Cited by 94Coffee research and impactsAdenosine and Purinergic SignalingTraumatic Brain Injury and Neurovascular Disturbances

Caffeine and the Control of Cerebral Hemodynamics

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Pelligrino, Dale A., Xu, Hao-Liang, Vetri, Francesco·2010·Journal of Alzheimer's Disease

Abstract

While the influence of caffeine on the regulation of brain perfusion has been the subject of multiple publications, the mechanisms involved in that regulation remain unclear. To some extent, that uncertainty is a function of a complex interplay of processes arising from multiple targets of caffeine located on a variety of different cells, many of which have influence, either directly or indirectly, on cerebral vascular smooth muscle tone. Adding to that complexity are the target-specific functional changes that may occur when comparing acute and chronic caffeine exposure. In the present review, we discuss some of the mechanisms behind caffeine influences on cerebrovascular function. The major effects of caffeine on the cerebral circulation can largely be ascribed to its inhibitory effects on adenosine receptors. Herein, we focus mostly on the A1, A2A, and A2B subtypes located in cells comprising the neurovascular unit (neurons, astrocytes, vascular smooth muscle); their roles in the coupling of increased neuronal (synaptic) activity to vasodilation; how caffeine, through blockade of these receptors, may interfere with the "neurovascular coupling" process; and receptor-linked changes that may occur in cerebrovascular regulation when comparing acute to chronic caffeine intake.

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Authors
Pelligrino, D. A., Xu, H.-L., & Vetri, F.
Affiliations
University of Illinois Chicago (US)
Corresponding author
Pelligrino, Dale A.
Venue
Journal of Alzheimer's Disease
Published
2010-04-14
Volume
20
Issue
s1
Pages
S51-S62
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1648853544
Cited by
93
References
73
Citations by year
2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 10 · 2017: 3 · 2016: 3 · 2015: 8 · 2014: 8 · 2013: 4 · 2012: 11
FWCI
0.83
Type
journal article
Language
en
Open access
Locations
  • Journal of Alzheimer s Disease (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • American Heart Association
  • National Institutes of Health (HL088259)
  • National Heart, Lung, and Blood Institute (R01HL088259, HL088259)
  • National Institute of Neurological Disorders and Stroke (R01NS063279)
Topics
  • Health Sciences › Medicine › Pharmacology › Coffee research and impacts
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
caffeine, cerebral hemodynamics
MeSH terms
Central Nervous System Stimulants, Animals, Blood Vessels, Caffeine, Cerebral Cortex, Cerebrovascular Circulation, Hemodynamics, Humans, Models, Biological, Receptors, Purinergic P1

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