Flaxseed supplementation in non-alcoholic fatty liver disease: a pilot randomized, open labeled, controlled study
Abstract
A two-arm randomized open labeled controlled clinical trial was conducted on 50 patients with non-alcoholic fatty liver disease (NAFLD). Participants were assigned to take either a lifestyle modification (LM), or LM +30 g/day brown milled flaxseed for 12 weeks. At the end of the study, body weight, liver enzymes, insulin resistance and hepatic fibrosis and steatosis decreased significantly in both groups (p< 0.05); however, this reduction was significantly greater in those who took flaxseed supplementation (p < 0.05). The significant mean differences were reached in hepatic markers between flaxseed and control group, respectively: ALT [-11.12 compared with -3.7 U/L; P< 0.001], AST [-8.29 compared with -4 U/L; p < 0.001], GGT [-15.7 compared with -2.62 U/L; p < 0.001], fibrosis score [-1.26 compared with -0.77 kPa; p = 0.013] and steatosis score [-47 compared with -15.45 dB/m; p = 0.022]. In conclusion, flaxseed supplementation plus lifestyle modification is more effective than lifestyle modification alone for NAFLD management.
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Six RCTs had low risk of bias for random sequence generation, three had high risk, and the remaining had unclear risk.
“Six RCTs indicated the method for random sequence generation was low risk [29, 34, 44, 47, 48, 52], three other studies indicated high risk [21, 41, 53], and the remaining studies have unclear risk of bias.”
From Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials (2021) · cites this paper as [48]
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- Authors
- Yari, Z., Rahimlou, M., Eslamparast, T., Ebrahimi-Daryani, N., Poustchi, H., & Hekmatdoost, A.
- Affiliations
- National Nutrition and Food Technology Research Institute (IR)
- Tehran University of Medical Sciences (IR)
- Imam Khomeini Hospital (IR)
- Digestive Disease Research Institute (IR)
- Corresponding author
- Hekmatdoost, Azita
- Venue
- International Journal of Food Sciences and Nutrition
- Publisher
- Informa UK Limited
- Published
- 2016-03-17
- Volume
- 67
- Issue
- 4
- Pages
- 461-469
- ISSN
- 0963-7486 (ISSN-L)
- 1465-3478
- OpenAlex
- W2298528870
- Cited by
- 118
- References
- 44
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 11 · 2023: 18 · 2022: 4 · 2021: 21 · 2020: 10 · 2019: 16 · 2018: 10 · 2017: 7 · 2016: 3 · 2012: 2
- FWCI
- 11.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Food Sciences and Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Silymarin and Mushroom Poisoning
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Keywords
- flaxseed supplementation, non-alcoholic fatty liver disease, lifestyle modification, hepatic steatosis, liver fibrosis, liver enzymes, insulin resistance, body weight, dietary fiber
- MeSH terms
- Healthy Lifestyle, Adult, Combined Modality Therapy, Female, Follow-Up Studies, Food Handling, Humans, Insulin Resistance, Iran, Liver, Male, Middle Aged, Patient Compliance, Pilot Projects, Seeds, Severity of Illness Index, Biomarkers, Dietary Supplements, Flax, Elasticity Imaging Techniques, Functional Food, Non-alcoholic Fatty Liver Disease
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