Contrasting roles for dopamine D1 and D2 receptor subtypes in the dorsomedial striatum but not the nucleus accumbens core during behavioral inhibition in the stop-signal task in rats
Open accessAbstract
Dopamine and dopamine-receptor function are often implicated in behavioral inhibition, and deficiencies within behavioral inhibition processes linked to attention deficit/hyperactivity disorder (ADHD), schizophrenia, obsessive-compulsive disorder, and drug addiction. In the stop-signal task, which measures the speed of the process of inhibition [stop-signal reaction time (SSRT)], psychostimulant-related improvement of SSRT in ADHD is linked with dopamine function. However, the precise nature of dopaminergic control over SSRT remains unclear. This study examined region- and receptor-specific modulation of SSRT in the rat using direct infusions of the dopamine D1 receptor (DRD1) antagonist SCH 23390 or dopamine D2 receptor (DRD2) antagonist sulpiride into the dorsomedial striatum (DMStr) or nucleus accumbens core (NAcbC). DRD1 and DRD2 antagonists had contrasting effects on SSRT that were specific to the DMStr. SCH 23390 decreased SSRT with little effect on the go response. Conversely, sulpiride increased SSRT but also increased go-trial reaction time and reduced trial completion at the highest doses. These results suggest that DRD1 and DRD2 function within the DMStr, but not the NAcbC, may act to balance behavioral inhibition in a manner that is independent of behavioral activation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Blocking D2 receptors in the dorsal striatum negatively affects SST performance.
“However, blocking D2 receptors in the dorsal striatum negatively affects SST performance (Eagle et al 2011).”
From Prefrontal cortex executive processes affected by stress in health and disease (2018) · cites this paper as Eagle et al 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
Statistical Methods for Psychology.
Gudgeon, A. C., & Howell, D. C. (1994) · Journal of the Royal Statistical Society Series D (The Statistician) · doi:10.2307/2348956 · Cited by 8,277 · see citing works
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340 · see citing works
AChE-stained horizontal sections of the rat brain in stereotaxic coordinates
Paxinos, G., WATSON, C. R. R., & Emson, P. C. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90021-7 · Cited by 4,497 · see citing works
Functional architecture of basal ganglia circuits: neural substrates of parallel processing
Alexander, G. E., & Crutcher, M. D. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90107-l · Cited by 4,131 · see citing works
Primate models of movement disorders of basal ganglia origin
DeLong, M. R. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90110-v · Cited by 3,824 · see citing works
On the ability to inhibit thought and action: a theory of an act of control
Logan, G. D., & Cowan, W. B. (1984) · Psychological Review · doi:10.1037/0033-295x.91.3.295 · Cited by 2,590 · see citing works
Aron, A. R., & Poldrack, R. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4682-05.2006 · Cited by 1,630 · see citing works
Functional significance of the cortico-subthalamo-pallidal “hyperdirect” pathway
Nambu, A., Tokuno, H., & Takada, M. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00027-5 · Cited by 1,371 · see citing works
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329 · see citing works
Self-citationAron, A. R. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.024 · Cited by 1,236 · see citing works
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
Dalley, J. W., Fryer, T. D., Brichard, L., Robinson, E. S. J., Theobald, D. E. H., Lääne, K., Peña, Y., Murphy, E. R., Shah, Y., Probst, K., et al. (2007) · Science · doi:10.1126/science.1137073 · Cited by 1,188 · see citing works
Self-citationPutting a spin on the dorsal-ventral divide of the striatum
Voorn, P., Vanderschuren, L. J. M. J., Groenewegen, H. J., Robbins, T. W., & Pennartz, C. M. A. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.06.006 · Cited by 1,188 · see citing works
Self-citationThe Neural Basis of Inhibition in Cognitive Control
Aron, A. R. (2007) · The Neuroscientist · doi:10.1177/1073858407299288 · Cited by 1,098 · see citing works
Everitt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W., & Robbins, T. W. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0089 · Cited by 974 · see citing works
Self-citationInsights into the neural basis of response inhibition from cognitive and clinical neuroscience
Chambers, C. D., Garavan, H., & Bellgrove, M. A. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.016 · Cited by 938 · see citing works
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924 · see citing works
Impulsive choice induced in rats by lesions of the nucleus accumbens core
Cardinal, R. N., Pennicott, D. R., Lakmali, C., Sugathapala, Robbins, T. W., & Everitt, B. J. (2001) · Science · doi:10.1126/science.1060818 · Cited by 923 · see citing works
Self-citationOn the ability to inhibit thought and action: General and special theories of an act of control.
Logan, G. D., Zandt, T. V., Verbruggen, F., & Wagenmakers, E. (2014) · Psychological Review · doi:10.1037/a0035230 · Cited by 878 · see citing works
Evaluating Dopamine Reward Pathway in ADHD: Clinical Implications
Volkow, N. D., Wang, G.-J., Kollins, S. H., Wigal, T. L., Newcorn, J. H., Telang, F., Fowler, J. S., Zhu, W., Logan, J., Ma, Y., et al. (2009) · JAMA · doi:10.1001/jama.2009.1308 · Cited by 728 · cited 1× · see citing works
“These deficits arise from dysregulation within frontal/basal ganglia circuitry that is often linked with dopamine dysfunction (Volkow et al., 2009; Pine et al., 2010).”
BackgroundProbing compulsive and impulsive behaviors, from animal models to endophenotypes: A narrative review
Fineberg, N. A., Potenza, M. N., Chamberlain, S. R., Berlin, H. A., Menzies, L., Bechara, A., Sahakian, B. J., Robbins, T. W., Bullmore, E. T., & Hollander, E. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.185 · Cited by 654 · see citing works
Self-citationExcitatory Cortical Inputs to Pallidal Neurons Via the Subthalamic Nucleus in the Monkey
Nambu, A., Tokuno, H., Hamada, I., Kita, H., Imanishi, M., Akazawa, T., Ikeuchi, Y., & Hasegawa, N. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.1.289 · Cited by 604 · see citing works
A new perspective on the role of the orbitofrontal cortex in adaptive behaviour
Schoenbaum, G., Roesch, M. R., Stalnaker, T. A., & Takahashi, Y. K. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2753 · Cited by 585 · see citing works
Aron, A. R., Durston, S., Eagle, D. M., Logan, G. D., Stinear, C. M., & Stuphorn, V. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3644-07.2007 · Cited by 539 · see citing works
Self-citationDuann, J., Ide, J. S., Luo, X., & Li, C. R. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1300-09.2009 · Cited by 476 · see citing works
Frank, M. J., & O'Reilly, R. C. (2006) · Behavioral Neuroscience · doi:10.1037/0735-7044.120.3.497 · Cited by 472 · see citing works
Stop-Signal Reaction-Time Task Performance: Role of Prefrontal Cortex and Subthalamic Nucleus
Eagle, D. M., Baunez, C., Hutcheson, D. M., Lehmann, O., Shah, A. P., & Robbins, T. W. (2008) · Cerebral Cortex · doi:10.1093/cercor/bhm044 · Cited by 404 · see citing works
Self-citationLee, B., London, E. D., Poldrack, R. A., Farahi, J., Nacca, A., Monterosso, J. R., Mumford, J. A., Bokarius, A. V., Dahlbom, M., Mukherjee, J., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3765-09.2009 · Cited by 374 · see citing works
Subcortical processes of motor response inhibition during a stop signal task
Li, C.-S. R., Yan, P., Sinha, R., & Lee, T. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.023 · Cited by 304 · see citing works
Dopamine, Time, and Impulsivity in Humans
Pine, A., Shiner, T., Seymour, B., & Dolan, R. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.6028-09.2010 · Cited by 300 · cited 1× · see citing works
“These deficits arise from dysregulation within frontal/basal ganglia circuitry that is often linked with dopamine dysfunction (Volkow et al., 2009; Pine et al., 2010).”
BackgroundMolecular imaging of the dopaminergic system and its association with human cognitive function.
Cropley, V., Fujita, M., Innis, R., & Nathan, P. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.004 · Cited by 299 · see citing works
Effects of methylphenidate on inhibitory control in hyperactive children
Tannock, R., Schachar, R. J., Carr, R. P., Chajczyk, D., & Logan, G. D. (1989) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf00916508 · Cited by 289 · see citing works
Christakou, A., Robbins, T. W., & Everitt, B. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0949-03.2004 · Cited by 281 · see citing works
Self-citationEagle, D. M., & Baunez, C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.003 · Cited by 280 · see citing works
Self-citationEffects of d-Amphetamine and alcohol on a measure of behavioral inhibition in rats.
Feola, T. W., de Wit, H., & Richards, J. B. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.4.838 · Cited by 278 · see citing works
Gerfen, C. R., & Wilson, C. J. (1996) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(96)80004-2 · Cited by 253 · see citing works
Eagle, D. M., & Robbins, T. W. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.6.1302 · Cited by 252 · see citing works
Self-citationBehavioral disinhibition requires dopamine receptor activation
van Gaalen, M. M., Brueggeman, R. J., Bronius, P. F. C., Schoffelmeer, A. N. M., & Vanderschuren, L. J. M. J. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0396-1 · Cited by 236 · see citing works
Frank, M. J., Santamaria, A., O'Reilly, R. C., & Willcutt, E. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301278 · Cited by 227 · see citing works
Pinning down response inhibition in the brain — Conjunction analyses of the Stop-signal task
Boehler, C. N., Appelbaum, L. G., Krebs, R. M., Hopf, J., & Woldorff, M. G. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.276 · Cited by 212 · see citing works
Pattij, T., Janssen, M. C. W., Vanderschuren, L. J. M. J., Schoffelmeer, A. N. M., & van Gaalen, M. M. (2006) · Psychopharmacology · doi:10.1007/s00213-006-0533-x · Cited by 208 · see citing works
Effects of d-Amphetamine and ethanol on a measure of behavioral inhibition in humans.
de Wit, H., Crean, J. P., & Richards, J. B. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.4.830 · Cited by 199 · see citing works
Bari, A., Eagle, D. M., Mar, A. C., Robinson, E. S. J., & Robbins, T. W. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1537-0 · Cited by 194 · see citing works
Self-citationThe orbital cortex in rats topographically projects to central parts of the caudate-putamen complex
Schilman, E. A., Uylings, H. B. M., Graaf, Y. G.-D., Joel, D., & Groenewegen, H. J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2007.12.024 · Cited by 187 · see citing works
Eagle, D. M., Tufft, M. R. A., Goodchild, H. L., & Robbins, T. W. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0701-7 · Cited by 176 · see citing works
Self-citationAssessing cognitive function in clinical trials of schizophrenia
Barnett, J. H., Robbins, T. W., Leeson, V. C., Sahakian, B. J., Joyce, E. M., & Blackwell, A. D. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.01.012 · Cited by 173 · see citing works
Self-citationRudebeck, P. H., Bannerman, D. M., & Rushworth, M. F. S. (2008) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/cabn.8.4.485 · Cited by 172 · see citing works
Pezze, M.-A., Dalley, J. W., & Robbins, T. W. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301073 · Cited by 170 · see citing works
Self-citationLawrence, A. D. (1998) · Brain · doi:10.1093/brain/121.7.1343 · Cited by 170 · see citing works
Whisker: A client—server high-performance multimedia research control system
Cardinal, R. N., & Aitken, M. R. F. (2010) · Behavior Research Methods · doi:10.3758/brm.42.4.1059 · Cited by 143 · see citing works
Overtoom, C. C. E., Verbaten, M. N., Kemner, C., Kenemans, J. L., van Engeland, H., Buitelaar, J. K., van der Molen, M. W., van der Gugten, J., Westenberg, H. G. M., Maes, R. A. A., et al. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00097-4 · Cited by 138 · see citing works
Eagle, D. M., & Robbins, T. W. (2003) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.09.022 · Cited by 129 · see citing works
Self-citationHamidovic, A., Dlugos, A., Skol, A., Palmer, A. A., & de Wit, H. (2009) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0017840 · Cited by 108 · see citing works
Hemsley, K. M. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00245-7 · Cited by 29 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Gerfen C Wilson C Swanson L Bjorklund A Hokfelt T The basal ganglia Handbook of chemical neuroanatomy 1996 Vol 12: Integrated systems of the CNS. Part III 371 468 Elsevier Amsterdam
Cited by
Sorted by citations
Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921 · see citing works
Self-citationFractionating impulsivity: neuropsychiatric implications
Dalley, J. W., & Robbins, T. W. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.8 · Cited by 607 · see citing works
Self-citationNothing tastes as good as skinny feels: the neurobiology of anorexia nervosa
Kaye, W. H., Wierenga, C. E., Bailer, U. F., Simmons, A. N., & Bischoff‐Grethe, A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.003 · Cited by 527 · see citing works
Dopamine, serotonin and impulsivity
Dalley, J. W., & Roiser, J. P. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.03.065 · Cited by 501 · see citing works
Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors
Burguière, E., Monteiro, P., Feng, G., & Graybiel, A. M. (2013) · Science · doi:10.1126/science.1232380 · Cited by 457 · see citing works
Control of Basal Ganglia Output by Direct and Indirect Pathway Projection Neurons
Freeze, B. S., Kravitz, A. V., Hammack, N., Berke, J. D., & Kreitzer, A. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1278-13.2013 · Cited by 397 · see citing works
Ersche, K. D., Barnes, A., Jones, P. S., Morein-Zamir, S., Robbins, T. W., & Bullmore, E. T. (2011) · Brain · doi:10.1093/brain/awr138 · Cited by 389 · see citing works
Self-citationNeurotransmitter Switching in the Adult Brain Regulates Behavior
Dulcis, D., Jamshidi, P., Leutgeb, S., & Spitzer, N. C. (2013) · Science · doi:10.1126/science.1234152 · Cited by 317 · see citing works
Dissecting impulsivity and its relationships to drug addictions
Jentsch, J. D., Ashenhurst, J. R., Cervantes, M. C., Groman, S. M., James, A. S., & Pennington, Z. T. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12388 · Cited by 281 · see citing works
Eagle, D. M., & Baunez, C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.07.003 · Cited by 280 · see citing works
Self-citationFrank, G. K., Shott, M. E., Hagman, J. O., & Mittal, V. A. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.12101294 · Cited by 237 · see citing works
Arkypallidal Cells Send a Stop Signal to Striatum
Mallet, N. P., Schmidt, R., Leventhal, D., Chen, F., Amer, N., Boraud, T., & Berke, J. D. (2016) · Neuron · doi:10.1016/j.neuron.2015.12.017 · Cited by 241 · see citing works
Ghahremani, D. G., Lee, B., Robertson, C. L., Tabibnia, G., Morgan, A. T., De Shetler, N., Brown, A. K., Monterosso, J. R., Aron, A. R., Mandelkern, M. A., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.4284-11.2012 · Cited by 227 · see citing works
Strickland, J. C., & Johnson, M. W. (2020) · Psychological Review · doi:10.1037/rev0000263 · Cited by 222 · see citing works
The role of (dis)inhibition in creativity: Decreased inhibition improves idea generation
Radel, R., Davranche, K., Fournier, M., & Dietrich, A. (2014) · Cognition · doi:10.1016/j.cognition.2014.09.001 · Cited by 222 · see citing works
Unbalanced neuronal circuits in addiction
Volkow, N. D., Wang, G.-J., Tomasi, D. G., & Baler, R. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.002 · Cited by 219 · see citing works
Prefrontal and monoaminergic contributions to stop-signal task performance in rats
Bari, A., Mar, A. C., Theobald, D. E., Elands, S. A., Oganya, K. C. N. A., Eagle, D. M., & Robbins, T. W. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1543-11.2011 · Cited by 188 · see citing works
Self-citationPrefrontal cortex executive processes affected by stress in health and disease
Girotti, M., Adler, S. M., Bulin, S. E., Fucich, E. A., Paredes, D., & Morilak, D. A. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.07.004 · Cited by 176 · see citing works
Multiple Modes of Impulsivity in Parkinson's Disease
Nombela, C., Rittman, T., Robbins, T. W., & Rowe, J. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085747 · Cited by 131 · see citing works
Self-citationReward, interrupted: Inhibitory control and its relevance to addictions
Jentsch, J. D., & Pennington, Z. T. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.022 · Cited by 134 · see citing works
Shaw, P., De Rossi, P., Watson, B., Wharton, A., Greenstein, D., Raznahan, A., Sharp, W., Lerch, J. P., & Chakravarty, M. M. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.05.003 · Cited by 126 · see citing works
Sharpe, M. J., Stalnaker, T. A., Schuck, N. W., Killcross, S., Schoenbaum, G. M., & Niv, Y. (2018) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-102824 · Cited by 107 · see citing works
Depression and impulse control disorders in Parkinson׳s disease: two sides of the same coin?
Vriend, C., Pattij, T., van der Werf, Y. D., Voorn, P., Booij, J., Rutten, S., Berendse, H. W., & van den Heuvel, O. A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.001 · Cited by 106 · see citing works
Bari, A., & Robbins, T. W. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3141-6 · Cited by 105 · see citing works
Self-citationAge and impulsive behavior in drug addiction: A review of past research and future directions
Argyriou, E., Um, M., Carron, C. R., & Cyders, M. A. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.07.013 · Cited by 103 · see citing works
Impulsivity and apathy in Parkinson's disease
Sinha, N., Manohar, S., & Masud Husain, B. (2013) · Journal of Neuropsychology · doi:10.1111/jnp.12013 · Cited by 104 · see citing works
The Stomach-Derived Hormone Ghrelin Increases Impulsive Behavior
Anderberg, R. H., Hansson, C., Fenander, M., Richard, J. E., Dickson, S. L., Nissbrandt, H., Bergquist, F., & Skibicka, K. P. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.297 · Cited by 103 · see citing works
Temperament‐based Treatment for Anorexia Nervosa
Kaye, W. H., Wierenga, C. E., Knatz, S., Liang, J., Boutelle, K. N., Hill, L., & Eisler, I. (2014) · European Eating Disorders Review · doi:10.1002/erv.2330 · Cited by 101 · see citing works
O’Callaghan, C., Hezemans, F. H., Ye, R., Rua, C., Jones, P. S., Murley, A. G., Holland, N., Regenthal, R., Tsvetanov, K. A., Wolpe, N., et al. (2021) · Brain · doi:10.1093/brain/awab142 · Cited by 93 · see citing works
Self-citationSalinas, E., & Stanford, T. R. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3977-12.2013 · Cited by 96 · see citing works
Cross‐species studies of cognition relevant to drug discovery: a translational approach
Robbins, T. W. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13826 · Cited by 94 · see citing works
Self-citationRobertson, C. L., Ishibashi, K., Mandelkern, M. A., Brown, A. K., Ghahremani, D. G., Sabb, F. W., Bilder, R. M., Cannon, T. D., Borg, J., & London, E. D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4850-14.2015 · Cited by 85 · see citing works
Obeso, I., Wilkinson, L., & Jahanshahi, M. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2793-x · Cited by 81 · see citing works
Gilmour, G., Arguello, P. A., Bari, A., Brown, V. J., Carter, C., Floresco, S., Jentsch, J. D., Tait, D. S., Young, J. W., & Robbins, T. W. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.04.006 · Cited by 78 · see citing works
Self-citationLiu, S., Li, X., Huo, Y., & Lü, F. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.02.006 · Cited by 77 · see citing works
Dopamine Agonists and the Suppression of Impulsive Motor Actions in Parkinson Disease
Wylie, S. A., Claassen, D. O., Huizenga, H. M., Schewel, K. D., Ridderinkhof, K. R., Bashore, T. R., & van den Wildenberg, W. P. M. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00241 · Cited by 76 · see citing works
Attention-deficit/hyperactive disorder updates
Kessi, M., Duan, H., Xiong, J., Chen, B., He, F., Yang, L., Ma, Y., Bamgbade, O. A., Peng, J., & Yin, F. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.925049 · Cited by 82 · see citing works
Burns, J. A., Kroll, D. S., Feldman, D. E., Liu, C. K., Manza, P., Wiers, C. E., Volkow, N. D., & Wang, G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00626 · Cited by 72 · see citing works
Motivating inhibition – reward prospect speeds up response cancellation
Boehler, C. N., Hopf, J., Stoppel, C. M., & Krebs, R. M. (2012) · Cognition · doi:10.1016/j.cognition.2012.07.018 · Cited by 72 · see citing works
Recent insights into the neurobiology of impulsivity
Mitchell, M. R., & Potenza, M. N. (2014) · Current Addiction Reports · doi:10.1007/s40429-014-0037-4 · Cited by 70 · see citing works
Using mice to model Obsessive Compulsive Disorder: From genes to circuits
Ahmari, S. E. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.009 · Cited by 68 · see citing works
Hinds, A. L., Woody, E. Z., Ameringen, M. V., Schmidt, L. A., & Szechtman, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030586 · Cited by 64 · see citing works
Jupp, B., Caprioli, D., & Dalley, J. W. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.010934 · Cited by 65 · see citing works
Zhang, T., Mou, D., Wang, C., Tan, F., Jiang, Y., Lijun, Z., & Li, H. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2015.04.010 · Cited by 57 · see citing works
Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models
Jupp, B., & Dalley, J. W. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12787 · Cited by 56 · see citing works
Torregrossa, M. M., Xie, M., & Taylor, J. R. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.11 · Cited by 55 · see citing works
Claassen, D. O., van den Wildenberg, W. P. M., Harrison, M. B., van Wouwe, N. C., Kanoff, K. E., Neimat, J. S., & Wylie, S. A. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.11.017 · Cited by 55 · see citing works
Sala‐Bayo, J., Fiddian, L., Nilsson, S. R. O., Hervig, M. E.-S., McKenzie, C., Mareschi, A., Boulos, M., Zhukovsky, P., Nicholson, J. R., Dalley, J. W., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0612-4 · Cited by 48 · see citing works
Self-citationFavre, É., Ballanger, B., Thobois, S., Broussolle, E., & Boulinguez, P. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0166-1 · Cited by 52 · see citing works
Dopamine D2 Receptor Modulation of Human Response Inhibition and Error Awareness
Nandam, L. S., Hester, R., Wagner, J., Dean, A. J., Messer, C., Honeysett, A., Nathan, P. J., & Bellgrove, M. A. (2013) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00327 · Cited by 50 · see citing works
Dopamine receptors D1 and D2 are related to observed maternal behavior
Mileva‐Seitz, V. R., Fleming, A. S., Meaney, M. J., Mastroianni, A., Sinnwell, J. P., Steiner, M. S., Atkinson, L. R., Levitan, R. D., Matthews, S. G., Kennedy, J. L., et al. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00804.x · Cited by 48 · see citing works
Zhuang, Q., Xu, L., Zhou, F., Yao, S., Zheng, X., Zhou, X., Li, J., Xu, X., Fu, M., Li, K., et al. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118269 · Cited by 44 · see citing works
Polito, M., Guiot, E., Gangarossa, G., Longueville, S., Doulazmi, M., Valjent, E., Hervé, D., Girault, J., Paupardin‐Tritsch, D., Castro, L. R., et al. (2015) · eNeuro · doi:10.1523/eneuro.0060-15.2015 · Cited by 45 · see citing works
Differences in response initiation and behavioral flexibility between adolescent and adult rats.
Simon, N. W., Gregory, T. A., Wood, J. T., & Moghaddam, B. (2013) · Behavioral Neuroscience · doi:10.1037/a0031328 · Cited by 42 · see citing works
Toxoplasma gondii, Suicidal Behavior, and Intermediate Phenotypes for Suicidal Behavior
Postolache, T. T., Wadhawan, A., Rujescu, D., Hoisington, A. J., Dagdag, A., Baca‐García, E., Lowry, C. A., Okusaga, O. O., & Brenner, L. A. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.665682 · Cited by 44 · see citing works
Ko, I., Kim, S., Kim, T.-W., Ji, E., Shin, M., Kim, C., Hong, M., & Bahn, G. H. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1531 · Cited by 41 · see citing works
Frau, R., Pillolla, G., Bini, V., Tambaro, S., Devoto, P., & Bortolato, M. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.07.014 · Cited by 42 · see citing works
Cortical dopamine release during a behavioral response inhibition task
Albrecht, D., Kareken, D. A., Christian, B. T., Džemidžić, M., & Yoder, K. K. (2014) · Synapse · doi:10.1002/syn.21736 · Cited by 41 · see citing works
Impulsivity, Stimulant Abuse, and Dopamine Receptor Signaling
London, E. D. (2016) · Advances in pharmacology · doi:10.1016/bs.apha.2016.01.002 · Cited by 40 · see citing works
The Psychopharmacology of Obsessive-Compulsive Disorder: A Preclinical Roadmap
Szechtman, H., Harvey, B. H., Woody, E. Z., & Hoffman, K. L. (2019) · Pharmacological Reviews · doi:10.1124/pr.119.017772 · Cited by 40 · see citing works
Drugs currently in Phase II clinical trials for cocaine addiction
Kim, J. H., & Lawrence, A. J. (2014) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2014.915312 · Cited by 40 · see citing works
Bluschke, A., Friedrich, J., Schreiter, M. L., Roessner, V., & Beste, C. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.10.027 · Cited by 58 · see citing works
Response inhibition signals and miscoding of direction in dorsomedial striatum
Bryden, D. W., Burton, A. C., Kashtelyan, V., Barnett, B. R., & Roesch, M. R. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00069 · Cited by 38 · see citing works
Beste, C., Stock, A., Epplen, J. T., & Arning, L. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.03.002 · Cited by 37 · see citing works
Opinion on monoaminergic contributions to traits and temperament
Robbins, T. W. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2017.0153 · Cited by 38 · see citing works
Self-citationDopamine Gene Profiling to Predict Impulse Control and Effects of Dopamine Agonist Ropinirole
MacDonald, H. J., Stinear, C. M., Ren, A., Coxon, J. P., Kao, J., Macdonald, L., Snow, B. J., Cramer, S. C., & Byblow, W. D. (2016) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00946 · Cited by 38 · see citing works
Nouchi, R., Nouchi, H., & Kawashima, R. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00179 · Cited by 35 · see citing works
Cognitive control of gaze in bipolar disorder and schizophrenia
Thakkar, K. N., Schall, J. D., Logan, G. D., & Park, S. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2014.12.033 · Cited by 34 · see citing works
Dysfunctional inhibitory control in Parkinson’s disease patients with levodopa-induced dyskinesias
Picazio, S., Ponzo, V., Caltagirone, C., Brusa, L., & Koch, G. (2018) · Journal of Neurology · doi:10.1007/s00415-018-8945-1 · Cited by 33 · see citing works
Lubec, J., Kalaba, P., Hussein, A. M., Feyissa, D. D., Kotob, M. H., Mahmmoud, R. R., Wieder, O., Garon, A., Sagheddu, C., Ilic, M., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01214-x · Cited by 31 · see citing works
Dissecting Impulsivity: Brain Mechanisms and Neuropsychiatric Implications
Robbins, T. W., & Dalley, J. W. (2017) · Nebraska Symposium on Motivation/The Nebraska symposium on motivation · doi:10.1007/978-3-319-51721-6_7 · Cited by 30 · see citing works
Self-citationGhin, F., Beste, C., & Stock, A. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.12.031 · Cited by 29 · see citing works
Ashbrook, D. G., Williams, R. W., Lu, L., & Hager, R. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00171 · Cited by 24 · see citing works
MR imaging central thalamic deep brain stimulation restored autistic-like social deficits in the rat
Lin, T.-C., Lo, Y., Lin, H., Li, S., Lin, S.-H., Wu, H.-F., Chu, M.-C., Lee, C. J., Lin, I., Chang, C.-W., et al. (2019) · Brain stimulation · doi:10.1016/j.brs.2019.07.004 · Cited by 25 · see citing works
The role of dopamine in action control: Insights from medication effects in Parkinson’s disease
Ruitenberg, M. F. L., van Wouwe, N. C., Wylie, S. A., & Abrahamse, E. L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.023 · Cited by 25 · see citing works
Criaud, M., Anton, J., Nazarian, B., Longcamp, M., Météreau, É., Boulinguez, P., & Ballanger, B. (2021) · Brain Sciences · doi:10.3390/brainsci11050560 · Cited by 25 · see citing works
Moallem, N. R., & Ray, L. A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.10.012 · Cited by 23 · see citing works
The effects of methylphenidate on cerebral activations to salient stimuli in healthy adults.
Farr, O. M., Hu, S., Matuskey, D., Zhang, S., Abdelghany, O., & Li, C. R. (2013) · Experimental and Clinical Psychopharmacology · doi:10.1037/a0034465 · Cited by 23 · see citing works
Rawji, V., Rocchi, L., Foltynie, T., Rothwell, J. C., & Jahanshahi, M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108278 · Cited by 21 · see citing works
Zhuang, Q., Qiao, L., Xu, L., Yao, S., Chen, S., Zheng, X., Li, J., Fu, M., Li, K., Vatansever, D., et al. (2023) · Psychoradiology · doi:10.1093/psyrad/kkad016 · Cited by 21 · see citing works
Cáceres, P., & Martín, R. S. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00204 · Cited by 22 · see citing works
Human Brain Imaging Links Dopaminergic Systems to Impulsivity
London, E. D. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2019_125 · Cited by 22 · see citing works
Jones, J. A., Zühlsdorff, K., & Dalley, J. W. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15380 · Cited by 22 · see citing works
Marr's Levels Revisited: Understanding How Brains Break
Hardcastle, V. G., & Hardcastle, K. (2015) · Topics in Cognitive Science · doi:10.1111/tops.12130 · Cited by 21 · see citing works
Rogers, R. D., Wong, A. C., McKinnon, C., & Winstanley, C. A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.8 · Cited by 21 · see citing works
Haloperidol 2 mg impairs inhibition but not visuospatial attention
Logemann, H. N. A., Böcker, K. B. E., Deschamps, P. K. H., van Harten, P. N., Koning, J., Kemner, C., Logemann-Molnár, Z., & Kenemans, J. L. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4454-z · Cited by 21 · see citing works
Korte, S. M., Prins, J., van den Bergh, F. S., Oosting, R. S., Dupree, R., Korte-Bouws, G. A. H., Westphal, K. G. C., Olivier, B., Denys, D. A. J. P., Garland, A., et al. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.11.024 · Cited by 19 · see citing works
Sanchís-Ollé, M., Fuentes, S., Úbeda-Contreras, J., Lalanza, J. F., Ramos-Prats, A., Armario, A., & Nadal, R. A. (2019) · Scientific Reports · doi:10.1038/s41598-019-40061-3 · Cited by 19 · see citing works
An insulin resistance associated neural correlate of impulsivity in type 2 diabetes mellitus
Eckstrand, K., Mummareddy, N., Kang, H., Cowan, R. L., Zhou, M., Zald, D. H., Silver, H. J., Niswender, K. D., & Avison, M. J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0189113 · Cited by 18 · see citing works
Neural correlates and role of medication in reactive motor impulsivity in Tourette disorder
Atkinson-Clément, C., Porte, C.-A., de Liege, A., Wattiez, N., Klein-Koerkamp, Y., Béranger, B., Valabrègue, R., Sofia, F., Hartmann, A., Pouget, P., et al. (2019) · Cortex · doi:10.1016/j.cortex.2019.12.007 · Cited by 15 · see citing works
Neural evidence for automatic value-modulated approach behaviour
Kim, H., & Anderson, B. A. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.12.050 · Cited by 18 · see citing works
A Single-Blind Study of ‘As-Needed’ Ecopipam for Gambling Disorder
Grant, J. E., Odlaug, B. L., Black, D. W., FONG, T. W., Davtian, M., Chipkin, R. E., & Kim, S. W. (2014) · Annals of Clinical Psychiatry · doi:10.1177/104012371402600304 · Cited by 17 · see citing works
Does Response Inhibition Have Pre- and Postdiagnostic Utility in Parkinson's Disease?
MacDonald, H. J., & Byblow, W. D. (2015) · Journal of Motor Behavior · doi:10.1080/00222895.2014.941784 · Cited by 16 · see citing works
Peng, X., Brenner, L. A., Mathai, A. J., Cook, T. B., Fuchs, D., Postolache, N., Groer, M. W., Pandey, J. P., Mohyuddin, F., Giegling, I., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.03.045 · Cited by 16 · see citing works
The Fyn kinase inhibitor, AZD0530 , suppresses mouse alcohol self‐administration and seeking
Morisot, N., Berger, A. L., Phamluong, K., Cross, A. J., & Dorit Ron, A. (2018) · Addiction Biology · doi:10.1111/adb.12699 · Cited by 16 · see citing works
Fallon, S. J., Kienast, A., Muhammed, K., Ang, Y., Manohar, S., & Masud Husain, B. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119872190 · Cited by 17 · see citing works
Shi, X., Guan, K., Peng, X., Xu, B., Zhou, X.-Y., Wang, S., Xu, S., Zheng, M., Huang, J. Y., Wan, X., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.029 · Cited by 16 · see citing works
Impulsivity, Risky Choice, and Impulse Control Disorders
Robbins, T. W., & Dalley, J. W. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-805308-9.00007-5 · Cited by 16 · see citing works
Self-citationHan, M., Park, C.-U., Kang, S., Kim, B., Nikolaidis, A., Milham, M. P., Hong, S., Kim, S., & Baeg, E. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118077 · Cited by 15 · see citing works
Ryding, S., Garnham, L. C., Abbey‐Lee, R. N., Petkova, I., Kreshchenko, A., & Løvlie, H. (2021) · Animal Behaviour · doi:10.1016/j.anbehav.2021.06.007 · Cited by 15 · see citing works
- Authors
- Eagle, D. M., Wong, J. C. K., Allan, M. E., Mar, A. C., Theobald, D. E., & Robbins, T. W.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Eagle, Dawn M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-05-18
- Volume
- 31
- Issue
- 20
- Pages
- 7349-7356
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3173842
- OpenAlex
- W2097947691
- Cited by
- 145
- References
- 54
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 15 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 13 · 2015: 11 · 2014: 15 · 2013: 22 · 2012: 14
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (089589/Z/09/Z, 089589, 093875)
- University of Cambridge
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D1 receptor, dopamine D2 receptor, dorsomedial striatum, nucleus accumbens core, behavioral inhibition, stop-signal task, stop-signal reaction time, SCH 23390, sulpiride, attention deficit hyperactivity disorder
- MeSH terms
- Animals, Behavior, Animal, Benzazepines, Corpus Striatum, Inhibition, Psychological, Male, Nucleus Accumbens, Psychomotor Performance, Reaction Time, Sulpiride, Receptors, Dopamine D1, Receptors, Dopamine D2, Rats, Dopamine D2 Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review