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Cited by 70Blood Pressure and Hypertension StudiesCardiovascular Disease and AdiposityCardiovascular Function and Risk Factors

Sex Differences in the Contributions of Visceral and Total Body Fat to Blood Pressure in Adolescence

Pausova, Zdenka, Mahboubi, Amel, Abrahamowicz, Michal, Leonard, Gabriel T., Perron, Michel, Richer, Louis, Veillette, Suzanne, Gaudet, Daniel +1 more·2012·Hypertension
DOI 10.1161/hypertensionaha.111.180372
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Abstract

Excess body fat deposited viscerally rather than elsewhere in the body is associated with higher risk for hypertension; this relationship is stronger in men than in women. Here we investigated whether similar sex dimorphism exists already in adolescence. A population-based sample of adolescent boys (n=237) and girls (n=262), age 12 to 18 years, was studied. Total body fat (TBF) was assessed with multifrequency bioelectrical impedance, and visceral fat (VF) was quantified with MRI. Blood pressure (BP) was measured beat by beat during an hour-long protocol, including supine, standing, sitting, mental stress, and poststress sections. Multivariate mixed-model analysis was used to assess the relative contributions of TBF and VF to BP during these sections. In boys, BP was strongly positively associated with VF (P<0.0001), whereas it was less strongly and negatively associated with TBF (P=0.004); these relationships did not substantially vary during the protocol. In contrast, in girls, BP was strongly positively associated with TBF (P=0.0006), whereas it was not associated with VF (P=0.08); the relationship with TBF varied during the protocol and was most apparent during mental stress (TBF*section interaction:P=0.002). Furthermore, when waist circumference was included in multivariate models instead of VF, it was not associated with BP in either sex; this indicates that waist circumference may not be an appropriate surrogate for VF. Thus, in adolescence, adiposity-related BP elevation is driven mainly by visceral fat in males and by fat deposited elsewhere in females. This dimorphism suggests sex-specific mechanisms of obesity-induced hypertension and the need for sex-specific criteria of its prevention.

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  • Patients with visceral or abdominal obesity are at the greatest risk of developing hypertension and other cardiovascular risks.

    “In particular, patients with visceral or abdominal obesity are at the greatest risk of developing hypertension and other cardiovascular risks (5;6).”

    From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [5]

  • Excess adiposity is the strongest known risk factor for hypertension in male and female subjects of different ages and races.

    “The close relationship between excess adipose mass and hypertension is well documented, with population-based studies showing excess adiposity as the strongest known risk factor for hypertension in male and female subjects of different ages and races (1–5).”

    From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [5]

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Authors
Pausova, Z., Mahboubi, A., Abrahamowicz, M., Leonard, G. T., Perron, M., Richer, L., Veillette, S., Gaudet, D., & Paus, T.
Affiliations
  • From the Hospital for Sick Children (Z.P.), Toronto, Ontario, Canada; Montreal Neurological Institute (G.T.L.), McGill University (A.M., M.A., T.P.), Montreal, Quebec, Canada; Université du Québec à Chicoutimi (M.P., L.R.), Chicoutimi, Quebec, Canada; Groupe ÉCOBES (S.V.), Recherche et Transfert, Cégep de Jonquière, Jonquière, Quebec, Canada; Community Genomic Centre (D.G.), Université de Montréal, Chicoutimi Hospital, Chicoutimi, Quebec, Canada; Rotman Research Institute (T.P.), Toronto, Ontario,...
  • Université du Québec à Chicoutimi (CA)
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-03
Volume
59
Issue
3
Pages
572-579
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.111.180372
OpenAlex
W2138893665
Cited by
70
References
54
Citations by year
2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 3 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 8 · 2014: 9 · 2013: 10 · 2012: 5
FWCI
6.58
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Keywords
sex differences, visceral fat, total body fat, blood pressure, adolescent obesity, obesity-related hypertension, psychological stress, waist circumference, adiposity, sexual dimorphism
MeSH terms
Adolescent, Blood Pressure, Child, Female, Humans, Hypertension, Male, Obesity, Quebec, Surveys and Questionnaires, Risk Factors, Sex Factors, Incidence, Prevalence, Intra-Abdominal Fat, Overweight, Body Fat Distribution

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