Cited by 1,765Nitric Oxide and Endothelin EffectsNeutrophil, Myeloperoxidase and Oxidative MechanismsAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Hypercholesterolemia increases endothelial superoxide anion production.

Open access

Ohara, Y, Peterson, T E, Harrison, D G·1993·Journal of Clinical Investigation

DOI 10.1172/jci116491PMC PMC443316

Open this paper in CoChat — free account Open PDF

Abstract

Indirect evidence suggests accelerated degradation of endothelium-derived nitric oxide (ENDO) by superoxide anion (O2-) in hypercholesterolemic vessels (HV). To directly measure O2- production by normal vessels (NV) and HV, we used an assay for O2- based on the chemiluminescence (CL) of lucigenin (L). HV (1 mo cholesterol-fed rabbits) produced threefold more O2- than NV (1.47 +/- 0.20 nM/mg tissue/min, n = 7 vs. 0.52 +/- 0.05 nmol/mg tissue/min, n = 8, P < 0.001). Endothelial removal increased O2- production in NV (0.73 +/- 0.08, n = 6, P < 0.05), while decreasing it in HV (0.76 +/- 0.15, n = 5, P < 0.05). There was no difference between denuded HV and denuded NV. Oxypurinol, a noncompetitive inhibitor of xanthine oxidase, normalized O2- production in HV, but had no effect in NV. In separate isometric tension studies treatment with oxypurinol improved acetylcholine induced relaxations in HV, while having no effect on responses in normal vessels. Oxypurinol did not alter relaxations to nitroprusside. Thus, the endothelium is a source of O2- in hypercholesterolemia probably via xanthine oxidase activation. Increased endothelial O2- production in HV may inactivate endothelium-derived nitric oxide and provide a source for other oxygen radicals, contributing to the early atherosclerotic process.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci116491

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent
Babior, B. M., Kipnes, R. S., & Curnutte, J. T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107236 · Cited by 2,931
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400
Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension
Panza, J. A., Quyyumi, A. A., Brush, J. E., & Epstein, S. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230105 · Cited by 2,366
Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine Oxidase
Fridovich, I. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62884-4 · Cited by 1,035
Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide
Myers, P. R., Minor, R. L., Guerra, R., Bates, J. N., & Harrison, D. G. (1990) · Nature · doi:10.1038/345161a0 · Cited by 973
Self-citation
Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity
Allen, R. C., STJERNHOLM, R. L., & Steele, R. H. (1972) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(72)90545-1 · Cited by 955
Endothelium-dependent vasodilation is attenuated in patients with heart failure.
Kubo, S. H., Rector, T. S., Bank, A. J., Williams, R. E., & Heifetz, S. M. (1991) · Circulation · doi:10.1161/01.cir.84.4.1589 · Cited by 775

Flagged first, then by citations

Show all 41 references

Sorted by citations

Items 201–300 of 999

Impact of oxidized low density lipoprotein on vascular cells
Galle, J., Hansen‐Hagge, T. E., Wanner, C., & Seibold, S. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.10.005 · Cited by 239
Molecular Characterization and Localization of the NAD(P)H Oxidase Components gp91- phox and p22- phox in Endothelial Cells
Bayraktutan, U., BLAYNEY, L. M., & Shah, A. M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.8.1903 · Cited by 239
Increased Autoantibody Titers Against Epitopes of Oxidized LDL in LDL Receptor–Deficient Mice With Increased Atherosclerosis
Palinski, W., Tangirala, R. K., Miller, E. R., Young, S. G., & Witztum, J. L. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.10.1569 · Cited by 239
17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine.
Keaney, J. F., Shwaery, G. T., Xu, A., Nicolosi, R. J., Loscalzo, J., Foxall, T. L., & Vita, J. A. (1994) · Circulation · doi:10.1161/01.cir.89.5.2251 · Cited by 238
Red and Black Rice Decrease Atherosclerotic Plaque Formation and Increase Antioxidant Status in Rabbits
Ling, W. H., Cheng, Q. X., Ma, J., & Wang, T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.5.1421 · Cited by 237
Increased Bioavailability of Nitric Oxide After Lipid-Lowering Therapy in Hypercholesterolemic Patients
John, S., Schlaich, M. P., Langenfeld, M. R. W., Weihprecht, H., Schmitz, G., Weidinger, G., & Schmieder, R. E. (1998) · Circulation · doi:10.1161/01.cir.98.3.211 · Cited by 237
PPARα Activator Effects on Ang II–Induced Vascular Oxidative Stress and Inflammation
Diep, Q. N., Amiri, F., Touyz, R. M., Cohn, J. S., Endemann, D., Neves, M. F., & Schiffrin, E. L. (2002) · Hypertension · doi:10.1161/01.hyp.0000037969.41360.cc · Cited by 235
Vascular NADPH oxidases as drug targets for novel antioxidant strategies
Guzik, T. J., & Harrison, D. G. (2006) · Drug Discovery Today · doi:10.1016/j.drudis.2006.04.003 · Cited by 238
Self-citation
The relationships among hyperuricemia, endothelial dysfunction, and cardiovascular diseases: Molecular mechanisms and clinical implications
Puddu, P., Puddu, G. M., Cravero, E., Vizioli, L., & Muscari, A. (2012) · Journal of Cardiology · doi:10.1016/j.jjcc.2012.01.013 · Cited by 245
Hydrogen Peroxide as a Paracrine Vascular Mediator: Regulation and Signaling Leading to Dysfunction
Ardanaz, N., & Pagano, P. J. (2006) · Experimental Biology and Medicine · doi:10.1177/153537020623100302 · Cited by 230
Evaluating Oxidative Stress in Human Cardiovascular Disease: Methodological Aspects and Considerations
Lee, R., Margaritis, M., Channon, K. M., & Antoniades, C. A. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800493057 · Cited by 233
Interaction of Oxidative Stress and Inflammatory Response in Coronary Plaque Instability
Kobayashi, S., Inoue, N., Ohashi, Y., Terashima, M., Matsui, K., Mori, T., Fujita, H., Awano, K., Kobayashi, K., Azumi, H., et al. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000081637.36475.bc · Cited by 230
Vascular gp91 phox
Pagano, P. J. (2000) · Circulation Research · doi:10.1161/01.res.87.1.1 · Cited by 229
Redox signaling in cardiovascular health and disease
Madamanchi, N. R., & Runge, M. S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.001 · Cited by 227
Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits.
Keaney, J. F., Gaziano, J. M., Xu, A., Frei, B. B., Curran-Celentano, J., Shwaery, G. T., Loscalzo, J., & Vita, J. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117039 · Cited by 225
Winter cardiovascular diseases phenomenon
Fares, A. (2013) · North American Journal of Medical Sciences · doi:10.4103/1947-2714.110430 · Cited by 226
Anatomic Heterogeneity of Vascular Aging
Barton, M., Cosentino, F., Brandes, R. P., Moreau, P. R., Shaw, S., & Lüscher, T. F. (1997) · Hypertension · doi:10.1161/01.hyp.30.4.817 · Cited by 222
Effect of YC‐1, an NO‐independent, superoxide‐sensitive stimulator of soluble guanylyl cyclase, on smooth muscle responsiveness to nitrovasodilators
Mülsch, A., Bauersachs, J. K., Schäfer, A., Stasch, J., Kast, R., & Busse, R. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0700982 · Cited by 222
Long-Term Antioxidant Administration Attenuates Mineralocorticoid Hypertension and Renal Inflammatory Response
Beswick, R. A., Zhang, H., Marable, D. R., Catravas, J. D., Hill, W., & Webb, R. C. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.781 · Cited by 221
Low density lipoprotein cholesterol and coronary microvascular dysfunction in hypercholesterolemia.
Kaufmann, P. A., Gnecchi-Ruscone, T., Schäfers, K. P., Lüscher, T. F., & Camici, P. G. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00697-5 · Cited by 217
Effect of Native and Oxidized Low-Density Lipoprotein on Endothelial Nitric Oxide and Superoxide Production
Vergnani, L., Hatrik, S., Ricci, F., Passaro, A., Manzoli, N., Zuliani, G., Brovkovych, V. M., Fellin, R., & Maliñski, T. (2000) · Circulation · doi:10.1161/01.cir.101.11.1261 · Cited by 219
Overexpression of Human Catalase Inhibits Proliferation and Promotes Apoptosis in Vascular Smooth Muscle Cells
Brown, M. R., Miller, F. J., Li, W.-G., Ellingson, A. N., Mozena, J. D., Chatterjee, P., Engelhardt, J. F., Zwacka, R. M., Oberley, L. W., Fang, X., et al. (1999) · Circulation Research · doi:10.1161/01.res.85.6.524 · Cited by 219
Nitric Oxide Regulates Monocyte Chemotactic Protein-1
Tsao, P. S., Wang, B., Buitrago, R., Shyy, J. Y.-J., & Cooke, J. P. (1997) · Circulation · doi:10.1161/01.cir.96.3.934 · Cited by 216
Molecular Characterization of a Superoxide-Generating NAD(P)H Oxidase in the Ventilatory Muscles
Javeshghani, D., Magder, S. A., Barreiro, E., Quinn, M. T., & Hussain, S. N. A. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.3.2103028 · Cited by 215
Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes
Madamanchi, N. R., Hakim, Z. S., & Runge, M. S. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.01085.x · Cited by 216
Critical Role for Tetrahydrobiopterin Recycling by Dihydrofolate Reductase in Regulation of Endothelial Nitric-oxide Synthase Coupling
Crabtree, M. J., Tatham, A. L., Hale, A. B., Alp, N. J., & Channon, K. M. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.041483 · Cited by 210
Angiotensin II Induces Endothelial Xanthine Oxidase Activation: Role for Endothelial Dysfunction in Patients With Coronary Disease
Landmesser, U., Spiekermann, S., Preuss, C., Sorrentino, S., Fischer, D., Manes, C., Mueller, M., & Drexler, H. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000258415.32883.bf · Cited by 210
Superoxide anion and endothelial regulation of arterial tone
Katušić, Z. S. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)02116-8 · Cited by 211
Biological effects of off-pump vs. on-pump coronary artery surgery: focus on inflammation, hemostasis and oxidative stress
Biglioli, P. (2003) · European Journal of Cardio-Thoracic Surgery · doi:10.1016/s1010-7940(03)00295-1 · Cited by 209
Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO production
Böger, R. H., Bode-Böger, S. M., Mügge, A., Kienke, S., Brandes, R., Dwenger, A., & Frölich, J. C. (1995) · Atherosclerosis · doi:10.1016/0021-9150(95)05582-h · Cited by 252
Effects of acute exercise on flow-mediated dilatation in healthy humans
Dawson, E. A., GREEN, D. J., Cable, N. T., & Thijssen, D. H. J. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00450.2013 · Cited by 207
Endothelial Dysfunction Is Associated With Cholesterol Levels in the High Normal Range in Humans
Steinberg, H. O., Bayazeed, B., Brechtel, G., Johnson, A., Cronin, J., & Baron, A. (1997) · Circulation · doi:10.1161/01.cir.96.10.3287 · Cited by 206
Improvement in Coronary Flow Reserve Determined by Positron Emission Tomography After 6 Months of Cholesterol-Lowering Therapy in Patients With Early Stages of Coronary Atherosclerosis
Baller, D., Notohamiprodjo, G., Gleichmann, U., Holzinger, J., Weise, R., & Lehmann, J. (1999) · Circulation · doi:10.1161/01.cir.99.22.2871 · Cited by 204
Impaired endothelial function following a meal rich in used cooking fat
Williams, M. J. A., Sutherland, W. H. F., McCormick, M. P., de Jong, S. A., Walker, R. J., & WILKINS, G. T. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00681-0 · Cited by 202
Simvastatin attenuates cisplatin-induced kidney and liver damage in rats
İşeri, S. Ö., Ercan, F., Gedik, N., Yüksel, M., & Ali̇can, İ. (2006) · Toxicology · doi:10.1016/j.tox.2006.11.073 · Cited by 201
Cardiovascular Effects of Estrogen and Lipid-Lowering Therapies in Postmenopausal Women
Guetta, V., & Cannon, R. O. (1996) · Circulation · doi:10.1161/01.cir.93.10.1928 · Cited by 207
Pulsatile Stretch Stimulates Superoxide Production and Activates Nuclear Factor-κB in Human Coronary Smooth Muscle
Hishikawa, K., Oemar, B. S., Yang, Z., & Lüscher, T. F. (1997) · Circulation Research · doi:10.1161/01.res.81.5.797 · Cited by 200
Quantitative Regulation of Intracellular Endothelial Nitric-oxide Synthase (eNOS) Coupling by Both Tetrahydrobiopterin-eNOS Stoichiometry and Biopterin Redox Status
Crabtree, M. J., Tatham, A. L., Al-Wakeel, Y., Warrick, N., Hale, A. B., Cai, S., Channon, K. M., & Alp, N. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m805403200 · Cited by 200
c-Jun N-terminal Kinase Activation by Hydrogen Peroxide in Endothelial Cells Involves Src-dependent Epidermal Growth Factor Receptor Transactivation
Chen, K., Vita, J. A., Berk, B. C., & Keaney, J. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011766200 · Cited by 200
Redox control of vascular smooth muscle proliferation
Griendling, K. K., & Ushio‐Fukai, M. (1998) · Journal of Laboratory and Clinical Medicine · doi:10.1016/s0022-2143(98)90019-1 · Cited by 199
Redox-regulated Signaling by Lactosylceramide in the Proliferation of Human Aortic Smooth Muscle Cells
Bhunia, A. K., Han, H., Snowden, A., & Chatterjee, S. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.15642 · Cited by 200
Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation.
Keaney, J. F., Xu, A., Cunningham, D., Jackson, T. S., Frei, B. B., & Vita, J. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117953 · Cited by 199
Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits.
Keaney, J. F., Gaziano, J. M., Xu, A., Frei, B. B., Curran-Celentano, J., Shwaery, G. T., Loscalzo, J., & Vita, J. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11880 · Cited by 198
Homocysteine-Induced Inhibition of Endothelium-Dependent Relaxation in Rabbit Aorta
Lang, D., Kredan, M. B., Moat, S. J., Hussain, S. A., Powell, C. A., Bellamy, M., Powers, H. J., & LEWIS, M. J. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.2.422 · Cited by 199
The role of oxidative stress in atherosclerosis.
Vogiatzi, G., Tousoulis, D., & Stefanadis, C. (2009) · PubMed · Cited by 197
Mechanisms of oxidative stress and vascular dysfunction
Nedeljkovic, Z. S., Gokce, N., & Loscalzo, J. (2003) · Postgraduate Medical Journal · doi:10.1136/pmj.79.930.195 · Cited by 195
Endothelium-Dependent Coronary Vasomotion Relates to the Susceptibility of LDL to Oxidation in Humans
Anderson, T. J., Meredith, I. T., Charbonneau, F., Yeung, A. C., Frei, B. B., Selwyn, A. P., & Ganz, P. (1996) · Circulation · doi:10.1161/01.cir.93.9.1647 · Cited by 198
Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action
Keaney, J. F., & Vita, J. A. (1995) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(05)80003-9 · Cited by 196
Puerarin decreases serum total cholesterol and enhances thoracic aorta endothelial nitric oxide synthase expression in diet-induced hypercholesterolemic rats
Yan, L.-P., Chan, S., Chan, A. S. C., Chen, S., Ma, X., & Xu, H. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.01.016 · Cited by 195
The effects of oxidative stress on the development of atherosclerosis
Khosravi, M., Poursaleh, A., Ghasempour, G., Shaikhnia, F., & Najafi, M. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0397 · Cited by 195
Shear Stress Inhibits H 2 O 2 -Induced Apoptosis of Human Endothelial Cells by Modulation of the Glutathione Redox Cycle and Nitric Oxide Synthase
Hermann, C., Zeiher, A. M., & Dimmeler, S. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3588 · Cited by 195
Superoxide anion formation from lucigenin: an electron spin resonance spin‐trapping study
Vasquez-Vivar, J. M., Hogg, N., Pritchard, K. A., Pavel Martasek, E., & Kalyanaraman, B. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00036-7 · Cited by 194
The Effect of Estrogen Replacement Therapy on Plasma Nitric Oxide and Endothelin-1 Levels in Postmenopausal Women
Best, P. J. M., Berger, P. B., Miller, V. M., & Lerman, A. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-4-199802150-00006 · Cited by 194
Dietary Correction of Hypercholesterolemia in the Rabbit Normalizes Endothelial Superoxide Anion Production
Ohara, Y., Peterson, T. E., Sayegh, H. S., Subramanian, R. R., Wilcox, J. N., & Harrison, D. G. (1995) · Circulation · doi:10.1161/01.cir.92.4.898 · Cited by 193
Self-citation
Modulation of particulate nitric oxide synthase activity and peroxynitrite synthesis in cholesterol enriched endothelial cell membranes
Deliconstantinos, G., Villiotou, V., & Stavrides, J. C. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00094-g · Cited by 193
Endothelial Dysfunction: From Molecular Mechanisms to Measurement, Clinical Implications, and Therapeutic Opportunities
Brocq, M. L. L., Leslie, S. J., Milliken, P. H., & Megson, I. L. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.2013 · Cited by 196
Oxidative Stress and Antioxidant Treatments in Cardiovascular Diseases
Wang, W., & Kang, P. M. (2020) · Antioxidants · doi:10.3390/antiox9121292 · Cited by 199
Endothelial Function and Oxidative Stress
Ogita, H., & Liao, J. K. (2004) · Endothelium · doi:10.1080/10623320490482664 · Cited by 191
The Role of Natural Antioxidants in Preserving the Biological Activity of Endothelium-Derived Nitric Oxide
Carr, A., & Frei, B. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00225-2 · Cited by 190
Oxidative stress in cardiovascular disease.
Lakshmi, S. V. V., Padmaja, G., Kuppusamy, P., & Kutala, V. K. (2009) · PubMed · Cited by 190
The multiple actions of angiotensin II in atherosclerosis
Schmidt-Ott, K. M., Kagiyama, S., & Phillips, M. I. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00178-6 · Cited by 190
Strategies to reduce oxidative stress in cardiovascular disease
Hamilton, C. A., MILLER, W. H., Al‐Benna, S., Brosnan, M. J., DRUMMOND, R. D., McBride, M., & Dominiczak, A. F. (2004) · Clinical Science · doi:10.1042/cs20030379 · Cited by 189
Recent Advances in Understanding Endothelial Dysfunction in Atherosclerosis
Yang, Z., & Ming, X. (2006) · Clinical Medicine & Research · doi:10.3121/cmr.4.1.53 · Cited by 191
Chronic treatment with a superoxide dismutase mimetic prevents vascular remodeling and progression of hypertension in salt-loaded stroke-prone spontaneously hypertensive rats
Park, J. B., Touyz, R. M., Chen, X., & Schiffrin, E. L. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02233-6 · Cited by 189
Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys
Asai, K., Kudej, R. K., Shen, Y.-T., Yang, G.-P., Takagi, G., Kudej, A. B., Geng, Y., Sato, N., Nazareno, J. B., Vatner, D. E., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1493 · Cited by 191
Validation of lucigenin as a chemiluminescent probe to monitor vascular superoxide as well as basal vascular nitric oxide production
Skatchkov, M. P., Sperling, D., Hink, U., Mülsch, A., Harrison, D. G., Sindermann, I., Meinertz, T., & Münzel, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9942 · Cited by 188
Self-citation
New insights on oxidative stress in the artery wall
STOCKER, R., & KEANEY, J. F. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01370.x · Cited by 188
Regression of Atherosclerosis in Female Monkeys
Williams, J. K., Anthony, M. S., Honoré, E. K., Herrington, D. M., Morgan, T. M., Register, T. C., & Clarkson, T. B. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.7.827 · Cited by 188
Changing Patterns in the Neuropathogenesis of HIV During the HAART Era
Langford, D., Letendre, S. L., Larrea, G., & Masliah, E. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00019.x · Cited by 186
eNOS phosphorylation in health and disease
Kolluru, G. K., Siamwala, J. H., & Chatterjee, S. (2010) · Biochimie · doi:10.1016/j.biochi.2010.03.020 · Cited by 183
Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012
Daiber, A., August, M., Baldus, S. E., Wendt, M., Oelze, M. W., Sydow, K., Kleschyov, A. L., & Münzel, T. F. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.012 · Cited by 184
Pulsatile Stretch Stimulates Superoxide Production in Human Aortic Endothelial Cells
Hishikawa, K., & Lüscher, T. F. (1997) · Circulation · doi:10.1161/01.cir.96.10.3610 · Cited by 183
Enhanced superoxide anion formation in vascular tissues from spontaneously hypertensive and desoxycorticosterone acetate-salt hypertensive rats
Wu, R., Millette, E., Wu, L., & de Champlain, J. (2001) · Journal of Hypertension · doi:10.1097/00004872-200104000-00011 · Cited by 183
Effects of Long-term Smoking on Myocardial Blood Flow, Coronary Vasomotion, and Vasodilator Capacity
Campisi, R., Czernin, J. G., Schöder, H. M., Sayre, J. W., Marengo, F. D., Phelps, M. E., & Schelbert, H. R. (1998) · Circulation · doi:10.1161/01.cir.98.2.119 · Cited by 180
Regression or Progression
Candipan, R. C., Wang, B., Buitrago, R., Tsao, P. S., & Cooke, J. P. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.1.44 · Cited by 180
Xanthine oxidoreductase in atherosclerosis pathogenesis: Not only oxidative stress
Battelli, M. G., Polito, L., & Bolognesi, A. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.10.006 · Cited by 179
Reactive oxygen species and vascular cell apoptosis in response to angiotensin II and pro-atherosclerotic factors
Dimmeler, S., & Zeiher, A. M. (2000) · Regulatory Peptides · doi:10.1016/s0167-0115(00)00105-1 · Cited by 178
Changes in flow-mediated brachial artery vasoactivity with lowering of desirable cholesterol levels in healthy middle-aged men
Vogel, R. A., Corretti, M. C., & Plotnick, G. D. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)89131-x · Cited by 178
Aging-Associated Endothelial Dysfunction in Humans Is Reversed by L-Arginine
Chauhan, A., More, R. S., Mullins, P. A., Taylor, G., Petch, M. C., & Schofield, P. M. (1996) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00394-4 · Cited by 174
Role of Uric Acid Metabolism-Related Inflammation in the Pathogenesis of Metabolic Syndrome Components Such as Atherosclerosis and Nonalcoholic Steatohepatitis
Kushiyama, A., Nakatsu, Y., Matsunaga, Y., Yamamotoya, T., Mori, K., Ueda, K., Inoue, Y., Sakoda, H., Fujishiro, M., Ono, H., et al. (2016) · Mediators of Inflammation · doi:10.1155/2016/8603164 · Cited by 188
Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells
Cui, X.-L., & Douglas, J. G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3771 · Cited by 174
Beyond LDL oxidation: ROS in vascular signal transduction
Chen, K. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00239-9 · Cited by 170
Tetrahydrobiopterin and endothelial nitric oxide synthase activity
Cosentino, F. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00134-0 · Cited by 173
The effects of flavanol-rich cocoa and aspirin on ex vivo platelet function
Pearson, D. A., Paglieroni, T. G., Rein, D., Wun, T., Schramm, D. D., Wang, J. F., Holt, R. R., Gosselin, R. C., Schmitz, H. H., & Keen, C. L. (2002) · Thrombosis Research · doi:10.1016/s0049-3848(02)00128-7 · Cited by 175
Free Radicals and Antioxidants in Cardiovascular Health and Disease
Bahoran, T., Soobrattee, M. A., Luximon‐Ramma, A., & Aruoma, O. I. (2007) · Internet Journal of Medical Update - EJOURNAL · doi:10.4314/ijmu.v1i2.39839 · Cited by 176
Impaired Superoxide Production Due to a Deficiency in Phagocyte NADPH Oxidase Fails to Inhibit Atherosclerosis in Mice
Kirk, E. A., Dinauer, M. C., Rosen, H., Chait, A., Heinecke, J. W., & LeBoeuf, R. C. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.6.1529 · Cited by 171
Dietary l-Arginine Supplementation Normalizes Platelet Aggregation in Hypercholesterolemic Humans
Wolf, A., Zalpour, C., Theilmeier, G., Wang, B., Ma, A. O., Anderson, B. E., Tsao, P. S., & Cooke, J. P. (1997) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00523-8 · Cited by 171
Atherosclerosis, Vascular Remodeling, and Impairment of Endothelium-Dependent Relaxation in Genetically Altered Hyperlipidemic Mice
Bonthu, S., Heistad, D. D., Chappell, D. A., Lamping, K. G., & Faraci, F. M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.11.2333 · Cited by 171
The l-arginine—nitric oxide pathway: role in atherosclerosis and therapeutic implications
Böger, R. H., Bode‐Böger, S. M., & Frölich, J. C. (1996) · Atherosclerosis · doi:10.1016/s0021-9150(96)05953-9 · Cited by 168
Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia
Gilligan, D. M., Sack, M. N., Guetta, V., Casino, P. R., Quyyumi, A. A., Rader, D. J., Panza, J. A., & Cannon, R. O. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90164-3 · Cited by 168
Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: Implications for impaired vasomotion
Harrison, D. G., & Ohara, Y. (1995) · The American Journal of Cardiology · doi:10.1016/0002-9149(95)80018-n · Cited by 163
Self-citation
Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies
Daiber, A., & Chłopicki, S. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.026 · Cited by 171
Oxidized low density lipoprotein induces apoptosis via generation of reactive oxygen species in vascular smooth muscle cells
Hsieh, C. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00218-2 · Cited by 167
Simvastatin Preserves Coronary Endothelial Function in Hypercholesterolemia in the Absence of Lipid Lowering
Wilson, S. H., Simari, R. D., Best, P. J. M., Peterson, T. E., Lerman, L. O., Aviram, M., Nath, K. A., Holmes, D. R., & Lerman, A. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.1.122 · Cited by 166
Self-citation
Impaired endothelial function in arterial hypertension and hypercholesterolemia
John, S., & Schmieder, R. E. (2000) · Journal of Hypertension · doi:10.1097/00004872-200018040-00002 · Cited by 167
Interactions among ACE, kinins and NO
Linz, W. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00091-7 · Cited by 166
The Nitric Oxide/Superoxide Assay
Kelm, M., Dahmann, R., Wink, D. A., & Feelisch, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9922 · Cited by 165
Angiostatin Inhibits Coronary Angiogenesis During Impaired Production of Nitric Oxide
Matsunaga, T., Weihrauch, D., Moniz, M., Tessmer, J. P., Warltier, D. C., & Chilian, W. M. (2002) · Circulation · doi:10.1161/01.cir.0000015856.84385.e9 · Cited by 163
Role of vascular nitric oxide in physiological and pathological conditions
Marín, J., & Rodríguez-Martínez, M. A. (1997) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(97)00051-x · Cited by 163
Matrix metalloproteinases, inflammation and atherosclerosis: therapeutic perspectives
Beaudeux, J., Giral, P., Bruckert, É., Foglietti, M. J., & Chapman, M. J. (2004) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2004.024 · Cited by 163

Authors: Ohara, Y., Peterson, T. E., & Harrison, D. G.
Affiliations: Emory University (US)
ORCID: Harrison, D G
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1993-06-01
Volume: 91
Issue: 6
Pages: 2546-2551
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci116491
PMC: PMC443316
OpenAlex: W2135633069
Cited by: 1,765
References: 41
Citations by year: 2026: 3 · 2025: 7 · 2024: 10 · 2023: 9 · 2022: 15 · 2021: 21 · 2020: 29 · 2019: 29 · 2018: 18 · 2017: 30 · 2016: 26 · 2015: 28 · 2014: 43 · 2013: 43 · 2012: 47
FWCI: 26.44
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health (5r01hl032717-09)
National Heart, Lung, and Blood Institute (R01HL039006, HL-32717, HL-39006)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: hypercholesterolemia, superoxide, endothelium, nitric oxide degradation, xanthine oxidase, oxypurinol, chemiluminescence, lucigenin, atherosclerosis, endothelial dysfunction, acetylcholine-induced relaxation, cholesterol-fed rabbits
MeSH terms: Acridines, Animals, Aorta, Cholesterol, Cholesterol, Dietary, Endothelium, Vascular, Hypercholesterolemia, Luminescent Measurements, Male, Oxypurinol, Rabbits, Superoxides, Xanthine Oxidase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hypercholesterolemia increases endothelial superoxide anion production.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks