The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Choriocapillaris Vascular Dropout Related to Density of Drusen in Human Eyes with Early Age-Related Macular Degeneration
Open accessAbstract
PURPOSE: Age-related macular degeneration (AMD) is a common, potentially blinding disease characterized by the presence of extracellular deposits beneath the retinal pigment epithelium (RPE). Choroidal vascular changes have also been noted in AMD. This study examined the relationship between the choroidal vasculature and extent of drusen and other sub-RPE deposits, the key pathologic landmarks of AMD. METHODS: Sections of the maculas of 45 human eyes (21 early AMD and 24 age-matched control) were evaluated morphometrically. The cross-sectional area of sub-RPE deposits, vascular density, number of CD45+ leukocytes, and number of "ghost vessels" were determined in a masked fashion and evaluated by regression analysis. In addition, the extramacular vascular density either directly beneath drusen or adjacent to drusen was evaluated in a separate set of donor eyes. RESULTS: The vascular density of the choriocapillaris showed a trend toward decreasing in association with AMD status. By linear regression analysis, vascular density was inversely associated with sub-RPE deposit density (r(2) = 0.22, P < 0.01). The number of ghost vessels was negatively correlated with vascular density (r(2) = 0.55, P < 0.001) and positively correlated with sub-RPE deposit density (r(2) = 0.57, P < 0.001). In morphologic studies of extramacular solitary drusen, vascular density beneath drusen was found to be 45% lower than adjacent to drusen (P < 0.01). CONCLUSIONS: These findings support the concept that microvascular changes are related to the pathogenesis of AMD and suggest that vascular endothelial cell loss occurs in association with sub-RPE deposit formation. Whether microvascular events are a cause or consequence of drusen or other deposit formation remains to be determined.
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Cites
Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961
Drusen proteome analysis: an approach to the etiology of age-related macular degeneration
Crabb, J. W., Miyagi, M., Gu, X., Shadrach, K., West, K. A., Sakaguchi, H., Kamei, M., Hasan, A., Yan, L., Rayborn, M. E., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222551899 · Cited by 1,208
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P. (2003) · Survey of Ophthalmology · doi:10.1016/s0039-6257(03)00030-4 · Cited by 959
Ageing and degeneration in the macular region: A clinico-pathological study
Sarks, S. H. (1976) · British Journal of Ophthalmology · doi:10.1136/bjo.60.5.324 · Cited by 891
Molecular pathology of age-related macular degeneration
Ding, X., Patel, M., & Chan, C.-C. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2008.10.001 · Cited by 582
Hypertension, cardiovascular disease, and age-related macular degeneration
Hyman, L. (2000) · Archives of Ophthalmology · doi:10.1001/archopht.118.3.351 · Cited by 441
A potential role for immune complex pathogenesis in drusen formation
JOHNSON, L. V., OZAKI, S., STAPLES, M. K., ERICKSON, P. A., & ANDERSON, D. H. (2000) · Experimental Eye Research · doi:10.1006/exer.1999.0798 · Cited by 353
The Genetics of Age-Related Macular Degeneration: A Review of Progress to Date
Haddad, S., Chen, C. A., Santangelo, S. L., & Seddon, J. M. (2006) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2006.05.001 · Cited by 299
Malek, G., Li, C.-M., Guidry, C., Medeiros, N. E., & Curcio, C. A. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63836-9 · Cited by 270
BRESSLER, N. M., SILVA, J. C., BRESSLER, S. B., FINE, S. L., & GREEN, W. R. (1994) · Retina · doi:10.1097/00006982-199414020-00006 · Cited by 200 · cited 3×
“It is possible that the observed choroidal microvascular changes are a secondary event that follows the formation of drusen and interference of trophic signaling by the RPE.”
ResultInfluentialIRON TOXICITY AS A POTENTIAL FACTOR IN AMD
WONG, R. W., RICHA, D. C., HAHN, P., GREEN, W. R., & DUNAIEF, J. L. (2007) · Retina · doi:10.1097/iae.0b013e318074c290 · Cited by 131
Cited by
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
Datta, S., Cano, M., Ebrahimi, K., Wang, L., & Handa, J. T. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.03.002 · Cited by 802
Jia, Y., Bailey, S. T., Hwang, T. S., McClintic, S. M., Gao, S. S., Pennesi, M. E., Flaxel, C. J., Lauer, A. K., Wilson, D. J., Hornegger, J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500185112 · Cited by 665
Curcio, C. A., Messinger, J. D., Sloan, K. R., McGwin, G., Medeiros, N. E., & Spaide, R. F. (2013) · Retina · doi:10.1097/iae.0b013e31827e25e0 · Cited by 384
Mechanisms of age‐related macular degeneration and therapeutic opportunities
van Lookeren Campagne, M., LeCouter, J., Yaspan, B. L., & Ye, W. (2014) · The Journal of Pathology · doi:10.1002/path.4266 · Cited by 382
Mettu, P. S., Allingham, M. J., & Cousins, S. W. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100906 · Cited by 370
Metadata
- Authors
- Mullins, R. F., Johnson, M. N., Faidley, E. A., Skeie, J. M., & Huang, J.
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2011-03-21
- Volume
- 52
- Issue
- 3
- Pages
- 1606
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W1996836034
- Cited by
- 394
- References
- 12
- FWCI
- 15.24
- Type
- journal article
- Language
- en
- Open access
- green
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