Cited by 315Fatty Acid Research and HealthLipid metabolism and biosynthesisDiet, Metabolism, and Disease

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Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

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Dentin, R.·2005·Journal of Clinical Investigation

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Abstract

Dietary polyunsaturated fatty acids (PUFAs) are potent inhibitors of hepatic glycolysis and lipogenesis. Recently, carbohydrate-responsive element-binding protein (ChREBP) was implicated in the regulation by glucose of glycolytic and lipogenic genes, including those encoding L-pyruvate kinase (L-PK) and fatty acid synthase (FAS). The aim of our study was to assess the role of ChREBP in the control of L-PK and FAS gene expression by PUFAs. We demonstrated in mice, both in vivo and in vitro, that PUFAs [linoleate (C18:2), eicosapentanoic acid (C20:5), and docosahexaenoic acid (C22:6)] suppressed ChREBP activity by increasing ChREBP mRNA decay and by altering ChREBP translocation from the cytosol to the nucleus, independently of an activation of the AMP-activated protein kinase, previously shown to regulate ChREBP activity. In contrast, saturated [stearate (C18)] and monounsaturated fatty acids [oleate (C18:1)] had no effect. Since glucose metabolism via the pentose phosphate pathway is determinant for ChREBP nuclear translocation, the decrease in xylulose 5-phosphate concentrations caused by a PUFA diet favors a PUFA-mediated inhibition of ChREBP translocation. In addition, overexpression of a constitutive nuclear ChREBP isoform in cultured hepatocytes significantly reduced the PUFA inhibition of both L-PK and FAS gene expression. Our results demonstrate that the suppressive effect of PUFAs on these genes is primarily caused by an alteration of ChREBP nuclear translocation. In conclusion, we describe a novel mechanism to explain the inhibitory effect of PUFAs on the genes encoding L-PK and FAS and demonstrate that ChREBP is a pivotal transcription factor responsible for coordinating the PUFA suppression of glycolytic and lipogenic genes.

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Poupeau, A., & Postic, C. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.03.015 · Cited by 91
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Lundsgaard, A., Holm, J. B., Sjøberg, K. A., Bojsen-Møller, K. N., Myrmel, L. S., Fjære, E., Jensen, B. A. H., Nicolaisen, T. S., Hingst, J. R., Hansen, S. L., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.022 · Cited by 85
The transcription factor carbohydrate-response element-binding protein (ChREBP): A possible link between metabolic disease and cancer
Iizuka, K. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.029 · Cited by 85
Elevated hepatic fatty acid elongase-5 activity affects multiple pathways controlling hepatic lipid and carbohydrate composition*
Wang, Y., Torres‐Gonzalez, M., Tripathy, S., Botolin, D., Christian, B., & Jump, D. Β. (2008) · Journal of Lipid Research · doi:10.1194/jlr.m800123-jlr200 · Cited by 87
Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice
Billet, S., Bardin, S., Verp, S., Baudrie, V., Michaud, A., Conchon, S., Muffat‐Joly, M., Escoubet, B., Souil, E., Hamard, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci28764 · Cited by 83
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Sato, S., Jung, H., Nakagawa, T., Pawlosky, R. J., Takeshima, T., Lee, W.-R., Sakiyama, H., Laxman, S., Wynn, R., Tu, B. P., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.708982 · Cited by 90
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Transcriptional Regulation of Hepatic Fatty Acid Metabolism
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Nutrigenomics of ω-3 fatty acids: Regulators of the master transcription factors
Rodríguez‐Cruz, M., & Serna, D. S. (2017) · Nutrition · doi:10.1016/j.nut.2017.04.012 · Cited by 78
Fatty acid desaturation and chain elongation in mammals
Miyazaki, M., & Ntambi, J. M. (2008) · Elsevier eBooks · doi:10.1016/b978-044453219-0.50009-x · Cited by 74
Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ
Tan, N. S., Vázquez‐Carrera, M., Montagner, A., Sng, M. K., Guillou, H., & Wahli, W. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.09.001 · Cited by 75
Differential Effects of Krill Oil and Fish Oil on the Hepatic Transcriptome in Mice
Burri, L., Berge, K., Wibrand, K., Berge, R. K., & Barger, J. L. (2011) · Frontiers in Genetics · doi:10.3389/fgene.2011.00045 · Cited by 73
Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking
Marmier, S., Dentin, R., Daujat‐Chavanieu, M., Guillou, H., Bertrand‐Michel, J., Gerbal‐Chaloin, S., Girard, J. R., Lotersztajn, S., & Postic, C. (2015) · Hepatology · doi:10.1002/hep.27778 · Cited by 71
Self-citation
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Larter, C. Z., Yeh, M. M., Cheng, J., Williams, J., Brown, S., Dela Pena, A., Bell‐Anderson, K. S., & Farrell, G. C. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.05157.x · Cited by 70
Docosapentaenoic acid (22:5n-3) down-regulates the expression of genes involved in fat synthesis in liver cells
Kaur, G., Sinclair, A. J., Cameron‐Smith, D., Barr, D. P., Molero, J. C., & Konstantopoulos, N. (2011) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2011.06.002 · Cited by 70
Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
Worthmann, A., Ridder, J., Piel, S., Evangelakos, I., Musfeldt, M., Voß, H., O’Farrell, M., Fischer, A. W., Adak, S., Sundd, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44364-y · Cited by 69
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Ducheix, S., Lobaccaro, J. A., Martin, P. G. P., & Guillou, H. (2011) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2011.06.004 · Cited by 71
Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity
Bindesbøll, C., Fan, Q., Nørgaard, R. C., MacPherson, L., Ruan, H., Wu, J., Pedersen, T. Å., Steffensen, K. R., Yang, X., Matthews, J. B., et al. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m049130 · Cited by 68
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del Pozo, C. H., Vesperinas, G., Rubio, M. Á., Corripio‐Sánchez, R., García, A. J. T., Obregón, M.-J., & Calvo, R. M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.07.016 · Cited by 65
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Hashimoto, K., Ishida, E., Matsumoto, S., Okada, S., Yamada, M., Satoh, T., Monden, T., & Mori, M. (2009) · Endocrinology · doi:10.1210/en.2009-0059 · Cited by 71
Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet
Hwang, B., Jeoung, N. H., & Harris, R. A. (2009) · Biochemical Journal · doi:10.1042/bj20090390 · Cited by 61
Diet & insulin resistance: a review & Asian Indian perspective.
Isharwal, S., Misra, A., Wasir, J. S., & Nigam, P. (2009) · PubMed · Cited by 62
Oil from transgenicCamelina sativacontaining over 25 %n-3 long-chain PUFA as the major lipid source in feed for Atlantic salmon (Salmo salar)
Betancor, M. B., Li, K., Bucerzan, V. S., Sprague, M., Sayanova, O. V., Usher, S. L., Han, L., Norambuena, F., Torrissen, O. J., Napier, J. A., et al. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114518001125 · Cited by 62
Effects of adipocyte lipoprotein lipase on de novo lipogenesis and white adipose tissue browning
Bartelt, A., Weigelt, C., Cherradi, M. L., Niemeier, A., Tödter, K., Heeren, J., & Scheja, L. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.11.011 · Cited by 59
Pharmacological Treatment of Geriatric Cachexia: Evidence and Safety in Perspective
Yeh, S., Lovitt, S., & Schuster, M. W. (2007) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2007.05.001 · Cited by 59
Metabolic effects of parenteral nutrition enriched with n-3 polyunsaturated fatty acids in critically ill patients
Tappy, L., Berger, M. M., Schwarz, J., Schneiter, P., Kim, S., Revelly, J., & Chioléro, R. L. (2006) · Clinical Nutrition · doi:10.1016/j.clnu.2006.03.008 · Cited by 58
Non-alcoholic fatty liver disease is characterised by a reduced polyunsaturated fatty acid transport via free fatty acids and high-density lipoproteins (HDL)
Mocciaro, G., Allison, M., Jenkins, B., Azzu, V., Huang‐Doran, I., Herrera-Marcos, L. V., Hall, Z., Murgia, A., Davies, S. E., Frontini, M., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101728 · Cited by 56

Authors: Dentin, R.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Dentin, R.
ORCID: Dentin, R.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2005-10-01
Volume: 115
Issue: 10
Pages: 2843-2854
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci25256
PMC: PMC1224299
OpenAlex: W2114472618
Cited by: 315
References: 50
Citations by year: 2026: 4 · 2025: 11 · 2024: 11 · 2023: 15 · 2022: 12 · 2021: 15 · 2020: 19 · 2019: 8 · 2018: 14 · 2017: 14 · 2016: 18 · 2015: 19 · 2014: 9 · 2013: 23 · 2012: 13
FWCI: 16.21
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: European Commission (LSHMCT-2004-005272)
Ministère de l'Enseignement Supérieur et de la Recherche
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Keywords: polyunsaturated fatty acids, ChREBP, nuclear translocation, hepatic glycolysis, lipogenesis, fatty acid synthase, mRNA degradation, xylulose-5-phosphate, pentose phosphate pathway, glucose metabolism, AMPK, linoleic acid, eicosapentaenoic acid, docosahexaenoic acid, saturated fatty acids, monounsaturated fatty acids, hepatocytes, transcriptional regulation
MeSH terms: Animals, Cells, Cultured, Dietary Fats, Unsaturated, Docosahexaenoic Acids, Glycolysis, Male, Multienzyme Complexes, Nuclear Proteins, Pentose Phosphate Pathway, Pyruvate Kinase, Transcription Factors, Eicosapentaenoic Acid, Down-Regulation, Gene Expression Regulation, Enzymologic, Protein Serine-Threonine Kinases, Hepatocytes, Lipogenesis, Mice, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, AMP-Activated Protein Kinases, Fatty Acid Synthases

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Polyunsaturated fatty acids suppress glycolytic and lipogenic genes through the inhibition of ChREBP nuclear protein translocation

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