeutic options for treating or preventing atherosclerosis include mainly platelet aggregation inhibitors, statins, antihypertensives, and thrombolytic agents.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [40]
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“In obesity, inflammatory factors in adipose tissue are the major contributors to systemic inflammation.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [45]
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“A positive correlation between serum lipopolysaccharide-binding protein level and carotid intima thickness and an association of Toll-like receptor 4 polymorphisms with decreased atherosclerosis have been found in humans.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [43]
- Not checked yetcites [44]
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“In the initial stage of atherosclerosis, injured or inflamed endothelium secretes adhesion molecules and chemokines to facilitate the recruitment and transmigration of leukocytes into the intima.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [10] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“However, the risks for fatal cardiovascular complications in these patients remain high because of the unsolved inflammation.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [10] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The mucus layer is enriched with various mucins that form a hydrated gel layer covering the mucosal surface to prevent adhesion of harmful bacteria.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [49]
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Animal-based studies have reported the effectiveness of several anti-inflammatory interventions in alleviating atherosclerosis, including the CD40-TNF receptor-associated factor 6-specific blockade and IL-1 neutralization, but clinical implications of these findings remain to be confirmed.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [39] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“The unresolved inflammation stimulates the expression of macrophage scavenger receptors and promotes the uptake of modified lipoproteins forming lipid-laden macrophages, which drives the inflammatory loop for further migration and proliferation of leukocytes and smooth muscle cells in the lesion area.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [10] source
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“A prebiotics-induced hypocholesterolemic effect has been reported in animals, suggesting a possible role in combating atherosclerosis.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [36]
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Tight junction is a multiple protein complex including occludin, claudins, and ZOs.”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Discussion
What the sources say
- Not checked yetcites [50]
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
The link between gut microbiota and obesity-related cardiovascular complications has not been explored.
“However, the link between gut microbiota and obesity-related cardiovascular complications has not been explored.”
The paper relies on this without support.
Direct evidence for the causative role of altered gut microbiota (dysbiosis) in the pathogenesis of atherosclerosis is still lacking.
“However, direct evidence for the causative role of altered gut microbiota (dysbiosis) in the pathogenesis of atherosclerosis is still lacking.”
The paper relies on this without support.
The beneficial role of A. muciniphila against obesity-related cardiovascular diseases remains to be addressed.
“However, its beneficial role against obesity-related cardiovascular diseases remains to be addressed.”
The paper relies on this without support.
Gut permeability is regulated by the mucus layer and tight junctions of the intestine.
“Gut permeability is regulated by the mucus layer and tight junctions of intestine.”
The paper relies on this without support.
Toll-like receptor 4 is expressed in various vascular cells, including endothelial cells, focal leukocytes, and macrophages.
“Toll-like receptor 4 is expressed in various vascular cells, including endothelial cells, focal leukocytes, and macrophages.”
The paper relies on this without support.
Activation of Toll-like receptor 4 by lipopolysaccharide stimulates release of proinflammatory molecules from vascular cells and inhibits cholesterol efflux from macrophages, facilitating foam cell formation.
“Its activation by lipopolysaccharide not only stimulates the release of proinflammatory molecules from these cells but also inhibits cholesterol efflux from macrophages and thus facilitates foam cell formation.”
The paper relies on this without support.
Lipopolysaccharide-induced inflammatory cytokines in perivascular adipose tissue can act in a paracrine manner to exacerbate vascular inflammation and atherosclerosis.
“Furthermore, lipopolysaccharide-induced inflammatory cytokines in perivascular adipose tissue, which surrounds almost all the blood vessels, can act in a paracrine manner to exacerbate vascular inflammation and atherosclerosis.”
The paper relies on this without support.
Whether altered gut microbiota contributes to the pathogenesis of atherosclerosis remains unknown.
“However, whether altered gut microbiota contributes to the pathogenesis of atherosclerosis remains unknown.”
The paper relies on this without support.
Hypercholesterolemia and chronic inflammation are the 2 important risk factors for atherosclerosis, which is a major cause of fatal cardiovascular complications.
“Hypercholesterolemia and chronic inflammation are the 2 important risk factors for atherosclerosis, which is a major cause of fatal cardiovascular complications, including coronary heart disease and myocardial infarction.”
The paper relies on this without support.
Although cholesterol-lowering drugs can effectively reduce the incidence of atherosclerosis, anti-inflammatory therapies against this disease have had limited success, partly because of the lack of understanding of etiological factors that trigger vascular inflammation.
“Although cholesterollowering drugs can effectively reduce the incidence of atherosclerosis, anti-inflammatory therapies against this disease have had limited success, partly because of the lack of the understanding of etiological factors that trigger vascular inflammation.”
The paper relies on this without support.
Previous clinical studies have reported a close association of bacterial infection and endotoxemia with cardiovascular diseases.
“Previous clinical studies have reported a close association of bacterial infection and endotoxemia with cardiovascular diseases.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Indeed, in preclinical models, gavage of western diet–fed Apoe−/− mice with live Akkermansia muciniphila decreased intestinal permeability and lowered fecal and circulating LPS levels, which was associated with reduced aortic atherosclerosis independent of lipid metabolism28.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [28]
In the citing paper
“In another recent study, provision of Akkermansia muciniphila was associated with reduced aortic atherosclerosis in the hypercholesterolemic Apoe−/− mouse model28.”
From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [28]
In the citing paper
“Endotoxemia is known to cause systemic inflammation leading to the disruption of innate and adaptive immunity and the development of atherosclerosis.[34][35][36]”
From Bacteroides vulgatus and Bacteroides dorei Reduce Gut Microbial Lipopolysaccharide Production and Inhibit Atherosclerosis (2018) · cites this paper as [35]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated major: it would touch a result — a value a result rests on, reported and recomputed p-values on opposite sides of the significance level, two passages that conflict with no sign which is right, or a cited work retracted before this paper was published.
In the paper
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Chronic Infusion of Lipopolysaccharide Abolished the Protective Effect of A muciniphila Against Western Diet-Induced Atherosclerosis in Apoe -/-Mice
“A muciniphila was orally gavaged daily to Apoe -/-mice for a total of 8 weeks, and during the last 4 weeks, either lipopolysaccharide (250 µg/kg body weight per day) or PBS (vehicle control) was infused long term”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > CLINICAL PERSPECTIVE
“either PBS (WD+PBS) or A muciniphila was given orally to Apoe -/-mice daily for 4 weeks, followed by long-term infusion of LPS (250 μg•kg -1 •d -1 ; WD+Akk+LPS) or vehicle control (WB+Akk) for another 4 weeks.”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > Abstract
“the germ-free atherogenic mice lacking apolipoprotein E (Apoe -/ ) mice, which are without the colonization of gut microbiota, show a worsening of atherosclerotic lesions after being fed a high-cholesterol diet compared with the conventionally raised mice”
§ Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe -/-Mice > References
“14. Stepankova R, Tonar Z, Bartova J, Nedorost L, Rossman P, Poledne R, Schwarzer M, Tlaskalova-Hogenova H. Absence of microbiota (germ-free conditions) accelerates the atherosclerosis in ApoE-deficient mice fed standard low cholesterol diet.”
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis
Koeth, R. A., Wang, Z., Levison, B. S., Buffa, J. A., Org, E., Sheehy, B. T., Britt, E. B., Fu, X., Wu, Y., Li, L., et al. (2013) · Nature Medicine · doi:10.1038/nm.3145 · Cited by 4,386
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952
Cited by
Sorted by citations
Items 101–200 of 773
The Therapeutic Role of Ketogenic Diet in Neurological Disorders
Pietrzak, D., Kasperek, K., Rękawek, P., & Piątkowska‐Chmiel, I. (2022) · Nutrients · doi:10.3390/nu14091952 · Cited by 136
Li, B., Xu, X., Gan, R., Sun, Q., Meng, J.-M., Shang, A., Mao, Q., & Li, H. (2019) · Foods · doi:10.3390/foods8100440 · Cited by 116
Gholizadeh, P., Mahallei, M., Pormohammad, A., Varshochi, M., Ganbarov, K., Zeinalzadeh, E., Yousefi, B., Bastami, M., Tanomand, A., Mahmood, S. S., et al. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.11.031 · Cited by 116
Gut Microbiota and Host Metabolism: From Proof of Concept to Therapeutic Intervention
Cani, P. D., de Hase, E. M., & Hul, M. V. (2021) · Microorganisms · doi:10.3390/microorganisms9061302 · Cited by 116
Oikonomou, E. K., Leopoulou, M., Theofilis, P., Antonopoulos, A. S., Siasos, G., Latsios, G., Mystakidi, V. C., Antoniades, C. A., & Tousoulis, D. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.07.027 · Cited by 117
Association of the gut microbiota with cognitive function in midlife
Meyer, K., Lulla, A., Debroy, K., Shikany, J. M., Yaffe, K., Meirelles, O., & Launer, L. J. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.43941 · Cited by 110
Insights into SGLT2 inhibitor treatment of diabetic cardiomyopathy: focus on the mechanisms
Huang, K., Luo, X., Liao, B., Li, G., & Feng, J. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01816-5 · Cited by 117
Kasahara, K., Tanoue, T., Yamashita, T., Yodoi, K., Matsumoto, T., Emoto, T., Mizoguchi, T., Hayashi, T., Kitano, N., Sasaki, N., et al. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m072165 · Cited by 105
Wade, H., Pan, K., Duan, Q., Kaluzny, S., Pandey, E., Fatumoju, L., Saraswathi, V., Wu, R., Harris, E. N., & Su, Q. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00935-1 · Cited by 112
Moreno‐Navarrete, J. M., & Fernández‐Real, J. M. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09523-x · Cited by 108
Chang, C., Liao, Y.-C., Huang, C., Lin, C.-M., Cheung, C. H. Y., Ruan, J., Yu, W.-H., Tsai, Y.-T., Lin, I.-J., Huang, C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110016 · Cited by 108
Alharris, E. S., Mohammed, A. K., Alghetaa, H., Zhou, J., Nagarkatti, M., & Nagarkatti, P. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.805770 · Cited by 105
Sun, B., Ma, T., Li, Y., Yang, N., Li, B., Zhou, X., Guo, S., Zhang, S., Kwok, L., Sun, Z., et al. (2022) · mSystems · doi:10.1128/msystems.00100-22 · Cited by 109
“Akkermansia muciniphila improved inflammation and reduced atherosclerotic lesions by restoring the intestinal barrier in hypercholesterolemic ApoE2/2 mice (15).”
BackgroundHan, Y., Ling, Q., Wu, L. M., Wang, X., Wang, Z., Chen, J., Zheng, Z., Zhou, Z., Jia, L., Li, L., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2221485 · Cited by 109
Mechanisms linking preterm birth to onset of cardiovascular disease later in adulthood
Bavineni, M., Wassenaar, T. M., Agnihotri, K., Ussery, D. W., Lüscher, T. F., & Mehta, J. L. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz025 · Cited by 109
Akkermansia muciniphila plays critical roles in host health
Zhao, Q., Yu, J., Hao, Y., Zhou, H., Hu, Y., Zhang, C., Zheng, H., Wang, X., Zeng, F., Hu, J., et al. (2022) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2037506 · Cited by 102
“A. muciniphila also reduced atherosclerotic lesions by restoring intestinal barriers and decreasing metabolic endotoxin-induced inflammation in apolipoprotein E-deficient (ApoE / ) mice (Li et al. 2016).”
BackgroundInfluentialSelf-citationZhuge, A., Li, S., Lou, P., Wu, W., Wang, K., Yuan, Y., Xia, J., Li, B., & Li, L. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.00047-22 · Cited by 100
Wu, F., Guo, X., Zhang, M., Ou, Z., Wu, D., Deng, L., Lü, Z., Zhang, J., Deng, G., Chen, S., et al. (2019) · Anaerobe · doi:10.1016/j.anaerobe.2019.102138 · Cited by 100
Akkermansia muciniphila in neuropsychiatric disorders: friend or foe?
Lei, W., Cheng, Y., Gao, J., Liu, X., Shao, L., Kong, Q., Zheng, N., Ling, Z., & Hu, W. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1224155 · Cited by 104
Tung, Y., Chang, W., Li, S., Wu, J.-C., Badmeav, V., Ho, C., & Pan, M. (2018) · Food & Function · doi:10.1039/c7fo02066j · Cited by 98
Akkermansia muciniphila: A key player in gut microbiota-based disease modulation
Shaheen, N., Khursheed, W., Gurung, B., & Wang, S. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128317 · Cited by 104
Gut microbiota and microbiota-derived metabolites in cardiovascular diseases
Chen, X., Zhang, H., Ren, S., Ding, Y.-N., Remex, N. S., Bhuiyan, M. S., Qu, J.-H., & Tang, X. (2023) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002206 · Cited by 101
“[60] In addition, cyclic D - and L - administration of - and - a -peptides inhibited the formation of atherosclerosis.”
BackgroundAkkermansia muciniphila: a potential candidate for ameliorating metabolic diseases
Niu, H., Zhou, M., Zogona, D., Xing, Z., Wu, T., Chen, R., Cui, D., Liang, F., & Xu, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1370658 · Cited by 112
Roshanravan, N., Mahdavi, R., Alizadeh, E., Ghavami, A., Saadat, Y. R., Alamdari, N. M., Alipour, S., Dastourı, M., & Ostadrahimi, A. (2017) · Journal of Cardiovascular and Thoracic Research · doi:10.15171/jcvtr.2017.32 · Cited by 98
Hsu, C., Hou, C., Chan, J. Y. H., Lee, C., & Tain, Y. (2019) · Nutrients · doi:10.3390/nu11122908 · Cited by 96
“This is consistent with what has been found in previous studies reporting Akkermansia, a genus in the phylum Verrucomicrobia, as a beneficial gut microbe [38,39].”
ResultRole of Akkermansia in Human Diseases: From Causation to Therapeutic Properties
Pellegrino, A., Coppola, G., Santopaolo, F., Gasbarrini, A., & Ponziani, F. R. (2023) · Nutrients · doi:10.3390/nu15081815 · Cited by 107
“2016 [21] Apoe (−/−) mice on Western diet Live A.”
BackgroundCitrus flavonoids and the intestinal barrier: Interactions and effects
Wang, M., Zhao, H., Wen, X., Ho, C., & Li, S. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12652 · Cited by 100
Abuqwider, J., Mauriello, G., & Altamimi, M. (2021) · Microorganisms · doi:10.3390/microorganisms9051098 · Cited by 102
“muciniphila can be involved in anti-cancer immune therapy [24] and may prevent from atherosclerosis [25].”
BackgroundDiet-gut microbiota interactions on cardiovascular disease
Zhang, X., & Gérard, P. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.03.028 · Cited by 98
“This hypothesis has been confirmed in animal models, in which ApoE / mice under western diet displayed an aggravation of atherosclerotic lesions with a significant increase of Proteobacteria (Gram-negative pro-inflammatory bacteria) and systemic LPS levels [75].”
ResultOndee, T., Pongpirul, K., Visitchanakun, P., Saisorn, W., Kanacharoen, S., Wongsaroj, L., Kullapanich, C., Ngamwongsatit, N., Settachaimongkon, S., Somboonna, N., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85449-2 · Cited by 90
Gut–Brain–Skin Axis in Psoriasis: A Review
Chen, G., Zai-ming, C., Fan, X., Jin, Y., Li, X., Wu, S.-R., Ge, W., Lv, C.-H., Wang, Y.-K., & Chen, J. (2020) · Dermatology and Therapy · doi:10.1007/s13555-020-00466-9 · Cited by 95
The Intestinal Microbiota and Metabolites in the Gut-Kidney-Heart Axis of Chronic Kidney Disease
Huang, Y., Xin, W., Xiong, J., Yao, M., Zhang, B., & Zhao, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.837500 · Cited by 93
“Metformin could increase Lactobacillus and Akkermansia in diabetic mice and patients, which can also improve atherosclerosis and gut barrier integrity (Lee and Ko, 2014; Li et al., 2016; de La Cuesta-Zuluaga et al., 2017; Caggiano et al., 2020).”
BackgroundNext‐Generation Probiotics: Microflora Intervention to Human Diseases
Zhang, H., Duan, Y., Cai, F., Cao, D., Wang, L., Qiao, Z., Hong, Q., Li, N., Zheng, Y., Su, M., et al. (2022) · BioMed Research International · doi:10.1155/2022/5633403 · Cited by 99
“muciniphila can reverse obesity induced by a high-fat diet, promote “passivation” of metabolic endotoxins, promote release of inflammatory bacterial lipopolysaccharides, and effectively reduce insulin resistance and heart metabolic complications [43].”
Gut Microbiota and Atherosclerosis
Li, D. Y., & Tang, W. H. W. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0675-9 · Cited by 90
Akkermansia in the gastrointestinal tract as a modifier of human health
Panzetta, M. E., & Valdivia, R. H. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2406379 · Cited by 97
“Mouse models of diseases of impaired lipid homeostasis such as atherosclerosis, 15 acute and chronic hyperlipidemia, 16 nonalcoholic fatty liver disease (NAFLD) 17–19 and nonalcoholic steatohepatitis (NASH) 20 also point to a beneficial role for Akkermansia .”
BackgroundLiu, J., Yue, T., Luo, Z., Cao, J., Yan, Z., Jin, L., Wan, T., Shuai, C., Wang, Z., Zhou, Y., et al. (2020) · Disease Models & Mechanisms · doi:10.1242/dmm.043620 · Cited by 90
Anto, L., & Blesso, C. N. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.108991 · Cited by 90
Clinical approach to the inflammatory etiology of cardiovascular diseases
Ruscica, M., Corsini, A., Ferri, N., Banach, M., & Sirtori, C. R. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104916 · Cited by 87
Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction
Battson, M. L., Lee, D. M., Jarrell, D. K., Hou, S., Ecton, K. E., Weir, T. L., & Gentile, C. L. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00187.2017 · Cited by 85
Li, Y., Xu, W., Zhang, F., Zhong, S. S., Sun, Y., Huo, J., Zhu, J., & Wu, C. (2020) · mSystems · doi:10.1128/msystems.00313-20 · Cited by 85
Evolving trends in next-generation probiotics: a 5W1H perspective
Almeida, D., Machado, D., Andrade, J. C., Mendo, S., Gomes, A. M., & Freitas, A. C. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2019.1599812 · Cited by 92
“Curiously, recent findings with direct administration of live A. muciniphila are also demonstrating the protective role the bacterium possesses against the development of cardiovascular disease (Li et al. 2016).”
BackgroundPanyod, S., Wu, W., Chen, P.-C., Chong, K.-V., Yang, Y.-T., Chuang, H.-L., Chen, C., Chen, R.-A., Liu, P., Chung, C., et al. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00266-3 · Cited by 85
Sellem, L., Srour, B., Javaux, G., Chazelas, E., Chassaing, B., Viennois, É., Debras, C., Salamé, C., Druesne‐Pecollo, N., Esseddik, Y., et al. (2023) · BMJ · doi:10.1136/bmj-2023-076058 · Cited by 94
The heart-gut axis: new target for atherosclerosis and congestive heart failure therapy
Forkosh, E., & Ilan, Y. (2019) · Open Heart · doi:10.1136/openhrt-2018-000993 · Cited by 86
Circulating Metabolites Originating from Gut Microbiota Control Endothelial Cell Function
Amedei, A., & Morbidelli, L. (2019) · Molecules · doi:10.3390/molecules24213992 · Cited by 84
“[39] demonstrated that abundant mucin-degrading bacterium (Akkermansia muciniphila) showed various beneficial effects on metabolism.”
BackgroundShi, M., Yue, Y., Ma, C., Dong, L., & Chen, F. (2022) · Nutrients · doi:10.3390/nu14040764 · Cited by 84
Epigenetics and neurodegeneration: role of early-life nutrition
Gabbianelli, R., & Damiani, E. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.01.014 · Cited by 84
Xu, M., Lv, C., Wang, H., Lu, Q., Ye, M., Zhu, X., & Liu, R. (2022) · Food Research International · doi:10.1016/j.foodres.2022.111014 · Cited by 83
Liu, S., Zhao, W., Liu, X., & Cheng, L. (2020) · The FASEB Journal · doi:10.1096/fj.202000622r · Cited by 79
Impact of Gut Dysbiosis on Neurohormonal Pathways in Chronic Kidney Disease
Jazani, N. H., Savoj, J., Lustgarten, M. S., Lau, W. L., & Vaziri, N. D. (2019) · Diseases · doi:10.3390/diseases7010021 · Cited by 84
Engineered bacterial extracellular vesicles for osteoporosis therapy
Liu, H., Li, M., Zhang, T., Liu, X., Zhang, H., Geng, Z., & Su, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138309 · Cited by 78
Effects of Prevotella copri on insulin, gut microbiota and bile acids
Gong, J., Zhang, Q.-J., Hu, R., Yang, X., Fang, C., Yao, L., Lv, J., Wang, L., Shi, M., Zhang, W., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2340487 · Cited by 79
“39 In this study, P. copri simultaneously decreased the relative abundance of Akkermansia in both HFD-fed mice and basal diet-fed mice but increased fasting blood glucose and insulin only in HFD-fed mice, which may relate to the varying impacts of Akkermansia .”
BackgroundGriffin, L. E., Djurić, Z., Angiletta, C. J., Mitchell, C. M., Baugh, M. E., Davy, K. P., & Neilson, A. P. (2019) · Food & Function · doi:10.1039/c9fo00333a · Cited by 78
Hamjane, N., Mechita, M. B., Nourouti, N. G., & Barakat, A. (2023) · Microvascular Research · doi:10.1016/j.mvr.2023.104601 · Cited by 92
Gut Microbiota and Coronary Artery Disease
Yamashita, T., Emoto, T., Sasaki, N., & Hirata, K. (2016) · International Heart Journal · doi:10.1536/ihj.16-414 · Cited by 73
Singh, R. P., Shadan, A., & Ma, Y. (2022) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-022-09992-8 · Cited by 85
Fujisaka, S., Usui, I., Nawaz, A., Igarashi, Y., Okabe, K., Furusawa, Y., Watanabe, S., Yamamoto, S., Sasahara, M., Watanabe, Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62506-w · Cited by 75
Zhang, L., Liu, J., Jin, T. Y., Qin, N., Ren, X., & Xia, X. (2022) · Food & Function · doi:10.1039/d2fo02702j · Cited by 77
Depommier, C., Vitale, R. M., Iannotti, F. A., Silvestri, C., Flamand, N., Druart, C., Everard, A., Pelicaen, R., Maiter, D. M., Thissen, J., et al. (2021) · Cells · doi:10.3390/cells10010185 · Cited by 73
Engineered microbial systems for advanced drug delivery
Shen, H., Aggarwal, N., Wun, K. S., Lee, Y. S., Hwang, I. Y., & Chang, M. W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114364 · Cited by 74
Commensal Obligate Anaerobic Bacteria and Health: Production, Storage, and Delivery Strategies
Andrade, J. C., Almeida, D., Domingos, M., Seabra, C. L., Machado, D., Freitas, A. C., & Gomes, A. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00550 · Cited by 80
“muciniphila with the improvement of blood glucose homeostasis, host lipidmetabolism, body fat distribution, and low-grade inflammation markers, amongst others (Derrien et al., 2011; Lukovac et al., 2014; Schneeberger et al., 2015; Dao et al., 2016a; Greer et al., 2016; Li et al., 2016; Wu et al., 2017; Chelakkot et al…”
BackgroundThe central role of the gut in intensive care
Corriero, A., Gadaleta, R. M., Puntillo, F., Inchingolo, F., Moschetta, A., & Brienza, N. (2022) · Critical Care · doi:10.1186/s13054-022-04259-8 · Cited by 78
“However, when administered with Akkermansia muciniphila, which prevents endotoxemia-induced inflammation, they present with smaller atherosclerotic plaques [63].”
BackgroundKatiraei, S., de Vries, M. R., Costain, A. H., Thiem, K., Hoving, L. R., van Diepen, J. A., Smits, H. H., Bouter, K. E. C., Rensen, P. C. N., Quax, P. H. A., et al. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900732 · Cited by 75
The mechanism of berberine alleviating metabolic disorder based on gut microbiome
Wang, H., Zhang, H., Gao, Z., Zhang, Q., & Gu, C. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.854885 · Cited by 69
“A study has also shown that he decrease of circulating endotoxin levels mediated by A muciniphila can be attributed to the induction of intestinal expression of tight junction proteins (occult band protein-1 and occludin), thus reversing the increase of intestinal permeability induced by Western diet (Li et al., 2016).”
BackgroundGut microbiome and cardiovascular disease
Zhao, Y., & Wang, Z. (2020) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000720 · Cited by 70
Function of Akkermansia muciniphila in type 2 diabetes and related diseases
Li, J., Yang, G., Zhang, Q., Liu, Z., Jiang, X. M., & Xin, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1172400 · Cited by 73
Self-citationThe Microbiota Promotes Arterial Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice
Kiouptsi, K., Jäckel, S., Pontarollo, G., Grill, A., Kuijpers, M. J. E., Wilms, E., Weber, C., Sommer, F., Nagy, M., Neideck, C., et al. (2019) · mBio · doi:10.1128/mbio.02298-19 · Cited by 70
“ment of atherosclerotic lesions (19, 20) and arterial thrombosis (11–13, 21).”
Sanada, T. J., Hosomi, K., Shoji, H., Park, J., Naito, A., Ikubo, Y., Yanagisawa, A., Kobayashi, T., Miwa, H., Suda, R., et al. (2020) · Pulmonary Circulation · doi:10.1177/2045894020929147 · Cited by 69
“Akkermansia suppresses vascular inflammation and the development of atherosclerosis via suppression of the expressed inflammatory cytokines, such as TNF-a and IL-1b.(37,38) Kim et al.”
BackgroundToxicological safety evaluation of pasteurized Akkermansia muciniphila
Druart, C., Plovier, H., Hul, M. V., Brient, A., Phipps, K. R., de Vos, W. M., & Cani, P. D. (2020) · Journal of Applied Toxicology · doi:10.1002/jat.4044 · Cited by 72
Fan, J., Wang, Y., You, Y., Ai, Z., Dai, W., Piao, C., Liu, J., & Wang, Y. (2019) · Food & Function · doi:10.1039/c9fo01415b · Cited by 70
Kim, E. S., Yoon, B. H., Lee, S. M., CHOI, M. H., Kim, E. H., Lee, B.-W., Kim, S., Pack, C., Sung, Y. H., Baek, I., et al. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00728-w · Cited by 67
Flavonifractor plautii Protects Against Elevated Arterial Stiffness
Luo, S., Zhao, Y., Zhu, S., Liu, L., Cheng, K., Ye, B., Han, Y., Fan, J., & Xia, M. (2022) · Circulation Research · doi:10.1161/circresaha.122.321975 · Cited by 73
Gut Microbiota-Associated Activation of TLR5 Induces Apolipoprotein A1 Production in the Liver
Yiu, J. H. C., Chan, K.-S., Cheung, J., Li, J., Liu, Y., Wang, Y., Fung, W. W. L., Cai, J., Cheung, S. W. M., Dorweiler, B., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317362 · Cited by 67
Self-citationZhang, K., Qin, X., Qiu, J., Sun, T. H., Qu, K., Din, A. U., Yan, W., Li, T., Chen, Y., Gu, W., et al. (2021) · Genes & Diseases · doi:10.1016/j.gendis.2021.09.007 · Cited by 67
“The leaking of LPS from the gut into the circulation is regulated by the mucin layer and depends on the expression levels of the major tight junction proteins of the intestine.(5,33,34) Therefore, we detected the thickness of the mucin layer and the number of goblet cells in the colon through Alcian blue staining and…”
BackgroundInfluentialAkkermansia muciniphila Improves Host Defense Against Influenza Virus Infection
Hu, X., Zhao, Y., Yang, Y. P., Gong, W., Sun, X., Yang, L., Zhang, Q., & Jin, M. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.586476 · Cited by 72
“It also has beneficial effects on other special diseases, such as atherosclerosis (Li et al., 2016) and liver inflammation (Wu et al., 2017).”
BackgroundAssociation of altered gut microbiota composition with chronic urticaria
Nabizadeh, E., Jazani, N. H., Bagheri, M., & Shahabi, S. (2017) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2017.05.006 · Cited by 69
Zeng, S.-Y., Liu, Y., Liu, J., Zeng, Z., Xie, H., & Liu, J. (2023) · Aging and Disease · doi:10.14336/ad.2023.0325 · Cited by 67
“First, oral administration of live A. muciniphila may enhance the intestinal barrier by reinforcing the mucus and epithelial barriers and upregulating the expression of tight junction proteins in the intestine [50, 91].”
BackgroundPark, M. J., Pilla, R., Panta, A., Pandey, S., Sarawichitr, B., Suchodolski, J. S., & Sohrabji, F. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00760-5 · Cited by 65
“This bacterium also attenuates inflammation-induced atherosclerotic lesions by restoring gut barrier integrity [69].”
BackgroundZhang, Y., Xu, J., Wang, X., Ren, X., & Liu, Y. (2019) · BMC Genomics · doi:10.1186/s12864-019-6251-7 · Cited by 63
From obesity through gut microbiota to cardiovascular diseases: a dangerous journey
Marzullo, P., Renzo, L. D., Pugliese, G., Siena, M. D., Barrea, L., Muscogiuri, G., Colao, A., & Savastano, S. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0017-1 · Cited by 64
Dong, Y., Cheng, H., Liu, Y., Xue, M., & Liang, H. W. (2019) · Food & Function · doi:10.1039/c9fo00583h · Cited by 64
Outlook on next-generation probiotics from the human gut
Filippis, F. D., Esposito, A., & Ercolini, D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04080-6 · Cited by 69
Aggarwal, V., Sunder, S., & Verma, S. R. (2022) · Folia Microbiologica · doi:10.1007/s12223-022-00973-6 · Cited by 66
“Amuc_1100 has been implicated in enhancing the expression of tight junction protein-1 (Tjp-1) and occludin (Li et al. 2016), thereby contributing to the gut barrier function.”
BackgroundMa, Y., Hu, C., Yan, W., Jiang, H., & Liu, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.591408 · Cited by 62
“…response (Ansaldo et al., 2019), but also relieve colonic mucosal damage caused by inflammation (Everard et al., 2013), by inducing the expression of tight junction proteins, including zona occludens protein-1 and occludin, and reducing the internal circulation of endotoxins (Li et al., 2016).”
BackgroundHan, R., Qiu, H., Zhong, J., Zheng, N., Li, B., Hong, Y., Ma, J., Wu, G., Chen, L., Sheng, L., et al. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153544 · Cited by 61
Heavy arch: from inflammatory bowel diseases to metabolic disorders
Adolph, T. E., Meyer, M., Jukic, A., & Tilg, H. (2024) · Gut · doi:10.1136/gutjnl-2024-331914 · Cited by 72
“56 Collectively, these studies indicated that patients with IBD are at risk for developing MASLD, which poses a risk for a poor patient outcome.”
BackgroundLi, L., Li, R., Zhu, R., Chen, B., Tian, Y., Zhang, H., Xia, B., Jia, Q., Wang, L., Zhao, D., et al. (2020) · Food & Function · doi:10.1039/d0fo01116a · Cited by 62
Zhao, T., Zhan, L., Zhou, W., Chen, W., Luo, J., Zhang, L., Weng, Z., Zhao, C., & Liu, S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.647529 · Cited by 61
“, 2017) reducing macrophage infiltration, proinflammatory cytokines, and chemokine expression, therefore reducing the risk of cardiovascular disease (Li et al., 2016).”
BackgroundPan, M., Qian, C., Huo, S., Wu, Y., Zhao, X., Ying, Y., Wang, B., Yang, H., Yeerken, A., Wang, T., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2024.2447834 · Cited by 64
Li, F., Zhang, T., He, Y., Gu, W., Yang, X., Zhao, R., & Yu, J. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112232 · Cited by 60
Zhang, S., Lin, L., Liu, W., Zou, B., Cai, Y., Liu, D., Xiao, D., Chen, J., Li, P., Zhong, Y., et al. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.10.001 · Cited by 57
Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases
Mutalub, Y. B., Abdulwahab, M., Mohammed, A., Yahkub, A. M., Al-Mhanna, S. B., Yusof, W., Tang, S. P., Rasool, A. H. G., & Mokhtar, S. S. (2022) · Foods · doi:10.3390/foods11172575 · Cited by 64
Novel therapeutic targets and emerging treatments for atherosclerotic cardiovascular disease
Zheng, W. C., Chan, W., Dart, A. M., & Shaw, J. A. (2023) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvad074 · Cited by 62
Sequence meets function—microbiota and cardiovascular disease
Kim, M., Huda, M. N., & Bennett, B. J. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab030 · Cited by 62
“muciniphila reduced intestinal permeability, circulating endotoxin and aortic atherosclerosis in ApoE mice.(77) A recent proof-of-concept study in humans found that administration of pasteurized A.”
BackgroundYu, Y., Ding, Y., Wang, S., & Jiang, L. (2025) · Metabolites · doi:10.3390/metabo15060397 · Cited by 72
“Akkermansia muciniphila , a species that resides in the intestinal mucus layer, has been shown to upregulate the expression of tight junction proteins, including zonula occludens-1 and occludin [143].”
Chen, H., Lin, Y., Lin, I.-C., Yu, H., Sheen, J., Tsai, C., Huang, L., & Tain, Y. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.04.002 · Cited by 58
Porphyromonas gingivalis, a Long-Range Pathogen: Systemic Impact and Therapeutic Implications
Mulhall, H., Huck, O., & Amar, S. (2020) · Microorganisms · doi:10.3390/microorganisms8060869 · Cited by 59
Possible Prevention of Diabetes with a Gluten-Free Diet
Haupt‐Jorgensen, M., Holm, L. J., Josefsen, K. E., & Buschard, K. (2018) · Nutrients · doi:10.3390/nu10111746 · Cited by 61
“First, increased intestinal permeability and leakage of LPS to the circulation may be reversed by the bacterial species Akkermansia muciniphila, as shown in Apoe−/−mice [62].”
BackgroundZhou, J., & Zhang, X. (2019) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(19)30101-3 · Cited by 55
“metabolic endotoxemia-induced inflammation in both the circulation and local atherosclerotic lesion ([24]).”
BackgroundLuo, T., Guo, Z., Liu, D., Guo, Z., Wu, Q., Li, Q., Lin, R., Chen, P., Ou, C., & Chen, M. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2077602 · Cited by 56
“muciniphila, as a nextgeneration beneficial microbe, has reduced plasma cholesterol and inflammation levels, improved insulin sensitivity and ameliorated atherosclerotic lesion areas in animal and human studies.(36) Adlercreutzia inhibits hyperlipidemia and obesity,(37) while Mucispirillum plays a role in inhibiting i…”
Background
Metadata
- Authors
- Li, J., Lin, S., Vanhoutte, P. M., Woo, C. W., & Xu, A.
- Affiliations
- Jinan University (CN)
- Venue
- Circulation
- Published
- 2016-06-14
- Volume
- 133
- Issue
- 24
- Pages
- 2434-2446
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2344498019
- Semantic Scholar
- c6057c9cf032a166c2516e352216f0144b27de52
- Cited by
- 775
- References
- 50
- Citations by year
- 2026: 44 · 2025: 92 · 2024: 107 · 2023: 91 · 2022: 124 · 2021: 88 · 2020: 82 · 2019: 62 · 2018: 38 · 2017: 41 · 2016: 6
- FWCI
- 25.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- Akkermansia muciniphila, atherosclerosis, metabolic endotoxemia, gut microbiota, ApoE-deficient mice, Western diet, intestinal permeability, tight junction proteins, macrophage infiltration, inflammatory cytokines, chemokines, intestinal barrier, obesity-related cardiovascular disease, hypercholesterolemia
- MeSH terms
- Animals, Disease Models, Animal, Humans, Inflammation, Intestines, Male, Mice, Transgenic, Treatment Outcome, Caco-2 Cells, Endotoxemia, Atherosclerosis, Mice, Verrucomicrobia
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