Cited by 174Mitochondrial Function and PathologyAdipose Tissue and MetabolismThyroid Disorders and Treatments

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Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

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Lebon, Vincent, Dufour, Sylvie, Petersen, Kitt Falk, Ren, Jianming, Jucker, Beat M., Slezak, Lori A., Cline, Gary W., Rothman, Douglas L., Shulman, Gerald I.·2001·Journal of Clinical Investigation

DOI 10.1172/jci200111775PMC PMC209375

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Abstract

The mechanism underlying the regulation of basal metabolic rate by thyroid hormone remains unclear. Although it has been suggested that thyroid hormone might uncouple substrate oxidation from ATP synthesis, there are no data from studies on humans to support this hypothesis. To examine this possibility, we used a novel combined 13C/31P nuclear magnetic resonance (NMR) approach to assess mitochondrial energy coupling in skeletal muscle of seven healthy adults before and after three days of triiodothyronine (T3) treatment. Rates of ATP synthesis and tricarboxylic acid (TCA) cycle fluxes were measured by 31P and 13C NMR spectroscopy, respectively, and mitochondrial energy coupling was assessed as the ratio. Muscle TCA cycle flux increased by approximately 70% following T3 treatment. In contrast, the rate of ATP synthesis remained unchanged. Given the disproportionate increase in TCA cycle flux compared with ATP synthesis, these data suggest that T3 promotes increased thermogenesis in part by promoting mitochondrial energy uncoupling in skeletal muscle.

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Authors: Lebon, V., Dufour, S., Petersen, K. F., Ren, J., Jucker, B. M., Slezak, L. A., Cline, G. W., Rothman, D. L., & Shulman, G. I.
Affiliations: Howard Hughes Medical Institute (US)
Yale University (US)
Bristol-Myers Squibb (United States) (US)
Corresponding author: Shulman, Gerald I.
ORCID: Dufour, Sylvie
Petersen, Kitt Falk
Cline, Gary W.
Rothman, Douglas L.
Shulman, Gerald I.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2001-09-01
Volume: 108
Issue: 5
Pages: 733-737
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci200111775
PMC: PMC209375
OpenAlex: W2141034558
Cited by: 174
References: 36
Citations by year: 2026: 2 · 2025: 4 · 2024: 3 · 2023: 4 · 2022: 1 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 6 · 2016: 11 · 2015: 8 · 2014: 4 · 2013: 8 · 2012: 9
FWCI: 3.27
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Yale University
U.S. Public Health Service (P30 DK45735, R01 DK-49230)
National Institute of Diabetes and Digestive and Kidney Diseases (P30DK45735, R01DK049230, R01 DK-49230, P30DK045735)
National Center for Research Resources (M01RR000125, M01 RR-00125)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Keywords: triiodothyronine, thyroid hormones, uncoupling, skeletal muscle, basal metabolic rate, thermogenesis, ATP production, TCA cycle flux, substrate oxidation
MeSH terms: Adenosine Triphosphate, Adult, Citric Acid Cycle, Female, Humans, Male, Mitochondria, Magnetic Resonance Spectroscopy, Oxidative Phosphorylation, Triiodothyronine, Muscle, Skeletal, Glutamic Acid

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Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

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