Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.

Weintraub, M S; Eisenberg, S; Breslow, J L

doi:10.1172/jci112926

Cited by 261Lipid metabolism and disordersLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.

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Weintraub, M S, Eisenberg, S, Breslow, J L·1987·Journal of Clinical Investigation

DOI 10.1172/jci112926PMC PMC424291

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Abstract

To study exogenous fat metabolism, we used the vitamin A-fat loading test, which specifically labels intestinally derived lipoproteins with retinyl palmitate (RP). Postprandial RP concentrations were followed in total plasma, and chylomicron (Sf greater than 1,000) and nonchylomicron (Sf less than 1,000) fractions. In normal subjects postprandial lipoproteins were present for more than 14 h, and chylomicron levels correlated inversely with lipoprotein lipase activity and fasting high density lipoprotein (HDL) cholesterol levels and nonchylomicron levels correlated inversely with hepatic triglyceride lipase activity. The main abnormality in type IV patients was a 5.6-fold increase in the chylomicron fraction, whereas in type III patients it was a 6.4-fold increase in nonchylomicrons. Type IIa patients had abnormally low chylomicron fractions. In type IV patients gemfibrozil decreased, whereas in type IIa patients cholestyramine increased the chylomicron fraction 66 and 88%, respectively. This study demonstrates an unexpectedly large magnitude and long duration of postprandial lipemia in normal subjects and patients. These particles are potentially atherogenic, and their role in human atherosclerosis warrants further study.

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Increased circulating chylomicron-remnant particles are preferentially taken up by the liver by a receptor-mediated process, resulting in nonalcoholic fatty liver disease and hepatic insulin resistance.
“Increased concentrations of circulating chylomicron-remnant particles are then preferentially taken up by the liver by means of a receptor-mediated process,18–22 resulting in non-alcoholic fatty liver disease and hepatic insulin resistance.”
From Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease (2010) · cites this paper as [22]

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Self-citation
Gemfibrozil reduces postprandial lipemia in non-insulin-dependent diabetes mellitus.
Syvänne, M., Vuorinen-Markkola, H., Hilden, H., & Taskinen, M. (1993) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.13.2.286 · Cited by 66 · see citing works
Postprandial Lipoprotein Metabolism in Obese Patients with Moderate Hypertriglyceridaemia: Effects of Gemfibrozil
DITSCHUNEIT, H. H., Flechtner‐Mors, M., Hagel, E., & DITSCHUNEIT, H. H. (1992) · Journal of International Medical Research · doi:10.1177/030006059202000301 · Cited by 8 · see citing works

Authors: Weintraub, M. S., Eisenberg, S., & Breslow, J. L.
Affiliations: Rockefeller University (US)
Hadassah Medical Center (IL)
ORCID: Breslow, J L
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1987-04-01
Volume: 79
Issue: 4
Pages: 1110-1119
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci112926
PMC: PMC424291
OpenAlex: W2156066000
Cited by: 261
References: 60
Citations by year: 2024: 1 · 2023: 1 · 2022: 5 · 2020: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 4 · 2012: 2
FWCI: 10.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Pew Charitable Trusts
American Heart Association
National Institutes of Health
National Institute on Aging (AG 04727)
National Heart, Lung, and Blood Institute (HL 33714, HL32435)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Keywords: postprandial lipemia, lipoprotein metabolism, chylomicrons, type IV hyperlipoproteinemia, type III hyperlipoproteinemia, type IIa hyperlipoproteinemia, cholestyramine, gemfibrozil, lipoprotein lipase, hepatic lipase, atherosclerosis, atherogenic lipoproteins
MeSH terms: Cholestyramine Resin, Chylomicrons, Dietary Fats, Female, Humans, Hyperlipoproteinemia Type II, Hyperlipoproteinemia Type III, Hyperlipoproteinemia Type IV, Lipoproteins, Male, Pentanoic Acids, Triglycerides, Valerates, Vitamin A, Gemfibrozil

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Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil.

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