Cited by 174Pregnancy and preeclampsia studiesMicroRNA in disease regulationNeurological Complications and Syndromes

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Hydroxysteroid (17-β) Dehydrogenase 1 Is Dysregulated by Mir-210 and Mir-518c That Are Aberrantly Expressed in Preeclamptic Placentas: A Novel Marker for Predicting Preeclampsia

Ishibashi, Osamu, Ohkuchi, Akihide, Ali, Md. Moksed, Kurashina, Ryuhei, Luo, Shan-Shun, Ishikawa, Tomoko, Takizawa, Takami, Hirashima, Chikako, Takahashi, Kayo, Migita, Makoto, Ishikawa, Gen, Yoneyama, Koichi, Asakura, Hirobumi, Izumi, Akio, Matsubara, Shigeki, Takeshita, Toshiyuki, Takizawa, Toshihiro·2012·Hypertension

DOI 10.1161/hypertensionaha.111.180232

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Abstract

In this study, to search for novel preeclampsia (PE) biomarkers, we focused on microRNA expression and function in the human placenta complicated with PE. By comprehensive analyses of microRNA expression, we identified 22 microRNAs significantly upregulated in preeclamptic placentas, 5 of which were predicted in silico to commonly target the mRNA encoding hydroxysteroid (17-β) dehydrogenase 1 (HSD17B1), a steroidogenetic enzyme expressed predominantly in the placenta. In vivo HSD17B1 expression, at both the mRNA and protein levels, was significantly decreased in preeclamptic placentas. Of these microRNAs, miR-210 and miR-518c were experimentally validated to target HSD17B1 by luciferase assay, real-time PCR, and ELISA. Furthermore, we found that plasma HSD17B1 protein levels in preeclamptic pregnant women reflected the decrease of its placental expression. Moreover, a prospective cohort study of plasma HSD17B1 revealed a significant reduction of plasma HSD17B1 levels in pregnant women at 20 to 23 and 27 to 30 weeks of gestation before PE onset compared with those with normal pregnancies. The sensitivities/specificities for predicting PE at 20 to 23 and 27 to 30 weeks of gestation were 0.75/0.67 (cutoff value=21.9 ng/mL) and 0.88/0.51 (cutoff value=30.5 ng/mL), and the odds ratios were 6.09 (95% CI: 2.35–15.77) and 7.83 (95% CI: 1.70–36.14), respectively. We conclude that HSD17B1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placenta and that reducing plasma level of HSD17B1 precedes the onset of PE and is a potential prognostic factor for PE.

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Self-citation
Profiling and identification of pregnancy-associated circulating microRNAs in dairy cattle
Markkandan, K., Ahn, K., Lee, D. J., Kim, T. I., Dang, C., Hong, S.-E., Yoon, H., Lim, H.-J., & Hong, C. P. (2018) · Genes & Genomics · doi:10.1007/s13258-018-0668-2 · Cited by 31
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Authors: Ishibashi, O., Ohkuchi, A., Ali, M. M., Kurashina, R., Luo, S.-S., Ishikawa, T., Takizawa, T., Hirashima, C., Takahashi, K., Migita, M., Ishikawa, G., Yoneyama, K., Asakura, H., Izumi, A., Matsubara, S., Takeshita, T., & Takizawa, T.
Affiliations: Jichi Medical University (JP)
ORCID: Ishibashi, Osamu
Ohkuchi, Akihide
Ishikawa, Tomoko
Hirashima, Chikako
Takahashi, Kayo
Ishikawa, Gen
Matsubara, Shigeki
Takizawa, Toshihiro
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-02
Volume: 59
Issue: 2
Pages: 265-273
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.111.180232
OpenAlex: W1987627565
Cited by: 173
References: 31
Citations by year: 2026: 4 · 2025: 7 · 2024: 7 · 2023: 4 · 2022: 11 · 2021: 15 · 2020: 11 · 2019: 11 · 2018: 17 · 2017: 13 · 2016: 16 · 2015: 19 · 2014: 14 · 2013: 18 · 2012: 5
FWCI: 15.24
Type: journal article
Language: en
Open access: closed
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Funders: Jichi Medical University
China Medical University
Japan Society for the Promotion of Science (22791554, 20390437, 23390386, 23592419)
RIKEN
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Health Sciences › Medicine › Clinical Neurology › Neurological Complications and Syndromes
Keywords: preeclampsia, HSD17B1, miR-210, microRNA, placenta, preeclampsia biomarkers, steroidogenesis, prognostic factors, microRNA target regulation
MeSH terms: Adult, Hypoxia, Cells, Cultured, Estradiol Dehydrogenases, Female, Humans, Placenta, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Pregnancy Complications, Cardiovascular, Pregnancy Trimester, Second, Pregnancy Trimester, Third, Prognosis, Prospective Studies, ROC Curve, Trophoblasts, Cohort Studies, Biomarkers, MicroRNAs

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Hydroxysteroid (17-β) Dehydrogenase 1 Is Dysregulated by Mir-210 and Mir-518c That Are Aberrantly Expressed in Preeclamptic Placentas: A Novel Marker for Predicting Preeclampsia

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