Cited by 331Renin-Angiotensin System StudiesVitamin D Research StudiesEicosanoids and Hypertension Pharmacology

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Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans

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Forman, John P., Williams, Jonathan S., Fisher, Naomi D.L.·2010·Hypertension

DOI 10.1161/hypertensionaha.109.148619PMC PMC3023301

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Abstract

Vitamin D regulates the renin-angiotensin system (RAS) in experimental animals, but corresponding human data are limited. We examined the relation between plasma 25-hydroxyvitamin D and elements of the RAS in 184 normotensive individuals in high sodium balance; these included circulating levels of plasma renin activity and angiotensin II (Ang II) and the renal plasma flow response to infused Ang II, which is an indirect measure of the intrinsic RAS activity in the kidney. Compared with individuals with sufficient 25-hydroxyvitamin D levels (≥30.0 ng/mL), those with insufficiency (15.0 to 29.9 ng/mL) and deficiency (<15.0 ng/mL) had higher circulating Ang II levels ( P for trend=0.03). Moreover, those with vitamin D deficiency had significantly blunted renal plasma flow responses to infused Ang II (mean decrease of 115 mL/min per 1.73 m 2 in renal plasma flow versus 145 mL/min per 1.73 m 2 among those with sufficient vitamin D levels; P for trend=0.009). Although plasma renin activity was higher among individuals with insufficient levels of vitamin D, the result was not statistically significant. These data suggest that low plasma 25-hydroxyvitamin D levels may result in upregulation of the RAS in otherwise healthy humans.

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Authors: Forman, J. P., Williams, J. S., & Fisher, N. D. L.
Affiliations: Brigham and Women's Hospital (US)
ORCID: Williams, Jonathan S.
Fisher, Naomi D.L.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2010-05
Volume: 55
Issue: 5
Pages: 1283-1288
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.109.148619
PMC: PMC3023301
OpenAlex: W2133707802
Cited by: 331
References: 54
Citations by year: 2026: 6 · 2025: 6 · 2024: 12 · 2023: 21 · 2022: 24 · 2021: 27 · 2020: 24 · 2019: 14 · 2018: 22 · 2017: 23 · 2016: 19 · 2015: 31 · 2014: 25 · 2013: 25 · 2012: 26
FWCI: 16.90
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Heart, Lung, and Blood Institute (K23HL084236, HL-079929, K08HL079929, HL084236)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Vitamin D Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: 25-hydroxyvitamin D, vitamin D deficiency, renin-angiotensin system, angiotensin II, plasma renin activity, renal plasma flow, normotensive subjects
MeSH terms: Adult, Angiotensin II, Female, Homeostasis, Humans, Infusions, Intravenous, Male, Middle Aged, p-Aminohippuric Acid, Reference Values, Renal Circulation, Renin-Angiotensin System, Sodium, Sodium, Dietary, Vitamin D, Patient Selection, Black People, White People

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Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans

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