Cited by 327Gut microbiota and healthObstructive Sleep Apnea ResearchOral microbiology and periodontitis research

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension

Open access

Durgan, David J., Ganesh, Bhanu P., Cope, Julia L., Ajami, Nadim J., Phillips, Sharon C., Petrosino, Joseph F., Hollister, Emily B., Bryan, Robert M.·2016·Hypertension

DOI 10.1161/hypertensionaha.115.06672PMC PMC4713369

Open this paper in CoChat — free account

Abstract

Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively ( P <0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate ( P <0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P <0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1161/hypertensionaha.115.06672

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Naive Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy
Wang, Q., Garrity, G. M., Tiedje, J. M., & Cole, J. R. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.00062-07 · Cited by 20,145
Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192
The Triad of Sleep Apnea, Hypertension, and Chronic Kidney Disease: A Spectrum of Common Pathology
Aziz, F., & Chaudhary, K. R. (2016) · Cardiorenal Medicine · doi:10.1159/000450796 · Cited by 3,285
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243
Gut Dysbiosis Is Linked to Hypertension
Yang, T., Santisteban, M. M., Rodriguez, V., Li, E., Ahmari, N., Carvajal, J. M., Zadeh, M., Gong, M., Qi, Y., Zubcevic, J., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05315 · Cited by 1,478
American Heart Association/American College of Cardiology Foundation/Heart Rhythm Society Scientific Statement on Noninvasive Risk Stratification Techniques for Identifying Patients at Risk for Sudden Cardiac Death: A Scientific Statement From the American Heart Association Council on Clinical Cardiology Committee on Electrocardiography and Arrhythmias and Council on Epidemiology and Prevention
Goldberger, J. J., Cain, M. E., Hohnloser, S. H., Kadish, A. H., Knight, B. P., Lauer, M. S., Maron, B. J., Page, R. L., Passman, R. S., Siscovick, D., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189375 · Cited by 1,450
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
Canani, R. B. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i12.1519 · Cited by 1,381
Sleep Apnea and Cardiovascular Disease
Somers, V. K., White, D. P., Amin, R. S., Abraham, W. T., Costa, F., Culebras, A., Daniels, S. R., Floras, J. S., Hunt, C. E., Olson, L. J., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.189420 · Cited by 1,347
Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation
Pluznick, J. L., Protzko, R. J., Gevorgyan, H., Peterlin, Z., Sipos, A., Han, J., Brunet, I., Wan, L.-X., Rey, F., Wang, T., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215927110 · Cited by 1,191
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
Duncan, S. H., Louis, P., & Flint, H. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5810-5817.2004 · Cited by 1,178

Show all 34 references

Research works printed but not linked: 1

10.3748/wjg.v17.i12 · DOI

Sorted by citations

Items 201–300 of 326

The role for ω-3 polyunsaturated and short chain fatty acids in hypertension: An updated view on the interaction with gut microbiota
Brosolo, G., Porto, A. D., Marcante, S., Capilupi, F., Bertin, N., Vivarelli, C., Bulfone, L., Vacca, A., Catena, C., & Sechi, L. A. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177107 · Cited by 16
Gut microbiota has important roles in the obstructive sleep apnea-induced inflammation and consequent neurocognitive impairment
Mingxing, T., Wu, Y., Liang, J., Yang, S., Huang, Z., Hu, J., Yang, Q., Liu, F., & Li, S. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1457348 · Cited by 15
Effects of continuous positive airway pressure on neurocognitive architecture and function in patients with obstructive sleep apnoea: study protocol for a multicentre randomised controlled trial
Xu, H., Wang, H., Guan, J., Yi, H., Qian, Y., Zou, J., Xia, Y., Fu, Y., Li, X., Jiao, X., et al. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-014932 · Cited by 15
Influence of dietary protein on Dahl salt-sensitive hypertension: a potential role for gut microbiota
Abais‐Battad, J. M., & Mattson, D. L. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00399.2017 · Cited by 14
Analysis of the characteristics of intestinal microbiota in patients with different severity of obstructive sleep apnea
Wang, P., Wang, L., Fan, Y.-Q., Dou, Z., Han, J.-X., & Wang, B. (2024) · Scientific Reports · doi:10.1038/s41598-024-72230-4 · Cited by 14
What You Eat Could Affect Your Sleep: Dietary Findings in Patients With Newly Diagnosed Obstructive Sleep Apnea
Bove, C., Jain, V., Younes, N., & Hynes, M. (2018) · American Journal of Lifestyle Medicine · doi:10.1177/1559827618765097 · Cited by 14
Gut–brain–bone marrow axis in hypertension
Li, J., Raizada, M. K., & Richards, E. M. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000678 · Cited by 13
Recent progresses in gut microbiome mediates obstructive sleep apnea‐induced cardiovascular diseases
Zhang, X., Zhang, H., Li, S. C., Fang, F., Yin, Y., & Wang, Q. (2024) · FASEB BioAdvances · doi:10.1096/fba.2023-00153 · Cited by 13
Evaluating the Alimentary and Respiratory Tracts in Health and disease (EARTH) research programme: a protocol for prospective, longitudinal, controlled, observational studies in children with chronic disease at an Australian tertiary paediatric hospital
Coffey, M. J., McKay, I. R., Doumit, M., Chuang, S., Adams, S. E., Stelzer‐Braid, S., Waters, S. A., Kasparian, N. A., Thomas, T., Jaffé, A., et al. (2020) · BMJ Open · doi:10.1136/bmjopen-2019-033916 · Cited by 13
Characteristics of salivary microbiota in children with obstructive sleep apnea: A prospective study with polysomnography
Huang, X., Chen, X., Gong, X., Xu, Y., Xu, Z., & Gao, X. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.945284 · Cited by 14
Anthropometric measures and obstructive sleep apnea in children and adolescents: a systematic review of the literature and meta-analysis
Lopes, L. L. D. A., Costa, F. W. G., Cevidanes, L., Silva, P. G. D. B., Gurgel, M., Carvalho, F. S. R., Chaves, C. M., & Ribeiro, T. R. (2023) · Sleep And Breathing · doi:10.1007/s11325-023-02861-w · Cited by 14
An Insight Into Intestinal Microbiota of Spontaneously Hypertensive Rats After Valsartan Administration
Qi, Y., Jiang, Y.-H., Jiang, L., Shao, L.-L., Yang, X., & Yang, C.-H. (2021) · Dose-Response · doi:10.1177/15593258211011342 · Cited by 12
Modulation of 11β-hydroxysteroid dehydrogenase functions by the cloud of endogenous metabolites in a local microenvironment: The glycyrrhetinic acid-like factor (GALF) hypothesis
Morris, D. J., Brem, A. S., & Odermatt, A. (2021) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2021.105988 · Cited by 13
Is the Gut Microbiome Implicated in the Excess Risk of Hypertension Associated with Obstructive Sleep Apnea? A Contemporary Review
Munir, S. S., Kuniyoshi, F. H. S., Singh, P., & Covassin, N. (2023) · Antioxidants · doi:10.3390/antiox12040866 · Cited by 12
Fecal Microbiota Transplantation Regulates Blood Pressure by Altering Gut Microbiota Composition and Intestinal Mucosal Barrier Function in Spontaneously Hypertensive Rats
Xu, X., Jin, H., Li, X., Yan, C., Zhang, Q., Yu, X., Liu, Z., Liu, S., & Zhu, F. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-024-10344-x · Cited by 13
Salt Appetite and its Effects on Cardiovascular Risk in Primary Aldosteronism
Adolf, C., Schneider, H., Heinrich, D. A., Handgriff, L., & Reincke, M. (2020) · Hormone and Metabolic Research · doi:10.1055/a-1116-2407 · Cited by 11
Associations of imbalance of intestinal flora with severity of disease, inflammatory factors, adiponectin, and vascular endothelial function of hypertension patients
Lin, Y., Wu, S., Wang, X.-H., Zhang, W., Li, B., & Liu, W. (2021) · Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12459 · Cited by 12
Circadian Rhythms Coordinated With Gut Microbiota Partially Account for Individual Differences in Hepatitis B-Related Cirrhosis
Wang, T., Rong, X., & Zhao, C. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.936815 · Cited by 10
Gastrointestinal Tract: a Promising Target for the Management of Hypertension
Xiong, S., Li, Q., Liu, D., & Zhu, Z. (2017) · Current Hypertension Reports · doi:10.1007/s11906-017-0726-1 · Cited by 10
Reoxygenation Mitigates Intermittent Hypoxia-Induced Systemic Inflammation and Gut Microbiota Dysbiosis in High-Fat Diet-Induced Obese Rats
Dong, M., Liang, X., Zhu, T., Xu, T., Xie, L., & Feng, Y. (2024) · Nature and Science of Sleep · doi:10.2147/nss.s454297 · Cited by 11
From-Toilet-to-Freezer: A Review on Requirements for an Automatic Protocol to Collect and Store Human Fecal Samples for Research Purposes
Widjaja, F., & Rietjens, I. M. C. M. (2023) · Biomedicines · doi:10.3390/biomedicines11102658 · Cited by 12
Gut microbiota and hypertension
Kotrova, A., Shishkin, A. N., Ермоленко, Е. И., Александровна, С. Д., & Воловникова, В. А. (2021) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2020-26-6-620-628 · Cited by 10
Chronic apnea during REM sleep increases arterial pressure and sympathetic modulation in rats
Pansani, A. P., Schoorlemmer, G. H. M., Ferreira, C. B., Rossi, M. V., Angheben, J. M. M., Ghazale, P. P., Gomes, K. P., & Cravo, S. L. D. (2020) · SLEEP · doi:10.1093/sleep/zsaa249 · Cited by 10
Gut microbiota-derived SCFAs and MetS-related nephropathy
Tian, X., Sun, L., Guo, S., Yuan, L., Zhang, T., Huang, C., He, T., Jiang, Q., & Zeng, Y. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1561271 · Cited by 11
Differential Effect of Light and Dark Period Sleep Fragmentation on Composition of Gut Microbiome and Inflammation in Mice
Sanford, L. D., Wellman, L. L., Ciavarra, R. P., Oldfield, E. C., Shams, R., Copare, J., & Johnson, D. A. (2021) · Life · doi:10.3390/life11121283 · Cited by 9
Sleep and the Gut Microbiome in Psoriasis: Clinical Implications for Disease Progression and the Development of Cardiometabolic Comorbidities
Myers, B. A., Reddy, V. D., Brownstone, N. D., Chan, S. Y., Thibodeaux, Q. G., Chang, H.-W., Bhutani, T., & Liao, W. J. (2020) · Journal of Psoriasis and Psoriatic Arthritis · doi:10.1177/2475530320964781 · Cited by 9
Effects of fecal microbiota transfer on blood pressure in animal models: A systematic review and meta-analysis
Lin, L., Xu, S., Cai, M., Li, S., Chen, Y., Chen, L., & Lin, Y. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300869 · Cited by 9
High-fat diet-induced obesity-related hypertension via altered gut microbiota-mediated histone butyrylation
Wang, H., Wang, Y., Wu, H., Shen, C., Li, Y., Bai, B., Sun, X., Liu, Y., Zhang, Q., & Shi, L. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2826-5 · Cited by 8
Microbiota and Metabolites as Factors Influencing Blood Pressure Regulation
Yang, T., Chakraborty, S., Mandal, J., Mei, X., & Joe, B. (2021) · Comprehensive physiology · doi:10.1002/cphy.c200009 · Cited by 8
Broadening horizons: intestinal microbiota as a novel biomarker and potential treatment for hypertensive disorders of pregnancy
Wang, M., Zheng, L., Meng, Y., Ma, S., Zhao, D., & Xu, Y. D. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1446580 · Cited by 7
Inulin alleviates intestinal barrier dysfunction induced by chronic intermittent hypoxia by modulating intestinal microbiota in mice
Yu, X. M., Tang, R., & Liu, Z. (2025) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00156.2025 · Cited by 7
A multi-omics study of the association between insomnia with objective short sleep duration phenotype and high blood pressure
Dai, Y., Vgontzas, A. N., Chen, L., Zheng, D., Chen, B., Wu, J., Shao, R., & Li, Y. (2025) · SLEEP · doi:10.1093/sleep/zsaf030 · Cited by 8
The role of gut microbiota in the development of metabolic syndrome
Kotrova, A., Шишкин, А. Н., Semienova, O. I., & Слепых, Л. А. (2019) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-172-12-101-108 · Cited by 7
Salt-Sensitive Ileal Microbiota Plays a Role in Atrial Natriuretic Peptide Deficiency-Induced Cardiac Injury
Li, S., Chen, S., Nie, M., Wen, L., Zou, B., Zhang, L., Xie, J., Ser, H., Lee, L., Wang, S., et al. (2022) · Nutrients · doi:10.3390/nu14153129 · Cited by 7
Interactive Effect of Combined Intermittent and Sustained Hypoxia and High-Fat Diet on the Colonic Mucosal Microbiome and Host Gene Expression in Mice
Mashaqi, S., Laubitz, D., Morales, E. J. D. C., Armond, R. D., Alameddin, H., Ghishan, F. K., Kiela, P. R., & Parthasarathy, S. (2022) · Nature and Science of Sleep · doi:10.2147/nss.s370957 · Cited by 7
Arterial hypertension: The role of gut microbiota
Barantsevich, N. E., Конради, А. О., & Barantsevich, E. P. (2020) · Arterial’naya Gipertenziya (Arterial Hypertension) · doi:10.18705/1607-419x-2019-25-5-460-466 · Cited by 7
The role of Western diet and gut microbiota in the pathogenesis of cardiovascular diseases
He, Z., Liu, B., Gong, A., & Jia, X. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1608563 · Cited by 8
New Progress regarding the Use of Lactic Acid Bacteria as Live Delivery Vectors, Treatment of Diseases and Induction of Immune Responses in Different Host Species Focusing on Lactobacillus Species
Shonyela, S. M., Wang, G., Yang, W., Yang, G., & Wang, C. (2017) · World Journal of Vaccines · doi:10.4236/wjv.2017.74004 · Cited by 6
Pathologic and hemodynamic changes of common carotid artery in obstructive sleep apnea hypopnea syndrome in a porcine model
Yongyi, L. I. U., Gao, L., Lv, W., Lın, L., Yi, W. A. N. G., JIANG, F., & Feng, F. (2019) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1807-170 · Cited by 6
A Review: Cereals on Modulating the Microbiota/Metabolome for Metabolic Health
Kulathunga, J., & Şimşek, Ş. (2022) · Current Nutrition Reports · doi:10.1007/s13668-022-00424-1 · Cited by 6
Local myelin damage in the hippocampus fluctuates gut microbiome profile and memory
Bostancıklıoğlu, M., Kaplan, D. S., Temiz, E., & Yiğit, E. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.01.006 · Cited by 6
Combating Hypertension Beyond GWAS: Microbiome and Artificial Intelligence as Opportunities for Precision Medicine
Aryal, S., Manandhar, I., Mei, X., Yeoh, B. S., Tummala, R., Saha, P., Osman, I., Zubcevic, J. A., Durgan, D. J., Vijay–Kumar, M., et al. (2023) · Cambridge Prisms Precision Medicine · doi:10.1017/pcm.2023.13 · Cited by 5
Self-citation
Obstructive Sleep Apnea and Atherosclerosis: Both the Gut Microbiome and Hypercapnia Matter
Almendros, I., & Farré, N. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2017-0253ed · Cited by 6
Sleep, Circadian Disruption, and Microbial-Immune Interactions
Mehra, R., & Teodorescu, M. (2018) · CHEST Journal · doi:10.1016/j.chest.2018.07.007 · Cited by 6
Disrupted bilirubin metabolism and gut microbiome dysregulation: A link to cardio-renal-hepatic-metabolic health in obstructive sleep apnea
Mohit, M., Maury, J., Bajpai, J., & Verma, S. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123872 · Cited by 5
Sex Differences in Cardiovascular Impact of Early Metabolic Impairment: Interplay between Dysbiosis and Adipose Inflammation
Dwaib, H. S., AlZaim, I., Ajouz, G., Eid, A. H., & EL‐Yazbi, A. F. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000338 · Cited by 5
Antibiotics in elderly Chinese population and their relations with hypertension and pulse pressure
Li, Z., Liu, K., Zhao, J., Yang, L., Chen, G., Liu, A., Wang, Q., Wang, S., Li, X., Cao, H., et al. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-20613-3 · Cited by 5
Assessing the causal association between sleep apnea and the human gut microbiome composition: A two-sample Mendelian randomization study
Yu, M., Chen, X., Huang, X., & Gao, X. (2024) · SAGE Open Medicine · doi:10.1177/20503121241248044 · Cited by 5
Behavioral Interventions in Hypertension: A Lifestyle Medicine Approach
Wani, R. T., Khader, K., & Udawat, P. (2023) · Indian Journal of Public Health · doi:10.4103/ijph.ijph_672_23 · Cited by 5
Gut Microbiota: A New Regulator of Cardiovascular Function
Bulgakova, S. V., Захарова, Н. О., & Иванович, Р. П. (2021) · Bulletin of Science and Practice · doi:10.33619/2414-2948/62/20 · Cited by 5
Evidence for a gut‐immune‐vascular axis in the development of hypertension
Durgan, D. J. (2019) · Acta Physiologica · doi:10.1111/apha.13338 · Cited by 5
Self-citation
Sacubitril/valsartan mitigated intermittent hypoxia related intestinal microbiota alteration and aortic injury
Wang, J., Zhang, H., Wu, L., & Lu, D. (2023) · Sleep And Breathing · doi:10.1007/s11325-023-02781-9 · Cited by 4
The oro- and nasopharyngeal microbiota as a revolutionary perspective on mental disorders and related psychopathology: a systematic review and meta-analysis
Hesami, Z., Atashrooz, M., Sardarzehi, R., Looha, M. A., Khorsand, B., & Houri, H. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06759-x · Cited by 4
Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000–2025)
Chen, Q., Ren, C., Shu, C., Yang, X., Jiang, H., Zhi, X., Wang, C., Liu, K., Zhao, X., & Li, Y. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1543258 · Cited by 4
Cardiovascular disease
Ramkanth, S., & Anitha, P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824312-1.00014-5 · Cited by 4
Catecholamine exposure and the gut microbiota in obstructive sleep apnea
Alcock, J., Lin, D., Setty, P., Brown, L. K., Dichosa, A. E. K., Burnett, B. J., Han, C. S., & Lin, H. C. (2025) · PeerJ · doi:10.7717/peerj.19203 · Cited by 4
Influence of different regimens of volumetric therapy on perioperative intestinal flora in the surgical patients with pancreas tumor, a randomized controlled trial study
Lu, X., Wang, Y., Luo, Y., & Yu, B. (2022) · BMC Anesthesiology · doi:10.1186/s12871-022-01693-7 · Cited by 4
Bacterial Extracellular Vesicles Mediate Microbiota-Host Communication to Regulate Blood Pressure in Male Rats
Shi, H., Shi, F., Wagle, R., González‐González, M. A., Mell, B., Oliver, B. A., Zhu, T., Joe, B., & Durgan, D. J. (2026) · Hypertension · doi:10.1161/hypertensionaha.125.25962 · Cited by 3
Self-citation
Obstructive sleep apnea and primary snoring in children are associated with oropharyngeal dysbiosis and a mild compositional imbalance in the gastrointestinal tract
Hudson, J., Akhand, A., Nwe, M. T., Coffey, M. J., van Dorst, J. M., Chuang, S., & Ooi, C. Y. (2026) · Journal of Clinical Sleep Medicine · doi:10.1007/s44470-026-00058-y · Cited by 3
Enabling rational gut microbiome manipulations by understanding gut ecology through experimentally-evidenced in silico models
Ortiz, J. P. M., McClure, D. D., Shanahan, E. R., Dehghani, F., Holmes, A. J., & Read, M. N. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1965698 · Cited by 4
Metabolomics and the Gut–Brain Axis
Caspani, G., Harvey, M., & Swann, J. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99971-7.00003-5 · Cited by 3
The role of gut microbiota and probiotics in managing hypertensive disorders of pregnancy
Soleimani, R. A., Salemkhoei, S., Milani, P. G., Soleimani, A. A., & Khayeri, S. (2025) · Gastrointestinal Nursing · doi:10.12968/gasn.2024.0081 · Cited by 3
Obstructive Sleep Apnea and Hypertension
Yao, X., Li, M., Yao, L., & Shao, L. (2019) · Springer eBooks · doi:10.1007/978-981-15-0591-1_13 · Cited by 3
Too Fatty, Too Salty, Too Western
Mishima, R. S., Hohl, M., Linz, B. M., Sanders, P., & Linz, D. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11832 · Cited by 3
Characterizing the gut microbiota composition in Taiwanese hypertensive patients using 16S rRNA sequencing analysis
Chen, M., Jiang, S.-K., Chong, Z.-Y., Chiang, J.-W., Chen, Y., Huang, H., & Chen, J. (2025) · International Journal of Medical Sciences · doi:10.7150/ijms.109340 · Cited by 2
Association between the gut microbiotic composition and dietary patterns in hypertensive elderly patients: a cross-sectional study
Hung, H.-C., Lin, Y.-Y., Tien, W.-J., Chen, Y.-Y., & Yang, S. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00963-8 · Cited by 2
Preliminary analysis of gut microbiome characteristics in children with obstructive sleep apnea hypopnea syndrome
Wang, Z., Zhou, L., He, Y., Xv, X., Lv, M., Zhang, Z., Wang, F., Wang, S., & Wang, Y. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1615891 · Cited by 2
Understanding gut microbiota dysbiosis as a plausible link between obstructive sleep apnea (OSA), viral infections, and lifestyle diseases
Shivram Karthik, S., Jadhav, P., Paul, A., Kumar, R., Paul, D., & Bose, S. (2026) · Microbial Pathogenesis · doi:10.1016/j.micpath.2026.108466 · Cited by 2
Microbiota intestinal e síndrome metabólica: utilização terapêutica de probióticos
da Silva, L. P., Rovai, R. B., Rezende, J. J. D., Mercês, B. G. D., Silva, C. B. F. T. D., & Masquio, D. C. L. (2023) · Revista da Associação Brasileira de Nutrição - RASBRAN · doi:10.47320/rasbran.2022.1451 · Cited by 4
Gut check: assessing the role of the gut microbiota in the adverse cardiovascular effects of obstructive sleep apnoea
Durgan, D. J., & Farré, R. (2023) · European Respiratory Journal · doi:10.1183/13993003.01974-2022 · Cited by 2
Self-citation
Metabolic aspects of therapeutic problems
Ei, T., & Гриневич, В. Б. (2020) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-179-7-52-61 · Cited by 2
Prolonged utilization of proton pump inhibitors in patients with ischemic and valvular heart disease is associated with surgical treatments, weight loss and aggravates anemia
Boban, M., Žulj, M., Peršić, V., Medved, I., Zekanović, D., & Včev, A. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.06.058 · Cited by 2
Gender Based Compositional Fluctuations in Gut Microbiota in Hypertension
Mushtaq, N., Hussain, S., Yuan, L., Zhang, S., Li, H., Ullah, S., & Xu, J. (2018) · Cardiovascular Pharmacology Open Access · doi:10.4172/2329-6607.1000248 · Cited by 2
[Research progress on correlation between childhood obesity and obstructive sleep apnea].
Li, J., Yang, Q., Xu, Y. C., Han, F., & Zhao, J. (2023) · PubMed Central · doi:10.13201/j.issn.2096-7993.2023.04.017 · Cited by 2
Could Probiotic Supplements Be an Effective Intervention to Reduce Hypertension? A Systematic Literature Review
Harris, M. D. (2022) · Online Journal of Complementary & Alternative Medicine · doi:10.33552/ojcam.2022.07.000661 · Cited by 1
The Relationship Between the Gut Microbiome and Sleep Examined Through Associated Human Disease
Flikkema, J. (2022) · doi:10.15760/honors.1202 · Cited by 2
Rationally Designed Dual Kinase Inhibitors for Management of Obstructive Sleep Apnea—A Computational Study
Gramatikoff, K., Stoykov, M., & Milkov, M. P. (2026) · Biomedicines · doi:10.3390/biomedicines14010181 · Cited by 1
Gut-derived bacterial extracellular vesicles: the microbial dark matter contributing to host inflammation and cardiometabolic disease
Oliver, B. A., Sun, M., Lee, Y. S., Cho, S., Zhu, T., Durgan, D. J., & Sweeney, G. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2672794 · Cited by 2
Self-citation
Gut microbiome drives glycodeoxycholic acid-mediated attenuation of hypertension
Aryal, S., Mell, B., Tummala, R., Manandhar, I., Kumariya, S., Kondapalli, N. B., Yeoh, B. S., Ahlidja, W., Akinola, O. M., Pachhain, S., et al. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2691346 · Cited by 1
Decoding the gut-sleep Nexus: a bibliometric mapping of gut microbiota and sleep disorders
Xu, D., Lu, Z., Li, Q., Cheng, Y., & Yang, Z. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1598173 · Cited by 2
Beyond the Microbiome: The Gut’s Role in Hypertension
Deng, W., Zhu, M., Lloyd, I., Nedunuri, M., Zhou, C., Liu, W., Li, Y., Li, Q., Wang, X., Zhang, Q., et al. (2025) · Function · doi:10.1093/function/zqaf037 · Cited by 2
Cardiovascular sequelae of sleep apnea: In your brain and in your gut
Joseph, V. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.11.027 · Cited by 1
PREBIOTICS FOR ACUTE ISCHEMIC STROKE
Renamastika, S. N., Wahyuningrum, D. R., PUTRI, V. A., & Aisy, R. (2021) · International Journal of Pharmacy and Pharmaceutical Sciences · doi:10.22159/ijpps.2021v13i5.41110 · Cited by 1
Raised Cecal Veillonella (Firmicutes)/S 24-7 (Bacteriodetes) May Not Cause Salt-Sensitive Hypertension
Chaudhury, A. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00118
Hypertension Editors’ Picks
(2016) · Hypertension · doi:10.1161/hypertensionaha.116.08146
Gut Microbiota, a Rising Star in Hypertension
Gong, H. (2017) · MOJ Anatomy & Physiology · doi:10.15406/mojap.2017.04.00140
Sleep Apnoea and Early Antecedents of Adult Disease
Gozal, D. (2018) · Barcelona Respiratory Network · doi:10.23866/brnrev:2017-0030
Interactive functional networks in microbiota
Hornung, B. (2018) · doi:10.18174/456782
Gut Microbiota and Risk for Atherosclerosis: Current Understanding of the Mechanisms
Dutta, B., Biswas, C., Arya, R. K., & Rahaman, S. O. (2020) · Springer eBooks · doi:10.1007/978-3-030-47384-6_8 · Cited by 1
Molecular mechanisms of neurodegeneration in neurotraumatic diseases
Farooqui, A. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821711-5.00003-6
Case Report: Miles Surgery Ameliorates High Blood Pressure in a Rectal Carcinoma Patient With Essential Hypertension
Zhang, M., Fan, B., & Yu, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.762959
Impaired metabolism in obstructive sleep apnea
Gu, C., Polotsky, V. Y., & Jun, J. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00172-9
Faculty Opinions recommendation of Examining the Role of the Microbiota-Gut-Brain Axis in Stroke.
Fisher, M. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736139345.793566137
Causal Effect of Gut Microbiome on Quantitative Traits of Obstructive Sleep Apnea: A Two Sample Mendelian Randomization StudyPreprint
Gao, Z., Yang, J., Li, N., Xu, C. B., Zhu, Y., Zhu, J., Wang, A., Xu, H., Wu, X., Guan, J., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3959678
The “brain-heart-gut” axis and novel mechanisms of future cardiovascular diseasePreprint
Hu, C. (2022) · doi:10.22541/au.167103365.55933131/v1
Microbiome Derived Metabolites in CKD and ESRD
Paul, R., Feibig, C., & Raj, D. S. (2022) · Springer eBooks · doi:10.1007/978-3-031-11942-2_4
Study on the Relationship between Intestinal Flora and Coronary Heart Disease
段, 豪. (2022) · Advances in Clinical Medicine · doi:10.12677/acm.2022.1291274
Action on the Cerebral Vascular Endothelium in the Prevention of Stroke
Herguedas, A. J. U., & Olmedo, M. P. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.111669
Additional file 3 of Improvement of intestinal flora: accompany with the antihypertensive effect of electroacupuncture on stage 1 hypertension
Wang, J., Yang, M., Wu, Q., Chen, J., Deng, S.-F., Chen, L., Wei, D., & Liang, F. (2021) · Figshare · doi:10.6084/m9.figshare.13545250
COVID-19 and microbiome
Michael, O. S., Adetunji, J. B., Badmus, O. O., Areola, E. D., Oshinjo, A. M., Adetunji, C. O., & Oyewole, O. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-91190-0.00005-9

Authors: Durgan, D. J., Ganesh, B. P., Cope, J. L., Ajami, N. J., Phillips, S. C., Petrosino, J. F., Hollister, E. B., & Bryan, R. M.
Affiliations: Baylor College of Medicine (US)
ORCID: Durgan, David J.
Ganesh, Bhanu P.
Cope, Julia L.
Ajami, Nadim J.
Petrosino, Joseph F.
Venue: Hypertension
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2016-02
Volume: 67
Issue: 2
Pages: 469-474
ISSN: 0194-911X (ISSN-L)
1524-4563
DOI: 10.1161/hypertensionaha.115.06672
PMC: PMC4713369
OpenAlex: W2225428785
Cited by: 327
References: 34
Citations by year: 2026: 16 · 2025: 23 · 2024: 27 · 2023: 26 · 2022: 48 · 2021: 48 · 2020: 43 · 2019: 28 · 2018: 28 · 2017: 28 · 2016: 12
FWCI: 9.84
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Hypertension (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK56338, P30DK056338)
National Institute of Neurological Disorders and Stroke (R01NS080531, R21NS094806)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: obstructive sleep apnea, gut microbiota, dysbiosis, high-fat diet, butyrate, short-chain fatty acids, fecal microbiota transplantation, blood pressure, microbiome manipulation
MeSH terms: Gastrointestinal Microbiome, Animals, Blood Pressure, Disease Models, Animal, Hypertension, Male, Sleep, Sleep Apnea Syndromes, Polysomnography, Rats, Long-Evans, Rats, Dysbiosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of the Gut Microbiome in Obstructive Sleep Apnea–Induced Hypertension

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks