Cited by 4,958Liver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Disease and Transplantation

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Liver fibrosis

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Bataller, Ramón, Brenner, David A.·2005·Journal of Clinical Investigation

DOI 10.1172/jci24282

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Abstract

Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types of chronic liver diseases. Advanced liver fibrosis results in cirrhosis, liver failure, and portal hypertension and often requires liver transplantation. Our knowledge of the cellular and molecular mechanisms of liver fibrosis has greatly advanced. Activated hepatic stellate cells, portal fibroblasts, and myofibroblasts of bone marrow origin have been identified as major collagen-producing cells in the injured liver. These cells are activated by fibrogenic cytokines such as TGF-beta1, angiotensin II, and leptin. Reversibility of advanced liver fibrosis in patients has been recently documented, which has stimulated researchers to develop antifibrotic drugs. Emerging antifibrotic therapies are aimed at inhibiting the accumulation of fibrogenic cells and/or preventing the deposition of extracellular matrix proteins. Although many therapeutic interventions are effective in experimental models of liver fibrosis, their efficacy and safety in humans is unknown. This review summarizes recent progress in the study of the pathogenesis and diagnosis of liver fibrosis and discusses current antifibrotic strategies.

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Authors: Bataller, R., & Brenner, D. A.
Affiliations: Columbia University (US)
Corresponding author: Brenner, David A.
ORCID: Brenner, David A.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2005-02-01
Volume: 115
Issue: 2
Pages: 209-218
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci24282
OpenAlex: W4255712601
Cited by: 4,958
References: 134
Citations by year: 2026: 177 · 2025: 236 · 2024: 285 · 2023: 289 · 2022: 307 · 2021: 321 · 2020: 294 · 2019: 275 · 2018: 284 · 2017: 295 · 2016: 281 · 2015: 307 · 2014: 229 · 2013: 224 · 2012: 222
FWCI: 17.47
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed (publishedVersion)
Funders: Ministerio de Ciencia y Tecnología
National Institutes of Health
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Keywords: liver fibrosis, extracellular matrix accumulation, collagen deposition, chronic liver disease, liver cirrhosis, hepatic stellate cells, portal fibroblasts, myofibroblasts, TGF-β1, angiotensin II, leptin, fibrogenic cytokines, antifibrotic agents, fibrosis pathogenesis, fibrosis diagnosis, liver transplantation
MeSH terms: Angiotensin II, Animals, Humans, Hypertension, Portal, Liver Cirrhosis, Transforming Growth Factor beta, Liver Failure, Leptin

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