Liver fibrosis

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323

The Versatile Role of microRNA-30a in Human Cancer

Wang, C., Yang, X., Chen, Y., & Chen, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471111 · Cited by 3,414

Natural history of liver fibrosis progression in patients with chronic hepatitis C

Poynard, T., Bedossa, P., & Opolon, P. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07642-8 · Cited by 3,011

Nonalcoholic Steatohepatitis

Ludwig, J., Viggiano, T. R., McGill, D. B., & Ott, B. J. (1980) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(24)00530-5 · Cited by 2,903

J. Submicrosc. Cytol. Pathol.

Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,800

Epithelial-mesenchymal transition and its implications for fibrosis

Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20530 · Cited by 2,715

Epithelial-mesenchymal transition and its implications for fibrosis

Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320530 · Cited by 2,171

Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection

Regev, A., Berho, M. E., Jeffers, L. J., Milikowski, C., Molina, E. G., Pyrsopoulos, N., Feng, Z.-Z., Reddy, K. R., & Schiff, E. R. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.06038.x · Cited by 2,078

Hepatogastroenterology

Xu, D., He, X., Chang, Y., Sun, S., Xu, C., & Lin, J. (2012) · Hepatogastroenterology · doi:10.5754/hge12458 · Cited by 1,977

Liver fibrosis – from bench to bedside

Friedman, S. L. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00429-4 · Cited by 1,780

Liver fibrogenic cells

Forbes, S. J., & Parola, M. (2011) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2011.02.006 · Cited by 115

Elevated Plasma IL-6 Associates with Increased Risk of Advanced Fibrosis and Cholangiocarcinoma in Individuals Infected by Opisthorchis viverrini

Sripa, B., Thinkhamrop, B., Mairiang, E., Laha, T., Kaewkes, S., Sithithaworn, P., Periago, M. V., Bhudhisawasdi, V., Yonglitthipagon, P., Mulvenna, J. P., et al. (2012) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0001654 · Cited by 115

p53 on the crossroad between regeneration and cancer

Charni‐Natan, M., Aloni-Grinstein, R., Molchadsky, A., & Rotter, V. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.117 · Cited by 115

Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis

Koyama, Y., Wang, P., Liang, S., Iwaisako, K., Liu, X., Xu, J., Zhang, M., Sun, M., Cong, M., Karin, D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88845 · Cited by 115

Platelets contribute to the reduction of liver fibrosis in mice

Watanabe, M., Murata, S., Hashimoto, I., Nakano, Y., Ikeda, O., Aoyagi, Y., Matsuo, R., Fukunaga, K., Yasue, H., & Ohkohchi, N. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05497.x · Cited by 115

Cytokines and STATs in Liver Fibrosis

Kong, X., Horiguchi, N., Mori, M., & Gao, B. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00069 · Cited by 115

Hypoxia, angiogenesis and liver fibrogenesis in the progression of chronic liver diseases

Paternostro, C. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i3.281 · Cited by 115

General mechanisms of nicotine‐induced fibrogenesis

Jensen, K. J., Nizamutdinov, D., Guerrier, M., Afroze, S. H., Dostal, D. E., & Glaser, S. S. (2012) · The FASEB Journal · doi:10.1096/fj.12-206458 · Cited by 115

Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin

Qin, L., Liu, N., Bao, C.-L.-M., Yang, D.-Z., Ma, G.-X., Yi, W.-H., Xiao, G.-Z., & Cao, H.-L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00952-0 · Cited by 114

Mimicking dynamic in vivo environments with stimuli-responsive materials for cell culture

Kim, J., & Hayward, R. C. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.04.003 · Cited by 114

Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells

Morán‐Salvador, E., Titos, E., Rius, B., González‐Périz, A., García‐Alonso, V., López‐Vicario, C., Miquel, R., Barak, Y., Arroyo, V., & Clària, J. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.06.023 · Cited by 114

Coffee and liver diseases

Muriel, P., & Arauz, J. (2009) · Fitoterapia · doi:10.1016/j.fitote.2009.10.003 · Cited by 114

Pathogenesis of Nonalcoholic Steatohepatitis: Interactions between Liver Parenchymal and Nonparenchymal Cells

Magee, N. S., Zou, A., & Zhang, Y. (2016) · BioMed Research International · doi:10.1155/2016/5170402 · Cited by 114

Platelets in liver disease, cancer and regeneration

Kurokawa, T., & Ohkohchi, N. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i18.3228 · Cited by 114

Restoration of mesenchymal retinal pigmented epithelial cells by TGFβ pathway inhibitors: implications for age-related macular degeneration

Radeke, M. J., Radeke, C. M., Shih, Y.-H., Hu, J. G., Bok, D., Johnson, L. V., & Coffey, P. J. (2015) · Genome Medicine · doi:10.1186/s13073-015-0183-x · Cited by 114

Ecto‐5′‐nucleotidase (CD73) ‐mediated extracellular adenosine production plays a critical role in hepatic fibrosis

Peng, Z., Fernández, P., Wilder, T., Yee, H. T., Chiriboga, L. A., Chan, E. S. L., & Cronstein, B. N. (2008) · The FASEB Journal · doi:10.1096/fj.07-100685 · Cited by 114

Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes

Wang, M., Chen, Y., Chen, I.-S., Hsieh, S., Chen, S., & Chiu, C. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.08.004 · Cited by 114

NOX1/nicotinamide adenine dinucleotide phosphate, reduced form (NADPH) oxidase promotes proliferation of stellate cells and aggravates liver fibrosis induced by bile duct ligation

Cui, W., Matsuno, K., Iwata, K., Ibi, M., Matsumoto, M., Zhang, J., Zhu, K., Katsuyama, M., Torok, N. J., & Yabe‐Nishimura, C. (2011) · Hepatology · doi:10.1002/hep.24465 · Cited by 113

Applications of Patient-Specific Induced Pluripotent Stem Cells; Focused on Disease Modeling, Drug Screening and Therapeutic Potentials for Liver Disease

Chun, Y. S., Chaudhari, P., & Jang, Y.-Y. (2010) · International Journal of Biological Sciences · doi:10.7150/ijbs.6.796 · Cited by 113

Dioscin alleviates BDL- and DMN-induced hepatic fibrosis via Sirt1/Nrf2-mediated inhibition of p38 MAPK pathway

Gu, L., Tao, X., Xu, Y., Han, X., Qi, Y., Xu, L., Yin, L., & Peng, J. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.12.024 · Cited by 113

Oncostatin M causes liver fibrosis by regulating cooperation between hepatic stellate cells and macrophages in mice

Matsuda, M., Tsurusaki, S., Miyata, N., Saijou, E., Okochi, H., Miyajima, A., & Tanaka, M. (2017) · Hepatology · doi:10.1002/hep.29421 · Cited by 113

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

Leu, J. I.-J., Murphy, M. E., & George, D. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821277116 · Cited by 113

Tissue Engineering in Liver Regenerative Medicine: Insights into Novel Translational Technologies

Heydari, Z., Najimi, M., Mirzaei, H., Shpichka, A. I., Ruoß, M., Farzaneh, Z., Montazeri, L., Piryaei, A., Timashev, P. S., Gramignoli, R., et al. (2020) · Cells · doi:10.3390/cells9020304 · Cited by 113

Molecular MR imaging of liver fibrosis: A feasibility study using rat and mouse models

Polášek, M., Fuchs, B. C., Uppal, R., Schühle, D. T., Alford, J. K., Loving, G. S., Yamada, S., Wei, L., Lauwers, G. Y., Guimarães, A. R., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.04.035 · Cited by 113

Hepatic stellate cells: balancing homeostasis, hepatoprotection and fibrogenesis in health and disease

Schwabe, R. F., & Brenner, D. A. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01068-6 · Cited by 112

Nitric oxide promotes caspase-independent hepatic stellate cell apoptosis through the generation of reactive oxygen species

Langer, D., Das, A., Semela, D., Kang, N., Hendrickson, H. I., Bronk, S. F., Katušić, Z. S., Gores, G. J., & Shah, V. H. (2008) · Hepatology · doi:10.1002/hep.22285 · Cited by 112

The stellate cell system (vitamin A-storing cell system)

Senoo, H., Mezaki, Y., & Fujiwara, M. (2017) · Anatomical Science International · doi:10.1007/s12565-017-0395-9 · Cited by 112

From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions

Caputo, T., Gilardi, F., & Desvergne, B. (2017) · FEBS Letters · doi:10.1002/1873-3468.12742 · Cited by 112

Distinct Populations of Hepatic Stellate Cells in the Mouse Liver Have Different Capacities for Retinoid and Lipid Storage

D’Ambrosio, D. N., Walewski, J. L., Clugston, R. D., Berk, P. D., Rippe, R. A., & Blaner, W. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024993 · Cited by 112

Bacterial translocation and changes in the intestinal microbiome associated with alcoholic liver disease

Yan, A. W. (2012) · World Journal of Hepatology · doi:10.4254/wjh.v4.i4.110 · Cited by 112

Puerarin mediates hepatoprotection against CCl4-induced hepatic fibrosis rats through attenuation of inflammation response and amelioration of metabolic function

Li, R., Xu, L., Liang, T., Li, Y., Zhang, S., & Duan, X. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.10.059 · Cited by 111

Hepatic Stellate Cells May Relate to Progression of Intrahepatic Cholangiocarcinoma

Okabe, H., Beppu, T., Hayashi, H., Horino, K., Masuda, T., Komori, H., Ishikawa, S., Watanabe, M., Takamori, H., Iyama, K.-I., et al. (2009) · Annals of Surgical Oncology · doi:10.1245/s10434-009-0568-4 · Cited by 111

Curcumin inhibits gene expression of receptor for advanced glycation end‐products (RAGE) in hepatic stellate cells in vitro by elevating PPARγ activity and attenuating oxidative stress

Lin, J., Tang, Y., Kang, Q., Feng, Y., & Chen, A. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01910.x · Cited by 111

Calcium Signaling in the Liver

Amaya, M. J., & Nathanson, M. H. (2012) · Comprehensive physiology · doi:10.1002/cphy.c120013 · Cited by 111

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Sugimoto, A., Saito, Y., Wang, G., Sun, Q., Yin, C., Lee, K. H., Geng, Y., Rajbhandari, P., Hernandez, C., Steffani, M., et al. (2025) · Nature · doi:10.1038/s41586-025-08677-w · Cited by 133

The rno‐miR‐34 family is upregulated and targets ACSL1 in dimethylnitrosamine‐induced hepatic fibrosis in rats

Li, W., Chen, C., Xu, M., Guo, J., Li, Y., Xia, Q., Liu, H., He, J., Yu, H., & Zhu, L. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08075.x · Cited by 110

Nrf2 pathway activation contributes to anti-fibrosis effects of ginsenoside Rg1 in a rat model of alcohol- and CCl4-induced hepatic fibrosis

Li, J.-P., Gao, Y., Chu, S., Zhang, Z., Xia, C., Mou, Z., Song, X., He, W., Guo, X., & Chen, N. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.41 · Cited by 110

Clinical Advancements in the Targeted Therapies against Liver Fibrosis

Bansal, R., Nagórniewicz, B., & Prakash, J. (2016) · Mediators of Inflammation · doi:10.1155/2016/7629724 · Cited by 110

Hepatocarcinogenesis in FXR−/− Mice Mimics Human HCC Progression That Operates through HNF1α Regulation of FXR Expression

Liu, N., Meng, Z., Lou, G., Zhou, W., Wang, X., Zhang, Y., Zhang, L., Liu, X., Yen, Y., Lai, L. L., et al. (2012) · Molecular Endocrinology · doi:10.1210/me.2011-1383 · Cited by 110

The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease

Hartmann, P., Chen, W., & Schnabl, B. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00402 · Cited by 110

α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β

Foo, N., Lin, S.-H., Lee, Y., Wu, M., & Wang, Y. (2011) · Toxicology · doi:10.1016/j.tox.2011.01.009 · Cited by 109

Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis

Qu, C., Zheng, D., Li, S., Liu, Y., Lidofsky, A., Holmes, J. A., Chen, J., He, L., Wei, L., Liao, Y., et al. (2018) · Hepatology · doi:10.1002/hep.29881 · Cited by 109

Asiatic acid attenuates CCl 4 -induced liver fibrosis in rats by regulating the PI3K/AKT/mTOR and Bcl-2/Bax signaling pathways

Wei, L., Chen, Q., Guo, A., Fan, J., Wang, R., & Zhang, H. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.04.016 · Cited by 109

Autocrine CTHRC1 Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Activating TGF-β Signaling

Li, J., Wang, Y., Ma, M., Jiang, S., Zhang, X., Zhang, Y., Yang, X., Xu, C., Tian, G.-A., Li, Q., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.009 · Cited by 109

Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice

Yan, J., Tung, H., Li, S., Niu, Y., Garbacz, W. G., Lu, P., Bi, Y., Li, Y., He, J., Xu, M., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.05.066 · Cited by 109

High-Throughput Glycomic Methods

Trbojević‐Akmačić, I., Lageveen‐Kammeijer, G. S. M., Heijs, B., Pribić, T., Deriš, H., Wuhrer, M., & Lauc, G. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c01031 · Cited by 109

THE ROLE OF GENETIC POLYMORPHISMS IN ALCOHOLIC LIVER DISEASE

Stickel, F., & Österreicher, C. (2006) · Alcohol and Alcoholism · doi:10.1093/alcalc/agl011 · Cited by 109

Thyroid hormones inhibit TGF-β signaling and attenuate fibrotic responses

Alonso-Merino, E., Martín Orozco, R., Ruíz-Llorente, L., Martínez-Iglesias, O. A., Velasco-Martín, J. P., Montero-Pedrazuela, A., Fanjul-Rodríguez, L., Contreras-Jurado, C., Regadera, J., & Aranda, A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506113113 · Cited by 108

Novel serological neo-epitope markers of extracellular matrix proteins for the detection of portal hypertension

Leeming, D. J., Karsdal, M. A., Byrjalsen, I., Bendtsen, F., Trebicka, J., Nielsen, M. J., Christiansen, C., Møller, S., & Krag, A. A. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12484 · Cited by 108

Non-invasive detection of liver fibrosis: MR imaging features vs. MR elastography

Venkatesh, S. K., Yin, M., Takahashi, N., Glockner, J. F., Talwalkar, J. A., & Ehman, R. L. (2015) · Abdominal Imaging · doi:10.1007/s00261-015-0347-6 · Cited by 108

The hepatitis B virus X protein induces paracrine activation of human hepatic stellate cells

Martín‐Vílchez, S., Sanz-Cameno, P., Rodríguez-Muñoz, Y., Majano, P. L., Molina‐Jiménez, F., López‐Cabrera, M., Moreno‐Otero, R., & Lara‐Pezzi, E. (2008) · Hepatology · doi:10.1002/hep.22265 · Cited by 108

Fibrosis is a common outcome following total knee arthroplasty

Abdul, N., Dixon, D., Walker, A. F., Horabin, J., Smith, N., Weir, D. J., Brewster, N., Deehan, D. J., Mann, D. A., & Borthwick, L. A. (2015) · Scientific Reports · doi:10.1038/srep16469 · Cited by 108

Ibrutinib Exerts Potent Antifibrotic and Antitumor Activities in Mouse Models of Pancreatic Adenocarcinoma

Massó-Vallés, D., Jauset, T., Serrano, E., Sodir, N. M., Pedersen, K., Affara, N. I., Whitfield, J. R., Beaulieu, M.-È., Evan, G. I., Elias, L., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2852 · Cited by 108

Prediagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: A nested case-control study

Fedirko, V., Duarte‐Salles, T., Bamia, C., Trichopoulou, A., Aleksandrova, K., Trichopoulos, D., Trépo, E., Tjønneland, A. M., Olsen, A., Overvad, K., et al. (2014) · Hepatology · doi:10.1002/hep.27079 · Cited by 108

Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation of Nrf2-ARE and TGF-β/Smad signaling pathways

Chen, Q., Zhang, H., Cao, Y. W., Li, Y., Sun, S., Zhang, J., & Zhang, G. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s137507 · Cited by 108

Maltol Mitigates Thioacetamide-induced Liver Fibrosis through TGF-β1-mediated Activation of PI3K/Akt Signaling Pathway

Mi, X.-J., Hou, J., Jiang, S., Liu, Z., Tang, S., Liu, X., Wang, Y., Chen, C., Wang, Z., & Li, W. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05943 · Cited by 108

T1 mapping, T2 mapping and MR elastography of the liver for detection and staging of liver fibrosis

Hoffman, D. H., Ayoola, A., Nickel, D. M., Han, F., Chandarana, H., & Shanbhogue, K. (2019) · Abdominal Radiology · doi:10.1007/s00261-019-02382-9 · Cited by 108

Hepatitis C Virus and Hepatocellular Carcinoma: When the Host Loses Its Grip

Goto, K., Suarez, A. A. R., Wrensch, F., Baumert, T. F., & Lupberger, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093057 · Cited by 108

Oncogenic driver genes and tumor microenvironment determine the type of liver cancer

Wang, G., Wang, Q., Liang, N. N., Xue, H., Yang, T., Chen, X., Qiu, Z., Zeng, C., Sun, T., Yuan, W., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2509-x · Cited by 108

Hepatic myofibroblasts: A heterogeneous population of multifunctional cells in liver fibrogenesis

Novo, E., di Bonzo, L. V., Cannito, S., Colombatto, S., & Parola, M. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.03.010 · Cited by 108

Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential #

Moles, A., Tarrats, N., Fernández-Checa, J. C., & Marı́, M. (2008) · Hepatology · doi:10.1002/hep.22753 · Cited by 108

Molecular Mechanisms of Liver Fibrosis in HIV/HCV Coinfection

Mastroianni, C. M., Lichtner, M., Mascia, C., Zuccalà, P., & Vullo, V. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15069184 · Cited by 108

Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts

Liu, X., Xu, J., Brenner, D. A., & Kisseleva, T. (2013) · Current Pathobiology Reports · doi:10.1007/s40139-013-0018-7 · Cited by 108

Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model

Xiao, J., Ching, Y. P., Liong, E. C., Nanji, A. A., Fung, M., & Tipoe, G. L. (2012) · European Journal of Nutrition · doi:10.1007/s00394-012-0301-0 · Cited by 108

The renin–angiotensin system in a rat model of hepatic fibrosis: Evidence for a protective role of Angiotensin-(1–7)

Pereira, R. M., Santos, R. A. S., Teixeira, M. M., Leite, V. H. R., Costa, L. P., Dias, F. L. D. C., Barcelos, L. S., Collares, G. B., & Silva, A. C. S. E. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.10.018 · Cited by 108

MR elastography for noninvasive assessment of hepatic fibrosis: Reproducibility of the examination and reproducibility and repeatability of the liver stiffness value measurement

Lee, Y. J., Lee, J. M., Lee, J. E., Lee, K. B., Lee, E. S., Yoon, J., Yu, M. H., Baek, J. H., Shin, C. I., Han, J. K., et al. (2013) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.24147 · Cited by 107

Obesity: An Immunometabolic Perspective

Ray, I., Mahata, S. K., & De, R. K. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00157 · Cited by 107

Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo

Yang, F., Luo, L., Zhu, Z., Zhou, X., Wang, Y., Xue, J., Zhang, J., Cai, X., Chen, Z.-L., Ma, Q., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00929 · Cited by 107

Adipocyte Fatty Acid Binding Protein Promotes the Onset and Progression of Liver Fibrosis via Mediating the Crosstalk between Liver Sinusoidal Endothelial Cells and Hepatic Stellate Cells

Wu, X., Shu, L., Zhang, Z., Li, J., Zong, J., Cheong, L. Y., Ye, D., Lam, K. S. L., Song, E., Wang, C., et al. (2021) · Advanced Science · doi:10.1002/advs.202003721 · Cited by 107

Liver fibrosis: An intravoxel incoherent motion (IVIM) study

Chow, A. M., Gao, D. S., Fan, S. J., Qiao, Z., Lee, F. Y., Yang, J., Man, K., & Wu, E. X. (2012) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.23607 · Cited by 107

The Adventures of Sonic Hedgehog in Development and Repair. II. Sonic hedgehog and liver development, inflammation, and cancer

Omenetti, A., & Diehl, A. M. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00543.2007 · Cited by 107

Potentiation of hepatic stellate cell activation by extracellular ATP is dependent on P2X7R-mediated NLRP3 inflammasome activation

Jiang, S., Zhang, Y., Zheng, J., Li, X., Yao, Y., Wu, Y., Song, S., Sun, P., Nan, J., & Lian, L. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.040 · Cited by 106

Tandem Enzymatic Self-Assembly and Slow Release of Dexamethasone Enhances Its Antihepatic Fibrosis Effect

Tang, W., Zhao, Z., Chong, Y., Wu, C., Liu, Q., Yang, J., Zhou, R., Lian, Z., & Liang, G. (2018) · ACS Nano · doi:10.1021/acsnano.8b04143 · Cited by 106

TGF-β1 Gene Silencing for Treating Liver Fibrosis

Cheng, K., Yang, N., & Mahato, R. I. (2009) · Molecular Pharmaceutics · doi:10.1021/mp9000469 · Cited by 106

Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine‐induced hepatic fibrosis in mice

Latella, G., Vetuschi, A., Sferra, R., Catitti, V., D’Angelo, A., Zanninelli, G., Flanders, K. C., & Gaudio, E. (2009) · Liver International · doi:10.1111/j.1478-3231.2009.02011.x · Cited by 106

Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice

Nan, Y., Wu, W., Fu, N., Liang, B.-L., Wang, R., Li, L.-X., Zhao, S., Zhao, J., & Yu, J. Q. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520903114912 · Cited by 106

Protective Role of Estrogen-induced miRNA-29 Expression in Carbon Tetrachloride-induced Mouse Liver Injury

Zhang, Y., Wu, L., Wang, Y., Zhang, M., Li, L., Zhu, D., Li, X., Gu, H., Zhang, C., & Zen, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.314922 · Cited by 106

Micro-RNA Profiling in Human Serum Reveals Compartment-Specific Roles of miR-571 and miR-652 in Liver Cirrhosis

Roderburg, C., Mollnow, T., Bongaerts, B. W. C., Elfimova, N., Cardenas, D. V., Janssen, K., Zimmermann, H. W., Koch, A. H., Vucur, M., Luedde, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032999 · Cited by 105

Transcriptional Repression of the Transforming Growth Factor β (TGF-β) Pseudoreceptor BMP and Activin Membrane-bound Inhibitor (BAMBI) by Nuclear Factor κB (NF-κB) p50 Enhances TGF-β Signaling in Hepatic Stellate Cells

Liu, C., Chen, X., Yang, L., Kisseleva, T., Brenner, D. A., & Seki, E. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.543769 · Cited by 105

Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs

Tian, X.-F., Ji, F., Zang, H.-L., & Cao, H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158657 · Cited by 105

Tissue- and Serum-Associated Biomarkers of Hepatocellular Carcinoma

Chauhan, R., & Lahiri, N. (2016) · Biomarkers in Cancer · doi:10.4137/bic.s34413 · Cited by 105

Targeting Senescent Cells in Fibrosis: Pathology, Paradox, and Practical Considerations

Schafer, M. J., Haak, A. J., Tschumperlin, D. J., & LeBrasseur, N. K. (2018) · Current Rheumatology Reports · doi:10.1007/s11926-018-0712-x · Cited by 106

Clinical prediction of HBV and HCV related hepatic fibrosis using machine learning

Wei, R., Wang, J., Wang, X., Xie, G., Wang, Y., Zhang, H., Peng, C., Rajani, C., Kwee, S. A., Liu, P., et al. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.07.041 · Cited by 105

Magnesium and liver disease

Liu, M., Yang, H., & Mao, Y. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2019.09.70 · Cited by 105

Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis

Zhang, Q., Qu, Y., Zhang, Q., Li, F., Li, B., Li, Z., Dong, Y., Lu, L., & Cai, X. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-021-09684-z · Cited by 105

Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease

Dong, J., Chen, L., Ye, F., Tang, J., Liu, B., Lin, J., Zhou, P., Lü, B., Wu, M., Lu, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44057-6 · Cited by 105

In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis

Li, G., Jiang, W., Tian, J., Qu, G., Zhu, H., & Fu, F. (2009) · Phytomedicine · doi:10.1016/j.phymed.2009.05.002 · Cited by 105

Effects and mechanisms of crude astragalosides fraction on liver fibrosis in rats

Gui, S., Wei, W., Wang, H., Wu, L., Sun, W., Chen, W., & Wu, C. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.07.025 · Cited by 105

The innate immune receptor TREM-1 promotes liver injury and fibrosis

Nguyen-Lefebvre, A. T., Ajith, A., Portik-Dobos, V., Horuzsko, D. D., Arbab, A. S., Dzutsev, A., Sadek, R., Trinchieri, G., & Horuzsko, A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98156 · Cited by 104

Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling

Szuster‐Ciesielska, A., Plewka, K., Daniluk, J., & Kandefer‐Szerszeń, M. (2010) · Toxicology · doi:10.1016/j.tox.2010.12.006 · Cited by 104

NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6

Yu, F., Jiang, Z., Chen, B., Dong, P., & Zheng, J. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1586-5 · Cited by 104

Hepatocellular carcinoma in a mouse model fed a choline‐deficient, L‐amino acid‐defined, high‐fat diet

Ikawa‐Yoshida, A., Matsuo, S., Kato, A., Ohmori, Y., Higashida, A., Kaneko, E., & Matsumoto, M. (2017) · International Journal of Experimental Pathology · doi:10.1111/iep.12240 · Cited by 104

Accelerated liver fibrosis in hepatitis B virus transgenic mice: Involvement of natural killer T cells

Jin, Z., Sun, R., Wei, H., Gao, X., Chen, Y., & Tian, Z. (2010) · Hepatology · doi:10.1002/hep.23983 · Cited by 104

Immune Interactions in Hepatic Fibrosis

Holt, A. P., Salmon, M., Buckley, C. D., & Adams, D. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2008.07.002 · Cited by 104

Interplay between oxidative stress and hepatic steatosis in the progression of chronic hepatitis C

Vidali, M., Tripodi, M., Ivaldi, A., Zampino, R., Occhino, G., Restivo, L., Sutti, S., Marrone, A., Ruggiero, G., Albano, E., et al. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.10.011 · Cited by 104

Update on new aspects of the renin–angiotensin system in liver disease: clinical implications and new therapeutic options

Grace, J., Herath, C. B., Mak, K. Y., Burrell, L. M., & Angus, P. (2012) · Clinical Science · doi:10.1042/cs20120030 · Cited by 104

A New Mdr2−/− Mouse Model of Sclerosing Cholangitis with Rapid Fibrosis Progression, Early-Onset Portal Hypertension, and Liver Cancer

Ikenaga, N., Liu, S. B., Sverdlov, D., Yoshida, S., Nasser, I. A., Ke, Q., Kang, P. M., & Popov, Y. V. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.10.013 · Cited by 104

Role of integrins in fibrosing liver diseases

Patsenker, E., & Stickel, F. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00050.2011 · Cited by 104

Role of oxidative stress in the pathogenesis of alcohol-induced liver disease

Sid, B., Verrax, J., & Calderón, P. B. (2013) · Free Radical Research · doi:10.3109/10715762.2013.819428 · Cited by 104

Anti-fibrotic effects of fresh and cryopreserved human amniotic membrane in a rat liver fibrosis model

Ricci, E., Vanosi, G., Lindenmair, A., Hennerbichler, S., Peterbauer-Scherb, A., Wolbank, S., Cargnoni, A., Signoroni, P. B., Campagnol, M., Gabriel, C., et al. (2012) · Cell and Tissue Banking · doi:10.1007/s10561-012-9337-x · Cited by 104

Fibrosis as a Major Mechanism of Chronic Liver Disease

Bechmann, L. P., & Friedman, S. L. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-866-9_5 · Cited by 1

Anti-fibrotic treatments for chronic liver diseases: The present and the future

Odagiri, N., Matsubara, T., Sato-Matsubara, M., Fujii, H., Enomoto, M., & Kawada, N. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0187 · Cited by 64

Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis

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Liver extracellular matrix in health and disease

Bédossa, P., & Paradis, V. (2003) · The Journal of Pathology · doi:10.1002/path.1397 · Cited by 300

Pathogenesis of Liver Fibrosis

Alcolado, R., Arthur, M. J. P., & Iredale, J. P. (1997) · Clinical Science · doi:10.1042/cs0920103 · Cited by 172