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Cited by 59Fatty Acid Research and HealthLipid metabolism and disordersEdible Oils Quality and Analysis

Moderate fish oil intake improves lipemic response to a standard fat meal: A study in 25 healthy men

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Brown, A J, Roberts, D C·1991·Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
DOI 10.1161/01.atv.11.3.457
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Abstract

To test the hypothesis that conditioning with a practical dose of fish oil will reduce postprandial lipemia, 25 healthy men were matched according to levels of fasting plasma triacylglyceride and allocated to 6 weeks of either fish oil or olive oil supplements (5 g/day). After a 12-hour overnight fast at the termination of the study period, the subjects were given a standard test meal containing 89% of energy as fat (0.73 g fat/kg body wt, polyunsaturated to saturated fat ratio = 0.4). Vitamin A (429 retinol equivalents/kg body wt) was included to endogenously label the chylomicrons. Venous blood samples were obtained before the test meal and hourly thereafter for 8 hours. Chylomicrons were separated by ultracentrifugation, plasma triacylglyceride concentration was determined enzymatically, and retinyl ester levels were measured by liquid chromatography. Postprandially, the fish oil-fed group exhibited mean total and chylomicron triacylglyceride concentrations that were significantly (p less than 0.05) less than those of the olive oil-fed group. Both the fish oil- and olive oil-fed groups had similar rises in chylomicron retinyl esters during the first 2 hours, but after this time the postprandial response of the fish oil-fed group was consistently and significantly (p less than 0.05) less than the response of the olive oil-fed group. Our results suggest that improvement in lipemic response, whether due to enhanced chylomicron clearance or decreased chylomicron entry into the plasma pool, can be achieved at a much lower intake of fish oil than previously reported.

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Research works printed but not linked: 5

  1. Weintraub MS, Zechner R, Brown A, Eisenberg S, Breslow JL: Dietary polyunsaturated fats of the co-6 and io-3 series reduce postprandial lipoprotein levels. / Clin Invest 1988;82: 1884-1894
  2. Weintraub MS, Eisenberg S, Breslow JL: Different patterns of postprandial lipoprotein metabolism in normal, Type Ila, Type III, and Type IV hyperlipoproteinemic individuals. / Clin Invest 1987;79:1110-1119
  3. Eason G, Coles CW, Gettinby G: Mathematics and Statistics for the Biosciences. New York, John Wiley & Sons, Inc, 1980, pp 317-318
  4. Harris WS, Windsor SL: Fish oils, chylomicrons, and lipopro- tein(a) (abstract). Artaiosclavsis 1989;9:738a
  5. Robins SJ, Fasulo JM, Robins VF, Patton GM: Response of serum triglycerides of endogenous origin to the administration of triglyeride-rich lipid particles. Am J Physiol 1989;257: E860-E865

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Authors
Brown, A. J., & Roberts, D. C.
Affiliations
The University of Sydney (AU)
ORCID
Brown, A J
Venue
Arteriosclerosis and Thrombosis: A Journal of Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1991-05
Volume
11
Issue
3
Pages
457-466
ISSN
1049-8834 (ISSN-L)
DOI
10.1161/01.atv.11.3.457
OpenAlex
W2060885702
Cited by
59
References
39
Citations by year
2021: 1 · 2020: 1 · 2018: 1 · 2014: 1 · 2012: 1
FWCI
7.49
Type
journal article
Language
en
Open access
Locations
  • Arteriosclerosis and Thrombosis A Journal of Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
Keywords
fish oil, olive oil, postprandial lipemia, chylomicrons, chylomicron clearance, plasma triglycerides, dietary fat supplementation, retinyl esters, polyunsaturated fatty acids
MeSH terms
Olive Oil, Adult, Energy Intake, Cholesterol, Chylomicrons, Dietary Fats, Dietary Fats, Unsaturated, Fish Oils, Humans, Kinetics, Lipids, Male, Patient Compliance, Plant Oils, Triglycerides, Vitamin A

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