Cited by 191Prenatal Substance Exposure EffectsNeonatal Respiratory Health ResearchSmoking Behavior and Cessation

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Maternal Nicotine Exposure Upregulates Collagen Gene Expression in Fetal Monkey Lung

Sekhon, Harmanjatinder S., Keller, Jennifer A., Proskocil, Becky J., Martin, Ellen L., Spindel, Eliot R.·2002·American Journal of Respiratory Cell and Molecular Biology

DOI 10.1165/ajrcmb.26.1.4170

Open this paper in CoChat — free account

Abstract

The recent identification of nicotinic acetylcholine receptors (nAChR) in pulmonary fibroblasts suggests that in utero nicotine exposure may alter collagen expression by these cells in the developing lung. To test this hypothesis, timed-pregnant rhesus monkeys were administered nicotine (1–1.5 mg/kg/d, subcutaneously) using osmotic minipumps from Days 26–134 or 26–160 of gestation (term = 165 d). In utero nicotine exposure significantly increased airway wall area per unit epithelial basement membrane. Collagen type I and III mRNA expression and immunostaining were significantly increased in the airway and alveolar walls of the nicotine-treated group. Elastin mRNA expression increased, but protein expression in parenchyma remained unchanged. Dual labeling studies colocalized α 7 nAChR and collagen to the same cells in airway wall cells, and colocalization of α 7 nAChR and collagen was confirmed in isolated pulmonary fibroblasts. These findings suggest that nicotine may directly interact with α 7 nAChR to increase collagen accumulation in airway and alveolar walls following in utero nicotine exposure. These data suggest that passage of nicotine across the placenta to increase collagen deposition and therefore increase airway wall dimensions in fetal lung may partially explain the observed alterations in lung mechanics in the infants of mothers who smoke during pregnancy.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1165/ajrcmb.26.1.4170

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Pharmacologic Aspects of Cigarette Smoking and Nicotine Addiction
Oates, J. A., Wood, A. J. J., & Benowitz, N. L. (1988) · New England Journal of Medicine · doi:10.1056/nejm198811173192005 · Cited by 969
Cardiovascular Toxicity of Nicotine: Implications for Nicotine Replacement Therapy 11All editorial decisions for this article, including selection of referees, were made by a Guest Editor. This policy applies to all articles with authors from the University of California San Francisco.
Benowitz, N. L., & Gourlay, S. G. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00079-x · Cited by 529
The Effect of Maternal Smoking during Pregnancy on Early Infant Lung Function
Hanrahan, J. P., Tager, I. B., Segal, M. R., Tosteson, T. D., Castile, R. G., Vunakis, H. V., Weiss, S. T., & Speizer, F. E. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.5.1129 · Cited by 527
Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily
Schoepfer, R., Conroy, W. G., Whiting, P. J., Gore, M., & Lindstrom, J. M. (1990) · Neuron · doi:10.1016/0896-6273(90)90031-a · Cited by 473
Extent of nicotine and cotinine transfer to the human fetus, placenta and amniotic fluid of smoking mothers
Luck, W., Nau, H., Hansen, R., & Steldinger, R. (2017) · Developmental Pharmacology and Therapeutics · doi:10.1159/000457063 · Cited by 444
Nicotinic acetylcholine receptors in health and disease
Lindstrom, J. (1997) · Molecular Neurobiology · doi:10.1007/bf02740634 · Cited by 443
Lung Function, Pre- and Post-natal Smoke Exposure, and Wheezing in the First Year of Life
Tager, I. B., Hanrahan, J. P., Tosteson, T. D., Castile, R. G., Brown, R. W., Weiss, S. T., & Speizer, F. E. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.4.811 · Cited by 315
Prenatal nicotine increases pulmonary α7 nicotinic receptor expression and alters fetal lung development in monkeys
Sekhon, H. S., Jia, Y., Raab, R., Kuryatov, A., Pankow, J. F., Whitsett, J. A., Lindstrom, J., & Spindel, E. R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5232 · Cited by 311
Self-citation
Maternal Smoking During Pregnancy. Effects on Lung Function During the First 18 Months of Life
Tager, I. B., Ngo, L. H., & Hanrahan, J. P. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.3.7663813 · Cited by 304
In utero exposure to cigarette smoking influences lung function at birth
Carlsen, K. L., Jaakkola, J. J. K., Nafstad, P. H. J., & Carlsen, K.-H. (1997) · European Respiratory Journal · doi:10.1183/09031936.97.10081774 · Cited by 260

Show all 34 references

Sorted by citations

Acetylcholine beyond neurons: the non‐neuronal cholinergic system in humans
Wessler, I. K., & Kirkpatrick, C. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.185 · Cited by 872
Risk factors and early origins of chronic obstructive pulmonary disease
Postma, D. S., Bush, A., & van den Berge, M. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60446-3 · Cited by 539
Long-Term Consequences of Fetal and Neonatal Nicotine Exposure: A Critical Review
Bruin, J. E., Gerstein, H. C., & Holloway, A. C. (2010) · Toxicological Sciences · doi:10.1093/toxsci/kfq103 · Cited by 379
Nicotine and the Developing Human
England, L. J., Bunnell, R. E., Pechacek, T. F., Tong, V. T., & McAfee, T. A. (2015) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2015.01.015 · Cited by 320
Maternal smoking in pregnancy and asthma in preschool children: a pooled analysis of eight birth cohorts
Neuman, Å., Hohmann, C., Orsini, N., Pershagen, G., Eller, E., Kjaer, H. F., Gehring, U., Granell, R., Henderson, J., Heinrich, J., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201203-0501oc · Cited by 260
Pulmonary Effects of Maternal Smoking on the Fetus and Child: Effects on Lung Development, Respiratory Morbidities, and Life Long Lung Health
McEvoy, C. T., & Spindel, E. R. (2016) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2016.08.005 · Cited by 285
Self-citation
Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma.
Song, P., Sekhon, H. S., Jia, Y., Keller, J. A., Blusztajn, J. K., Mark, G. P., & Spindel, E. R. (2003) · PubMed · Cited by 234
Self-citation
Vitamin C Supplementation for Pregnant Smoking Women and Pulmonary Function in Their Newborn Infants: A Randomized Clinical Trial
McEvoy, C. T., Schilling, D., Clay, N., Jackson, K., Go, M. D., Spitale, P., Bunten, C., Leiva, M., Gonzales, D., Hollister-Smith, J., et al. (2014) · JAMA · doi:10.1001/jama.2014.5217 · Cited by 217
“Respiratory rate, bpmd 53 (12) 57 (12) 57 (12) −0.”
Self-citation
Acetylcholine Is an Autocrine or Paracrine Hormone Synthesized and Secreted by Airway Bronchial Epithelial Cells
Proskocil, B. J., Sekhon, H. S., Jia, Y., Savchenko, V. L., Blakely, R., Lindstrom, J. M., & Spindel, E. R. (2004) · Endocrinology · doi:10.1210/en.2003-1728 · Cited by 200
Self-citation
Environmental factors and developmental outcomes in the lung
Kajekar, R. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.01.011 · Cited by 209
Developmental toxicity of nicotine: A transdisciplinary synthesis and implications for emerging tobacco products
England, L. J., Aagaard, K., Bloch, M., Conway, K., Cosgrove, K., Grana, R., Gould, T. J., Hatsukami, D., Jensen, F., Kandel, D., et al. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.013 · Cited by 181
Self-citation
The effect of parental smoking on lung function and development during infancy
Stocks, J., & Dezateux, C. A. (2003) · Respirology · doi:10.1046/j.1440-1843.2003.00478.x · Cited by 174
Perinatal nicotine exposure induces asthma in second generation offspring
Rehan, V. K., Liu, J., Naeem, E., Tian, J., Sakurai, R., Kwong, K., Akbari, O., & Torday, J. S. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-129 · Cited by 175
The effects of nicotine on human fetal development
Holbrook, B. D. (2016) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21128 · Cited by 173
Cigarette smoking induces atrial fibrosis in humans via nicotine
Goette, A., Lendeckel, U., Kuchenbecker, A., Bukowska, A., Peters, B., Klein, H., Huth, C., & Röcken, C. (2007) · Heart · doi:10.1136/hrt.2005.087171 · Cited by 163
Inflammatory Diseases of the Lung Induced by Conventional Cigarette Smoke
Alexander, L. E. C., Shin, S., & Hwang, J. H. (2015) · CHEST Journal · doi:10.1378/chest.15-0409 · Cited by 165
Pathophysiological Mechanisms of Asthma
Bush, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00068 · Cited by 173
The role of nicotine in the effects of maternal smoking during pregnancy on lung development and childhood respiratory disease. Implications for dangers of e-cigarettes
Spindel, E. R., & McEvoy, C. T. (2016) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201510-2013pp · Cited by 154
Self-citation
Prenatal Nicotine Exposure Alters Lung Function and Airway Geometry through α7 Nicotinic Receptors
Wongtrakool, C., Wang, N., Hyde, D. M., Roman, J., & Spindel, E. R. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0028oc · Cited by 147
Self-citation
Multiple roles of nicotine on cell proliferation and inhibition of apoptosis: Implications on lung carcinogenesis
Catassi, A., Servent, D., Paleari, L., Cesario, A., & Russo, P. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.04.002 · Cited by 146
The airway cholinergic system: physiology and pharmacology
Racké, K., & Matthiesen, S. (2004) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2004.03.001 · Cited by 139
Recent updates on electronic cigarette aerosol and inhaled nicotine effects on periodontal and pulmonary tissues
Javed, F., Kellesarian, S. V., Sundar, I., Romanos, G., & Rahman, I. (2017) · Oral Diseases · doi:10.1111/odi.12652 · Cited by 138
Pre- and Postnatal Exposure to Parental Smoking and Allergic Disease Through Adolescence
Thacher, J. D., Gruzieva, O., Pershagen, G., Neuman, Å., Wickman, M. C., Kull, I., Melén, E., & Bergström, A. (2014) · PEDIATRICS · doi:10.1542/peds.2014-0427 · Cited by 135
Lung Development and Aging
Bush, A. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-112aw · Cited by 125
Control by cholinergic mechanisms
Racké, K., Juergens, U. R., & Matthiesen, S. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.12.050 · Cited by 120
Muscarinic Receptors Mediate Stimulation of Human Lung Fibroblast Proliferation
Matthiesen, S., Bahulayan, A., Kempkens, S., Haag, S., Fuhrmann, M., Stichnote, C., Juergens, U. R., & Racké, K. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0343rc · Cited by 114
Smoking and Smoking Cessation in Pregnancy
Murin, S., Rafii, R., & Bilello, K. L. (2011) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2010.11.004 · Cited by 111
Prenatal Household Air Pollution Is Associated with Impaired Infant Lung Function with Sex-Specific Effects. Evidence from GRAPHS, a Cluster Randomized Cookstove Intervention Trial
Lee, A., Kaali, S., Quinn, A., Delimini, R., Burkart, K. G., Opoku-Mensah, J., Wylie, B. J., Yawson, A. K., Kinney, P. L., Ae-Ngibise, K. A., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201804-0694oc · Cited by 110
General mechanisms of nicotine‐induced fibrogenesis
Jensen, K. J., Nizamutdinov, D., Guerrier, M., Afroze, S. H., Dostal, D. E., & Glaser, S. S. (2012) · The FASEB Journal · doi:10.1096/fj.12-206458 · Cited by 115
Maternal smoking during pregnancy induces airway remodelling in mice offspring
Blacquiere, M. J., Timens, W., Melgert, B. N., Geerlings, M., Postma, D. S., & Hylkema, M. N. (2009) · European Respiratory Journal · doi:10.1183/09031936.00129608 · Cited by 104
Central Role of Fibroblast α3 Nicotinic Acetylcholine Receptor in Mediating Cutaneous Effects of Nicotine
Arredondo, J., Hall, L. L., Ndoye, A., Nguyen, V. T., Chernyavsky, A. I., Bercovich, D., Orr‐Urtreger, A., Beaudet, A. L., & Grando, S. A. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000053917.46614.12 · Cited by 104
Early developmental origins of impaired lung structure and function
Maritz, G. S., Morley, C. J., & Harding, R. (2005) · Early Human Development · doi:10.1016/j.earlhumdev.2005.07.002 · Cited by 104
A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research
Yeatts, K. B., Sly, P. D., Shore, S., Weiss, S. T., Martínez, F. D., Geller, A. M., Bromberg, P. A., Enright, P., Koren, H. S., Weissman, D. N., et al. (2006) · Environmental Health Perspectives · doi:10.1289/ehp.8381 · Cited by 105
Phenotypic Differences between Pediatric and Adult Asthma
Bush, A., & Menzies-Gow, A. N. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200906-046dp · Cited by 100
The Effects of Smoking on the Developing Lung: Insights from a Biologic Model for Lung Development, Homeostasis, and Repair
Rehan, V. K., Asotra, K., & Torday, J. S. (2009) · Lung · doi:10.1007/s00408-009-9158-2 · Cited by 93
Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts
Carlisle, D. L., Hopkins, T. M., Gaither‐Davis, A., Silhanek, M. J., Luketich, J. D., Christie, N. A., & Siegfried, J. M. (2004) · Respiratory Research · doi:10.1186/1465-9921-5-27 · Cited by 94
Regulation of lipid production by acetylcholine signalling in human sebaceous glands
Li, Z. J., Park, S. B., Sohn, K., Lee, Y., Seo, Y., Kim, C. D., Kim, Y. S., Lee, J. H., & Im, M. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.06.009 · Cited by 93
Cardiorespiratory effects of nicotine exposure during development
Hafström, O., Milerad, J., Sandberg, K. L., & Sundell, H. W. (2005) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2005.05.004 · Cited by 96
Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis
En-Nosse, M., Hartmann, S., Trinkaus, K., Alt, V., Stigler, B., Heiß, C., Kilián, O., Schnettler, R., & Lips, K. S. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0871-1 · Cited by 88
Smoking cessation in pregnancy: a continuing challenge in the United States
Scherman, A. J., Tolosa, J. E., & McEvoy, C. T. (2018) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098618775366 · Cited by 85
Immunohistochemical and histochemical findings favoring the occurrence of autocrine/paracrine as well as nerve‐related cholinergic effects in chronic painful patellar tendon tendinosis
Danielson, P., Alfredson, H., & Forsgren, S. (2006) · Microscopy Research and Technique · doi:10.1002/jemt.20351 · Cited by 83
Nicotine alters lung branching morphogenesis through the α7 nicotinic acetylcholine receptor
Wongtrakool, C., Roser-Page, S., Rivera, H. N., & Roman, J. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00038.2007 · Cited by 82
Prenatal nicotine exposure increases connective tissue expression in foetal monkey pulmonary vessels
Sekhon, H. S., Proskocil, B. J., Clark, J. A., & Spindel, E. R. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00069604 · Cited by 81
Self-citation
Vitamin C prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys
Proskocil, B. J., Sekhon, H. S., Clark, J. A., Lupo, S. L., Jia, Y., Hull, W. M., Whitsett, J. A., Starcher, B. C., & Spindel, E. R. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200408-1029oc · Cited by 76
Self-citation
Respiratory effects of tobacco smoking on infants and young children
Carlsen, K., & Carlsen, K. C. L. (2008) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2007.11.007 · Cited by 73
Inhibition of Uncoupling Protein Expression during Lactation: Role of Leptin
Xiao, X. Q., Grove, K. L., Grayson, B. E., & Smith, M. S. (2003) · Endocrinology · doi:10.1210/en.2003-0836 · Cited by 74
E-Cigarettes and Cardiopulmonary Health
Tarran, R., Barr, R. G., Benowitz, N. L., Bhatnagar, A., Chu, H. W., Dalton, P., Doerschuk, C. M., Drummond, M., Gold, D. R., Goniewicz, M. L., et al. (2021) · Function · doi:10.1093/function/zqab004 · Cited by 85
How Early Do Airway Inflammation and Remodeling Occur?
Bush, A. (2008) · Allergology International · doi:10.2332/allergolint.r-07-155 · Cited by 71
Mechanism of nicotine-induced pulmonary fibroblast transdifferentiation
Rehan, V. K., Wang, Y., Sugano, S. K., Romero, S., Chen, X., Santos, J., Khazanchi, A., & Torday, J. S. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00358.2004 · Cited by 70
In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism
Rehan, V. K., Wang, Y., Sugano, S. K., Santos, J., Patel, S., Sakurai, R., Boros, L., Lee, W.-P., & Torday, J. S. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00071.2006 · Cited by 70
Prenatal Nicotine Exposure Increases GABA Signaling and Mucin Expression in Airway Epithelium
Fu, X. W., Wood, K. J., & Spindel, E. R. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0109oc · Cited by 67
Self-citation
Nicotine replacement therapy for smoking cessation during pregnancy
Bar‐Zeev, Y., Lim, L. L., Bonevski, B., Gruppetta, M., & Gould, G. S. (2018) · Medical Journal of Australia · doi:10.5694/mja17.00446 · Cited by 66
Nicotine Activates and Up-Regulates Nicotinic Acetylcholine Receptors in Bronchial Epithelial Cells
Fu, X. W., Lindstrom, J. M., & Spindel, E. R. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0352oc · Cited by 65
Self-citation
Parental Smoking and Airway Reactivity in Healthy Infants
Tepper, R. S., Williams, T., Martinez, T., Kisling, J., Coates, C., & Daggy, J. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-711oc · Cited by 62
Impact of early life exposures on respiratory disease
Bush, A. (2021) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2021.05.006 · Cited by 64
RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking
Haley, K. J., Lasky-Su, J., Manoli, S. E., Smith, L. A., Shahsafaei, A., Weiss, S. T., & Tantisira, K. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00348.2010 · Cited by 58
Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy)
Bjur, D., Danielson, P., Alfredson, H., & Forsgren, S. (2007) · Cell and Tissue Research · doi:10.1007/s00441-007-0524-1 · Cited by 58
Trajectories of Lung Function in Infants and Children: Setting a Course for Lifelong Lung Health
Jordan, B. K., & McEvoy, C. T. (2020) · PEDIATRICS · doi:10.1542/peds.2020-0417 · Cited by 55
PPARγ agonist rosiglitazone prevents perinatal nicotine exposure-induced asthma in rat offspring
Liu, J., Sakurai, R., O'Roark, E. M., Kenyon, N. J., Torday, J. S., & Rehan, V. K. (2011) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00337.2010 · Cited by 52
Oral Vitamin C (500 mg/d) to Pregnant Smokers Improves Infant Airway Function at 3 Months (VCSIP). A Randomized Trial
McEvoy, C. T., Shorey‐Kendrick, L. E., Milner, K. F., Schilling, D., Tiller, C. J., Vuylsteke, B., Scherman, A. J., Jackson, K., Haas, D. M., Harris, J., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201805-1011oc · Cited by 50
Self-citation
Perinatal factors in neonatal and pediatric lung diseases
Britt, R. D., Faksh, A., Vogel, E. R., Martin, R. J., Pabelick, C. M., & Prakash, Y. S. (2013) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2013.838020 · Cited by 46
Neuroimmune regulation of lung infection and inflammation
Huang, Y., Zhao, C., & Su, X. (2018) · QJM · doi:10.1093/qjmed/hcy154 · Cited by 49
The role of environmental tobacco smoke in the origins and progression of asthma
Thomson, N. C. (2007) · Current Allergy and Asthma Reports · doi:10.1007/s11882-007-0045-8 · Cited by 48
Reviving the “biochemical” hypothesis for tendinopathy: new findings suggest the involvement of locally produced signal substances
Danielson, P. (2008) · British Journal of Sports Medicine · doi:10.1136/bjsm.2008.054593 · Cited by 47
Reversal of Nicotine-Induced Alveolar Lipofibroblast-to-Myofibroblast Transdifferentiation by Stimulants of Parathyroid Hormone-Related Protein Signaling
Rehan, V. K., Sakurai, R., Wang, Y., Santos, J., Huynh, K., & Torday, J. S. (2007) · Lung · doi:10.1007/s00408-007-9007-0 · Cited by 46
Expression of the High-affinity Choline Transporter CHT1 in Rat and Human Arteries
Lips, K. S., Pfeil, U., Reiners, K., Rimasch, C., Kuchelmeister, K., Braun-Dullaeus, R. C., Haberberger, R. V., Schmidt, R., & Kummer, W. (2003) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540305101208 · Cited by 46
Mechanism for nicotine-induced up-regulation of Wnt signaling in human alveolar interstitial fibroblasts
Sakurai, R., Cerny, L. M., Torday, J. S., & Rehan, V. K. (2010) · Experimental Lung Research · doi:10.3109/01902148.2010.490288 · Cited by 46
α7-Nicotinic receptor antagonists at the beginning of a clinical era for NSCLC and Mesothelioma?
Paleari, L., Cesario, A., Fini, M., & Russo, P. (2009) · Drug Discovery Today · doi:10.1016/j.drudis.2009.06.016 · Cited by 45
The genomic origins of asthma
Sharma, S., Chhabra, D., Kho, A. T., Hayden, L. P., Tantisira, K. G., & Weiss, S. T. (2014) · Thorax · doi:10.1136/thoraxjnl-2014-205166 · Cited by 43
Tobacco use disorder and the lungs
McRobbie, H. J., & Kwan, B. C. H. (2020) · Addiction · doi:10.1111/add.15309 · Cited by 45
Evidence for in vivo nicotine-induced alveolar interstitial fibroblast-to-myofibroblast transdifferentiation
Krebs, M., Sakurai, R., Torday, J. S., & Rehan, V. K. (2010) · Experimental Lung Research · doi:10.3109/01902141003714023 · Cited by 43
Unexpected finding of a marked non-neuronal cholinergic system in human knee joint synovial tissue
Grimsholm, O., Rantapää‐Dahlqvist, S., Dalén, T., & Forsgren, S. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.06.082 · Cited by 42
Effect of long-term maternal smoking on the offspring’s lung health
Sukjamnong, S., Chan, Y. L., Zakarya, R., Saad, S., Sharma, P. K., Santiyanont, R., Chen, H., & Oliver, B. G. G. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00134.2017 · Cited by 42
Parental Smoking and Childhood Asthma
Carlsen, K.-H. K., & Carlsen, K. C. L. D. (2005) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200504050-00005 · Cited by 40
Maternal smoking and the retinoid pathway in the developing lung
Manoli, S. E., Smith, L. A., Vyhlidal, C. A., An, C. H., Porrata, Y., Cardoso, W. V., Baron, R. M., & Haley, K. J. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-42 · Cited by 41
Altered Lung Development after Prenatal Nicotine Exposure in Young Lambs
Sandberg, K. L., Poole, S. D., Hamdan, A., Arbogast, P. G., & Sundell, H. W. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000136276.52104.61 · Cited by 41
The role of ADAM33 in the pathogenesis of asthma
Cakebread, J. A., Haitchi, H. M., Holloway, J. W., Powell, R. M., Keith, T. P., Davies, D. E., & Holgate, S. T. (2004) · Springer Seminars in Immunopathology · doi:10.1007/s00281-003-0153-z · Cited by 41
Prenatal Nicotine Exposure and Abnormal Lung Function
Pierce, R. A., & Nguyen, N. M. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.1.f225 · Cited by 40
The Peter Pan paradigm
Cohen, J., & Larson, J. E. (2008) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-5-1 · Cited by 40
Chaperoning α7 neuronal nicotinic acetylcholine receptors.
Vallés, A. S., & Barrantes, F. (2012) · Biochimica et Biophysica Acta · doi:10.1016/j.bbamem.2011.10.012 · Cited by 35
CFTR and Wnt/beta-catenin signaling in lung development
Cohen, J., Larson, J. E., Killeen, E., Love, D. K., & Takemaru, K. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-70 · Cited by 39
Adverse early-life environmental exposures and their repercussions on adult respiratory health
Mocelin, H. T., Fischer, G. B., & Bush, A. (2021) · Jornal de Pediatria · doi:10.1016/j.jped.2021.11.005 · Cited by 40
Quantitative analyses of bone composition in acetylcholine receptor M3R and alpha7 knockout mice
Kliemann, K. R., Kneffel, M., Bergen, I., Kampschulte, M., Langheinrich, A. C., Dürselen, L., Ignatius, A. A., Kilián, O., Schnettler, R., & Lips, K. S. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.07.024 · Cited by 35
The impact of perinatal nicotine exposure on fetal lung development and subsequent respiratory morbidity
Kuniyoshi, K. M., & Rehan, V. K. (2019) · Birth Defects Research · doi:10.1002/bdr2.1595 · Cited by 36
Deficiency of α7 Nicotinic Acetylcholine Receptor Attenuates Bleomycin-Induced Lung Fibrosis in Mice
Sun, P., Li, L., Zhao, C., Pan, M., Qian, Z., & Su, X. (2017) · Molecular Medicine · doi:10.2119/molmed.2016.00083 · Cited by 32
Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium
Fu, X. W., Song, P., & Spindel, E. R. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.05.022 · Cited by 33
Self-citation
Nicotine Modulates Growth Factors and MicroRNA to Promote Inflammatory and Fibrotic Processes
Ebrahimpour, A., Shrestha, S., Bonnen, M., Eissa, N. T., Raghu, G., & Ghebre, Y. T. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.252650 · Cited by 35
Beneficial effects of melatonin on nicotine-induced vasculopathy
Rodella, L. F., Filippini, F., Bonomini, F., Bresciani, R., Reiter, R. J., & Rezzani, R. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00735.x · Cited by 32
The Pulmonary Surfactant: Impact of Tobacco Smoke and Related Compounds on Surfactant and Lung Development
Scott, J. E. (2004) · Tobacco Induced Diseases · doi:10.1186/1617-9625-2-1-3 · Cited by 32
Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure
Sekhon, H. S., Song, P., Jia, Y., Lindstrom, J., & Spindel, E. R. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-1077-9 · Cited by 31
Self-citation
Changes in pro/antioxidant balance in smoking and non-smoking pregnant women with intrauterine growth restriction
Bizoń, A., Milnerowicz-Nabzdyk, E., Zalewska, M., Zimmer, M., & Milnerowicz, H. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.08.007 · Cited by 31
Vitamin C to pregnant smokers persistently improves infant airway function to 12 months of age: a randomised trial
McEvoy, C. T., Shorey‐Kendrick, L. E., Milner, K. F., Schilling, D., Tiller, C. J., Vuylsteke, B., Scherman, A. J., Jackson, K., Haas, D. M., Harris, J., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.02208-2019 · Cited by 30
Self-citation
Pathophysiologic consequences following inhibition of a CFTR-dependent developmental cascade in the lung
Cohen, J., & Larson, J. E. (2005) · BMC Developmental Biology · doi:10.1186/1471-213x-5-2 · Cited by 31
Cystic fibrosis transmembrane conductance regulator (CFTR) dependent cytoskeletal tension during lung organogenesis
Cohen, J., & Larson, J. E. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20912 · Cited by 31
Are nicotine replacement therapy, varenicline or bupropion options for pregnant mothers to quit smoking? Effects on the respiratory system of the offspring
Maritz, G. S. (2009) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465809343712 · Cited by 30
The time-dependent expression of α7nAChR during skeletal muscle wound healing in rats
Fan, Y., Zhang, S., Yu, L., Ye, G.-H., Lin, K.-Z., Wu, S., Dong, M., Han, J.-G., Feng, X., & Li, X.-B. (2014) · International Journal of Legal Medicine · doi:10.1007/s00414-014-1001-5 · Cited by 30
Nicotine stimulates collagen type I expression in lung via α7 nicotinic acetylcholine receptors
Vicary, G. W., Ritzenthaler, J. D., Panchabhai, T. S., Torres-González, E., & Roman, J. (2017) · Respiratory Research · doi:10.1186/s12931-017-0596-8 · Cited by 31
Cytokines and Chemokines as Biomarkers of Future Asthma
Bush, A. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00072 · Cited by 30
Spirometry and Impulse Oscillometry in Preschool Children: Acceptability and Relationship to Maternal Smoking in Pregnancy
Kattan, M., Bacharier, L. B., O’Connor, G. T., Cohen, R. T., Sorkness, R. L., Morgan, W. J., Gergen, P. J., Jaffee, K. F., Visness, C. M., Wood, R. A., et al. (2018) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.12.028 · Cited by 30
Developmental nicotine exposure results in programming of alveolar simplification and interstitial pulmonary fibrosis in adult male rats
Dasgupta, C., Xiao, D., Xu, Z., Yang, S., & Zhang, L. (2012) · Reproductive Toxicology · doi:10.1016/j.reprotox.2012.05.100 · Cited by 29

Authors: Sekhon, H. S., Keller, J. A., Proskocil, B. J., Martin, E. L., & Spindel, E. R.
Affiliations: Oregon Health & Science University (US)
ORCID: Keller, Jennifer A.
Proskocil, Becky J.
Spindel, Eliot R.
Venue: American Journal of Respiratory Cell and Molecular Biology
Publisher: Oxford University Press (OUP)
Published: 2002-01-01
Volume: 26
Issue: 1
Pages: 31-41
ISSN: 1044-1549 (ISSN-L)
1535-4989
DOI: 10.1165/ajrcmb.26.1.4170
OpenAlex: W1914845986
Cited by: 191
References: 34
Citations by year: 2026: 5 · 2025: 4 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 7 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 9 · 2016: 10 · 2015: 6 · 2014: 10 · 2013: 4 · 2012: 15
FWCI: 8.78
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory Cell and Molecular Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Center for Research Resources (RR-00163.)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD/HL-37131)
Topics: Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
Keywords: maternal nicotine exposure, alpha7 nicotinic acetylcholine receptor, collagen gene expression, type I collagen, type III collagen, elastin, lung fibroblasts, fetal lung development, airway wall thickening, smoking during pregnancy, rhesus monkeys
MeSH terms: Animals, Bungarotoxins, Cells, Cultured, Collagen, Dose-Response Relationship, Drug, Female, Fibroblasts, Humans, Immunohistochemistry, Lung, Macaca mulatta, Nicotine, Pregnancy, Protein Binding, Pulmonary Alveoli, Receptors, Nicotinic, RNA, Messenger, Smoking, Time Factors, Up-Regulation, In Situ Hybridization, Nicotinic Agonists, Maternal Exposure, Reverse Transcriptase Polymerase Chain Reaction, alpha7 Nicotinic Acetylcholine Receptor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Maternal Nicotine Exposure Upregulates Collagen Gene Expression in Fetal Monkey Lung

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks