The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension
Open accessAbstract
Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively ( P <0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate ( P <0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P <0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.
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“Similarly, an obstructive sleep apnea (OSA) model also demonstrated that cecal microbial transplantation from the OSA mice transmitted elevated blood pressure to the recipient85.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [85]
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Metadata
- Authors
- Durgan, D. J., Ganesh, B. P., Cope, J. L., Ajami, N. J., Phillips, S. C., Petrosino, J. F., Hollister, E. B., & Bryan, R. M.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Hypertension
- Published
- 2016-02
- Volume
- 67
- Issue
- 2
- Pages
- 469-474
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC4713369
- OpenAlex
- W2225428785
- Cited by
- 327
- References
- 34
- Citations by year
- 2026: 16 · 2025: 23 · 2024: 27 · 2023: 26 · 2022: 48 · 2021: 48 · 2020: 43 · 2019: 28 · 2018: 28 · 2017: 28 · 2016: 12
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK56338, P30DK056338)
- National Institute of Neurological Disorders and Stroke (R01NS080531, R21NS094806)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- obstructive sleep apnea, gut microbiota, dysbiosis, high-fat diet, butyrate, short-chain fatty acids, fecal microbiota transplantation, blood pressure, microbiome manipulation
- MeSH terms
- Gastrointestinal Microbiome, Animals, Blood Pressure, Disease Models, Animal, Hypertension, Male, Sleep, Sleep Apnea Syndromes, Polysomnography, Rats, Long-Evans, Rats, Dysbiosis
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