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Cited by 316

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Interferences from blood collection tube components on clinical chemistry assays

Open access
Bowen, Raffick A.R., Remaley, Alan T.·2014·Biochemia Medica
DOI 10.11613/bm.2014.006
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Abstract

Improper design or use of blood collection devices can adversely affect the accuracy of laboratory test results. Vascular access devices, such as catheters and needles, exert shear forces during blood flow, which creates a predisposition to cell lysis. Components from blood collection tubes, such as stoppers, lubricants, surfactants, and separator gels, can leach into specimens and/or adsorb analytes from a specimen; special tube additives may also alter analyte stability. Because of these interactions with blood specimens, blood collection devices are a potential source of pre-analytical error in laboratory testing. Accurate laboratory testing requires an understanding of the complex interactions between collection devices and blood specimens. Manufacturers, vendors, and clinical laboratorians must consider the pre-analytical challenges in laboratory testing. Although other authors have described the effects of endogenous substances on clinical assay results, the effects/impact of blood collection tube additives and components have not been well systematically described or explained. This review aims to identify and describe blood collection tube additives and their components and the strategies used to minimize their effects on clinical chemistry assays.

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Metadata

Authors
Bowen, R. A. R., & Remaley, A. T.
Venue
Biochemia Medica
Publisher
Croatian Society for Medical Biochemistry and Laboratory Medicine
Published
2014
Volume
24
Issue
1
Pages
31-44
ISSN
  • 1330-0962 (ISSN-L)
  • 1846-7482
DOI
10.11613/bm.2014.006
OpenAlex
W2169625443
Cited by
316
References
50
FWCI
11.86
Type
journal article
Language
en
Open access
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