CoChat
Sign Up
Cited by 598Cardiovascular and exercise physiologyMuscle metabolism and nutritionMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.

Glucose metabolism during leg exercise in man

Open access
Wahren, John, Felig, Philip, Ahlborg, Gunvor, Jorfeldt, Lennart·1971·Journal of Clinical Investigation
DOI 10.1172/jci106772PMC PMC292221
Open this paper in CoChat — free accountOpen PDF

Abstract

Arterial concentrations and net substrate exchange across the leg and splanchnic vascular bed were determined for glucose, lactate, pyruvate, and glycerol in healthy postabsorptive subjects at rest and during 40 min of exercise on a bicycle ergometer at work intensities of 400, 800, and 1200 kg-m/min. Rising arterial glucose levels and small decreases in plasma insulin concentrations were found during heavy exercise. Significant arterial-femoral venous differences for glucose were demonstrated both at rest and during exercise, their magnitude increasing with work intensity as well as duration of the exercise performed. Estimated glucose uptake by the leg increased 7-fold after 40 min of light exercise and 10- to 20-fold at moderate to heavy exercise. Blood glucose uptake could at this time account for 28-37% of total substrate oxidation by leg muscle and 75-89% of the estimated carbohydrate oxidation. Splanchnic glucose production increased progressively during exercise reaching levels 3 to 5-fold above resting values at the heavy work loads. Close agreement was observed between estimates of total glucose turnover during exercise based on leg glucose uptake and splanchnic glucose production. Hepatic gluconeogenesis-estimated from splanchnic removal of lactate, pyruvate, glycerol, and glycogenic amino acids-could supply a maximum of 25% of the resting hepatic glucose production but could account for only 6-11% of splanchnic glucose production after 40 min of moderate to heavy exercise. IT IS CONCLUDED THAT: (a) blood glucose becomes an increasingly important substrate for muscle oxidation during prolonged exercise of this type: (b) peripheral glucose utilization increases in exercise despite a reduction in circulating insulin levels: (c) increased hepatic output of glucose, primarily by means of augmented glycogenolysis, contributes to blood glucose homeostasis in exercise and provides an important source of substrate for exercising muscle.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci106772

Cites

63 of 63 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 3

  1. Cahill, G. F., Jr., and 0. E. Owen. 1968. Some ob- servations on carbohydrate metabolism in man. In Car- bohydrate Metabolism and its Disorders. F. Dickens, P. J. Randle, and W. J. Whelan, editors. Academic Press, Inc., New York. 1: 497.
  2. Bradley, S. E. 1946. Liver function as studied by hepatic vein catheterization. In Transactions of the Fifth Con- ference on Liver Injury. Josiah Macy, Jr. Foundation, New York. 38.
  3. Jorfeldt, L., and J. Wahren. 1971. Leg blood flow dur- ing exercise. Clin. Sci. (London). In press.

Cited by

Sorted by citations

See all 598

Related

See all

Metadata

Authors
Wahren, J., Felig, P., Ahlborg, G., & Jorfeldt, L.
Affiliations
Karolinska Institutet (SE)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1971-12-01
Volume
50
Issue
12
Pages
2715-2725
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci106772
PMC
PMC292221
OpenAlex
W2011985622
Cited by
598
References
63
Citations by year
2026: 5 · 2025: 4 · 2024: 10 · 2023: 9 · 2022: 16 · 2021: 19 · 2020: 14 · 2019: 6 · 2018: 10 · 2017: 7 · 2016: 11 · 2015: 10 · 2014: 10 · 2013: 11 · 2012: 5
FWCI
21.19
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Medical Research Council
Topics
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
glucose metabolism, leg exercise, glucose uptake, hepatic gluconeogenesis, glycogenolysis, insulin, blood glucose, carbohydrate oxidation, lactate, pyruvate, glycerol, blood flow, exercise intensity, blood glucose homeostasis
MeSH terms
Abdomen, Adult, Blood Glucose, Physical Exertion, Fatty Acids, Nonesterified, Glucose, Glycerol, Heart Rate, Humans, Insulin, Lactates, Leg, Liver, Male, Methods, Muscles, Oxygen, Oxygen Consumption, Pyruvates, Regional Blood Flow, Rest, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review