Dopamine D2 Receptor Modulation of Human Response Inhibition and Error Awareness
Abstract
Response inhibition, comprising action cancellation and action restraint, and error awareness are executive functions of considerable clinical relevance to neuropsychiatric disorders. Nevertheless, our understanding of their underlying catecholamine mechanisms, particularly regarding dopamine, is limited. Here, we used the dopamine D2 agonist cabergoline to study its ability to improve inhibitory control and modulate awareness of performance errors. A randomized, double-blind, placebo-controlled, crossover design with a single dose of cabergoline (1.25 mg) and placebo (dextrose) was employed in 25 healthy participants. They each performed the stop-signal task, a well-validated measure of action cancellation, and the Error Awareness Task, a go/no-go measure of action restraint and error awareness, under each drug condition. Cabergoline was able to selectively reduce stop-signal RT, compared with placebo, indicative of enhanced action cancellation (p < .05). This enhancement occurred without concomitant changes in overall response speed or RT variability and was not seen for errors of commission on the Error Awareness Task. Awareness of performance errors on the go/no-go task was, however, significantly improved by cabergoline compared with placebo (p < .05). Our results contribute to growing evidence for the dopaminergic control of distinct aspects of human executive ability, namely, action cancellation and error awareness. The findings may aid the development of new, or the repurposing of existing, pharmacotherapy that targets the cognitive dysfunction of psychiatric and neurological disorders. They also provide further evidence that specific cognitive paradigms have correspondingly specific neurochemical bases.
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Administration of a D2-receptor agonist improves action cancelation.
“Also, administration of a D2-receptor agonist improved action cancelation (Nandam et al., 2013).”
From Response Inhibition and Interference Control in Obsessive–Compulsive Spectrum Disorders (2014) · cites this paper as Nandam et al., 2013
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Cato, D. J., & Holiwski, F. (2025) · doi:10.31234/osf.io/s8q7b_v3
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(2025) · doi:10.31234/osf.io/s8q7b_v4
Cato, D. J., & Holiwski, F. (2025) · doi:10.31234/osf.io/s8q7b_v5
Cato, D. J., & Holiwski, F. (2025) · doi:10.31234/osf.io/s8q7b_v9
Huang, X., Wu, J., Zhou, M., & Zhang, X. (2026) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3772318.3790889
Whitaker, G. A., Poliakoff, E., Martin, S. L., Neill, J. C., Silverdale, M., Kobylecki, C., & El‐Deredy, W. (2026) · Experimental Brain Research · doi:10.1007/s00221-026-07355-1
- Authors
- Nandam, L. S., Hester, R., Wagner, J., Dean, A. J., Messer, C., Honeysett, A., Nathan, P. J., & Bellgrove, M. A.
- Affiliations
- The University of Queensland (AU)
- The University of Melbourne (AU)
- University of Cambridge (GB)
- Venue
- Journal of Cognitive Neuroscience
- Publisher
- MIT Press - Journals
- Published
- 2013-04-01
- Volume
- 25
- Issue
- 4
- Pages
- 649-656
- ISSN
- 0898-929X (ISSN-L)
- 1530-8898
- OpenAlex
- W2109637643
- Cited by
- 50
- References
- 51
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 1 · 2018: 6 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 9 · 2013: 4
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cognitive Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopamine D2 receptor, cabergoline, response inhibition, error awareness, action cancellation, executive function, stop-signal task, go/no-go task, commission errors, catecholamines, dopaminergic modulation
- MeSH terms
- Cabergoline, Adolescent, Adult, Awareness, Double-Blind Method, Ergolines, Humans, Inhibition, Psychological, Male, Motor Activity, Neuropsychological Tests, Psychomotor Performance, Reaction Time, Time Factors, Receptors, Dopamine D2, Signal Detection, Psychological, Dopamine Agonists, Young Adult
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