Oxidative and nitrosative stress in Parkinson's disease

α-Synuclein in Lewy bodies

Spillantini, M. G., Schmidt, M. L., Lee, V. M.-Y., Trojanowski, J. Q., Jakes, R., & Goedert, M. (1997) · Nature · doi:10.1038/42166 · Cited by 8,382 · see citing works

Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease

Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455 · see citing works

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227 · see citing works

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914 · see citing works

Neurodegenerative diseases and oxidative stress

Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683 · see citing works

Mitochondrial free radical generation, oxidative stress, and aging

Cadenas, E., & Davies, K. J. A. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00317-8 · Cited by 3,010 · see citing works

Reconciling the chemistry and biology of reactive oxygen species

Winterbourn, C. C. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.85 · Cited by 2,504 · see citing works

Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures.

Dawson, V. L., Dawson, T. M., London, E. D., Bredt, D. S., & Snyder, S. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.14.6368 · Cited by 2,174 · see citing works

Protein S-nitrosylation: Purview and parameters

Hess, D. T., Matsumoto, A., Kim, S.-O., Marshall, H. E., & Stamler, J. S. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1569 · Cited by 2,153 · see citing works

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics

Szabó, C., Ischiropoulos, H., & Radi, R. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2222 · Cited by 2,134 · see citing works

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Shimura, H., Hattori, N., Kubo, S.-I., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., et al. (2000) · Nature Genetics · doi:10.1038/77060 · Cited by 2,024 · see citing works

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

Travers, K. J., Patil, C. K., Wodicka, L. M., Lockhart, D. J., Weissman, J. S., & Walter, P. (2000) · Cell · doi:10.1016/s0092-8674(00)80835-1 · Cited by 1,994 · see citing works

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788 · see citing works

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

Masliah, E., Rockenstein, E. M., Veinbergs, I., Mallory, M. E., Hashimoto, M., Takeda, A., Sagara, Y., Sisk, A., & Mucke, L. (2000) · Science · doi:10.1126/science.287.5456.1265 · Cited by 1,763 · see citing works

MITOCHONDRIAL COMPLEX I DEFICIENCY IN PARKINSON'S DISEASE

Schapira, A. H. V., Cooper, J. A. D., Dexter, D. T., Jenner, P. G., Clark, J. B., & MARSDEN, C. D. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92366-0 · Cited by 1,757 · see citing works

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705 · see citing works

Molecular Pathways of Neurodegeneration in Parkinson's Disease

Dawson, T. M., & Dawson, V. L. (2003) · Science · doi:10.1126/science.1087753 · Cited by 1,659 · see citing works

The roles of intracellular protein-degradation pathways in neurodegeneration

Rubinsztein, D. C. (2006) · Nature · doi:10.1038/nature05291 · Cited by 1,625 · see citing works

Apoptosis in neurodegenerative disorders

Mattson, M. P. (2000) · Nature Reviews Molecular Cell Biology · doi:10.1038/35040009 · Cited by 1,605 · see citing works

Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions

Giasson, B. I., Duda, J. E., Murray, I. V. J., Chen, Q., Souza, J. M., Hurtig, H. I., Ischiropoulos, H., Trojanowski, J. Q., & Lee, V. M. ‐. (2000) · Science · doi:10.1126/science.290.5493.985 · Cited by 1,551 · see citing works

Nitric oxide in the central nervous system: neuroprotection versus neurotoxicity

Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D. A., & Giuffrida Stella, A. M. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2214 · Cited by 1,543 · cited 2× · see citing works

S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds.

Stamler, J. S., Simon, D. I., Osborne, J. A., Mullins, M. E., Jaraki, O., Michel, T. M., Singel, D. J., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.444 · Cited by 1,471 · see citing works

Alpha-synuclein and neurodegenerative diseases

Goedert, M. (2001) · Nature reviews. Neuroscience · doi:10.1038/35081564 · Cited by 1,402 · see citing works

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

Nicklas, W. J., Vyas, I. L., & Heikkila, R. E. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90146-8 · Cited by 1,266 · see citing works

Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct

Conway, K. A., Rochet, J.-C., Bieganski, R. M., & Lansbury, P. T. (2001) · Science · doi:10.1126/science.1063522 · Cited by 1,127 · see citing works

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding

Hara, M. R., Agrawal, N., Kim, S. F., Cascio, M. B., Fujimuro, M., Ozeki, Y., Takahashi, M., Cheah, J. H., Tankou, S. K., Hester, L. D., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1268 · Cited by 1,071 · see citing works

Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease

Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046 · cited 1× · see citing works

Neurodegenerative diseases and oxidative stress

Emerit, J., Edeas, M. A., & Bricaire, F. (2003) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2003.11.004 · Cited by 1,031 · see citing works

Modulation of neurodegeneration by molecular chaperones

Muchowski, P. J., & Wacker, J. L. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1587 · Cited by 1,021 · see citing works

Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

Goldberg, M. S., Fleming, S. M., Palacino, J. J., Cepeda, C., Lam, H. A., Bhatnagar, A., Meloni, E. G., Wu, N., Ackerson, L. C., Klapstein, G. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308947200 · Cited by 913 · see citing works

S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration

Uehara, T., Nakamura, T., Yao, D., Shi, Z., Gu, Z., Ma, Y., Masliah, E., Nomura, Y., & Lipton, S. A. (2006) · Nature · doi:10.1038/nature04782 · Cited by 908 · see citing works

Mitochondria in the aetiology and pathogenesis of Parkinson's disease

Schapira, A. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70327-7 · Cited by 883 · see citing works

Expanding insights of mitochondrial dysfunction in Parkinson's disease

Abou-Sleiman, P. M., Muqit, M. M. K., & Wood, N. W. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1868 · Cited by 869 · see citing works

From acute ER stress to physiological roles of the Unfolded Protein Response

Wu, J., & Kaufman, R. J. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401840 · Cited by 868 · see citing works

Persistent inhibition of cell respiration by nitric oxide: Crucial role of <i>S</i> -nitrosylation of mitochondrial complex I and protective action of glutathione

Clementi, E., Brown, G. C., Feelisch, M., & Moncada, S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7631 · Cited by 863 · see citing works

Degradation of oxidized proteins by the 20S proteasome

Davies, K. J. A. (2001) · Biochimie · doi:10.1016/s0300-9084(01)01250-0 · Cited by 849 · see citing works

MEF2: a central regulator of diverse developmental programs

Potthoff, M. J., & Olson, E. N. (2007) · Development · doi:10.1242/dev.008367 · Cited by 834 · see citing works

Cyclic guanosine monophosphate as a mediator of vasodilation.

Murad, F. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112536 · Cited by 799 · see citing works

Endogenous nitric oxide synthesis: Biological functions and pathophysiology

Bredt, D. S. (1999) · Free Radical Research · doi:10.1080/10715769900301161 · Cited by 796 · see citing works

S -Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function

Chung, K. K. K., Thomas, B., Li, X., Pletniková, O., Troncoso, J. C., Marsh, L., Dawson, V. L., & Dawson, T. M. (2004) · Science · doi:10.1126/science.1093891 · Cited by 765 · see citing works

CENTRAL CERVICAL CORD SYNDROME AFTER HEADING A FOOTBALL

Scoppetta, C., & Vaccario, M. L. (1978) · The Lancet · doi:10.1016/s0140-6736(78)92517-5 · Cited by 755 · see citing works

Parkinson's disease

Thomas, B., & Beal, M. F. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm159 · Cited by 748 · see citing works

Fas-Induced Caspase Denitrosylation

Mannick, J. B., Hausladen, A., Liu, L., Hess, D. T., Zeng, M., Miao, Q., Kane, L. S., Gow, A. J., & Stamler, J. S. (1999) · Science · doi:10.1126/science.284.5414.651 · Cited by 743 · see citing works

Dopamine covalently modifies and functionally inactivates parkin

LaVoie, M. J., Ostaszewski, B. L., Weihofen, A., Schlossmacher, M. G., & Selkoe, D. J. (2005) · Nature Medicine · doi:10.1038/nm1314 · Cited by 722 · see citing works

Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease

Hartmann, A., Hunot, S., Michel, P. P., Muriel, M., Vyas, S., Faucheux, B. A., Prigent, A., Turmel, H., Srinivasan, A. N., Ruberg, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040556597 · Cited by 717 · see citing works

The physiology and pathophysiology of nitric oxide in the brain

Guix, F. X., Uribesalgo, I., Coma, M., & Muñoz, F. J. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.001 · Cited by 708 · see citing works

Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress

Gautier, C. A., Kitada, T., & Shen, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802076105 · Cited by 698 · see citing works

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

Kim, R. H., Smith, P. D., Aleyasin, H., Hayley, S. P., Mount, M. P., Pownall, S., Wakeham, A. C., You-Ten, A. J., Kalia, S. K., Horne, P., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501282102 · Cited by 697 · see citing works

Vesicle Permeabilization by Protofibrillar α-Synuclein: Implications for the Pathogenesis and Treatment of Parkinson's Disease

Volles, M. J., Lee, S., Rochet, J., Shtilerman, M. D., Ding, T. T., Kessler, J. C., & Lansbury, P. T. (2001) · Biochemistry · doi:10.1021/bi0102398 · Cited by 682 · see citing works

Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and ‘aggresomes’ during oxidative stress, aging, and disease

Grune, T., Jung, T., Merker, K., & Davies, K. J. A. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.020 · Cited by 653 · see citing works

Diagnosis and treatment of Parkinson disease: molecules to medicine

Savitt, J. M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29178 · Cited by 649 · see citing works

Reactive Oxygen-Mediated Protein Oxidation in Aging and Disease

Stadtman, E. R., & Berlett, B. S. (1997) · Chemical Research in Toxicology · doi:10.1021/tx960133r · Cited by 645 · see citing works

Origin and functional consequences of the complex I defect in Parkinson's disease

Swerdlow, R. H., Parks, J. K., Miller, S. W., Davis, R. E., Tuttle, J. B., Trimmer, P. A., Sheehan, J. P., Bennett, J. P., & Parker, W. D. (1996) · Annals of Neurology · doi:10.1002/ana.410400417 · Cited by 638 · see citing works

Dopamine-modified α-synuclein blocks chaperone-mediated autophagy

Martínez‐Vicente, M., Tallóczy, Z., Kaushik, S., Massey, A. C., Mazzulli, J. R., Mosharov, E. V., Hodara, R., Fredenburg, R. A., Wu, D.-C., Follenzi, A., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32806 · Cited by 633 · see citing works

Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity.

Przedborski, S., Jackson-Lewis, V. R., Yokoyama, R., Shibata, T., Dawson, V. L., & Dawson, T. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.4565 · Cited by 624 · see citing works

Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease

Sulzer, D. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.009 · Cited by 583 · see citing works

Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP

Dauer, W. T., Kholodilov, N. G., Vila, M., Trillat, A., Goodchild, R. E., Larsen, K. E., Staal, R. G. W., Tieu, K., Schmitz, Y., Yuan, C. A., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172514599 · Cited by 580 · see citing works

Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention

Tansey, M. G., McCoy, M. K., & Frank-Cannon, T. C. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.07.004 · Cited by 580 · see citing works

Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental lewy body disease

Jenner, P. G., Dexter, D. T., Sian, J., Schapira, A. H. V., & MARSDEN, C. D. (1992) · Annals of Neurology · doi:10.1002/ana.410320714 · Cited by 545 · see citing works

Targeting programmed cell death in neurodegenerative diseases

Vila, M., & Przedborski, S. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1100 · Cited by 545 · see citing works

Nigrostriatal Dopaminergic Deficits and Hypokinesia Caused by Inactivation of the Familial Parkinsonism-Linked Gene DJ-1

Goldberg, M. S., Pisani, A., Haburčák, M., Vortherms, T. A., Kitada, T., Costa, C., Tong, Y., Martella, G., Tscherter, A., Martins, A., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.041 · Cited by 532 · see citing works

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity

Yao, D., Gu, Z., Nakamura, T., Shi, Z., Ma, Y., Gaston, B. M., Palmer, L. A., Rockenstein, E. M., Zhang, Z., Masliah, E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404161101 · Cited by 516 · see citing works

Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse

Itier, J. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg239 · Cited by 507 · see citing works

DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

Andrés‐Mateos, E., Perier, C., Zhang, L., Blanchard-Fillion, B., Greco, T. M., Thomas, B., Ko, H. S., Sasaki, M., Ischiropoulos, H., Przedborski, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703219104 · Cited by 478 · see citing works

A regulatory link between ER-associated protein degradation and the unfolded-protein response

Friedlander, R., Jarosch, E., Urban, J., Volkwein, C., & Sommer, T. (2000) · Nature Cell Biology · doi:10.1038/35017001 · Cited by 474 · see citing works

The pathogenesis of cell death in Parkinson's disease

Jenner, P. G., & Olanow, C. W. (2006) · Neurology · doi:10.1212/wnl.66.10_suppl_4.s24 · Cited by 449 · see citing works

Lewy bodies are ubiquitinated

Kuzuhara, S., Mori, H., Izumiyama, N., Yoshimura, M., & Ihara, Y. (1988) · Acta Neuropathologica · doi:10.1007/bf00687787 · Cited by 409 · see citing works

Oxidative Stress and Genetics in the Pathogenesis of Parkinson's Disease

Zhang, Y., Dawson, V. L., & Dawson, T. M. (2000) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0319 · Cited by 406 · see citing works

cGMP and S-nitrosylation: two routes for modulation of neuronal excitability by NO

Ahern, G. P. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02254-3 · Cited by 379 · see citing works

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

Benner, E. J., Banerjee, R., Reynolds, A. D., Sherman, S., Писарев, В. М., Tsiperson, V., Nemachek, C., Ciborowski, P. S., Przedborski, S., Mosley, R. L., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001376 · Cited by 359 · see citing works

Dopamine Transporter Is Required for In Vivo MPTP Neurotoxicity: Evidence from Mice Lacking the Transporter

Gainetdinov, R. R., Fumagalli, F., Jones, S. R., & Caron, M. G. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69031322.x · Cited by 353 · see citing works

Loss of locus coeruleus neurons and reduced startle in parkin null mice

von Coelln, R., Thomas, B., Savitt, J. M., Lim, K. L., Sasaki, M., Hess, E. J., Dawson, V. L., & Dawson, T. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401297101 · Cited by 347 · see citing works

S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities

Martı́nez-Ruiz, A., Villanueva, L., de Orduña, C. G., López‐Ferrer, D., Higueras, M. Á., Tarín, C., Rodríguez‐Crespo, I., Vázquez, J., & Lamas, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407294102 · Cited by 330 · see citing works

Glyceraldehyde-3-phosphate dehydrogenase: Nuclear translocation participates in neuronal and nonneuronal cell death

Sawa, A., Khan, A. A., Hester, L. D., & Snyder, S. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.21.11669 · Cited by 316 · see citing works

Tumour maintenance is mediated by eNOS

Lim, K., Ancrile, B. B., Kashatus, D. F., & Counter, C. M. (2008) · Nature · doi:10.1038/nature06778 · Cited by 315 · see citing works

Redox imbalance in Parkinson's disease

Chinta, S. J., & Andersen, J. K. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.02.005 · Cited by 302 · see citing works

Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine

Mitchell, D. A., & Marletta, M. A. (2005) · Nature Chemical Biology · doi:10.1038/nchembio720 · Cited by 292 · see citing works

Functional Consequences of α-Synuclein Tyrosine Nitration

Hodara, R., Norris, E. H., Giasson, B. I., Mishizen-Eberz, A. J., Lynch, D. R., Lee, V. M. ‐., & Ischiropoulos, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408906200 · Cited by 286 · see citing works

Protein oxidation and cellular homeostasis: Emphasis on metabolism

Cecarini, V., Gee, J., Fioretti, E., Amici, M., Angeletti, M., Eleuteri, A. M., & Keller, J. N. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.08.039 · Cited by 274 · see citing works

Reversible Inhibition of α-Synuclein Fibrillization by Dopaminochrome-mediated Conformational Alterations

Norris, E. H., Giasson, B. I., Hodara, R., Xu, S., Trojanowski, J. Q., Ischiropoulos, H., & Lee, V. M.-Y. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412621200 · Cited by 273 · see citing works

Inhibition of the multicatalytic proteinase (proteasome) by 4‐hydroxy‐2‐nonenal cross‐linked protein

Friguet, B., & Szweda, L. I. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00148-8 · Cited by 261 · see citing works

Role of Cdk5-Mediated Phosphorylation of Prx2 in MPTP Toxicity and Parkinson's Disease

Qu, D., Rashidian, J., Mount, M. P., Aleyasin, H., Parsanejad, M., Lira, A., Haque, E., Zhang, Y., Callaghan, S. M., Daigle, M., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.033 · Cited by 251 · see citing works

Neuroprotection by pharmacologic blockade of the GAPDH death cascade

Hara, M. R., Thomas, B., Cascio, M. B., Bae, B.-I., Hester, L. D., Dawson, V. L., Dawson, T. M., Sawa, A., & Snyder, S. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511321103 · Cited by 238 · see citing works

The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders

Chung, K. K. K., Dawson, V. L., & Dawson, T. M. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01998-6 · Cited by 223 · see citing works

Potential role of nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase in apoptosis and oxidative stress

Dastoor, Z., & Dreyer, J. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.9.1643 · Cited by 217 · see citing works

Inhibition of Caspase-3 by S-Nitrosation and Oxidation Caused by Nitric Oxide

Mohr, S., Zech, B., Lapetina, E. G., & Brüne, B. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7304 · Cited by 215 · see citing works

The pathogenesis of cell death in Parkinson's disease – 2007

Olanow, C. W. (2007) · Movement Disorders · doi:10.1002/mds.21675 · Cited by 212 · see citing works

Oxidative and nitrative protein modifications in Parkinson's disease

Danielson, S. R., & Andersen, J. K. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.03.005 · Cited by 201 · see citing works

Signalling by NO-induced protein S-nitrosylation and S-glutathionylation: Convergences and divergences

Martı́nez-Ruiz, A., & Lamas, S. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.016 · Cited by 197 · see citing works

S-Nitrosylation of Bcl-2 Inhibits Its Ubiquitin-Proteasomal Degradation

Azad, N., Vallyathan, V., Wang, L., Tantishaiyakul, V., Stehlik, C., Leonard, S. S., & Rojanasakul, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602551200 · Cited by 194 · see citing works

Mitochondrial medicine--molecular pathology of defective oxidative phosphorylation.

Fosslien, E. (2001) · PubMed · Cited by 186 · see citing works

Synaptic Roles of Cdk5: Implications in Higher Cognitive Functions and Neurodegenerative Diseases

Cheung, Z. H., Fu, A. K. Y., & Ip, N. Y. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.024 · Cited by 182 · see citing works

Calpain-Regulated p35/cdk5 Plays a Central Role in Dopaminergic Neuron Death through Modulation of the Transcription Factor Myocyte Enhancer Factor 2

Smith, P. D., Mount, M. P., Shree, R. S., Callaghan, S. M., Slack, R. S., Anisman, H., Vincent, I. J., Wang, X., Mao, Z., & Park, D. S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2875-05.2006 · Cited by 180 · see citing works

Oxidative modification of H-ras: S-thiolation and S-nitrosylation of reactive cysteines

Mallis, R. J., Buss, J. E., & Thomas, J. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3550145 · Cited by 168 · see citing works

α-Synuclein Overexpression Increases Cytosolic Catecholamine Concentration

Mosharov, E. V., Staal, R. G. W., Bové, J., Prou, D., Hananiya, A., Markov, D., Poulsen, N., Larsen, K. E., Moore, C. M. H., Troyer, M. D., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0519-06.2006 · Cited by 165 · see citing works

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage

Aleyasin, H., Rousseaux, M. W. C., Phillips, M., Kim, R. H., Bland, R. J., Callaghan, S. M., Slack, R. S., During, M. J., Mak, T. W., & Park, D. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709379104 · Cited by 160 · see citing works

Cytosolic Catechols Inhibit α-Synuclein Aggregation and Facilitate the Formation of Intracellular Soluble Oligomeric Intermediates

Mazzulli, J. R., Mishizen-Eberz, A. J., Giasson, B. I., Lynch, D. R., THOMAS, S. A., Nakashima, A., Nagatsu, T., Ota, A., & Ischiropoulos, H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0896-06.2006 · Cited by 152 · see citing works

Inactivation of Parkin by Oxidative Stress and C-terminal Truncations

Winklhofer, K. F., Henn, I. H., Kay-Jackson, P. C., Heller, U., & Tatzelt, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306769200 · Cited by 143 · see citing works

Differential Regulation of Bax and Bak by Anti-apoptotic Bcl-2 Family Proteins Bcl-B and Mcl-1

Zhai, D., Jin, C., Huang, Z., Satterthwait, A. C., & Reed, J. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708426200 · Cited by 138 · see citing works

An overview of the mechanisms of mutagenesis and carcinogenesis

Sarasin, A. R. (2003) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2003.06.024 · Cited by 138 · see citing works

Apoptotic neuronal death in Parkinson's disease: Involvement of nitric oxide

Singh, S., & Dikshit, M. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.02.001 · Cited by 127 · see citing works

Differential Roles of Nuclear and Cytoplasmic Cyclin-Dependent Kinase 5 in Apoptotic and Excitotoxic Neuronal Death

O'Hare, M. J., Kushwaha, N., Zhang, Y., Aleyasin, H., Callaghan, S. M., Slack, R. S., Albert, P. R., Vincent, I. J., & Park, D. S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.2899-05.2005 · Cited by 125 · see citing works

Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease

Jicha, G. A., Berenfeld, B., & Davies, P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990315)55:6 · Cited by 123 · see citing works

Multiple steps in carcinogenesis involving alterations of multiple tumor suppressor genes

Yokota, J., & Sügimura, T. (1993) · The FASEB Journal · doi:10.1096/fasebj.7.10.8344488 · Cited by 115 · see citing works

Nitration in Neurodegeneration: Deciphering the “Hows” “nYs”

Reynolds, M. R., Berry, R. W., & Binder, L. I. (2007) · Biochemistry · doi:10.1021/bi700430y · Cited by 114 · see citing works

Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis

England, K., & Cotter, T. G. (2005) · Redox Report · doi:10.1179/135100005x70224 · Cited by 113 · see citing works

Nitric oxide synthase regulation and diversity: Implications in Parkinson’s disease

Kavya, R., Saluja, R., Singh, S., & Dikshit, M. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.07.003 · Cited by 110 · see citing works

Oxidation of glyceraldehyde-3-phosphate dehydrogenase enhances its binding to nucleic acids

Arutyunova, E. I., Danshina, P. V., Domnina, L. V., Pleten, A. P., & Muronetz, V. I. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01222-1 · Cited by 102 · see citing works

Tyrosine 125 of α-synuclein plays a critical role for dimerization following nitrative stress

Takahashi, T., Yamashita, H., Nakamura, T., Nagano, Y., & Nakamura, S. (2002) · Brain Research · doi:10.1016/s0006-8993(02)02498-8 · Cited by 97 · see citing works

Cdk5: mediator of neuronal death and survival

Cheung, Z. H., & Ip, N. Y. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.12.117 · Cited by 85 · see citing works

Identification of Spanish familial Parkinson's disease and screening for the Ala53Thr mutation of the α-synuclein gene in early onset patients

Muñoz, E., Oliva, R., Obach, V., Martı́, M. J., Pástor, P., Ballesta, F., & TOLOSA, E. S. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00710-6 · Cited by 70 · see citing works

MPTP and DSP-4 susceptibility of substantia nigra and locus coeruleus catecholaminergic neurons in mice is independent of parkin activity

Thomas, B., von Coelln, R., Mandir, A. S., Trinkaus, D. B., Farah, M. H., Lim, K. L., Calingasan, N. Y., Beal, M. F., Dawson, V. L., & Dawson, T. M. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.12.021 · Cited by 67 · see citing works

Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases

Raines, K. W., Bonini, M. G., & Campbell, S. L. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.04.013 · Cited by 63 · see citing works

Effects of MPTP, MPP+ and paraquat on mitochondrial potential and oxidative stress

Lambert, C. E., & Bondy, S. C. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90365-2 · Cited by 59 · see citing works

New insights into Parkinson?s disease

Chung, K. K. K., Dawson, V. L., & Dawson, T. M. (2003) · Journal of Neurology · doi:10.1007/s00415-003-1304-9 · Cited by 59 · see citing works

Activation of cyclin‐dependent kinase 5 by calpains contributes to human immunodeficiency virus‐induced neurotoxicity

Wáng, Y., White, M. G., Akay, C., Chodroff, R. A., Robinson, J., Lindl, K. A., Dichter, M. A., Qian, Y., Mao, Z., Kolson, D. L., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04746.x · Cited by 58 · see citing works

Cdk5: A New Player at Synapses

Cheng, K., & Ip, N. Y. (2003) · Neurosignals · doi:10.1159/000074619 · Cited by 54 · see citing works

Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice

Crocker, S. J., Liston, P., Anisman, H., Lee, C. J., Smith, P. D., Earl, N., Thompson, C. S., Park, D. S., Korneluk, R. G., & Robertson, G. S. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(02)00020-7 · Cited by 52 · see citing works

SIAH1 causes growth arrest and apoptosis in hepatoma cells through β-catenin degradation-dependent and -independent mechanisms

Yoshibayashi, H., Okabe, H., Satoh, S., Hida, K., Kawashima, K., Hamasu, S., Nomura, A., Hasegawa, S., Ikai, I., & Sakai, Y. (2007) · Oncology Reports · doi:10.3892/or.17.3.549 · Cited by 45 · see citing works

Neuronal nitric oxide synthase-induced S-nitrosylation of H-Ras inhibits calcium ionophore-mediated extracellular-signal-regulated kinase activity

Raines, K. W., Cao, G.-L., Lee, E. K., Rosen, G. M., & Shapiro, P. S. (2006) · Biochemical Journal · doi:10.1042/bj20052002 · Cited by 39 · see citing works

Heat shock protein 27 stimulates recovery of RNA and protein synthesis following a heat shock

Carper, S. W., Rocheleau, T. A., Cimino, D. F., & Storm, F. K. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19970801)66:2 · Cited by 35 · see citing works

Say NO to Neurodegeneration: Role of S-Nitrosylation in Neurodegenerative Disorders

Chung, K. K. K. (2006) · Neurosignals · doi:10.1159/000109071 · Cited by 30 · see citing works

Theoretical Studies on Mechanism of Mptp Action: Et Interference by Mpp+(1-Methyl-4-Phenylpyridinium) With Mitochondrial Respiration vs. Oxidative Stress

Kovacic, P., Edwards, W. D., & Ming, G. (1991) · Free Radical Research Communications · doi:10.3109/10715769109088938 · Cited by 19 · see citing works

Tyrosine hydroxylase and regulation of dopamine synthesis

Daubner, S. C., Le, T., & Wang, S. (2011) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.12.017 · Cited by 1,092 · see citing works

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

Buendía, I., Michalska, P., Navarro, E., Gameiro‐Ros, I., Egea, J., & Leon, R. M. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.11.003 · Cited by 683 · see citing works

Basic mechanisms of neurodegeneration: a critical update

Jellinger, K. A. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01010.x · Cited by 608 · see citing works

Redox regulation of mitochondrial function

Handy, D. E., & Loscalzo, J. (2012) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588 · see citing works

Uncoupling proteins and the control of mitochondrial reactive oxygen species production

Mailloux, R. J., & Harper, M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.022 · Cited by 534 · see citing works

Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System

Slominski, A. T., Zmijewski, M. A., Skobowiat, C., Zbytek, B., Slominski, R. M., & Steketee, J. D. (2012) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-642-19683-6 · Cited by 502 · see citing works

Untitled work

Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461 · see citing works

L‐tyrosine and L‐dihydroxyphenylalanine as hormone‐like regulators of melanocyte functions

Slominski, A. T., Zmijewski, M. A., & Pawelek, J. M. (2011) · Pigment Cell & Melanoma Research · doi:10.1111/j.1755-148x.2011.00898.x · Cited by 449 · see citing works

Lipid peroxidation and neurodegenerative disease

Reed, T. T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.06.027 · Cited by 380 · see citing works

Mitochondria-targeted antioxidants for treatment of Parkinson's disease: Preclinical and clinical outcomes

Jin, H., Kanthasamy, A., Ghosh, A., Anantharam, V., Kalyanaraman, B., & Kanthasamy, A. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.09.007 · Cited by 362 · see citing works

Manganese Superoxide Dismutase: Guardian of the Powerhouse

Holley, A. K., Bakthavatchalu, V., Velez-Roman, J. M., & St. Clair, D. K. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12107114 · Cited by 358 · see citing works

Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction

Park, K. M., & Bowers, W. J. (2010) · Cellular Signalling · doi:10.1016/j.cellsig.2010.01.010 · Cited by 282 · see citing works

Recent advances in our understanding of neurodegeneration

Jellinger, K. A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0240-y · Cited by 274 · see citing works

Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro

Lee, D.-H., Kim, C., & Lee, Y. J. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.10.029 · Cited by 214 · see citing works

Molecular Hydrogen Improves Obesity and Diabetes by Inducing Hepatic FGF21 and Stimulating Energy Metabolism in db/db Mice

Kamimura, N., Nishimaki, K., Ohsawa, I., & Ohta, S. (2011) · Obesity · doi:10.1038/oby.2011.6 · Cited by 208 · see citing works

Copper at synapse: Release, binding and modulation of neurotransmission

D’Ambrosi, N., & Rossi, L. C. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.006 · Cited by 187 · see citing works

Chronic mild stress damages mitochondrial ultrastructure and function in mouse brain

Gong, Y. L., Chai, Y., Ding, J., Sun, X., & Hu, G. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.11.006 · Cited by 183 · see citing works

Central pathways causing fatigue in neuro-inflammatory and autoimmune illnesses

Morris, G., Berk, M., Walder, K. R., & Maes, M. H. J. (2015) · BMC Medicine · doi:10.1186/s12916-014-0259-2 · Cited by 179 · see citing works

Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology

Yu, S., Zhu, L., Shen, Q., Bai, X., & Di, X. (2015) · Behavioural Neurology · doi:10.1155/2015/103969 · Cited by 176 · see citing works

Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease

Greene, J. G., Noorian, A. R., & Srinivasan, S. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.04.023 · Cited by 165 · see citing works

Reprint of: Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

Perfeito, R., Cunha‐Oliveira, T., & Rego, A. C. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.042 · Cited by 165 · see citing works

Novel tactics for neuroprotection in Parkinson's disease: role of antibiotics, polyphenols and neuropeptides

Reglodi, D., Renaud, J., Tamas, A., Tizabi, Y., Socías, S. B., Del-Bel, E., & Raisman-Vozari, R. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.10.004 · Cited by 162 · see citing works

Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease

Castro-Caldas, M., Carvalho, A. N., Rodrigues, E., Henderson, C. J., Wolf, C. R., Rodrigues, C. M. P., & Gama, M. J. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8295-4 · Cited by 156 · see citing works

Lipid-Mediated Oxidative Stress and Inflammation in the Pathogenesis of Parkinson's Disease

Farooqui, T., & Farooqui, A. A. (2011) · Parkinson s Disease · doi:10.4061/2011/247467 · Cited by 155 · see citing works

Astrocytic Oxidative/Nitrosative Stress Contributes to Parkinson’s Disease Pathogenesis: The Dual Role of Reactive Astrocytes

Rizor, A., Pajarillo, E. A. B., Johnson, J., Aschner, M., & Lee, E.-S. (2019) · Antioxidants · doi:10.3390/antiox8080265 · Cited by 159 · see citing works

Lysosomal storage disorders and Parkinson's disease: Gaucher disease and beyond

Shachar, T., Bianco, C. L., Recchia, A., Wießner, C., Raas‐Rothschild, A., & Futerman, A. H. (2011) · Movement Disorders · doi:10.1002/mds.23774 · Cited by 150 · see citing works

Peroxiredoxin-2 Protects against 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration via Attenuation of the Apoptosis Signal-Regulating Kinase (ASK1) Signaling Cascade

Hu, X., Weng, Z., Chu, C. T., Zhang, L., Cao, G., Gao, Y., Signore, A. P., Zhu, J., Hastings, T. G., Greenamyre, J. T., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4589-10.2011 · Cited by 147 · see citing works

Oxidative Stress, Neuroinflammation, and NADPH Oxidase: Implications in the Pathogenesis and Treatment of Alzheimer’s Disease

Ganguly, U., Kaur, U., Chakrabarti, S. S., Sharma, P., Agrawal, B. K., Saso, L., & Chakrabarti, S. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7086512 · Cited by 150 · see citing works

Target- and Mechanism-Based Therapeutics for Neurodegenerative Diseases: Strength in Numbers

Trippier, P. C., Labby, K. J., Hawker, D. D., Mataka, J., & Silverman, R. B. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm3015926 · Cited by 141 · see citing works

Polyphenols content and antioxidant capacity of thirteen faba bean (Vicia faba L.) genotypes cultivated in Tunisia

Chaieb, N., González, J. L., López‐Mesas, M., Bouslama, M., & Valiente, M. (2011) · Food Research International · doi:10.1016/j.foodres.2011.02.026 · Cited by 143 · see citing works

Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease

Li, X., Long, J., He, T., Belshaw, R. D., & Scott, J. (2015) · Scientific Reports · doi:10.1038/srep12393 · Cited by 138 · see citing works

Quercetin prevents chronic unpredictable stress induced behavioral dysfunction in mice by alleviating hippocampal oxidative and inflammatory stress

Mehta, V., Parashar, A., & Malairaman, U. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.01.006 · Cited by 136 · see citing works

Targeting urate to reduce oxidative stress in Parkinson disease

Crotty, G. F., Ascherio, A., & Schwarzschild, M. A. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.06.017 · Cited by 131 · see citing works

α-Synuclein and Neuronal Cell Death

Yasuda, T., Nakata, Y., & Mochizuki, H. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8327-0 · Cited by 130 · see citing works

Early Life Stress, Depression And Parkinson’s Disease: A New Approach

Dallé, E., & Mabandla, M. V. (2018) · Molecular Brain · doi:10.1186/s13041-018-0356-9 · Cited by 124 · see citing works

Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease

Butterfield, D. A., Reed, T. T., & Rukhsana Sultana, A. (2010) · Free Radical Research · doi:10.3109/10715762.2010.520014 · Cited by 123 · see citing works

Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease

Fernandes, V. S., dos Santos, J. R., Leão, A. H. F. F., Medeiros, A. M., Melo, T. G., Izídio, G. S., Cabral, A., Ribeiro, R. A., Abílio, V. C., Ribeiro, A. M., et al. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.008 · Cited by 116 · see citing works

Neuroprotective effects of Danshensu on rotenone-induced Parkinson’s disease models in vitro and in vivo

Wang, T., Li, C., Han, B., Wang, Z., Meng, X., Zhang, L., He, J., & Fu, F. (2020) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-019-2738-7 · Cited by 117 · see citing works

Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: Implications in dopamine cytotoxicity and pathogenesis of Parkinson's disease

Jana, S., Sinha, M. S., Chanda, D., Roy, T., Banerjee, K., Munshi, S., Patro, B. S., & Chakrabarti, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.02.013 · Cited by 115 · see citing works

Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents

Asghar, N., Naqvi, S. A. R., Hussain, Z., Rasool, N., Khan, Z. A., Shahzad, S. A., Sherazi, T. A., Janjua, M. R. S. A., Nagra, S. A., Zia‐Ul‐Haq, M., et al. (2016) · Chemistry Central Journal · doi:10.1186/s13065-016-0149-0 · Cited by 109 · see citing works

The Endotoxin-Induced Neuroinflammation Model of Parkinson's Disease

Tüfekçi, K. U., Genç, Ş., & Genç, K. (2011) · Parkinson s Disease · doi:10.4061/2011/487450 · Cited by 108 · see citing works

Revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease—resemblance to the effect of amphetamine drugs of abuse

Perfeito, R., Cunha‐Oliveira, T., & Rego, A. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.08.569 · Cited by 108 · see citing works

Crosstalk between Neuron and Glial Cells in Oxidative Injury and Neuroprotection

Lee, K. H., Cha, M., & Lee, B. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413315 · Cited by 104 · see citing works

Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity

Brocker, C. N., Cantore, M., Failli, P., & Vasiliou, V. (2011) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2011.02.016 · Cited by 102 · see citing works

Protective Effects of Salidroside in the MPTP/MPP+-Induced Model of Parkinson's Disease through ROS–NO-Related Mitochondrion Pathway

Wang, S., He, H., Chen, L., Zhang, W., Zhang, X., & Chen, J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8755-0 · Cited by 95 · see citing works

Evaluation of antioxidant potential of Lavandula x intermedia Emeric ex Loisel.'Budrovka': a comparative study with L. angustifolia Mill

Blažeković, B., Vladimir-Knežević, S., Brantner, A., & Štefan, M. B. (2010) · Molecules · doi:10.3390/molecules15095971 · Cited by 95 · see citing works

Peripheral markers in neurodegenerative patients and their first-degree relatives

Cristalli, D. O., Arnal, N., Marra, F. A., de Alaniz, M. J. T., & Marra, C. A. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.11.001 · Cited by 92 · see citing works

Oxidative/Nitrosative Stress, Apoptosis, and Redox Signaling: Key Players in Neurodegenerative Diseases

Üremiş, N., & Üremi̇ş, M. M. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70133 · Cited by 98 · see citing works

Evaluation of basil extract ( Ocimum basilicum L.) on oxidative, anti-genotoxic and anti-inflammatory effects in human leukocytes cell cultures exposed to challenging agents

Güez, C. M., de Souza, R. O., Fischer, P., Leão, M. F. D. M., Duarte, J. A., Boligon, A. A., Athayde, M. L., Zuravski, L., de Oliveira, L. F. S., & Machado, M. M. (2017) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902017000115098 · Cited by 89 · see citing works

Neuroprotective effects of anthocyanins on apoptosis induced by mitochondrial oxidative stress

Kelsey, N. A., Hulick, W., Winter, A. N., Ross, E., & Linseman, D. A. (2011) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000020 · Cited by 88 · see citing works

Biological functions of selenium and its potential influence on Parkinson's disease

Ellwanger, J. H., Franke, S. I. R., Bordin, D. L., Prá, D., & Henriques, J. A. P. (2016) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201620150595 · Cited by 85 · see citing works

Association of Neuropeptide Y (NPY), Interleukin-1B (IL1B) Genetic Variants and Correlation of IL1B Transcript Levels with Vitiligo Susceptibility

Laddha, N. C., Dwivedi, M., Mansuri, M. S., Singh, M., Patel, H. H., Agarwal, N., Shah, A. M., & Begum, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107020 · Cited by 83 · see citing works

The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson’s disease mouse model

Lee, S., Kim, S., Park, Y. J., Yun, S. P., Kwon, S., Kim, D., Kim, D.-Y., Shin, J. S., Cho, D. J., Lee, G. Y., et al. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy143 · Cited by 82 · see citing works

Quercetin and Sesamin Protect Neuronal PC12 Cells from High-Glucose-Induced Oxidation, Nitrosative Stress, and Apoptosis

Bournival, J., Francoeur, M.-A., Renaud, J., & Martinoli, M. (2012) · Rejuvenation Research · doi:10.1089/rej.2011.1242 · Cited by 82 · see citing works

Dopaminergic neurotoxicant 6-OHDA induces oxidative damage through proteolytic activation of PKCδ in cell culture and animal models of Parkinson's disease

Latchoumycandane, C., Anantharam, V., Jin, H., Kanthasamy, A. G., & Kanthasamy, A. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.07.021 · Cited by 82 · see citing works

Mitochondrial medicine for neurodegenerative diseases

Du, H., & Yan, S. S. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.01.004 · Cited by 81 · see citing works

Sirtuin 1 protects the aging heart from contractile dysfunction mediated through the inhibition of endoplasmic reticulum stress-mediated apoptosis in cardiac-specific Sirtuin 1 knockout mouse model

Hsu, Y., Hsu, S.-C., Hsu, C., Chen, Y., Chang, Y., Sadoshima, J., Huang, S., Tsai, C., & Lin, C.-Y. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.247 · Cited by 81 · see citing works

Parkinson's disease: Insights from non-traditional model organisms

Pienaar, I. S., Götz, J., & Feany, M. Β. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.001 · Cited by 78 · see citing works

Urate in Parkinson’s Disease: More Than a Biomarker?

Chen, X. M., Wu, G.-H., & Schwarzschild, M. A. (2012) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-012-0282-7 · Cited by 74 · see citing works

Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress

Menges, S., Minakaki, G., Schaefer, P. M., Meixner, H., Prots, I., Schlötzer-Schrehardt, U., Friedland, K., Winner, B., Outeiro, T., Winklhofer, K., et al. (2017) · Scientific Reports · doi:10.1038/srep42942 · Cited by 74 · see citing works

NF‐κB/p53‐activated inflammatory response involves in diquat‐induced mitochondrial dysfunction and apoptosis

Choi, S. E., Park, Y. S., & Koh, H. C. (2018) · Environmental Toxicology · doi:10.1002/tox.22552 · Cited by 71 · see citing works

The role of lipids in α-synuclein misfolding and neurotoxicity

Ugalde, C. L., Lawson, V., Finkelstein, D. I., & Hill, A. F. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007500 · Cited by 72 · see citing works

Chronic administration of quercetin prevent spatial learning and memory deficits provoked by chronic stress in rats

Mohammadi, H. S., Goudarzi, I., Lashkarbolouki, T., Abrari, K., & Salmani, M. E. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.05.015 · Cited by 70 · see citing works

The pathomechanisms underlying Parkinson's disease

Jellinger, K. A. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.877842 · Cited by 69 · see citing works

Magnetic Resveratrol Liposomes as a New Theranostic Platform for Magnetic Resonance Imaging Guided Parkinson’s Disease Targeting Therapy

Wang, M., Li, L., Zhang, X., Liu, Y., Zhu, R., Liu, L., Fang, Y., Gao, Z., & Gao, D. (2018) · ACS Sustainable Chemistry & Engineering · doi:10.1021/acssuschemeng.8b04507 · Cited by 69 · see citing works

Novel action of metformin in the prevention of haloperidol-induced catalepsy in mice: Potential in the treatment of Parkinson's disease?

Adedeji, H. A., Ishola, I. O., & Adeyemi, O. O. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.014 · Cited by 68 · see citing works

Toxicity and multigenerational effects of bisphenol S exposure to Caenorhabditis elegans on developmental, biochemical, reproductive and oxidative stress

Xiao, X., Zhang, X., Zhang, C., Li, J., Zhao, Y., Zhu, Y. G., Zhang, J., & Zhou, X. (2019) · Toxicology Research · doi:10.1039/c9tx00055k · Cited by 67 · see citing works

Molecular Mechanisms Underlying Neuroinflammation Elicited by Occupational Injuries and Toxicants

Pathak, D., & Sriram, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032272 · Cited by 69 · see citing works

Associations Between Diabetes Mellitus and Neurodegenerative Diseases

Szablewski, L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020542 · Cited by 74 · see citing works

Antioxidant and antifungal activities of Camellia sinensis (L.) Kuntze leaves obtained by different forms of production

Camargo, L. E. A., Pedroso, L. S., Vendrame, S. C., Mainardes, R. M., & Khalil, N. M. (2016) · Brazilian Journal of Biology · doi:10.1590/1519-6984.18814 · Cited by 64 · see citing works

Nitric oxide: promoter or suppressor of programmed cell death?

Wang, Y., Chen, C., Loake, G. J., & Chu, C. (2010) · Protein & Cell · doi:10.1007/s13238-010-0018-x · Cited by 63 · see citing works

New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease

Xie, W., Wan, O. W., & Chung, K. K. K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.07.014 · Cited by 64 · see citing works

Are Polyphenols Strong Dietary Agents Against Neurotoxicity and Neurodegeneration?

Almeida, S., Alves, M. G., Sousa, M., Oliveira, P. F., & Silva, B. M. (2016) · Neurotoxicity Research · doi:10.1007/s12640-015-9590-4 · Cited by 64 · see citing works

Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model

Achour, I., Arel-Dubeau, A.-M., Renaud, J., Legrand, M., Attard, E., Germain, M., & Martinoli, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081293 · Cited by 64 · see citing works

Drosophila DJ-1 Decreases Neural Sensitivity to Stress by Negatively Regulating Daxx-Like Protein through dFOXO

Hwang, S., Song, S., Hong, Y. K., Choi, G., Suh, Y. S., Han, S. Y., Lee, M., Park, S. H., Lee, J. H., Lee, S., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003412 · Cited by 62 · see citing works

A Brief Review on the Neuroprotective Mechanisms of Vitexin

Lima, L. K. F., Pereira, S. K. S., Sousa, R. D. S., Santos, F. P. D. S., Nascimento, A. D. S., Feitosa, C. M., Figuerêdo, J. D. S., Cavalcante, A. D. N., Araújo, E. C. D. C., & Rai, M. (2018) · BioMed Research International · doi:10.1155/2018/4785089 · Cited by 61 · see citing works

Effect of a phytopharmaceutical medicine, Ginko biloba extract 761, in an animal model of Parkinson's disease: Therapeutic perspectives

Rojas, P., Montes, P., Rojas, C., Serrano‐García, N., & Rojas‐Castañeda, J. C. (2012) · Nutrition · doi:10.1016/j.nut.2012.03.007 · Cited by 61 · see citing works

Coordination and redox properties of copper interaction with α-synuclein

Valensin, D., Dell’Acqua, S., Kozłowski, H., & Casella, L. (2016) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2016.04.012 · Cited by 61 · see citing works

ER Stress Induced by Tunicamycin Triggers α-Synuclein Oligomerization, Dopaminergic Neurons Death and Locomotor Impairment: a New Model of Parkinson’s Disease

Cóppola-Segovia, V., Cavarsan, C. F., Maia, F. G., Ferraz, A. C., Nakao, L. S., Lima, M. M., & Zanata, S. M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0114-x · Cited by 61 · see citing works

Mechanism of cleavage of alpha-synuclein by the 20S proteasome and modulation of its degradation by the RedOx state of the N-terminal methionines

Alvarez‐Castelao, B., Goethals, M., Vandekerckhove, J. S., & Castaño, J. G. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.11.018 · Cited by 60 · see citing works

Exploring the potential of natural and synthetic neuroprotective steroids against neurodegenerative disorders: A literature review

Bansal, R., & Singh, R. (2017) · Medicinal Research Reviews · doi:10.1002/med.21458 · Cited by 59 · see citing works

Salidroside protects PC12 cells from MPP+-induced apoptosis via activation of the PI3K/Akt pathway

Zhang, L., Ding, W., Sun, H., Zhou, Q., Huang, J., Li, X., Xie, Y., & Chen, J. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.05.045 · Cited by 58 · see citing works

Emerging roles of nitric oxide in neurodegeneration

Chung, K. K. K., & David, K. K. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.02.002 · Cited by 56 · see citing works

Biological Potential, Gastrointestinal Digestion, Absorption, and Bioavailability of Algae-Derived Compounds with Neuroprotective Activity: A Comprehensive Review

Martins, B., Vieira, M., Delerue-Matos, C. M., Grosso, C., & Soares, C. M. D. (2022) · Marine Drugs · doi:10.3390/md20060362 · Cited by 56 · see citing works

Neuropathology and pathogenesis of extrapyramidal movement disorders: a critical update—I. Hypokinetic-rigid movement disorders

Jellinger, K. A. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-02028-6 · Cited by 55 · see citing works

Epigallocatechin-3-Gallate, a Promising Molecule for Parkinson's Disease?

Renaud, J., Nabavi, S. F., Daglia, M., Nabavi, S. M., & Martinoli, M. (2015) · Rejuvenation Research · doi:10.1089/rej.2014.1639 · Cited by 53 · see citing works

trans-Resveratrol as A Neuroprotectant

Robb, E. L., & Stuart, J. A. (2010) · Molecules · doi:10.3390/molecules15031196 · Cited by 51 · see citing works

The Toll-Like Receptor Radical Cycle Pathway: A New Drug Target in Immune-Related Chronic Fatigue

Lucas, K., Morris, G., Anderson, G., & Maes, M. H. J. (2015) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527314666150317224645 · Cited by 50 · see citing works

Neurodegenerative signaling factors and mechanisms in Parkinson's pathology

Goswami, P., Joshi, N., & Singh, S. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.06.008 · Cited by 50 · see citing works

Neuroprotective and Neurorescue Mode of Action of Bacopa monnieri (L.) Wettst in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-Induced Parkinson’s Disease: An In Silico and In Vivo Study

Singh, B., Pandey, S., Rumman, M., Kumar, S., Kushwaha, P. P., Verma, R., & Mahdi, A. A. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.616413 · Cited by 49 · see citing works

Oxidative and nitrosative stress in ADHD: possible causes and the potential of antioxidant-targeted therapies

Lopresti, A. L. (2015) · ADHD Attention Deficit and Hyperactivity Disorders · doi:10.1007/s12402-015-0170-5 · Cited by 47 · see citing works

The Role of Cyclo(His-Pro) in Neurodegeneration

Grottelli, S., Ferrari, I., Pietrini, G., Peirce, M. J., Minelli, A., & Bellezza, I. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081332 · Cited by 47 · see citing works

Apocyanin, a Microglial NADPH Oxidase Inhibitor Prevents Dopaminergic Neuronal Degeneration in Lipopolysaccharide-Induced Parkinson’s Disease Model

Sharma, N., & Nehru, B. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9267-2 · Cited by 47 · see citing works

Role of Nitric Oxide in Motor Control: Implications for Parkinson's Disease Pathophysiology and Treatment

Del-Bel, E., Padovan‐Neto, F. E., Raisman‐Vozari, R., & Lazzarini, M. (2011) · Current Pharmaceutical Design · doi:10.2174/138161211795164176 · Cited by 46 · see citing works

Enhanced Sample Multiplexing for Nitrotyrosine-Modified Proteins Using Combined Precursor Isotopic Labeling and Isobaric Tagging

Robinson, R. A. S., & Evans, A. R. (2012) · Analytical Chemistry · doi:10.1021/ac202000v · Cited by 45 · see citing works

GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson’s disease in a Japanese population

Kiyohara, C., Miyake, Y., Koyanagi, M., Fujimoto, T., Shirasawa, S., Tanaka, K., Fukushima, W., Sasaki, S., Tsuboi, Y., Yamada, T., et al. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.04.009 · Cited by 44 · see citing works

α-Synuclein in Parkinson's Disease: Pathogenic Function and Translation into Animal Models

Eschbach, J., & Danzer, K. M. (2013) · Neurodegenerative Diseases · doi:10.1159/000354615 · Cited by 44 · see citing works

Glutathione metabolism is modulated by postmortem interval, gender difference and agonal state in postmortem human brains

Harish, G., Venkateshappa, C., Mahadevan, A., Pruthi, N., Bharath, M. M. S., & Shankar, S. K. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.08.024 · Cited by 42 · see citing works

Oxidative and nitrosative stress in serum of patients with Parkinson’s disease

Çubukçu, H. C., Yurtdaş, M., Durak, İ., Aytaç, B., Güneş, H. N., Çokal, B. G., Yoldaş, T. K., & Durak, İ. (2016) · Neurological Sciences · doi:10.1007/s10072-016-2663-1 · Cited by 43 · see citing works

Zinc and linoleic acid pre-treatment attenuates biochemical and histological changes in the midbrain of rats with rotenone-induced Parkinsonism

Mbiydzenyuy, N. E., Ninsiima, H. I., Valladares, M. B., & Pieme, C. A. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0429-9 · Cited by 43 · see citing works

The Role of Oxidative Stress in Parkinson's Disease

Dias, V., Junn, E., & Mouradian, M. M. (2013) · Journal of Parkinson’s Disease · doi:10.3233/jpd-130230 · Cited by 1,845 · see citing works

Oxidative stress in Parkinson's disease

Jenner, P. (2003) · Annals of Neurology · doi:10.1002/ana.10483 · Cited by 2,053 · see citing works

Oxidative stress and Parkinson’s disease

Blesa, J., Trigo-Damas, I., Quiroga-Varela, A., & Jackson-Lewis, V. R. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00091 · Cited by 878 · see citing works

Role of Oxidative Stress in Parkinson's Disease

Hwang, O. (2013) · Experimental Neurobiology · doi:10.5607/en.2013.22.1.11 · Cited by 845 · see citing works

Challenging conventional wisdom: The etiologic role of dopamine oxidative stress in Parkinson's disease

Ahlskog, J. E. (2004) · Movement Disorders · doi:10.1002/mds.20362 · Cited by 83 · see citing works