Brain-specific repression of AMPKα1 alleviates pathophysiology in Alzheimer’s model mice
Open accessAbstract
AMPK is a key regulator at the molecular level for maintaining energy metabolism homeostasis. Mammalian AMPK is a heterotrimeric complex, and its catalytic α subunit exists in 2 isoforms: AMPKα1 and AMPKα2. Recent studies suggest a role of AMPKα overactivation in Alzheimer's disease-associated (AD-associated) synaptic failure. However, whether AD-associated dementia can be improved by targeting AMPK remains unclear, and roles of AMPKα isoforms in AD pathophysiology are not understood. Here, we showed distinct disruption of hippocampal AMPKα isoform expression patterns in postmortem human AD patients and AD model mice. We further investigated the effects of brain- and isoform-specific AMPKα repression on AD pathophysiology. We found that repression of AMPKα1 alleviated cognitive deficits and synaptic failure displayed in 2 separate lines of AD model mice. In contrast, AMPKα2 suppression did not alter AD pathophysiology. Using unbiased mass spectrometry-based proteomics analysis, we identified distinct patterns of protein expression associated with specific AMPKα isoform suppression in AD model mice. Further, AD-associated hyperphosphorylation of eukaryotic elongation factor 2 (eEF2) was blunted with selective AMPKα1 inhibition. Our findings reveal isoform-specific roles of AMPKα in AD pathophysiology, thus providing insights into potential therapeutic strategies for AD and related dementia syndromes.
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Strategies that attenuate AMPK activity rescued cognitive deficits in Alzheimer's disease models.
“strategies that attenuate AMPK activity rescued cognitive deficits in Alzheimer’s disease models [60, 61].”
From AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma (2021) · cites this paper as [61]
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Self-citation
- Authors
- Zimmermann, H. R., Yang, W., Kasica, N. P., Zhou, X., Wang, X., Beckelman, B. C., Lee, J., Furdui, C. M., Keene, C. D., & Ma, T.
- Affiliations
- Atrium Health Wake Forest Baptist (US)
- Wake Forest University Health Sciences (US)
- University of Washington (US)
- Corresponding author
- Ma, Tao
- Venue
- Journal of Clinical Investigation
- Published
- 2020-05-26
- Volume
- 130
- Issue
- 7
- Pages
- 3511-3527
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W3013065605
- Cited by
- 86
- References
- 72
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 23 · 2023: 9 · 2022: 10 · 2021: 14 · 2020: 9
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (K99/R00 AG044469,R01 AG055581,R01 AG056622)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- AMPK, AMPKα1, AMPKα2, Alzheimer's disease, hippocampus, cognitive impairment, synaptic failure, energy metabolism, proteomics, dementia
- MeSH terms
- Aged, 80 and over, Alzheimer Disease, Animals, Brain, Disease Models, Animal, Female, Humans, Isoenzymes, Male, Mice, Transgenic, Gene Expression Regulation, Enzymologic, Mice, AMP-Activated Protein Kinases
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