Matrix biomechanics and dynamics in pulmonary fibrosis
Open accessAbstract
The composition and mechanical properties of the extracellular matrix are dramatically altered during the development and progression of pulmonary fibrosis. Recent evidence indicates that these changes in matrix composition and mechanics are not only end-results of fibrotic remodeling, but active participants in driving disease progression. These insights have stimulated interest in identifying the components and physical aspects of the matrix that contribute to cell activation and disease initiation and progression. This review summarizes current knowledge regarding the biomechanics and dynamics of the ECM in mouse models and human IPF, and discusses how matrix mechanical and compositional changes might be non-invasively assessed, therapeutically targeted, and biologically restored to resolve fibrosis.
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In the fibrotic lung tissue, excessively accumulated fibrillar collagen is often aligned in dense bundles as a result of active ECM remodeling by contractile myofibroblasts.
“In the fibrotic lung tissue, the excessively accumulated fibrillar collagen is often aligned in dense bundles, as a result of the active extracellular matrix (ECM) remodeling by contractile myofibroblasts (17).”
From Modeling mechanical activation of macrophages during pulmonary fibrogenesis for targeted anti-fibrosis therapy (2024) · cites this paper as [17]
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- Authors
- Haak, A. J., Tan, Q., & Tschumperlin, D. J.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Tschumperlin, Daniel J.
- Venue
- Matrix Biology
- Publisher
- Elsevier BV
- Published
- 2018-11
- Volume
- 73
- Pages
- 64-76
- ISSN
- 0945-053X (ISSN-L)
- PMC
- PMC6013326
- OpenAlex
- W2778599139
- Cited by
- 95
- References
- 162
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 12 · 2023: 15 · 2022: 10 · 2021: 8 · 2020: 14 · 2019: 9 · 2018: 8
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Matrix Biology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (HL092961, HL133320)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Keywords
- pulmonary fibrosis, idiopathic pulmonary fibrosis, extracellular matrix, matrix mechanics, matrix composition, fibrotic remodeling, disease progression, cell activation, non-invasive assessment, therapeutic targeting, mouse model
- MeSH terms
- Animals, Biomechanical Phenomena, Disease Models, Animal, Extracellular Matrix, Humans, Pulmonary Fibrosis, Extracellular Matrix Proteins, Disease Progression, Mice
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