The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension
Open accessAbstract
Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively ( P <0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate ( P <0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P <0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Similarly, an obstructive sleep apnea (OSA) model also demonstrated that cecal microbial transplantation from the OSA mice transmitted elevated blood pressure to the recipient85.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [85]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology
Aziz, F., & Chaudhary, K. R. (2016) · Cardiorenal Medicine · doi:10.1159/000450796 · Cited by 3,285
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243
Gut Dysbiosis Is Linked to Hypertension
Yang, T., Santisteban, M. M., Rodriguez, V., Li, E., Ahmari, N., Carvajal, J. M., Zadeh, M., Gong, M., Qi, Y., Zubcevic, J., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05315 · Cited by 1,478
Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189375 · Cited by 1,450
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
Canani, R. B. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i12.1519 · Cited by 1,381
Sleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189420 · Cited by 1,347
Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191
Duncan, S. H., Louis, P., & Flint, H. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5810-5817.2004 · Cited by 1,178
Vaishnava, S., Behrendt, C. L., Ismail, A. S., Eckmann, L., & Hooper, L. V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808723105 · Cited by 1,019
Identifying biologically relevant differences between metagenomic communities
Parks, D. H., & Beiko, R. G. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq041 · Cited by 958
Pedrosa, R. P., Drager, L. F., Gonzaga, C. C., Sousa, M. G., de Paula, L. K. G., Amaro, A. C. S., Amodeo, C., Bortolotto, L. A., Krieger, E. M., Bradley, T. D., et al. (2011) · Hypertension · doi:10.1161/hypertensionaha.111.179788 · Cited by 668
The contributory role of gut microbiota in cardiovascular disease
Tang, W. H. W., & Hazen, S. L. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72331 · Cited by 641
Diabetes, obesity and gut microbiota
Everard, A., & Cani, P. D. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.007 · Cited by 578
Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity
Bruce-Keller, A. J., Salbaum, J. M., Luo, M., Blanchard, E., Taylor, C. M., Welsh, D. A., & Berthoud, H.-R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.012 · Cited by 563
The epigenetic effects of butyrate: potential therapeutic implications for clinical practice
Berni Canani, R., Di Costanzo, M., & Leone, L. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-4 · Cited by 431
Immune Responses to the Microbiota at the Intestinal Mucosal Surface
Duerkop, B. A., Vaishnava, S., & Hooper, L. V. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.009 · Cited by 424
Evidence for a link between gut microbiota and hypertension in the Dahl rat
Mell, B., Jala, V. R., Mathew, A. V., Byun, J., Waghulde, H., Zhang, Y., Haribabu, B., Vijay-Kumar, M., Pennathur, S., & Joe, B. (2015) · Physiological Genomics · doi:10.1152/physiolgenomics.00136.2014 · Cited by 400
Sleep Apnea and Cardiovascular Disease
Kasai, T., Floras, J. S., & Bradley, T. D. (2012) · Circulation · doi:10.1161/circulationaha.111.070813 · Cited by 391
Refractory hypertension and sleep apnoea: effect of CPAP on blood pressure and baroreflex
Logan, A. G., Tkacova, R., Perlikowski, S. M., Leung, R. S. T., Tislér, A., Floras, J. S., & Bradley, T. D. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00035402 · Cited by 296
Exercise induction of gut microbiota modifications in obese, non-obese and hypertensive rats
Petriz, B. A., Castro, A. P., Almeida, J. A., Gomes, C. P., Fernandes, G. R., Kruger, R. H., Pereira, R. W., & Franco, O. L. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-511 · Cited by 293
Dysbiotic Events in Gut Microbiota: Impact on Human Health
Schippa, S., & Conte, M. (2014) · Nutrients · doi:10.3390/nu6125786 · Cited by 256
The “psychomicrobiotic”: targeting microbiota in major psychiatric disorders: a systematic review
Fond, G., Boukouaci, W., Chevalier, G., Regnault, A., Eberl, G., Hamdani, N., Dickerson, F., Macgregor, A., Boyer, L., Dargel, A., et al. (2015) · Pathologie Biologie · doi:10.1016/j.patbio.2014.10.003 · Cited by 219
Microbial endocrinology: Host-microbiota neuroendocrine interactions influencing brain and behavior
Lyte, M. (2014) · Gut Microbes · doi:10.4161/gmic.28682 · Cited by 217
Sleep apnea: epidemiology, pathophysiology, and relation to cardiovascular risk
Parati, G., Lombardi, C., & Narkiewicz, K. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00400.2007 · Cited by 205
Cerebrovascular Consequences of Obstructive Sleep Apnea
Durgan, D. J., & Bryan, R. M. (2012) · Journal of the American Heart Association · doi:10.1161/jaha.111.000091 · Cited by 196
Self-citationThe immune system and hypertension
Singh, M. V., Chapleau, M. W., Harwani, S. C., & Abboud, F. M. (2014) · Immunologic Research · doi:10.1007/s12026-014-8548-6 · Cited by 176
Prevalence of sleep apnoea and snoring in hypertensive men: a population based study
Sjöström, C. D. (2002) · Thorax · doi:10.1136/thorax.57.7.602 · Cited by 146
Sun, Y., Fihn, B.-M., Sjövall, H., & Jodal, M. (2004) · Gut · doi:10.1136/gut.2003.015867 · Cited by 58
Plasma Lactate and Incident Hypertension in the Atherosclerosis Risk in Communities Study
Juraschek, S. P., Bower, J. K., Selvin, E., Shantha, G. P. S., Hoogeveen, R. C., Ballantyne, C. M., & Young, J. H. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu117 · Cited by 57
Crossland, R. F., Durgan, D. J., Lloyd, E. E., Phillips, S. C., Reddy, A. K., Marrelli, S. P., & Bryan, R. M. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00244.2013 · Cited by 42
Self-citationDurgan, D. J., Crossland, R. F., Lloyd, E. E., Phillips, S. C., & Bryan, R. M. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.214 · Cited by 24
Self-citationLloyd, E. E., Durgan, D. J., Martini, S. R., & Bryan, R. M. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05764 · Cited by 16
Self-citation
Research works printed but not linked: 1
- 10.3748/wjg.v17.i12 · DOI
Cited by
Sorted by citations
Gut microbiota dysbiosis contributes to the development of hypertension
Li, J., Zhao, F., Wang, Y., Chen, J., Tao, J., Tian, G., Wu, S., Liu, W., Cui, Q., Geng, B., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0222-x · Cited by 1,685
Dietary metabolism, the gut microbiome, and heart failure
Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789
The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753
Kim, S., Goel, R., Kumar, A., Qi, Y., Lobaton, G. O., Hosaka, K., Mohammed, M., Handberg, E. M., Richards, E. M., Pepine, C. J., et al. (2018) · Clinical Science · doi:10.1042/cs20180087 · Cited by 559
Hypertension-Linked Pathophysiological Alterations in the Gut
Santisteban, M. M., Qi, Y., Zubcevic, J., Kim, S., Yang, T., Shenoy, V., Cole-Jeffrey, C. T., Lobaton, G. O., Stewart, D. C., Rubiano, A., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.309006 · Cited by 525
Metadata
- Authors
- Durgan, D. J., Ganesh, B. P., Cope, J. L., Ajami, N. J., Phillips, S. C., Petrosino, J. F., Hollister, E. B., & Bryan, R. M.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Hypertension
- Published
- 2016-02
- Volume
- 67
- Issue
- 2
- Pages
- 469-474
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC4713369
- OpenAlex
- W2225428785
- Cited by
- 327
- References
- 34
- Citations by year
- 2026: 16 · 2025: 23 · 2024: 27 · 2023: 26 · 2022: 48 · 2021: 48 · 2020: 43 · 2019: 28 · 2018: 28 · 2017: 28 · 2016: 12
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK56338, P30DK056338)
- National Institute of Neurological Disorders and Stroke (R01NS080531, R21NS094806)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- obstructive sleep apnea, gut microbiota, dysbiosis, high-fat diet, butyrate, short-chain fatty acids, fecal microbiota transplantation, blood pressure, microbiome manipulation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Blood Pressure, Disease Models, Animal, Hypertension, Male, Sleep, Sleep Apnea Syndromes, Polysomnography, Rats, Long-Evans, Rats, Dysbiosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
