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The low density lipoprotein receptor: Structure, function and pharmacological modulation
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LDLR is a receptor normally localized to the cell membrane, where it binds cholesterol-rich LDLs and mediates their entry into cells.
“LDLR is a receptor normally localizd to the cell membrane, where it binds to cholesterol-rich LDLs and mediates their entry into cells (Catapano, 1989).”
From ENO1–BACE2-mediated LDLR cleavage promotes liver cancer progression by remodelling cholesterol metabolism (2025) · cites this paper as Catapano, 1989
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Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.
Brown, M. S., & Goldstein, J. L. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111044 · Cited by 545
Davis, C. G., Goldstein, J. L., Südhof, T. C., Anderson, R. G. W., Russell, D. W., & Brown, M. S. (1987) · Nature · doi:10.1038/326760a0 · Cited by 411
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Research works printed but not linked: 112
- Anderson, 1982, Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies, J. Cell Biol., 93, 523, 10.1083/jcb.93.3.523 · DOI
- Anderson, 1977, Role for the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts, Cell, 10, 351, 10.1016/0092-8674(77)90022-8 · DOI · Paper page
- Anderson, 1977, A mutation that impairs the ability of lipoprotein receptors to localize in pits on the cell surface of human fibroblasts, Nature, 270, 695, 10.1038/270695a0 · DOI
- Anderson, 1978, Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution, Cell, 15, 919, 10.1016/0092-8674(78)90276-3 · DOI
- Beynen, 1986, Mechanism of casein-induced hypercholesterolemia: primary and secondary features, Atherosclerosis, 60, 291, 10.1016/0021-9150(86)90177-2 · DOI
- Bhattacharya, 1986, Regulation of low-density-lipoprotein metabolism in the rat, Biochem. J., 234, 493, 10.1042/bj2340493 · DOI
- Bilheimer, 1984, Liver transplantation to provide low density lipoprotein receptors and lower plasma cholesterol in a child with homozygous familial hypercholesterolemia, New Engl. J. Med., 311, 1658, 10.1056/NEJM198412273112603 · DOI
- Brown, 1981, Lowering plasma cholesterol by raising LDL receptors, New Engl. J. Med., 305, 515, 10.1056/NEJM198108273050909 · DOI
- Brown, 1983, Recycling receptors: the round-trip itinerary of migrant membrane proteins, Cell, 32, 666, 10.1016/0092-8674(83)90052-1 · DOI · Paper page
- Brown, 1986, A receptor-mediated pathway for cholesterol homeostasis, Science, 232, 34, 10.1126/science.3513311 · DOI · Paper page
- Brown, 1981, Regulation of plasma cholesterol by lipoprotein receptors, Science, 212, 628, 10.1126/science.6261329 · DOI · Paper page
- Buchwald, 1985, Surgical intervention in atherosclerosis: partial ileal bypass and the program on surgical control of the hyperlipidemias (POSCH), Pharmac. Ther., 29, 93, 10.1016/0163-7258(85)90018-X · DOI
- Cayen, 1979, Pharmacokinetics and hypolipidemic activity of clofibrate-nicotinic acid combinations in rats, Biochem. Pharmac., 28, 1163, 10.1016/0006-2952(79)90323-X · DOI
- Carpentier, 1986, Internalization of polypeptide hormones and receptor recycling, Experientia, 42, 734, 10.1007/BF01941519 · DOI
- Catapano, 1987, Binding sites for HDL and HDL catabolism, Atherosclerosis Rev., 16, 109
- Catapano, 1989, Competitive inhibitors of HMG-CoA reductase, Pharmac. Res. Commun.
- Chait, 1979, Regulatory role of triiodothyronine in the degradation of low density lipoprotein by cultured human skin fibroblast, J. clin. Endocr. Metab., 48, 887, 10.1210/jcem-48-5-887 · DOI
- Chait, 1979, Low density lipoprotein receptor activity in cultured human skin fibroblasts; mechanisms of insulin-induced stimulation, J. clin. Invest., 64, 1309, 10.1172/JCI109587 · DOI
- Chait, 1981, Acceleration of low-density lipoprotein catabolism in man by total parenteral nutrition (41240), P.E.E.B.M., 168, 97
- Chao, 1982, Effects of cholestyramine on low density lipoprotein binding sites on liver membranes from rabbits with endogenous hypercholesterolemia induced by a wheat starch-casein diet, J. biol. Chem., 257, 3623, 10.1016/S0021-9258(18)34825-7 · DOI
- Chute, 1985, Reducing of plasma cholesterol and LDL-cholesterol by continuous intravenous insulin infusion, Surgery, 98, 656
- Corsini, 1986, Calcium antagonists and low density lipoprotein metabolism by human fibroblasts and by human hepatoma cell line Hep G2, Pharmac. Res. Commun., 18, 1, 10.1016/0031-6989(86)90155-4 · DOI
- Cummings, 1983, Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor, J. biol. Chem., 258, 15261, 10.1016/S0021-9258(17)43802-6 · DOI
- Davis, 1986, Deletion of clustered O-linked carbohydrates does not impair function of low density lipoprotein receptor in transfected fibroblasts, J. biol. Chem., 261, 2828, 10.1016/S0021-9258(17)35862-3 · DOI
- Davis, 1986, The D.J. Mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL Receptor, Cell, 45, 15, 10.1016/0092-8674(86)90533-7 · DOI · Paper page
- Davis, 1987, The low density lipoprotein receptor, J. biol. Chem., 262, 4075, 10.1016/S0021-9258(18)61313-4 · DOI · Paper page
- Eisenberg, 1984, Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia, J. clin. Invest., 74, 470, 10.1172/JCI111444 · DOI
- Endo, 1985, Drugs inhibiting HMG-CoA reductase, Pharmac. Ther., 31, 257, 10.1016/0163-7258(85)90025-7 · DOI
- Epstein, 1983, Cholesterol coronary heart disease cancer and diet: some current controversies, Atherosclerosis Rev., 11, 1
- Fears, 1984, Drug treatment of hyperlipidaemia, Drugs of Today, 20, 257
- Filipovic, 1986, Calcium channels stimulate LDL receptor synthesis in human skin fibroblasts, Biochem. biophys. Res. Commun., 136, 845, 10.1016/0006-291X(86)90409-2 · DOI
- Frick, 1987, Helsinki heart study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia, New Engl. J. Med., 317, 1237, 10.1056/NEJM198711123172001 · DOI · Paper page
- Gofman, 1951, Lipoproteins and atherosclerosis, J. Gerontol., 6, 105, 10.1093/geronj/6.2.105 · DOI
- Goldstein, 1974, Binding and degradation of low density lipoproteins by cultured human fibroblasts: comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia, J. biol. Chem., 249, 5153, 10.1016/S0021-9258(19)42341-7 · DOI · Paper page
- Goldstein, 1977, The low-density lipoprotein pathway and its relation to atherosclerosis, A. Rev. Biochem., 46, 897, 10.1146/annurev.bi.46.070177.004341 · DOI · Paper page
- Goldstein, 1984, Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol, J. Lipid Res., 25, 1450, 10.1016/S0022-2275(20)34418-7 · DOI
- Goldstein, 1987, Regulation of low-density lipoproteins receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis, Circulation, 76, 504, 10.1161/01.CIR.76.3.504 · DOI · Paper page
- Goldstein, 1978, Role of lysosomal acid lipase in the metabolism of plasma low density lipoproteins, J. biol. Chem., 250, 8487, 10.1016/S0021-9258(19)40786-2 · DOI
- Goldstein, 1979, Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor, J. biol. Chem., 254, 5403, 10.1016/S0021-9258(18)50610-4 · DOI
- Gordon, 1977, High density lipoprotein as a protective factor against coronary heart disease. The Framingham study, Am. J. Med., 62, 707, 10.1016/0002-9343(77)90874-9 · DOI · Paper page
- Grundy, 1986, Liver lipoproteins and atherosclerosis: an overview, Atherosclerosis Rev., 15, 1
- Grundy, 1987, Dietary therapy for different forms of hyperlipoproteinemia, Circulation, 76, 523, 10.1161/01.CIR.76.3.523 · DOI
- Hegsted, 1965, Quantitative effects of dietary fat on serum cholesterol in man, Am. J. clin. Nutr., 17, 281, 10.1093/ajcn/17.5.281 · DOI
- Hobbs, 1986, Deletion of exon encoding cysteine-rich repeat of low density lipoprotein receptor alters its binding specificity in a subject with familial hypercholesterolemia, J. biol. Chem., 261, 13114, 10.1016/S0021-9258(18)69278-6 · DOI
- Hobbs, 1987, Deletion in the gene for the low-density-lipoprotein receptor in a majority of French Canadians with familial hypercholesterolemia, New Engl. J. Med., 317, 734, 10.1056/NEJM198709173171204 · DOI
- Hoeg, 1987, 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of hypercholesterolemia, JAMA, 258, 3532, 10.1001/jama.258.24.3532 · DOI
- Hoeg, 1986, An approach to the management of hyperlipoproteinemia, JAMA, 255, 512, 10.1001/jama.255.4.512 · DOI
- Horsthemke, 1987, Unequal crossing-over between two alu-repetitive DNA sequences in the low density lipoprotein receptor gene. A possible mechanism for the defect in a patient with familial hypercholesterolemia, Eur. J. Biochem., 164, 77, 10.1111/j.1432-1033.1987.tb10995.x · DOI
- Hui, 1986, Isolation and characterization of the apolipoprotein E receptor from canine and human liver, J. biol. Chem., 261, 4256, 10.1016/S0021-9258(17)35655-7 · DOI
- Kempen, 1987, Effect of ketoconazole on cholesterol synthesis and on HMG-CoA reductase and LDL-receptor activities in hep G2 cells, Biochem. Pharmac., 36, 1245, 10.1016/0006-2952(87)90077-3 · DOI
- Kesäniemi, 1983, Receptor-mediated catabolism of low density lipoprotein, J. clin. Invest., 71, 950, 10.1172/JCI110849 · DOI
- Keys, 1970, Coronary heart disease in seven countries, Circulation, 41, I
- Keys, 1965, Serum cholesterol responses to changes in diet. IV. Particular saturated fatty acids in the diet, Metabolism, 14, 776, 10.1016/0026-0495(65)90004-1 · DOI
- Kishimoto, 1987, Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II, J. biol. Chem., 262, 1344, 10.1016/S0021-9258(19)75792-5 · DOI
- Knott, 1986, Complete protein sequence and identification of structural domains of human apolipoprotein B, Nature, 323, 734, 10.1038/323734a0 · DOI
- Koo, 1986, Uptake of canine β very low density lipoprotein by mouse peritoneal macrophages is mediated by a low density lipoprotein receptor, J. biol. Chem., 261, 11194, 10.1016/S0021-9258(18)67367-3 · DOI
- Kovanen, 1979, Increased binding of low density lipoprotein of liver membranes from rats treated with 17 alpha-ethinyl estradiol, J. biol. Chem., 254, 11367, 10.1016/S0021-9258(19)86495-5 · DOI
- Lehrman, 1985, Internalization-defective LDL receptors produced by gene with nonsense and frameshift mutations that truncate the cytoplasmic domain, Cell, 41, 735, 10.1016/S0092-8674(85)80054-4 · DOI
- Lehrman, 1987, Duplication of seven exons in LDL receptor gene causes by alu-alu recombination in a subject with familial hypercholesterolemia, Cell, 48, 827, 10.1016/0092-8674(87)90079-1 · DOI
- Lehrman, 1987, Alu-alu recombination deletes splice acceptor sites and produces secreted low density lipoprotein receptors in a subject with familial hypercholesterolemia, J. biol. Chem., 262, 3354, 10.1016/S0021-9258(18)61510-8 · DOI
- Lehrman, 1987, The lebanese allele at the low density lipoprotein receptor locus, J. biol. Chem., 262, 401, 10.1016/S0021-9258(19)75941-9 · DOI
- Lehrman, 1985, Mutation in LDL receptor: alu-alu recombination deletes exons encoding transmembrane and cytoplasmic domains, Science, 227, 140, 10.1126/science.3155573 · DOI
- Lipid Research Clinics Program, 1984, The lipid research clinics coronary primary prevention trial results: I. Reduction in incidence of coronary heart disease, JAMA, 251, 351, 10.1001/jama.251.3.351 · DOI · Paper page
- Lovati, 1987, Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients, J. clin. Invest., 80, 1498, 10.1172/JCI113232 · DOI
- Mahley, 1983, Lipoprotein receptors and cholesterol homeostasis, Biochim. biophys. Acta, 737, 197, 10.1016/0304-4157(83)90001-1 · DOI
- Miettinen, 1975, Bile acid metabolism, Vol. 41, 109
- Nishikura, 1986, Studies and perspectives of protein kinase C, Science, 233, 305, 10.1126/science.3014651 · DOI
- Oram, 1983, Regulation of high density lipoprotein receptor activity in cultured human skin fibroblasts and human arterial smooth muscle cells, J. clin. Invest., 72, 1611, 10.1172/JCI111120 · DOI
- Prasad, 1985, Coat formation in coated vesicles, Biochemistry, 24, 6421, 10.1021/bi00344a017 · DOI
- Ranganathan, 1982, Effect of Ca2+ blocking agents on the metabolism of low density lipoprotein in human skin fibroblasts, Biochem. biophys. Res. Commun., 107, 217, 10.1016/0006-291X(82)91691-6 · DOI
- Roach, 1987, The effects of dietary fish oil on hepatic high density and low density lipoprotein receptor activities in the rat, FEBS Lett., 222, 159, 10.1016/0014-5793(87)80211-9 · DOI
- Russell, 1984, Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor, Cell, 37, 577, 10.1016/0092-8674(84)90388-X · DOI · Paper page
- Salter, 1987, Binding of low density lipoprotein to monolayer cultures of rat hepatocytes is increased by insulin and decreased by dexamethasone, FEBS Lett., 220, 159, 10.1016/0014-5793(87)80895-5 · DOI
- Scarabottolo, 1986, Experimental hypothyroidism modulates the expression of the low density lipoprotein receptor by the liver, Atherosclerosis, 59, 329, 10.1016/0021-9150(86)90129-2 · DOI
- Schneider, 1983, Reconstitution of low density lipoprotein receptor, J. Cell. Biochem., 23, 95, 10.1002/jcb.240230110 · DOI
- Schneider, 1982, Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight, J. biol. Chem., 257, 2664, 10.1016/S0021-9258(18)34975-5 · DOI · Paper page
- Sege, 1984, Expression and regulation of human low density lipoprotein receptors in Chinese hamster ovary cells, Nature, 307, 742, 10.1038/307742a0 · DOI
- Semenkovich, 1987, Estrogen induced low-density lipoprotein receptor activity and decrease intracellular cholesterol in human hepatoma cell line hep G2, Biochem., 26, 4987, 10.1021/bi00390a016 · DOI
- Series, 1988, Influence of etofibrate on low density lipoprotein metabolism, Atherosclerosis, 69, 233, 10.1016/0021-9150(88)90019-6 · DOI
- Shannon-Moore, 1987, Assembly of clathrin-coated pits onto purified plasma membranes, Science, 236, 558, 10.1126/science.2883727 · DOI
- Shepherd, 1979, Receptor-mediated low density lipoprotein catabolism in man, J. Lipid Res., 20, 999, 10.1016/S0022-2275(20)40002-1 · DOI
- Shepherd, 1980, Cholestyramine promotes receptor-mediated low-density-lipoprotein catabolism, New Engl. J. Med., 302, 1219, 10.1056/NEJM198005293022202 · DOI
- Sirtori, 1977, Soy bean-protein diet in the treatment of type II hyperlipoproteinemia, Lancet, II, 275, 10.1016/S0140-6736(77)91823-2 · DOI
- Sirtori, 1984, Effects of dietary proteins on the regulation of liver lipoprotein receptors in rats, J. Nutr., 114, 1493, 10.1093/jn/114.8.1493 · DOI
- Slater, 1980, Effects of cholestyramine on receptor-mediated plasma clearance and tissue uptake of human low density lipoproteins in the rabbit, J. biol. Chem., 255, 10210, 10.1016/S0021-9258(19)70450-5 · DOI
- Spady, 1985, Rates of low density lipoprotein uptake and cholesterol synthesis are regulated indepently in the liver, J. Lipid Res., 26, 465, 10.1016/S0022-2275(20)34361-3 · DOI
- Spady, 1986, Kinetic constants for receptor-dependent and receptor-independent low density lipoprotein transport in the tissues of the rat and hamster, J. clin. Invest., 77, 1474, 10.1172/JCI112460 · DOI
- Spengel, 1981, Superiority of partial ileal bypass over cholestyramine in reducing cholesterol in familial hypercholesterolemia, Lancet, I, 768, 10.1016/S0140-6736(81)90183-5 · DOI
- Stahl, 1986, Receptor-mediated endocytosis, J. clin. Invest., 77, 657, 10.1172/JCI112359 · DOI
- Stalenhoef, 1984, Partial ileal bypass reduces the production rate of low density lipoproteins in Watanabe heritable hyperlipemid rabbits, J. Lipid Res., 25, 1350, 10.1016/S0022-2275(20)34452-7 · DOI
- Stange, 1984, Age-related decreases in tissue sterol aquisition are mediated by changes in cholesterol synthesis and not low density lipoprotein uptake in the rat, J. Lipid Res., 25, 703, 10.1016/S0022-2275(20)37759-2 · DOI
- Stein, 1985, Verapamil enhances receptor-mediated endocytosis of low density lipoproteins by aortic cells in culture, Atherosclerosis, 5, 35
- Stewart, 1982, Effects of bezafibrate on receptor-mediated and receptor-independent low density lipoprotein catabolism in type II hyperlipoproteinaemic subject, Atherosclerosis, 44, 355, 10.1016/0021-9150(82)90010-7 · DOI
- Storlien, 1987, Fish oil prevents insulin resistance induced by high-fat feeding in rats, Science, 237, 885, 10.1126/science.3303333 · DOI
- Südhof, 1985, The LDL receptor gene: a mosaic of exons shared with dofferent proteins, Science, 228, 815, 10.1126/science.2988123 · DOI · Paper page
- Südhof, 1985, Cassette of eight exons shared by genes for LDL receptors and EGF precursor, Science, 228, 893, 10.1126/science.3873704 · DOI
- Südhof, 1987, 4ä bp element of LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter, Cell, 48, 1061, 10.1016/0092-8674(87)90713-6 · DOI · Paper page
- Südhof, 1987, Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene, J. biol. Chem., 262, 10773, 10.1016/S0021-9258(18)61030-0 · DOI · Paper page
- Sykes, 1981, The effects of hypothyroidism, age and nutrition on LDL catabolism in the rat, Metabolism, 30, 733, 10.1016/0026-0495(81)90017-2 · DOI
- Tobert, 1987, New developments in lipid lowering therapy: the role of inhibitors of hydroxymethylglutaryl coenzyme A reductase, Circulation, 76, 534, 10.1161/01.CIR.76.3.534 · DOI
- Tolleshaug, 1982, Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia, Cell, 30, 715, 10.1016/0092-8674(82)90276-8 · DOI · Paper page
- Tolleshaug, 1983, The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor, Cell, 32, 914, 10.1016/0092-8674(83)90079-X · DOI
- Trezzi, 1984, Effects of insulin defiency on the catabolism of plasma lipoproteins and on the expression of hepatic lipoprotein receptors in rat, Pharm. Res. Commun., 16, 539, 10.1016/S0031-6989(84)80035-1 · DOI
- Trezzi, 1983, Effect of partial ileal bypass on plasma clearance and binding of lipoproteins to liver membranes in the rabbit, Atherosclerosis, 46, 269, 10.1016/0021-9150(83)90177-6 · DOI
- Undewood, 1986, A thyromimetic that decreases plasma cholesterol levels without increasing cardiac activity, Nature, 324, 425, 10.1038/324425a0 · DOI
- Van Niekerk, 1983, Partial ileal bypass inhibits atherosclerosis in WHHL rabbits, Atherosclerosis, 48, 243, 10.1016/0021-9150(83)90042-4 · DOI
- Vega, 1988, Lovastatin therapy in familial dysbetalipoproteinemia: effect on kinetics of apolipoprotein B, Atherosclerosis, 70, 131, 10.1016/0021-9150(88)90107-4 · DOI
- Weinstein, 1987, Antiatherogenic properties of calcium antagonists, Am. J. Cardiol., 59, 163B, 10.1016/0002-9149(87)90097-X · DOI
- Wileman, 1985, Receptor-mediated endocytosis, Biochem. J., 232, 1, 10.1042/bj2320001 · DOI
- Wong, 1987, Eicosapentaenoc acid inhibits the secretion of triacylglycerol and of apoprotein B and the binding of LDL in Hep G2 cells, Atherosclerosis, 64, 139, 10.1016/0021-9150(87)90239-5 · DOI
- Yamamoto, 1985, Deletion in cysteine-rich of LDL receptor impedes transport to cell surface in WHHL rabbit, Science, 232, 1230, 10.1126/science.3010466 · DOI
- Yamamoto, 1984, The human LDL receptor: a cysteine-rich protein with multiple alu sequences in its mRNA, Cell, 39, 27, 10.1016/0092-8674(84)90188-0 · DOI · Paper page
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Sorted by citations
Li, Z., Fan, K., Suo, C., Gu, X., Zhu, C., Wei, H., Chen, L., Gao, P., & Sun, L. (2025) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjaf001 · Cited by 13
Metadata
- Authors
- Catapano, A. L.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 43
- Issue
- 2
- Pages
- 187-219
- ISSN
- 0163-7258
- Cited by
- 9
- References
- 2
- Language
- en
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