Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.

Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A., & Kahn, C. R. (2000) · Molecular Cell · doi:10.1016/s1097-2765(05)00015-8 · Cited by 1,296

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

Brüning, J. C., Michael, M. D., Winnay, J. N., Hayashi, T., Hörsch, D., Accili, D., Goodyear, L. J., & Kahn, C. R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80155-0 · Cited by 1,173

Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation

Coffer, P. J., Jin, J., & Woodgett, J. R. (1998) · Biochemical Journal · doi:10.1042/bj3350001 · Cited by 1,064

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

Cheatham, B., Vlahos, C. J., Cheatham, L. A., Wang, L., Blenis, J., & Kahn, C. R. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.7.4902-4911.1994 · Cited by 1,062

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

Rameh, L. E., & Cantley, L. C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8347 · Cited by 989

Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

SHEPHERD, P. R., WITHERS, D. J., & SIDDLE, K. (1998) · Biochemical Journal · doi:10.1042/bj3330471 · Cited by 953

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

Okada, T., Kawano, Y., Sakakibara, T., Hazeki, O., & Ui, M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41901-6 · Cited by 911

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

Brüning, J. C., Winnay, J. N., Bonner‐Weir, S., Taylor, S. I., Accili, D., & Kahn, C. R. (1997) · Cell · doi:10.1016/s0092-8674(00)81896-6 · Cited by 539

Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

Yu, J., Zhang, Y., McIlroy, J., Rordorf-Nikolic, T., Orr, G. A., & Backer, J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1379 · Cited by 527

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

Fruman, D. A., Snapper, S. B., Yballe, C. M., Davidson, L., Yu, J. Y., Alt, F. W., & Cantley, L. C. (1999) · Science · doi:10.1126/science.283.5400.393 · Cited by 516

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM

Boden, G. (1997) · Diabetes · doi:10.2337/diabetes.46.1.3 · Cited by 479

Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase

Bi, L., Okabe, I., Bernard, D. J., Wynshaw-Boris, A. J., & Nussbaum, R. L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10963 · Cited by 444

1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells.

Hara, K., Yonezawa, K., Sakaue, H., Ando, A., Kotani, K., Kitamura, T., Kitamura, Y., Ueda, H., Stephens, L., & Jackson, T. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7415 · Cited by 433

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

Terauchi, Y., Tsuji, Y., Satoh, S., Minoura, H., Murakami, K., Okuno, A., Inukai, K., Asano, T., Kaburagi, Y., Ueki, K., et al. (1999) · Nature Genetics · doi:10.1038/6023 · Cited by 399

Potential Role of Protein Kinase B in Insulin-induced Glucose Transport, Glycogen Synthesis, and Protein Synthesis

Ueki, K., Yamamoto‐Honda, R., Kaburagi, Y., Yamauchi, T., Tobe, K., Burgering, B. M. T., Coffer, P. J., Komuro, I., Akanuma, Y., Yazaki, Y., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5315 · Cited by 357

Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.

Kerouz, N., Hörsch, D., Pons, S., & Kahn, C. R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119872 · Cited by 296

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α

Fruman, D. A., Mauvais‐Jarvis, F., Pollard, D. A., Yballe, C. M., Brazil, D. P., Bronson, R. T., Kahn, C. R., & Cantley, L. C. (2000) · Nature Genetics · doi:10.1038/81715 · Cited by 287

Exocytosis of Insulin Promotes Insulin Gene Transcription via the Insulin Receptor/PI-3 Kinase/p70 s6 Kinase and CaM Kinase Pathways

Leibiger, I. B., Leibiger, B., Moede, T., & Berggren, P. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80093-3 · Cited by 283

The Structure and Function of P55 PIK Reveal a New Regulatory Subunit for Phosphatidylinositol 3-Kinase

Pons, S., Asano, T., Glasheen, E. M., Miralpeix, M., Zhang, Y., Fisher, T. L., Myers, M. G., Sun, X., & White, M. F. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.8.4453 · Cited by 240

The Contribution of Insulin-Dependent and Insulin-Independent Glucose Uptake to Intravenous Glucose Tolerance in Healthy Human Subjects

Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., Palmer, J., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.4.587 · Cited by 240

Regulation of the p85/p110α Phosphatidylinositol 3′-Kinase

Yu, J., Wjasow, C., & Backer, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30199 · Cited by 187

INSULIN ACTION IN THE POLYCYSTIC OVARY SYNDROME

Dunaif, A. E. (1999) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70073-6 · Cited by 180

Altered Expression Levels and Impaired Steps in the Pathway to Phosphatidylinositol 3-Kinase Activation via Insulin Receptor Substrates 1 and 2 in Zucker Fatty Rats

Anai, M., Funaki, M., Ogihara, T., Terasaki, J., Inukai, K., Katagiri, H., Fukushima, Y., Yazaki, Y., Kikuchi, M., Oka, Y., et al. (1998) · Diabetes · doi:10.2337/diab.47.1.13 · Cited by 180

p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin

Inukai, K., Funaki, M., Ogihara, T., Katagiri, H., Kanda, A., Anai, M., Fukushima, Y., Hosaka, T., Suzuki, M., Shin, B., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.12.7873 · Cited by 166

Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85α Regulatory Subunit

Ueki, K., Algenstaedt, P., Mauvais-Jarvis, F., & Kahn, C. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8035-8046.2000 · Cited by 148

Insulin Receptor Substrate 1 Binds Two Novel Splice Variants of the Regulatory Subunit of Phosphatidylinositol 3-Kinase in Muscle and Brain

Antonetti, D. A., Algenstaedt, P., & Kahn, C. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2195 · Cited by 147

Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway

Gabbay, R. A., Sutherland, C. D., Gnudi, L., Kahn, B. B., O’Brien, R. M., Granner, D. K., & Flier, J. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.4.1890 · Cited by 129

A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85α Gene

Inukai, K., Anai, M., van Breda, E., Hosaka, T., Katagiri, H., Funaki, M., Fukushima, Y., Ogihara, T., Yazaki, Y., Kikuchi, M., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.10.5317 · Cited by 124

Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene

Fruman, D. A., Cantley, L. C., & Carpenter, C. L. (1996) · Genomics · doi:10.1006/geno.1996.0527 · Cited by 115

The missing link with obesity?

Flier, J. S. (2001) · Nature · doi:10.1038/35053251 · Cited by 108

Specific Increase in p85α Expression in Response to Dexamethasone Is Associated with Inhibition of Insulin-like Growth Factor-I Stimulated Phosphatidylinositol 3-Kinase Activity in Cultured Muscle Cells

Giorgino, F., Pedrini, M. T., Matera, L., & Smith, R. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.7455 · Cited by 80

Assessment of the Roles of Mitogen-activated Protein Kinase, Phosphatidylinositol 3-Kinase, Protein Kinase B, and Protein Kinase C in Insulin Inhibition of cAMP-induced Phosphoenolpyruvate Carboxykinase Gene Transcription

Agati, J. M., Yeagley, D., & Quinn, P. G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.18751 · Cited by 80

Signaling Pathway Involved in the Activation of Heart 6-Phosphofructo-2-kinase by Insulin

Lefebvre, V., Máchin, M.-C., Louckx, M. P., Rider, M. H., & Hue, L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.37.22289 · Cited by 68

Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats

Anai, M., Funaki, M., Ogihara, T., et al. (1998) · Diabetes · doi:10.2337/diabetes.47.1.13 · Cited by 62

Restored insulin-sensitivity in IRS-1–deficient mice treated by adenovirus-mediated gene therapy

Ueki, K., Yamauchi, T., Tamemoto, H., Tobe, K., Yamamoto‐Honda, R., Kaburagi, Y., Akanuma, Y., Yazaki, Y., Aizawa, S., Nagai, R., et al. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7656 · Cited by 60

Signalling pathways involved in the stimulation of glycogen synthesis by insulin in rat hepatocytes

Peak, M., Rochford, J. J., Borthwick, A. C., Yeaman, S. J., & Agius, L. (1998) · Diabetologia · doi:10.1007/s001250050861 · Cited by 59

Critical nodes in signalling pathways: insights into insulin action

Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760

Endocrine regulation of energy metabolism by the skeleton

Lee, N. K., Sowa, H., Hinoi, E., Ferron, M., Ahn, J. D., Confavreux, C., Dacquin, R., Mee, P. J., McKee, M. D., Jung, D. Y., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.047 · Cited by 2,554

Insulin sensitivity: Modulation by nutrients and inflammation

Schenk, S., Saberi, M., & Olefsky, J. M. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34260 · Cited by 1,191

Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training

Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110062 · Cited by 966

Regulation of glucose homeostasis by glucocorticoids

Kuo, T., McQueen, A., Chen, T.-C., & Wang, J.-C. (2015) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-2895-8_5 · Cited by 723

Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase

Ueki, K., Yballe, C. M., Brachmann, S. M., Vicent, D., Watt, J. M., Kahn, C. R., & Cantley, L. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012581799 · Cited by 229

Phosphoinositide 3-kinase regulatory subunit p85α suppresses insulin action via positive regulation of PTEN

Taniguchi, C. M., Tran, T. T., Kondo, T., Luo, J., Ueki, K., Cantley, L. C., & Kahn, C. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604628103 · Cited by 153

Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice

Brachmann, S. M., Ueki, K., Engelman, J. A., Kahn, R., & Cantley, L. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.5.1596-1607.2005 · Cited by 181

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

Terauchi, Y., Tsuji, Y., Satoh, S., Minoura, H., Murakami, K., Okuno, A., Inukai, K., Asano, T., Kaburagi, Y., Ueki, K., et al. (1999) · Nature Genetics · doi:10.1038/6023 · Cited by 399

Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85α Regulatory Subunit

Ueki, K., Algenstaedt, P., Mauvais-Jarvis, F., & Kahn, C. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.21.8035-8046.2000 · Cited by 148