Cited by 545Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthLipid metabolism and disorders

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Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

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Brown, M S, Goldstein, J L·1983·Journal of Clinical Investigation

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Abstract

A decade of intense investigation has established a central role for lipoprotein receptors in regulating plasma cholesterol traffic. These receptors bind cholesterol-carrying lipoproteins and transport them into cells by receptor-mediated endocytosis. The receptor for low density lipoprotein (LDL) was the first discovered; it has been purified and its structure characterized. The LDL receptor was described in cultured human fibroblasts; identical receptors are now known to function in liver as well as in extrahepatic tissues. Operationally, the LDL/LDL receptor system can be considered the primary transport mechanism for endogenous cholesterol. Dietary cholesterol, on the other hand, is transported from the intestine in chylomicron remnants, which enter hepatocytes via distinct chylomicron remnant receptors. The chylomicron remnant/remnant receptor system is to exogenous cholesterol transport as the LDL/LDL receptor system is to endogenous cholesterol transport. In this article, we review recent developments in this rapidly advancing field.

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Authors: Brown, M. S., & Goldstein, J. L.
ORCID: Goldstein, J L
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1983-09-01
Volume: 72
Issue: 3
Pages: 743-747
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci111044
PMC: PMC1129238
OpenAlex: W2137716547
Cited by: 545
References: 48
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 2 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 6 · 2014: 9 · 2013: 5 · 2012: 13
FWCI: 66.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (HL20948)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: lipoprotein receptors, liver, LDL receptor, receptor-mediated endocytosis, chylomicron remnants, dietary cholesterol, hepatocytes
MeSH terms: Animals, Apolipoproteins, Apolipoproteins E, Apoproteins, Binding, Competitive, Cholesterol, Cyclohexanones, Dogs, Guinea Pigs, Cricetinae, Humans, Hyperlipoproteinemia Type II, Liver, Macaca mulatta, Molecular Weight, Rabbits, Receptors, Cell Surface, Receptors, LDL, Receptors, Lipoprotein, Rats

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Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

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