Caffeine and the Control of Cerebral Hemodynamics
Open accessAbstract
While the influence of caffeine on the regulation of brain perfusion has been the subject of multiple publications, the mechanisms involved in that regulation remain unclear. To some extent, that uncertainty is a function of a complex interplay of processes arising from multiple targets of caffeine located on a variety of different cells, many of which have influence, either directly or indirectly, on cerebral vascular smooth muscle tone. Adding to that complexity are the target-specific functional changes that may occur when comparing acute and chronic caffeine exposure. In the present review, we discuss some of the mechanisms behind caffeine influences on cerebrovascular function. The major effects of caffeine on the cerebral circulation can largely be ascribed to its inhibitory effects on adenosine receptors. Herein, we focus mostly on the A1, A2A, and A2B subtypes located in cells comprising the neurovascular unit (neurons, astrocytes, vascular smooth muscle); their roles in the coupling of increased neuronal (synaptic) activity to vasodilation; how caffeine, through blockade of these receptors, may interfere with the "neurovascular coupling" process; and receptor-linked changes that may occur in cerebrovascular regulation when comparing acute to chronic caffeine intake.
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Caffeine is a CNS-stimulating drug that acts as an adenosine receptor antagonist in the brain.
“Caffeine is a CNS-stimulating drug that acts as an adenosine receptor antagonist in the brain [10,11].”
From Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses (2012) · cites this paper as [11]
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- Authors
- Pelligrino, D. A., Xu, H.-L., & Vetri, F.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Pelligrino, Dale A.
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2010-04-14
- Volume
- 20
- Issue
- s1
- Pages
- S51-S62
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC2944660
- OpenAlex
- W1648853544
- Cited by
- 93
- References
- 73
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 7 · 2019: 3 · 2018: 10 · 2017: 3 · 2016: 3 · 2015: 8 · 2014: 8 · 2013: 4 · 2012: 11
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Alzheimer s Disease (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association
- National Institutes of Health (HL088259)
- National Heart, Lung, and Blood Institute (R01HL088259, HL088259)
- National Institute of Neurological Disorders and Stroke (R01NS063279)
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- caffeine, cerebral hemodynamics
- MeSH terms
- Central Nervous System Stimulants, Animals, Blood Vessels, Caffeine, Cerebral Cortex, Cerebrovascular Circulation, Hemodynamics, Humans, Models, Biological, Receptors, Purinergic P1
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