Liver fibrosis

Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin

Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323

The Versatile Role of microRNA-30a in Human Cancer

Wang, C., Yang, X., Chen, Y., & Chen, L. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000471111 · Cited by 3,414

Natural history of liver fibrosis progression in patients with chronic hepatitis C

Poynard, T., Bedossa, P., & Opolon, P. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07642-8 · Cited by 3,011

Nonalcoholic Steatohepatitis

Ludwig, J., Viggiano, T. R., McGill, D. B., & Ott, B. J. (1980) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(24)00530-5 · Cited by 2,903

J. Submicrosc. Cytol. Pathol.

Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,800

Epithelial-mesenchymal transition and its implications for fibrosis

Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20530 · Cited by 2,715

Epithelial-mesenchymal transition and its implications for fibrosis

Kalluri, R., & Neilson, E. G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320530 · Cited by 2,171

Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection

Regev, A., Berho, M. E., Jeffers, L. J., Milikowski, C., Molina, E. G., Pyrsopoulos, N., Feng, Z.-Z., Reddy, K. R., & Schiff, E. R. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.06038.x · Cited by 2,078

Hepatogastroenterology

Xu, D., He, X., Chang, Y., Sun, S., Xu, C., & Lin, J. (2012) · Hepatogastroenterology · doi:10.5754/hge12458 · Cited by 1,977

Liver fibrosis – from bench to bedside

Friedman, S. L. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00429-4 · Cited by 1,780

Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS/TLR4/NF-κB signaling pathway in rats

Lai, L., Chen, Y., Tian, X., Li, X., Zhang, X., Lei, J., Bi, Y., Fang, B., & Song, X. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.040 · Cited by 81

Time profiles of the expression of metalloproteinases, tissue inhibitors of metalloproteases, cytokines and collagens in hamsters infected with Opisthorchis viverrini with special reference to peribiliary fibrosis and liver injury

Prakobwong, S., Pinlaor, S., Yongvanit, P., Sithithaworn, P., Pairojkul, C., & Hiraku, Y. (2009) · International Journal for Parasitology · doi:10.1016/j.ijpara.2008.12.002 · Cited by 81

Current concepts on the role of nitric oxide in portal hypertension

Hu, L. S. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i11.1707 · Cited by 81

Antifibrotic activity of galangin, a novel function evaluated in animal liver fibrosis model

Wang, X., Gong, G., Yang, W.-H., Li, Y., Jiang, M., & Li, L. (2013) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2013.04.004 · Cited by 81

Inhibition of soluble epoxide hydrolase attenuates hepatic fibrosis and endoplasmic reticulum stress induced by carbon tetrachloride in mice

Harris, T. R., Bettaieb, A., Kodani, S. D., Dong, H., Myers, R., Chiamvimonvat, N., Haj, F. G., & Hammock, B. D. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.03.022 · Cited by 81

Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats

Lee, E., Shin, M.-O., Yoon, S., & Moon, J. (2010) · Archives of Pharmacal Research · doi:10.1007/s12272-010-0616-4 · Cited by 81

Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go?

Gressner, O. A., Rizk, M. S., Kovalenko, E. P., Weiskirchen, R., & Gressner, A. M. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05345.x · Cited by 81

Angiotensin II-induced pro-fibrotic effects require p38MAPK activity and transforming growth factor beta 1 expression in skeletal muscle cells

Morales, M. G., Vázquez, Y., Acuña, M. J., Rivera, J. C. A., Simón, F., Salas, J. D., Álvarez‐Ruf, J., Brandan, E., & Cabello‐Verrugio, C. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.07.028 · Cited by 81

p38α Inhibits Liver Fibrogenesis and Consequent Hepatocarcinogenesis by Curtailing Accumulation of Reactive Oxygen Species

Sakurai, T., Kudo, M., Umemura, A., He, G., Elsharkawy, A. M., Seki, E., & Karin, M. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1602 · Cited by 81

Mesenchymal Stromal Cells Engineered to Produce IGF-I by Recombinant Adenovirus Ameliorate Liver Fibrosis in Mice

Fiore, E. J., Bayo, J., García, M. G., Malvicini, M., Lloyd, R., Piccioni, F., Rizzo, M., Peixoto, E., Sola, M. B., Atorrasagasti, C., et al. (2014) · Stem Cells and Development · doi:10.1089/scd.2014.0174 · Cited by 81

AT1 receptor antagonist Candesartan in selected cirrhotic patients: Effect on portal pressure and liver fibrosis markers

Debernardi-Venon, W., Martini, S., Biasi, F., Vizio, B., Termine, A., Poli, G., Brunello, F., Alessandria, C., Bonardi, R., Saracco, G. M., et al. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.01.017 · Cited by 81

Frontal fibrosing alopecia: reflections and hypotheses on aetiology and pathogenesis

Tziotzios, C., Stefanato, C. M., Fenton, D. A., Simpson, M. A., & McGrath, J. A. (2016) · Experimental Dermatology · doi:10.1111/exd.13071 · Cited by 81

MiR-130a-3p attenuates activation and induces apoptosis of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis by directly targeting TGFBR1 and TGFBR2

Wang, Y., Du, J., Niu, X., Fu, N., Wang, R., Zhang, Y., Zhao, S., Sun, D., & Nan, Y. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.10 · Cited by 81

Metabolic Signature of Hepatic Fibrosis: From Individual Pathways to Systems Biology

Chang, M.-L., & Yang, S.-S. (2019) · Cells · doi:10.3390/cells8111423 · Cited by 81

Review article: the reversibility of cirrhosis

Sohrabpour, A. A., Mohamadnejad, M., & Malekzadeh, R. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12044 · Cited by 80

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

Norona, L. M., Nguyen, D. G., Gerber, D. A., Presnell, S. C., Mosedale, M., & Watkins, P. B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0208958 · Cited by 81

Fibrosis in Chronic Liver Disease: An Update on Diagnostic and Treatment Modalities

Manka, P. P., Zeller, A. C., & Syn, W. (2019) · Drugs · doi:10.1007/s40265-019-01126-9 · Cited by 80

Liver fibrosis and Gd-EOB-DTPA-enhanced MRI: A histopathologic correlation

Verloh, N., Utpatel, K., Haimerl, M., Zeman, F., Fellner, C., Fichtner‐Feigl, S., Teufel, A., Stroszczynski, C., Evert, M., & Wiggermann, P. (2015) · Scientific Reports · doi:10.1038/srep15408 · Cited by 80

Expression of HLA-G by mast cells is associated with hepatitis C virus-induced liver fibrosis

Amiot, L., Vu, N., Rauch, M., L’Helgoualc’h, A., Chalmel, F., Gascan, H., Turlin, B., Guyader, D., & Samson, M. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.09.006 · Cited by 80

Effects of interferon-gamma liposomes targeted to platelet-derived growth factor receptor–beta on hepatic fibrosis in rats

Li, F., Li, Q., Wang, J., Zhan, C., Xie, C., & Lu, W. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.023 · Cited by 80

Renin-angiotensin system in the pathogenesis of liver fibrosis

Pereira, R. M., Santos, R. A. S., Dias, F. L. D. C., Teixeira, M. M., & Silva, A. C. S. E. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.2579 · Cited by 80

Intravenous administration of multipotent stromal cells prevents the onset of non-alcoholic steatohepatitis in obese mice with metabolic syndrome

Ezquer, M., Ezquer, F. E., Ricca, M., Allers, C., & Conget, P. A. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.020 · Cited by 80

Inflammatory status in human hepatic cirrhosis

Martinez‐Esparza, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i41.11522 · Cited by 80

Role of canonical Hedgehog signaling pathway in liver

Gao, L., Zhang, Z., Zhang, P., Yu, M., & Yang, T. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.28089 · Cited by 80

The role of iNOS in cholesterol-induced liver fibrosis

Anavi, S., Eisenberg‐Bord, M., Hahn-Obercyger, M., Genin, O., Pines, M., & Tirosh, O. (2015) · Laboratory Investigation · doi:10.1038/labinvest.2015.67 · Cited by 80

LOXL2—A New Target in Antifibrogenic Therapy?

Puente, A., Fortea, J. I., Cabezas, J., Arias Loste, M. T., Iruzubieta, P., Llerena, S., Huelin, P., Fábrega, E., & Crespo, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071634 · Cited by 79

It’s all about the spaces between cells: role of extracellular matrix in liver fibrosis

Khurana, A., Sayed, N., Allawadhi, P., & Weiskirchen, R. (2021) · Annals of Translational Medicine · doi:10.21037/atm-20-2948 · Cited by 79

Identifying cancer-associated fibroblasts as emerging targets for hepatocellular carcinoma

Zhang, J., Gu, C., Song, Q., Zhu, M., Xu, Y., Xiao, M., & Zheng, W. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00488-y · Cited by 79

Emerging Roles of the Iron Chelators in Inflammation

Paola, A. D., Tortora, C., Argenziano, M., Marrapodi, M. M., & Rossi, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147977 · Cited by 80

Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway

Baltă, C., Herman, H., Boldura, O. M., Gasca, I., Roșu, M., Ardelean, A., & Hermenean, A. O. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.08.013 · Cited by 79

Non-invasive diagnostic assessment tools for the detection of liver fibrosis in patients with suspected alcohol-related liver disease: a systematic review and economic evaluation

Stevenson, M., Lloyd-Jones, M., Morgan, M. Y., & Wong, R. (2012) · Health Technology Assessment · doi:10.3310/hta16040 · Cited by 79

Zinc in gastrointestinal and liver disease

Faa, G., Nurchi, V. M., Ravarino, A., Fanni, D., Nemolato, S., Gerosa, C., Eyken, P. V., & Geboes, K. (2007) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2007.09.024 · Cited by 79

Morin ameliorates chemically induced liver fibrosis in vivo and inhibits stellate cell proliferation in vitro by suppressing Wnt/β-catenin signaling

Perumal, M. K., Perumal, N., Samidurai, M., Devaraj, H., & NiranjaliDevaraj, S. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.03.008 · Cited by 79

Eosinophil‐derived cytokines in health and disease: unraveling novel mechanisms of selective secretion

Melo, R. C. N., Liu, L., Xenakis, J. J., & Spencer, L. A. (2013) · Allergy · doi:10.1111/all.12103 · Cited by 79

Protective Effects of Selenium-Enriched Probiotics on Carbon Tetrachloride-Induced Liver Fibrosis in Rats

Liu, Y., Liu, Q., Ye, G., Khan, A., Liu, J., Gan, F., Zhang, X., Kumbhar, S., & Huang, K. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5039184 · Cited by 79

The Chemokine CCL3 Promotes Experimental Liver Fibrosis in Mice

Heinrichs, D., Berres, M., Nellen, A., Fischer, P., Scholten, D., Trautwein, C., Wasmuth, H. E., & Sahin, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066106 · Cited by 79

Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection

Li, Y., Chang, M., Abar, O. T., Garcia, V., Rowland, C. M., Catanese, J. J., Ross, D. A., Broder, S. E., Shiffman, M. L., Cheung, R. C., et al. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2009.04.027 · Cited by 79

Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating activated hepatic stellate cells

Oh, Y., Park, O., Swierczewska, M., Hamilton, J. P., Park, J. S., Kim, T. H., Lim, S., Eom, H., Jo, D., Lee, C., et al. (2015) · Hepatology · doi:10.1002/hep.28432 · Cited by 79

Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy

Beyoğlu, D., & Idle, J. R. (2020) · Metabolites · doi:10.3390/metabo10020050 · Cited by 79

Lower urinary tract symptoms in men

Hollingsworth, J. M., & Wilt, T. J. (2014) · BMJ · doi:10.1136/bmj.g4474 · Cited by 78

The Roles of NRF2-Regulated Oxidative Stress and Mitochondrial Quality Control in Chronic Liver Diseases

Park, J.-S., Rustamov, N., & Roh, Y. (2023) · Antioxidants · doi:10.3390/antiox12111928 · Cited by 78

Identification of a novel TGF-β-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis

Zeng, C., Wang, Y., Xie, C., Sang, Y., Li, T.-J., Zhang, M., Wang, R., Zhang, Q., Zheng, L., & Zhuang, S. (2015) · Oncotarget · doi:10.18632/oncotarget.3652 · Cited by 78

Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice

Nan, Y., Fu, N., Wu, W., Liang, B.-L., Wang, R., Zhao, S., Zhao, J., & Yu, J. Q. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802530861 · Cited by 78

Matrix metalloproteinases in inflammatory pathologies of the horse

Clutterbuck, A. L., Harris, P. A., Allaway, D., & Mobasheri, A. (2008) · The Veterinary Journal · doi:10.1016/j.tvjl.2008.09.022 · Cited by 78

Measurement of liver T1 and T2 relaxation times in an experimental mouse model of liver fibrosis

Chow, A. M., Gao, D. S., Fan, S. J., Qiao, Z., Lee, F. Y., Yang, J., Man, K., & Wu, E. X. (2012) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.23606 · Cited by 78

Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols

Ferré, N., Martínez‐Clemente, M., López‐Parra, M., González‐Périz, A., Horrillo, R., Planagumà, A., Camps, J., Joven, J., Tres, A., Guardiola, F., et al. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00547.2007 · Cited by 78

Molecular Pathways: The Complex Roles of Inflammation Pathways in the Development and Treatment of Liver Cancer

Nikolaou, K., Sarris, M. E., & Talianidis, I. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1961 · Cited by 78

Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis

Patsenker, E., Stoll, M., Millonig, G., Agaimy, A., Wissniowski, T., Schneider, V., Mueller, S., Brenneisen, R., Seitz, H. K., Ocker, M., et al. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00149 · Cited by 78

Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis

Hirata, M., Ishigami, M., Matsushita, Y., Ito, T., Hattori, H., Hibi, H., Goto, H., Ueda, M., & Yamamoto, A. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0353 · Cited by 78

Caffeine intake decreases oxidative stress and inflammatory biomarkers in experimental liver diseases induced by thioacetamide: Biochemical and histological study

Amer, M. G., Mazen, N. F., & Mohamed, A. M. (2017) · International Journal of Immunopathology and Pharmacology · doi:10.1177/0394632017694898 · Cited by 78

Collagen networks determine viscoelastic properties of connective tissues yet do not hinder diffusion of the aqueous solvent

Sauer, F., Oswald, L., de Schellenberger, A. A., Tzschätzsch, H., Schrank, F., Fischer, T., Braun, J., Mierke, C. T., Valiullin, R., Sack, I., et al. (2019) · Soft Matter · doi:10.1039/c8sm02264j · Cited by 78

IL‐20 and IL‐20R1 antibodies protect against liver fibrosis

Chiu, Y.-S., Wei, C.-C., Lin, Y.-J., Hsu, Y.-H., & Chang, M.-S. (2014) · Hepatology · doi:10.1002/hep.27189 · Cited by 77

Cerium Oxide Nanoparticles: A New Therapeutic Tool in Liver Diseases

Casals, G., Perramón, M., Casals, E., Portolés, I., Fernández‐Varo, G., Morales‐Ruiz, M., Puntes, V., & Jiménez, W. (2021) · Antioxidants · doi:10.3390/antiox10050660 · Cited by 77

Schisantherin A ameliorates liver fibrosis through TGF-β1mediated activation of TAK1/MAPK and NF-κB pathways in vitro and in vivo

Wang, H., Che, J.-Y., Cui, K., Zhuang, W., Li, H., Sun, J., Chen, J., & Wang, C. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153609 · Cited by 77

Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment

El‐Khateeb, E., Achour, B., Al‐Majdoub, Z. M., Barber, J., & Rostami‐Hodjegan, A. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00462 · Cited by 77

Updated Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of Natural Product Geniposide

Liu, L., Wu, Q. J., Chen, Y., Guoxiang, G., Gao, R., Peng, B., Wang, Y., Li, A., Guo, J., Xu, X., et al. (2022) · Molecules · doi:10.3390/molecules27103319 · Cited by 77

Chronic Inflammation and Hepatocellular Carcinoma

Alison, M. R., Nicholson, L. J., & Lin, W. (2011) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-03503-6_8 · Cited by 77

Influence of splenectomy in patients with liver cirrhosis and hypersplenism

Nomura, Y., Kage, M., Ogata, T., Kondou, R., Kinoshita, H., Ohshima, K., & Yano, H. (2013) · Hepatology Research · doi:10.1111/hepr.12234 · Cited by 77

Adipose-Derived Stem Cells Can Abrogate Chemical-Induced Liver Fibrosis and Facilitate Recovery of Liver Function

Harn, H., Lin, S., Hung, S.-H., Subeq, Y., Li, Y.-S., Syu, W., Ding, D., Lee, R.-P., Hsieh, D.-K., Lin, P., et al. (2012) · Cell Transplantation · doi:10.3727/096368912x652959 · Cited by 77

New Insights into the Role of Oxidative Stress in Scleroderma Fibrosis

Gabrielli, A., Svegliati, S., Moroncini, G., & Amico, D. (2012) · The Open Rheumatology Journal · doi:10.2174/1874312901206010087 · Cited by 77

Molecular therapy for hepatic injury and fibrosis: Where are we

Prosser, C. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i4.509 · Cited by 77

Molecular Pathogenesis of Alcohol‐Induced Hepatic Fibrosis

Siegmund, S., & Brenner, D. A. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000189275.97419.58 · Cited by 77

Piezo1 specific deletion in macrophage protects the progression of liver fibrosis in mice

Luo, S., Zhao, X., Jiang, J., Deng, B., Liu, S., Xu, H., Tan, Q., Chen, Y., Zhang, Z., Pan, X., et al. (2023) · Theranostics · doi:10.7150/thno.86103 · Cited by 76

Activation of Insulin-PI3K/Akt-p70S6K Pathway in Hepatic Stellate Cells Contributes to Fibrosis in Nonalcoholic Steatohepatitis

Cai, C. X., Buddha, H., Castelino‐Prabhu, S., Zhang, Z., Britton, R. S., Bacon, B. R., & Neuschwander‐Tetri, B. A. (2017) · Digestive Diseases and Sciences · doi:10.1007/s10620-017-4470-9 · Cited by 76

Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression

Kaltenecker, D., Themanns, M., Mueller, K. M., Spirk, K., Suske, T., Merkel, O., Kenner, L., Luís, A., Kozlov, A. V., Haybaeck, J., et al. (2018) · Cytokine · doi:10.1016/j.cyto.2018.10.010 · Cited by 76

Hepatitis B Virus Promotes Angiopoietin-2 Expression in Liver Tissue

Sanz-Cameno, P., Martín‐Vílchez, S., Lara‐Pezzi, E., Borque, M. J., Salmerón, J., de Rueda, P. M., Solís, J. A., López‐Cabrera, M., & Moreno‐Otero, R. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051246 · Cited by 76

Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines

huang, L.-L., Wan, J., Wang, B., He, C., Ma, H., LI, T. W., & Kang, J. X. (2013) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.02.002 · Cited by 76

Local Inhibition of Liver Fibrosis by Specific Delivery of a Platelet-Derived Growth Factor Kinase Inhibitor to Hepatic Stellate Cells

Gonzalo, T., Beljaars, L., van de Bovenkamp, M., Temming, K., van Loenen-Weemaes, A. M., Reker‐Smit, C., Meijer, D. K. F., Lacombe, M., Opdam, F., Kéri, G., et al. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.114496 · Cited by 76

Thymoquinone alleviates nonalcoholic fatty liver disease in rats via suppression of oxidative stress, inflammation, apoptosis

Awad, A. S., Haleem, E. N. A. A., El‐Bakly, W. M., & Sherief, M. A. (2016) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-015-1207-1 · Cited by 76

Involvement of epithelial-mesenchymal transition in liver fibrosis

Li, N., Yu, K., Li, Q., & Shi, G. (2018) · Saudi Journal of Gastroenterology · doi:10.4103/sjg.sjg_297_17 · Cited by 76

Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells

Kumar, P., Smith, T., Raeman, R., Chopyk, D. M., Brink, H., Liu, Y., Sulchek, T., & Anania, F. A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001601 · Cited by 76

Distinct role of endocytosis for Smad and non-Smad TGF-β signaling regulation in hepatocytes

Meyer, C., Godoy, P., Bachmann, A., Liu, Y., Barzan, D., Ilkavets, I., Maier, P. J., Herskind, C., Hengstler, J. G., & Dooley, S. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.11.027 · Cited by 75

Detecting Transforming Growth Factor-β Release from Liver Cells Using an Aptasensor Integrated with Microfluidics

Matharu, Z., Patel, D., Gao, Y., Haque, A., Zhou, Q., & Revzin, A. (2014) · Analytical Chemistry · doi:10.1021/ac502383e · Cited by 75

Liver fibrosis in biliary atresia

Shen, W.-J., Chen, G., Wang, M., & Zheng, S. (2018) · World Journal of Pediatrics · doi:10.1007/s12519-018-0203-1 · Cited by 75

Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma

Tan, S., Zhao, J., Sun, Z., Cao, S., Niu, K., Zhong, Y., Wang, H., Shi, L., Pan, H., Hu, J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2005353117 · Cited by 75

The Lactobacillus as a Probiotic: Focusing on Liver Diseases

Jeong, J., Park, H., Cha, M. G., Park, E., Won, S., Ganesan, R., Gupta, H., Gebru, Y. A., Sharma, S. P., Lee, S. B., et al. (2022) · Microorganisms · doi:10.3390/microorganisms10020288 · Cited by 75

Chlorogenic acids: A pharmacological systematic review on their hepatoprotective effects

Xue, H., Wei, M., & Ji, L. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.154961 · Cited by 75

Regulation of Hepatic Stellate Cell Phenotypes in Metabolic Dysfunction–Associated Steatohepatitis

Kisseleva, T., Ganguly, S., Murad, R., Wang, A., & Brenner, D. A. (2025) · Gastroenterology · doi:10.1053/j.gastro.2025.03.010 · Cited by 75

Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress

Szuster‐Ciesielska, A., Mizerska-Kowalska, M., Daniluk, J., & Kandefer‐Szerszeń, M. (2012) · Journal of Gastroenterology · doi:10.1007/s00535-012-0619-7 · Cited by 75

Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver

Rashid, S. T., Humphries, J. D., Byron, A., Dhar, A., Askari, J. A., Selley, J. N., Knight, D., Goldin, R. D., Thursz, M. R., & Humphries, M. J. (2012) · Journal of Proteome Research · doi:10.1021/pr3000927 · Cited by 75

Recombinant human manganese superoxide dismutase reduces liver fibrosis and portal pressure in CCl4-cirrhotic rats

Guillaume, M., Rodrı́guez-Vilarrupla, A., Gracia‐Sancho, J., Rosado, E., Mancini, A., Bosch, J., & García‐Pagán, J. C. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.09.010 · Cited by 75

Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing Cholangitis

Mair, M., Zollner, G., Schneller, D., Musteanu, M., Fickert, P., Gumhold, J., Schuster, C., Fuchsbichler, A., Bilban, M., Tauber, S., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.02.049 · Cited by 75

Animal models for the study of liver fibrosis: new insights from knockout mouse models

Hayashi, H., & Sakai, T. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00013.2011 · Cited by 75

Mitochondria protection as a mechanism underlying the hepatoprotective effects of glycine in cholestatic mice

Heidari, R., Ghanbarinejad, V., Mohammadi, H., Ahmadi, A., Ommati, M. M., Abdoli, N., Aghaei, F., Esfandiari, A., Azarpira, N., & Niknahad, H. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.166 · Cited by 75

Cellular Interplay as a Consequence of Inflammatory Signals Leading to Liver Fibrosis Development

Ignat, S.-R., Dinescu, S., Hermenean, A. O., & Costache, M. (2020) · Cells · doi:10.3390/cells9020461 · Cited by 75

Integrins as a drug target in liver fibrosis

Rahman, S. R., Roper, J. A., Grove, J. I., Aithal, G. P., Pun, K. T., & Bennett, A. J. (2022) · Liver International · doi:10.1111/liv.15157 · Cited by 74

Induction of Heme Oxygenase-1 Can Halt and Even Reverse Renal Tubule-Interstitial Fibrosis

Corrêa-Costa, M., Semedo, P., Monteiro, A. P. F. D. S., Silva, R. C., Pereira, R. L., Gonçalves, G. M., Marques, G. D. M., Cenedeze, M. A., Faleiros, A. C. G., Keller, A. C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014298 · Cited by 74

Cirrhosis and autoimmune liver disease: Current understanding

Liberal, R., & Grant, C. R. (2016) · World Journal of Hepatology · doi:10.4254/wjh.v8.i28.1157 · Cited by 74

SCARNA10, a nuclear-retained long non-coding RNA, promotes liver fibrosis and serves as a potential biomarker

Zhang, K., Han, Y., Hu, Z., Zhang, Z., Shao, S., Yao, Q., Zheng, L., Wang, J., Han, X., Zhang, Y., et al. (2019) · Theranostics · doi:10.7150/thno.32935 · Cited by 74

Fibrotic Scar After Spinal Cord Injury: Crosstalk With Other Cells, Cellular Origin, Function, and Mechanism

Li, Z., Yu, S., Hu, X., Li, Y., You, X., Tian, D., Cheng, L., Zheng, M., & Jing, J. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.720938 · Cited by 74

The NRF-2/HO-1 Signaling Pathway: A Promising Therapeutic Target for Metabolic Dysfunction-Associated Steatotic Liver Disease

Li, N., Hao, L., Li, S., Deng, J., Yu, F., Zhang, J., Nie, A., & Hu, X. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s490418 · Cited by 74

Using ultrasound Nakagami imaging to assess liver fibrosis in rats

Ho, M., Lin, J.-J., Shu, Y., Chen, C., Chang, K., Chang, C.-C., & Tsui, P. (2011) · Ultrasonics · doi:10.1016/j.ultras.2011.08.005 · Cited by 74

Genome-wide association studies and genetic risk assessment of liver diseases

Krawczyk, M. J., Müllenbach, R., Weber, S. N., Zimmer, V., & Lammert, F. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.170 · Cited by 74

Hsian-tsao (Mesona procumbens Heml.) prevents against rat liver fibrosis induced by CCl4 via inhibition of hepatic stellate cells activation

Shyu, M.-H., Kao, T.-C., & Yen, G. (2008) · Food and Chemical Toxicology · doi:10.1016/j.fct.2008.09.051 · Cited by 74

Synergistic effect of pro-inflammatory TNFα and IL-17 in periostin mediated collagen deposition: Potential role in liver fibrosis

Amara, S., López, K., Banan, B., Brown, S.-K., Whalen, M. M., Myles, E. L., Ivy, M. T., Johnson, T. L., Schey, K. L., & Tiriveedhi, V. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.10.021 · Cited by 74

Recent Advances in Cytogenetics and Molecular Biology of Adult Hepatocellular Tumors: Implications for Imaging and Management

Shanbhogue, K., Prasad, S. R., Takahashi, N., Vikram, R., & Sahani, D. V. (2011) · Radiology · doi:10.1148/radiol.10100376 · Cited by 74

Sorafenib: A potential therapeutic drug for hepatic fibrosis and its outcomes

Ma, R., Chen, J., Liang, Y., Lin, S., Zhu, L., Liang, X., & Cai, X. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.107 · Cited by 74

Matrix Mechanics as Regulatory Factors and Therapeutic Targets in Hepatic Fibrosis

Chen, G., Xia, B., Fu, Q., Xiang, H., Wang, F., Chen, Z., & Lv, Y. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.37500 · Cited by 75

Therapeutic Effect of Dunaliella salina Microalgae on Thioacetamide- (TAA-) Induced Hepatic Liver Fibrosis in Rats: Role of TGF- β and MMP9

El-Baz, F. K., Salama, A., & Elgohary, R. (2019) · BioMed Research International · doi:10.1155/2019/7028314 · Cited by 73

Fibrosis as a Major Mechanism of Chronic Liver Disease

Bechmann, L. P., & Friedman, S. L. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-866-9_5 · Cited by 1

Anti-fibrotic treatments for chronic liver diseases: The present and the future

Odagiri, N., Matsubara, T., Sato-Matsubara, M., Fujii, H., Enomoto, M., & Kawada, N. (2020) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2020.0187 · Cited by 64

Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis

Kisseleva, T., & Brenner, D. A. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2006.04658.x · Cited by 291

Liver extracellular matrix in health and disease

Bédossa, P., & Paradis, V. (2003) · The Journal of Pathology · doi:10.1002/path.1397 · Cited by 300

Pathogenesis of Liver Fibrosis

Alcolado, R., Arthur, M. J. P., & Iredale, J. P. (1997) · Clinical Science · doi:10.1042/cs0920103 · Cited by 172