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Cited by 222

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Clonal Hematopoiesis Is Associated With Higher Risk of Stroke

Bhattacharya, Romit, Zekavat, Seyedeh M., Haessler, Jeffrey, Fornage, Myriam, Raffield, Laura, Uddin, Md Mesbah, Bick, Alexander G., Niroula, Abhishek, Yu, Bing, Gibson, Christopher, Griffin, Gabriel, Morrison, Alanna C., Psaty, Bruce M., Longstreth, William T., Bis, Joshua C., Rich, Stephen S., Rotter, Jerome I., Tracy, Russell P., Correa, Adolfo, Seshadri, Sudha, Johnson, Andrew, Collins, Jason M., Hayden, Kathleen M., Madsen, Tracy E., Ballantyne, Christie M., Jaiswal, Siddhartha, Ebert, Benjamin L., Kooperberg, Charles, Manson, JoAnn E., Whitsel, Eric A., NHLBI Trans-Omics for Precision Medicine Program, Natarajan, Pradeep, Reiner, Alexander P.·2022·Stroke
DOI 10.1161/strokeaha.121.037388PMC PMC8885769
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Abstract

Background and Purpose: Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease–related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was reported previously in an exploratory analysis including a small number of incident stroke cases without replication and lack of stroke subphenotyping. The purpose of this study was to discover whether CHIP is a risk factor for ischemic or hemorrhagic stroke. Methods: We utilized plasma genome sequence data of blood DNA to identify CHIP in 78 752 individuals from 8 prospective cohorts and biobanks. We then assessed the association of CHIP and commonly mutated individual CHIP driver genes ( DNMT3A , TET2 , and ASXL1 ) with any stroke, ischemic stroke, and hemorrhagic stroke. Results: CHIP was associated with an increased risk of total stroke (hazard ratio, 1.14 [95% CI, 1.03–1.27]; P =0.01) after adjustment for age, sex, and race. We observed associations with CHIP with risk of hemorrhagic stroke (hazard ratio, 1.24 [95% CI, 1.01–1.51]; P =0.04) and with small vessel ischemic stroke subtypes. In gene-specific association results, TET2 showed the strongest association with total stroke and ischemic stroke, whereas DMNT3A and TET2 were each associated with increased risk of hemorrhagic stroke. Conclusions: CHIP is associated with an increased risk of stroke, particularly with hemorrhagic and small vessel ischemic stroke. Future studies clarifying the relationship between CHIP and subtypes of stroke are needed.

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Cites

Research works printed but not linked: 23

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Metadata

Authors
Bhattacharya, R., Zekavat, S. M., Haessler, J., Fornage, M., Raffield, L., Uddin, M. M., Bick, A. G., Niroula, A., Yu, B., Gibson, C., Griffin, G., Morrison, A. C., Psaty, B. M., Longstreth, W. T., Bis, J. C., Rich, S. S., Rotter, J. I., Tracy, R. P., Correa, A., Seshadri, S., Johnson, A., Collins, J. M., Hayden, K. M., Madsen, T. E., Ballantyne, C. M., Jaiswal, S., Ebert, B. L., Kooperberg, C., Manson, J. E., Whitsel, E. A., Program, N. T.-O. F. P. M., Natarajan, P., & Reiner, A. P.
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2022-03
Volume
53
Issue
3
Pages
788-797
ISSN
  • 0039-2499
  • 1524-4628
DOI
10.1161/strokeaha.121.037388
PMC
PMC8885769
Cited by
222
References
11
Language
en
Update notices
correction (2022-08-22)

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