Cited by 327Gut microbiota and healthObstructive Sleep Apnea ResearchOral microbiology and periodontitis research

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension

Open access

Durgan, David J., Ganesh, Bhanu P., Cope, Julia L., Ajami, Nadim J., Phillips, Sharon C., Petrosino, Joseph F., Hollister, Emily B., Bryan, Robert M.·2016·Hypertension

DOI 10.1161/hypertensionaha.115.06672PMC PMC4713369

Open this paper in CoChat — free account

Abstract

Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively ( P <0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate ( P <0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P <0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.115.06672

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology
Aziz, F., & Chaudhary, K. R. (2016) · Cardiorenal Medicine · doi:10.1159/000450796 · Cited by 3,285
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243
Gut Dysbiosis Is Linked to Hypertension
Yang, T., Santisteban, M. M., Rodriguez, V., Li, E., Ahmari, N., Carvajal, J. M., Zadeh, M., Gong, M., Qi, Y., Zubcevic, J., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05315 · Cited by 1,478
American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death: A Scientific Statement From the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention
Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189375 · Cited by 1,450
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
Canani, R. B. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i12.1519 · Cited by 1,381
Sleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189420 · Cited by 1,347
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
Duncan, S. H., Louis, P., & Flint, H. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5810-5817.2004 · Cited by 1,178

Show all 34 references

Research works printed but not linked: 1

10.3748/wjg.v17.i12 · DOI

Sorted by citations

Gut microbiota dysbiosis contributes to the development of hypertension
Li, J., Zhao, F., Wang, Y., Chen, J., Tao, J., Tian, G., Wu, S., Liu, W., Cui, Q., Geng, B., et al. (2017) · Microbiome · doi:10.1186/s40168-016-0222-x · Cited by 1,685
Dietary metabolism, the gut microbiome, and heart failure
Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789
The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease
Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753
Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure
Kim, S., Goel, R., Kumar, A., Qi, Y., Lobaton, G. O., Hosaka, K., Mohammed, M., Handberg, E. M., Richards, E. M., Pepine, C. J., et al. (2018) · Clinical Science · doi:10.1042/cs20180087 · Cited by 559
Hypertension-Linked Pathophysiological Alterations in the Gut
Santisteban, M. M., Qi, Y., Zubcevic, J., Kim, S., Yang, T., Shenoy, V., Cole-Jeffrey, C. T., Lobaton, G. O., Stewart, D. C., Rubiano, A., et al. (2017) · Circulation Research · doi:10.1161/circresaha.116.309006 · Cited by 525
Alterations of the Gut Microbiome in Hypertension
Yan, Q., Gu, Y., Li, X., Yang, W. Q., Jia, L., Chen, C., Han, X., Huang, Y., Zhao, L., Li, P., et al. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00381 · Cited by 511
Intestinal Microbiota in Cardiovascular Health and Disease
Tang, W. H. W., Bäckhed, F., Landmesser, U., & Hazen, S. L. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.024 · Cited by 524
Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome
Lv, R., Liu, X., Zhang, Y., Dong, N., Wang, X., He, Y., Yue, H., & Yin, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01496-3 · Cited by 555
Microbial modulation of cardiovascular disease
Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.149 · Cited by 440
Beyond gut feelings: how the gut microbiota regulates blood pressure
Marques, F. Z., Mackay, C. R., & Kaye, D. M. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.120 · Cited by 408
Increased Systolic and Diastolic Blood Pressure Is Associated With Altered Gut Microbiota Composition and Butyrate Production in Early Pregnancy
Gómez-Arango, L. F., Barrett, H. L., McIntyre, D. H., Callaway, L. K., Morrison, M., & Nitert, M. D. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07910 · Cited by 388
Alterations in the gut microbiota can elicit hypertension in rats
Adnan, S., Nelson, J. W., Ajami, N. J., Venna, V. R., Petrosino, J. F., Bryan, R. M., & Durgan, D. J. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00081.2016 · Cited by 386
Self-citation
Microbial Short-Chain Fatty Acids and Blood Pressure Regulation
Pluznick, J. L. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0722-5 · Cited by 301
Gut Microbiota Composition and Blood Pressure
Sun, S., Lulla, A., Sioda, M., Winglee, K., Wu, M. C., Jacobs, D. R., Shikany, J. M., Lloyd‐Jones, D. M., Launer, L. J., Fodor, A. A., et al. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12109 · Cited by 287
Revisit gut microbiota and its impact on human health and disease
Ding, R., Goh, W.-R., Wu, R., Yue, X., Luo, X. G., Khine, W. W. T., Wu, J., & Lee, Y. K. (2019) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2018.12.012 · Cited by 287
Intestinal Flora Modulates Blood Pressure by Regulating the Synthesis of Intestinal-Derived Corticosterone in High Salt-Induced Hypertension
Yan, X., Jin, J., Su, X., Yin, X., Gao, J., Wang, X., Zhang, S., Bu, P., Wang, M., Zhang, Y., et al. (2020) · Circulation Research · doi:10.1161/circresaha.119.316394 · Cited by 236
Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study
Calderón-Pérez, L., Gosalbes, M. J., Yuste, S., Valls, R. M., Pedret, A., Llauradó, E., Jiménez‐Hernández, N., Artacho, A., Pla‐Pagà, L., Companys, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-63475-w · Cited by 232
Biological Effects of Indole-3-Propionic Acid, a Gut Microbiota-Derived Metabolite, and Its Precursor Tryptophan in Mammals’ Health and Disease
Konopelski, P., & Mogilnicka, I. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031222 · Cited by 220
Gut dysbiosis, defective autophagy and altered immune responses in neurodegenerative diseases: Tales of a vicious cycle
Chidambaram, S. B., Essa, M. M., Rathipriya, A. G., Bishir, M., Ray, B., Mahalakshmi, A. M., Tousif, A. H., Sakharkar, M. K., Kashyap, R. S., Friedland, R. P., et al. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107988 · Cited by 204
Prebiotics, Probiotics, and Acetate Supplementation Prevent Hypertension in a Model of Obstructive Sleep Apnea
Ganesh, B. P., Nelson, J. W., Eskew, J. R., Ganesan, A., Ajami, N. J., Petrosino, J. F., Bryan, R. M., & Durgan, D. J. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11695 · Cited by 193
Self-citation
Short-chain fatty acid, acylation and cardiovascular diseases
Chen, X., Chen, X., & Tang, X. (2020) · Clinical Science · doi:10.1042/cs20200128 · Cited by 189
The gut microbiota as a novel regulator of cardiovascular function and disease
Battson, M. L., Lee, D. M., Weir, T. L., & Gentile, C. L. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.12.010 · Cited by 191
Gut microbiota in obstructive sleep apnea–hypopnea syndrome: disease-related dysbiosis and metabolic comorbidities
Ko, C., Liu, Q., Su, H., Zhang, H.-P., Fan, J., Yang, J., Hu, A., Liu, Y., Chou, D., & Zeng, Y. (2019) · Clinical Science · doi:10.1042/cs20180891 · Cited by 176
The impact of gut microbiota on kidney function and pathogenesis
Mahmoodpoor, F., Saadat, Y. R., Barzegari, A., Ardalan, M., & Vahed, S. Z. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.066 · Cited by 172
The Role of the Gut Microbiome in Diabetes and Obesity-Related Kidney Disease
Zaky, A. A., Glastras, S. J., Wong, M. Y. W., Pollock, C. A., & Saad, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179641 · Cited by 176
Gut microbiota and hypertension: association, mechanisms and treatment
Yang, Z., Wang, Q., Liu, Y., Wang, L., Ge, Z., Li, Z., Feng, S., & Wu, C. (2023) · Clinical and Experimental Hypertension · doi:10.1080/10641963.2023.2195135 · Cited by 186
Examining the Role of the Microbiota-Gut-Brain Axis in Stroke
Durgan, D. J., Lee, J., McCullough, L. D., & Bryan, R. M. (2019) · Stroke · doi:10.1161/strokeaha.119.025140 · Cited by 169
Self-citation
The Influence of Gut Dysbiosis in the Pathogenesis and Management of Ischemic Stroke
Chidambaram, S. B., Rathipriya, A. G., Mahalakshmi, A. M., Sonali, S., Hediyal, T. A., Ray, B., Sunanda, T., Rungratanawanich, W., Kashyap, R. S., Qoronfleh, M. W., et al. (2022) · Cells · doi:10.3390/cells11071239 · Cited by 168
Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis
Tomášová, L., Konopelski, P., & Ufnal, M. (2016) · Molecules · doi:10.3390/molecules21111558 · Cited by 161
Differential Analysis of Hypertension-Associated Intestinal Microbiota
Dan, X., Mushi, Z., Baili, W., Han, L., Enqi, W., Huanhu, Z., & Li, S. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.29322 · Cited by 158
The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus
Kanbay, M., Onal, E. M., Afşar, B., Dağel, T., Yerlikaya, A., Covic, A. C., & Vaziri, N. D. (2018) · International Urology and Nephrology · doi:10.1007/s11255-018-1873-2 · Cited by 157
The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases
Jiang, Z., Zhuo, L., He, Y., Fu, Y., Shen, L., Xu, F., Gou, W., Miao, Z., Shuai, M., Liang, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30712-x · Cited by 161
The gut microbiota: An emerging risk factor for cardiovascular and cerebrovascular disease
Ascher, S., & Reinhardt, C. (2017) · European Journal of Immunology · doi:10.1002/eji.201646879 · Cited by 154
Gut microbiota in renal physiology: focus on short-chain fatty acids and their receptors
Pluznick, J. L. (2016) · Kidney International · doi:10.1016/j.kint.2016.06.033 · Cited by 153
Gut Microbiota-Derived Short-Chain Fatty Acids Facilitate Microbiota:Host Cross talk and Modulate Obesity and Hypertension
Overby, H., & Ferguson, J. F. (2021) · Current Hypertension Reports · doi:10.1007/s11906-020-01125-2 · Cited by 160
Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat
Xia, W.-J., Xu, M., Yu, X., Du, M., Li, X., Yang, T., Lu, L., Li, Y., Kang, K. B., Su, Q., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1854642 · Cited by 146
Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling
Yan, J., Pan, Y., Shao, W., Wang, C., Wang, R., He, Y., Zhang, M., Wang, Y., Li, T., Wang, Z., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01390-0 · Cited by 150
Gut microbes in cardiovascular diseases and their potential therapeutic applications
Jin, L., Shi, X., Yang, J., Zhao, Y., Xue, L., Xu, L., & Cai, J. (2020) · Protein & Cell · doi:10.1007/s13238-020-00785-9 · Cited by 143
Antihypertensive Effects of Probiotics
Robles‐Vera, I., Toral, M., Romero, M., Jiménez, R., Sánchez, M., Pérez‐Vizcaíno, F., & Duarte, J. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0723-4 · Cited by 138
The relationship between obstructive sleep apnea syndrome and obesity: A new perspective on the pathogenesis in terms of organ crosstalk
Kuvat, N., Tanrıverdi, H., & Armutçu, F. (2020) · The Clinical Respiratory Journal · doi:10.1111/crj.13175 · Cited by 145
The Gut, Its Microbiome, and Hypertension
Richards, E. M., Pepine, C. J., Raizada, M. K., & Kim, S. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0734-1 · Cited by 137
Fecal microbiota transplantation alleviates myocardial damage in myocarditis by restoring the microbiota composition
Hu, X.-F., Zhang, W., Wen, Q., Chen, W., Wang, Z., Chen, J., Zhu, F., Liu, K., Cheng, L., Yang, J., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.042 · Cited by 135
Gut microbiota-derived short-chain fatty acids and hypertension: Mechanism and treatment
Yang, F., Chen, H., Gao, Y., An, N., Li, X., Pan, X., Yang, X., Tian, L., Sun, J., Xiong, X., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110503 · Cited by 135
Alterations in the gut microbiota contribute to cognitive impairment induced by the ketogenic diet and hypoxia
Olson, C. A., Iñiguez, A. J., Yang, G. E., Fang, P., Pronovost, G. N., Jameson, K. G., Rendon, T. K., Paramo, J., Barlow, J. T., Ismagilov, R. F., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.07.004 · Cited by 126
The Microbiome and Blood Pressure: Can Microbes Regulate Our Blood Pressure?
Khodor, S. A., Reichert, B., & Shatat, I. F. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00138 · Cited by 123
Hypertension as a Metabolic Disorder and the Novel Role of the Gut
Tanaka, M., & Itoh, H. (2019) · Current Hypertension Reports · doi:10.1007/s11906-019-0964-5 · Cited by 120
Hypertension Is Associated With Intestinal Microbiota Dysbiosis and Inflammation in a Brazilian Population
Silveira‐Nunes, G., Durso, D. F., Júnior, L. R. A. D. O., Cunha, E. H. M., Maioli, T. U., Vieira, A. T., Speziali, E., Corrêa‐Oliveira, R., Martins‐Filho, O. A., Teixeira‐Carvalho, A., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00258 · Cited by 121
Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals
Palmu, J., Salosensaari, A., Havulinna, A. S., Cheng, S. C., Inouye, M., Jain, M., Salido, R. A., Sanders, K., Brennan, C., Humphrey, G., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.120.016641 · Cited by 121
Improving obesity and blood pressure
Tanaka, M. (2019) · Hypertension Research · doi:10.1038/s41440-019-0348-x · Cited by 113
Restructuring the Gut Microbiota by Intermittent Fasting Lowers Blood Pressure
Shi, H., Zhang, B., Abo‐Hamzy, T., Nelson, J. W., Ambati, C. S. R., Petrosino, J. F., Bryan, R. M., & Durgan, D. J. (2021) · Circulation Research · doi:10.1161/circresaha.120.318155 · Cited by 114
Self-citation
Gut Microbiome and Neuroinflammation in Hypertension
Richards, E. M., Li, J., Stevens, B. R., Pepine, C. J., & Raizada, M. K. (2022) · Circulation Research · doi:10.1161/circresaha.121.319816 · Cited by 115
The Role of a Gut Microbial-Derived Metabolite, Trimethylamine N-Oxide (TMAO), in Neurological Disorders
Praveenraj, S. S., Sonali, S., Anand, N., Hediyal, T. A., Vichitra, C., Kalyan, M., Kanna, P. V., Chandana, K. A., Paneyala, S., Mahalakshmi, A. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02990-5 · Cited by 116
The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke
Winek, K., Dirnagl, U., & Meisel, A. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0475-x · Cited by 108
Targeting of microbe-derived metabolites to improve human health: The next frontier for drug discovery
Brown, J. M., & Hazen, S. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r116.765388 · Cited by 108
Retracted: Role of the immune system in vascular function and blood pressure control induced by faecal microbiota transplantation in rats
Toral, M., Robles‐Vera, I., de la Visitación, N., Romero, M., Sánchez, M., Gómez‐Guzmán, M., Rodríguez‐Nogales, A., Yang, T., Jiménez, R., Algieri, F., et al. (2019) · Acta Physiologica · doi:10.1111/apha.13285 · Cited by 105
Retracted
The Local and Peripheral Immune Responses to Stroke: Implications for Therapeutic Development
Zera, K. A., & Buckwalter, M. S. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00844-3 · Cited by 103
Gut microbiota in cardiovascular disease and heart failure
Kitai, T., & Tang, W. H. W. (2018) · Clinical Science · doi:10.1042/cs20171090 · Cited by 106
Gut microbiota composition in children with obstructive sleep apnoea syndrome: a pilot study
Valentini, F., Evangelisti, M., Arpinelli, M., Nardo, G. D., Borro, M., Simmaco, M., & Villa, M. P. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.10.017 · Cited by 107
The Immunomodulatory Effect of the Gut Microbiota in Kidney Disease
Chi, M., Ma, K., Wang, J., Ding, Z., Li, Y., Zhu, S., Liang, X., Zhang, Q., Song, L., & Liu, C. (2021) · Journal of Immunology Research · doi:10.1155/2021/5516035 · Cited by 103
Gut Microbiota Plays a Central Role to Modulate the Plasma and Fecal Metabolomes in Response to Angiotensin II
Cheema, M. U., & Pluznick, J. L. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13155 · Cited by 93
Sleep fragmentation increases blood pressure and is associated with alterations in the gut microbiome and fecal metabolome in rats
Maki, K. A., Burke, L., Calik, M. W., Watanabe‐Chailland, M., Sweeney, D., Romick‐Rosendale, L. E., Green, S. J., & Fink, A. M. (2020) · Physiological Genomics · doi:10.1152/physiolgenomics.00039.2020 · Cited by 98
A cross-talk between gut microbiome, salt and hypertension
Naqvi, S., Asar, T. O., Kumar, V., Al-Abbasi, F. A., Alhayyani, S., Kamal, M. A., & Anwar, F. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111156 · Cited by 95
The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature
Ghaffari, S., & Roshanravan, N. (2019) · Food Research International · doi:10.1016/j.foodres.2019.108749 · Cited by 95
Pregnant women who develop preeclampsia have lower abundance of the butyrate-producer Coprococcus in their gut microbiota
Altemani, F. H., Barrett, H. L., Gómez-Arango, L. F., Josh, P. F., McIntyre, D. H., Callaway, L. K., Morrison, M., Tyson, G. W., & Nitert, M. D. (2021) · Pregnancy Hypertension · doi:10.1016/j.preghy.2021.01.002 · Cited by 100
The gut microbiome and hypertension
Pevsner‐Fischer, M., Blacher, E., Tatirovsky, E., Ben‐Dov, I. Z., & Elinav, E. (2016) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000293 · Cited by 93
Disparate effects of antibiotics on hypertension
Galla, S., Chakraborty, S., Cheng, X., Yeo, J., Mell, B., Zhang, H. Y., Mathew, A. V., Vijay–Kumar, M., & Joe, B. (2018) · Physiological Genomics · doi:10.1152/physiolgenomics.00073.2018 · Cited by 85
Gut microbiota, hypertension and chronic kidney disease: Recent advances
Sircana, A., Michieli, F. D., Parente, R., Framarin, L., Leone, N., Berrutti, M., Paschetta, E., Bongiovanni, D., & Musso, G. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.013 · Cited by 87
Lactobacillus rhamnosus GG strain mitigated the development of obstructive sleep apnea-induced hypertension in a high salt diet via regulating TMAO level and CD4+ T cell induced-type I inflammation
Liu, J., Li, T., Wu, H., Shi, H., Bai, J., Zhao, W., Jiang, D., & Jiang, X. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.01.041 · Cited by 87
Gut microbiota and hypertension: From pathogenesis to new therapeutic strategies
Kang, Y., & Cai, Y. (2017) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2017.09.006 · Cited by 84
Suppression of gut dysbiosis reverses Western diet-induced vascular dysfunction
Battson, M. L., Lee, D. M., Jarrell, D. K., Hou, S., Ecton, K. E., Weir, T. L., & Gentile, C. L. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00187.2017 · Cited by 85
Obstructive Sleep Apnea and Systemic Hypertension: Gut Dysbiosis as the Mediator?
Mashaqi, S., & Gozal, D. (2019) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7990 · Cited by 81
Fecal microbiota transplantation from mice exposed to chronic intermittent hypoxia elicits sleep disturbances in naïve mice
Badran, M., Khalyfa, A., Ericsson, A. C., & Gozal, D. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113439 · Cited by 86
Severe Obstructive Sleep Apnea Is Associated with Alterations in the Nasal Microbiome and an Increase in Inflammation
Wu, B. G., Sulaiman, I., Wang, J., Shen, N., Clemente, J. C., Li, Y., Laumbach, R. J., Lu, S., Udasin, I. G., Le-Hoang, O. T., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201801-0119oc · Cited by 83
Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon
Yang, T., Ahmari, N., Schmidt, J. T., Redler, T., Arocha, R., Pacholec, K., Magee, K. L., Malphurs, W. L., Owen, J. L., Krane, G. A., et al. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00220 · Cited by 83
Metabolomics and microbiome profiling as biomarkers in obstructive sleep apnoea: a comprehensive review
Zhang, X., Wang, S., Xu, H., Yi, H., Guan, J., & Yin, S. (2021) · European Respiratory Review · doi:10.1183/16000617.0220-2020 · Cited by 84
The bidirectional interaction between the sympathetic nervous system and immune mechanisms in the pathogenesis of hypertension
Carnagarin, R., Matthews, V. B., Zaldivia, M. T. K., Peter, K., & Schlaich, M. P. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14481 · Cited by 85
Chains of evidence from correlations to causal molecules in microbiome-linked diseases
Chaudhari, S. N., McCurry, M. D., & Devlin, A. S. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00861-z · Cited by 82
Chronic intermittent hypoxia disrupts cardiorespiratory homeostasis and gut microbiota composition in adult male guinea-pigs
Lucking, E. F., O’Connor, K. M., Strain, C., Fouhy, F., Bastiaanssen, T. F. S., Burns, D. P., Golubeva, A. V., Stanton, C., Clarke, G. A., Cryan, J. F., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.010 · Cited by 78
Metabolomics Profiling for Obstructive Sleep Apnea and Simple Snorers
Xu, H., Zheng, X., Qian, Y., Guan, J., Yi, H., Zou, J., Wang, Y., Meng, L., Zhao, A., Yin, S., et al. (2016) · Scientific Reports · doi:10.1038/srep30958 · Cited by 73
Understanding the pathophysiological mechanisms of cardiometabolic complications in obstructive sleep apnoea: towards personalised treatment approaches
Ryan, S., Cummins, E. P., Farré, R., Gileles‐Hillel, A., Jun, J. C., Oster, H., Pépin, J., Ray, D. W., Reutrakul, S., Sánchez‐de‐la‐Torre, M., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.02295-2019 · Cited by 74
Probiotics: Protecting Our Health from the Gut
Varela-Trinidad, G. U., Domínguez-Díaz, C., Solórzano-Castanedo, K., Íñiguez-Gutiérrez, L., Hernández-Flores, T. D. J., & Fafutis‐Morris, M. (2022) · Microorganisms · doi:10.3390/microorganisms10071428 · Cited by 80
Sleep Apnea Morbidity
Farré, N., Farré, R., & Gozal, D. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.03.001 · Cited by 71
Gut Microbiota Dysbiosis in Human Hypertension: A Systematic Review of Observational Studies
Guo, Y., Li, X., Wang, Z., & Yu, B. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.650227 · Cited by 68
Plant-Based Diets and Hypertension
Joshi, S., Ettinger, L., & Liebman, S. E. (2019) · American Journal of Lifestyle Medicine · doi:10.1177/1559827619875411 · Cited by 72
Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation
Raizada, M. K., Joe, B., Bryan, N. S., Chang, E. B., Dewhirst, F. E., Borisy, G. G., Galis, Z. S., Henderson, W. A., José, P. A., Ketchum, C. J., et al. (2017) · Hypertension · doi:10.1161/hypertensionaha.117.09699 · Cited by 66
Molecular characterization of alterations in the intestinal microbiota of patients with grade 3 hypertension
Mushtaq, N., Hussain, S., Zhang, S., Lü, Y., Li, H., Ullah, S., Wang, Y., & Xu, J. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4235 · Cited by 65
From obesity through gut microbiota to cardiovascular diseases: a dangerous journey
Marzullo, P., Renzo, L. D., Pugliese, G., Siena, M. D., Barrea, L., Muscogiuri, G., Colao, A., & Savastano, S. (2020) · International Journal of Obesity Supplements · doi:10.1038/s41367-020-0017-1 · Cited by 64
Glucocorticoids and gut bacteria: “The GALF Hypothesis” in the metagenomic era
Morris, D. J., & Ridlon, J. M. (2017) · Steroids · doi:10.1016/j.steroids.2017.06.002 · Cited by 63
Pediatric Obstructive Sleep Apnea is Associated With Changes in the Oral Microbiome and Urinary Metabolomics Profile: A Pilot Study
Xu, H., Li, X., Zheng, X., Xia, Y., Fu, Y., Li, X., Qian, Y., Zou, J., Zhao, A., Guan, J., et al. (2018) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.7336 · Cited by 64
Causality of gut microbiome and hypertension: A bidirectional mendelian randomization study
Li, Y., Fu, R., Li, R., Zeng, J., Liu, T., Li, X., & Jiang, W. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1167346 · Cited by 61
Sodium, hypertension, and the gut: does the gut microbiota go salty?
Smiljanec, K., & Lennon, S. L. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00312.2019 · Cited by 62
Temporal and region-specific effects of sleep fragmentation on gut microbiota and intestinal morphology in Sprague Dawley rats
Triplett, J. C., Ellis, D., Braddock, A., Roberts, E., Ingram, K., Perez, E., Short, A. Y., Brown, D., Hutzley, V., Webb, C., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2019.1701352 · Cited by 57
Obstructive sleep apnea is related to alterations in fecal microbiome and impaired intestinal barrier function
Li, Q., Xu, T., Shao, C., Gao, W., Wang, M., Dong, Y., Wang, X., Lu, F., Li, D., Tan, H., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-27784-0 · Cited by 62
Identification of a Gut Commensal That Compromises the Blood Pressure-Lowering Effect of Ester Angiotensin-Converting Enzyme Inhibitors
Yang, T., Mei, X., Tackie‐Yarboi, E., Akere, M. T., Kyoung, J., Mell, B., Yeo, J., Cheng, X., Zubcevic, J. A., Richards, E. M., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.18711 · Cited by 58
Microbiota and Hypertension: Role of the Sympathetic Nervous System and the Immune System
Robles‐Vera, I., Toral, M., & Duarte, J. (2020) · American Journal of Hypertension · doi:10.1093/ajh/hpaa103 · Cited by 57
Manipulation of gut microbiota blunts the ventilatory response to hypercapnia in adult rats
O’Connor, K. M., Lucking, E. F., Golubeva, A. V., Strain, C., Fouhy, F., Cénit, M. C., Dhaliwal, P., Bastiaanssen, T. F. S., Burns, D. P., Stanton, C., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.03.029 · Cited by 53
Show Me What You Have Inside—The Complex Interplay between SIBO and Multiple Medical Conditions—A Systematic Review
Sroka, N., Rydzewska–Rosołowska, A., Kakareko, K., Rosołowski, M., Głowińska, I., & Hryszko, T. (2022) · Nutrients · doi:10.3390/nu15010090 · Cited by 63
Studying microbial functionality within the gut ecosystem by systems biology
Hornung, B., dos Santos, V. A. P. M., Smidt, H., & Schaap, P. J. (2018) · Genes & Nutrition · doi:10.1186/s12263-018-0594-6 · Cited by 60
Childhood Obesity and Respiratory Diseases: Which Link?
di Palmo, E., Filice, E., Cavallo, A., Caffarelli, C., Maltoni, G., Miniaci, A., Ricci, G., & Pession, A. (2021) · Children · doi:10.3390/children8030177 · Cited by 65
Disruptive physiology: olfaction and the microbiome–gut–brain axis
Bienenstock, J., Kunze, W., & Forsythe, P. (2017) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12348 · Cited by 53

Authors: Durgan, D. J., Ganesh, B. P., Cope, J. L., Ajami, N. J., Phillips, S. C., Petrosino, J. F., Hollister, E. B., & Bryan, R. M.
Affiliations: Baylor College of Medicine (US)
ORCID: Durgan, David J.
Ganesh, Bhanu P.
Cope, Julia L.
Ajami, Nadim J.
Petrosino, Joseph F.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2016-02
Volume: 67
Issue: 2
Pages: 469-474
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.115.06672
PMC: PMC4713369
OpenAlex: W2225428785
Cited by: 327
References: 34
Citations by year: 2026: 16 · 2025: 23 · 2024: 27 · 2023: 26 · 2022: 48 · 2021: 48 · 2020: 43 · 2019: 28 · 2018: 28 · 2017: 28 · 2016: 12
FWCI: 9.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK56338, P30DK056338)
National Institute of Neurological Disorders and Stroke (R01NS080531, R21NS094806)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: obstructive sleep apnea, gut microbiota, dysbiosis, high-fat diet, butyrate, short-chain fatty acids, fecal microbiota transplantation, blood pressure, microbiome manipulation
MeSH terms: Gastrointestinal Microbiome, Animals, Blood Pressure, Disease Models, Animal, Hypertension, Male, Sleep, Sleep Apnea Syndromes, Polysomnography, Rats, Long-Evans, Rats, Dysbiosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks