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Cited by 441Retinal Diseases and TreatmentsRetinal Imaging and AnalysisBlood Pressure and Hypertension Studies

Hypertension, cardiovascular disease, and age-related macular degeneration

Hyman, Leslie·2000·Archives of Ophthalmology
DOI 10.1001/archopht.118.3.351
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Abstract

OBJECTIVES: To describe a case-control study of risk factors for neovascular and non-neovascular age-related macular degeneration (AMD) and to present findings on associations with systemic hypertension and cardiovascular disease. METHODS: Participants with and without neovascular and non-neovascular AMD were recruited from 11 ophthalmology practices in the New York, NY, metropolitan area. Comprehensive data collection included (1) a standardized interview, (2) blood pressure measurements, and (3) blood samples. Cases and controls were classified from fundus photograph gradings. Polychotomous logistic regression analyses were used to evaluate associations. RESULTS: Classification of 1222 sets of available photographs resulted in the inclusion of a neovascular case group (n = 182), a non-neovascular case group (n = 227), and a control group (n = 235). Neovascular AMD was positively associated with diastolic blood pressure greater than 95 mm Hg (odds ratio [OR] = 4.4), self-reported use of potent antihypertensive medication (OR = 2.1), physician-reported history of hypertension (OR = 1.8), use of antihypertensive medication (OR = 2.5), combinations of self-reported and physician-reported data on hypertension and its treatment (OR = 1. 7), high-density lipoprotein level (OR = 2.3), and dietary cholesterol level (OR = 2.2). Non-neovascular AMD was unrelated to hypertension or cholesterol level. No associations were found between either AMD type and other definitions of hypertension or other cardiovascular disease. CONCLUSIONS: These findings suggest that neovascular AMD is associated with moderate to severe hypertension, particularly among patients receiving antihypertensive treatment. They also support the hypotheses that neovascular and non-neovascular AMD may have a different pathogenesis and that neovascular AMD and hypertensive disease may have a similar underlying systemic process.

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  • Increased concentrations of HDL cholesterol have been shown to be associated with a reduced risk of age-related macular degeneration.

    “Increased concentrations of HDL cholesterol—considered to be cardioprotective—have been shown to be associated with a reduced risk of age-related macular degeneration.80,81”

    From Age-related macular degeneration (2008) · cites this paper as [80]

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Authors
Hyman, L.
Affiliations
Stony Brook University Hospital (US)
Corresponding author
Hyman, Leslie
ORCID
Hyman, Leslie
Venue
Archives of Ophthalmology
Publisher
American Medical Association (AMA)
Published
2000-03-01
Volume
118
Issue
3
Pages
351
ISSN
0003-9950 (ISSN-L)
DOI
10.1001/archopht.118.3.351
OpenAlex
W2117696490
Cited by
441
References
48
Citations by year
2026: 4 · 2025: 15 · 2024: 16 · 2023: 8 · 2022: 9 · 2021: 19 · 2020: 13 · 2019: 19 · 2018: 14 · 2017: 16 · 2016: 21 · 2015: 23 · 2014: 26 · 2013: 24 · 2012: 17
FWCI
11.77
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Ophthalmology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Macula Foundation
  • National Institutes of Health (2r01ey005653-04)
  • National Eye Institute (R01 EY05653)
Topics
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
neovascular age-related macular degeneration, non-neovascular age-related macular degeneration, hypertension, cardiovascular disease, diastolic blood pressure, antihypertensive drugs, high-density lipoprotein, dietary cholesterol, risk factors, pathogenesis
MeSH terms
Aged, Antihypertensive Agents, Blood Pressure, Cardiovascular Diseases, Female, Humans, Hypertension, Intraocular Pressure, Cholesterol, HDL, Macular Degeneration, Male, Middle Aged, Risk Factors, Retinal Neovascularization, Odds Ratio, Case-Control Studies

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