Cited by 327Gut microbiota and healthObstructive Sleep Apnea ResearchOral microbiology and periodontitis research

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Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension

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Durgan, David J., Ganesh, Bhanu P., Cope, Julia L., Ajami, Nadim J., Phillips, Sharon C., Petrosino, Joseph F., Hollister, Emily B., Bryan, Robert M.·2016·Hypertension

DOI 10.1161/hypertensionaha.115.06672PMC PMC4713369

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Abstract

Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively ( P <0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate ( P <0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P <0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.

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Authors: Durgan, D. J., Ganesh, B. P., Cope, J. L., Ajami, N. J., Phillips, S. C., Petrosino, J. F., Hollister, E. B., & Bryan, R. M.
Affiliations: Baylor College of Medicine (US)
ORCID: Durgan, David J.
Ganesh, Bhanu P.
Cope, Julia L.
Ajami, Nadim J.
Petrosino, Joseph F.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2016-02
Volume: 67
Issue: 2
Pages: 469-474
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.115.06672
PMC: PMC4713369
OpenAlex: W2225428785
Cited by: 327
References: 34
Citations by year: 2026: 16 · 2025: 23 · 2024: 27 · 2023: 26 · 2022: 48 · 2021: 48 · 2020: 43 · 2019: 28 · 2018: 28 · 2017: 28 · 2016: 12
FWCI: 9.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK56338, P30DK056338)
National Institute of Neurological Disorders and Stroke (R01NS080531, R21NS094806)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: obstructive sleep apnea, gut microbiota, dysbiosis, high-fat diet, butyrate, short-chain fatty acids, fecal microbiota transplantation, blood pressure, microbiome manipulation
MeSH terms: Gastrointestinal Microbiome, Animals, Blood Pressure, Disease Models, Animal, Hypertension, Male, Sleep, Sleep Apnea Syndromes, Polysomnography, Rats, Long-Evans, Rats, Dysbiosis

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Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension

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