Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis
Open accessAbstract
More than 100 million people in the United States live in areas that exceed current ozone air quality standards. In addition to its known pulmonary effects, environmental ozone exposures have been associated with increased hospital admissions related to cardiovascular events, but to date, no studies have elucidated the potential molecular mechanisms that may account for exposure-related vascular impacts. Because of the known pulmonary redox and immune biology stemming from ozone exposure, we hypothesized that ozone inhalation would initiate oxidant stress, mitochondrial damage, and dysfunction within the vasculature. Accordingly, these factors were quantified in mice consequent to a cyclic, intermittent pattern of ozone or filtered air control exposure. Ozone significantly modulated vascular tone regulation and increased oxidant stress and mitochondrial DNA damage (mtDNA), which was accompanied by significantly decreased vascular endothelial nitric oxide synthase protein and indices of nitric oxide production. To examine influences on atherosclerotic lesion formation, apoE-/- mice were exposed as above, and aortic plaques were quantified. Exposure resulted in significantly increased atherogenesis compared with filtered air controls. Vascular mitochondrial damage was additionally quantified in ozone- and filtered air-exposed infant macaque monkeys. These studies revealed that ozone increased vascular mtDNA damage in nonhuman primates in a fashion consistent with known atherosclerotic lesion susceptibility in humans. Consequently, inhaled ozone, in the absence of other environmental toxicants, promotes increased vascular dysfunction, oxidative stress, mitochondrial damage, and atherogenesis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Animal studies with high ozone exposures have generated more consistent findings on cardiovascular effects of ozone through altering vascular tone, mRNA for genes encoding thrombogenic factors, and atherogenesis.
“In contrast, animal studies with high ozone exposures have generated more consistent findings on cardiovascular effects of ozone through altering vascular tone (60–62), mRNA for genes encoding thrombogenic factors (63), and atherogenesis (60).”
From Ozone pollution: A Major health hazard worldwide (2019) · cites this paper as [60]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007 · see citing works
Air Pollution and Cardiovascular Disease
Brook, R. D., Franklin, B. A., Cascio, W. E., Hong, Y., Howard, G., D, M. L. M., Luepker, R. V., Mittleman, M. A., Samet, J. M., Smith, S. C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000128587.30041.c8 · Cited by 2,417 · see citing works
Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263 · see citing works
Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
Eiserich, J. P., Hristova, M., Cross, C. E., Jones, A. D., Freeman, B. A., Halliwell, B., & van der Vliet, A. (1998) · Nature · doi:10.1038/34923 · Cited by 1,496 · see citing works
Ozone and short-term mortality in 95 US urban communities, 1987–2000
Bell, M. L. (2004) · JAMA · doi:10.1001/jama.292.19.2372 · Cited by 1,202 · see citing works
Brook, R. D., Brook, J. R., Urch, B., Vincent, R., Rajagopalan, S., & Silverman, F. (2002) · Circulation · doi:10.1161/01.cir.0000013838.94747.64 · Cited by 845 · see citing works
Wong, G. H. W., Elwell, J. H., Oberley, L. W., & Goeddel, D. V. (1989) · Cell · doi:10.1016/0092-8674(89)90944-6 · Cited by 802 · see citing works
National Ambient Air Quality Standards
Brunner, C. R. (1985) · Springer eBooks · doi:10.1007/978-1-4613-2539-0_3 · Cited by 597 · see citing works
Goossens, V., Grooten, J., Vos, K. J. D., & Fiers, W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8115 · Cited by 595 · see citing works
Schulze‐Osthoff, K., Beyaert, R., Vandevoorde, V., Haegeman, G., & Fiers, W. C. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05978.x · Cited by 577 · see citing works
Morrow, J. D., Harris, T. M., & Roberts, L. J. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90002-q · Cited by 479 · see citing works
Air pollution and hospital admissions for respiratory and cardiovascular diseases in Hong Kong.
Wong, T. W., Lau, T. S., Yu, T.-H., Neller, A., Wong, S. L., Tam, W., & Pang, S. W. (1999) · Occupational and Environmental Medicine · doi:10.1136/oem.56.10.679 · Cited by 380 · see citing works
Acute Blood Pressure Responses in Healthy Adults During Controlled Air Pollution Exposures
Urch, B., Silverman, F., Corey, P., Brook, J. R., Lukic, K. Z., Rajagopalan, S., & Brook, R. D. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.7785 · Cited by 340 · see citing works
The cascade mechanism to explain ozone toxicity: The role of lipid ozonation products
Pryor, W. A., Squadrito, G. L., & Friedman, M. B. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02033-7 · Cited by 340 · see citing works
TNF- downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
Valerio, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28570 · Cited by 327 · see citing works
Air pollution and daily mortality in London: 1987-92
ANDERSON, H. R., de León, A. P., Bland, J. M., Bower, J. S., & Strachan, D. P. (1996) · BMJ · doi:10.1136/bmj.312.7032.665 · Cited by 303 · see citing works
Ozone Air Pollution Is Associated With Acute Myocardial Infarction
Ruidavets, J., Cournot, M., Cassadou, S., Giroux, M., Meybeck, M. P., & Ferrières, J. (2005) · Circulation · doi:10.1161/01.cir.0000154546.32135.6e · Cited by 247 · see citing works
Knight-Lozano, C. A., Young, C. G., Burow, D. L., Hu, Z., Uyeminami, D. L., Pinkerton, K. E., Ischiropoulos, H., & Ballinger, S. W. (2002) · Circulation · doi:10.1161/hc0702.103977 · Cited by 217 · see citing works
Mortality and ambient fine particles in southwest Mexico City, 1993-1995.
Borja‐Aburto, V. H., Castillejos, M., Gold, D. R., Bierzwinski, S., & LOOMIS, D. P. (1998) · Environmental Health Perspectives · doi:10.1289/ehp.106-1533229 · Cited by 192 · see citing works
TNF-α Contributes to Endothelial Dysfunction by Upregulating Arginase in Ischemia/Reperfusion Injury
Gao, X. J., Xu, X., Belmadani, S., Park, Y., Tang, Z., Feldman, A. M., Chilian, W. M., & Zhang, C. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.142521 · Cited by 151 · see citing works
Yan, G., You, B., Chen, S., Liao, J. K., & Sun, J. (2008) · Circulation Research · doi:10.1161/circresaha.108.173963 · Cited by 151 · see citing works
[4] Measuring nitric oxide and superoxide: Rate constants for aconitase reactivity
Hausladen, A., & Fridovich, I. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)69007-7 · Cited by 137 · see citing works
Kojda, G. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00315-0 · Cited by 132 · see citing works
Lippmann, M., Frampton, M. W., Schwartz, J. D., Dockery, D. W., Schlesinger, R., Koutrakis, P., Froines, J. R., Nel, A. E., Finkelstein, J., Godleski, J. J., et al. (2003) · Environmental Health Perspectives · doi:10.1289/ehp.5750 · Cited by 131 · see citing works
Mills, N. L., Robinson, S. D., Fokkens, P. H. B., Leseman, D. L. A. C., Miller, M. R., Anderson, D. R., Freney, E. J., Heal, M. R., Donovan, R. J., Blomberg, A., et al. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.11016 · Cited by 122 · see citing works
Rodríguez‐Iturbe, B., Sepassi, L., Quiroz, Y., Ni, Z., & Vaziri, N. D. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00513.2006 · Cited by 115 · see citing works
Goodwin, B. L., Pendleton, L. C., Levy, M. M., Solomonson, L. P., & Eichler, D. C. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01100.2006 · Cited by 110 · see citing works
Schelegle, E. S., Miller, L. A., Gershwin, L. J., Fanucchi, M. V., Winkle, L. S. V., Gerriets, J. E., Walby, W. F., Mitchell, V. L., Tarkington, B. K., Wong, V. J., et al. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(03)00218-7 · Cited by 105 · see citing works
Antioxidant-mediated augmentation of ozone-induced membrane oxidation
Ballinger, C. A., Cueto, R., Squadrito, G. L., Coffin, J. F., Velsor, L. W., Pryor, W. A., & Postlethwait, E. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.009 · Cited by 102 · see citing works
Penn, A. L., & Snyder, C. A. (1996) · Circulation · doi:10.1161/01.cir.93.3.552 · Cited by 102 · see citing works
Induction of Inflammatory Mediators in Human Airway Epithelial Cells by Lipid Ozonation Products
Kafoury, R., Pryor, W. A., Squadrito, G. L., Salgo, M. G., Zou, X., & Friedman, M. B. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.6.9902025 · Cited by 102 · see citing works
Signal Transduction Pathways of Tumor Necrosis Factor–mediated Lung Injury Induced by Ozone in Mice
Cho, H., Morgan, D. L., Bauer, A. K., & Kleeberger, S. R. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200509-1527oc · Cited by 94 · see citing works
Seasonal variation of effect of air pollution on blood pressure
Choi, J.-H., Xu, Q.-S., Park, S.-Y., Kim, J. H., Hwang, S.-S., Lee, K.-H., Lee, H.-J., & Hong, Y. (2007) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2006.049205 · Cited by 89 · see citing works
Cardiovascular Effects of Ozone Exposure in Human Volunteers
Gong, H., Wong, R. G., SARMA, R. J., Linn, W. S., SULLIVAN, E. D., Shamoo, D. A., Anderson, K. R., & PRASAD, S. B. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.2.9709034 · Cited by 86 · see citing works
Endothelial dysfunction is induced by proinflammatory oxidant hypochlorous acid
Zhang, C., Patel, R. P., Eiserich, J. P., Zhou, F., Kelpke, S. S., Ma, W., Parks, D. A., Darley-Usmar, V. M., & White, C. R. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.281.4.h1469 · Cited by 73 · see citing works
Wilson, D. W., Plopper, C. G., & Dungworth, D. L. (1984) · PubMed · Cited by 72 · see citing works
Comparative primate atherosclerosis
Bullock, B. C., Lehner, N. D. M., Clarkson, T. B., Feldner, M. A., Wagner, W. D., & Lofland, H. B. (1975) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(75)90060-x · Cited by 72 · see citing works
Rat lung antioxidant enzyme induction by ozone
Rahman, I., Clerch, L. B., & Massaro, D. (1991) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1991.260.6.l412 · Cited by 70 · see citing works
Lipid Ozonation Products Activate Phospholipases A2, C, and D
Kafoury, R., Pryor, W. A., Squadrito, G. L., Salgo, M. G., Zou, X., & Friedman, M. B. (1998) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8418 · Cited by 64 · see citing works
Ozone-Reactive Absorption by Pulmonary Epithelial Lining Fluid Constituents
Langford, S. D., Bidani, A., & Postlethwait, E. M. (1995) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1995.1093 · Cited by 53 · see citing works
Last, J. A., Gohil, K., Mathrani, V. C., & Kenyon, N. J. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2005.02.001 · Cited by 45 · see citing works
O3-induced formation of bioactive lipids: estimated surface concentrations and lining layer effects
Postlethwait, E. M., Cueto, R., Velsor, L. W., & Pryor, W. A. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.6.l1006 · Cited by 45 · see citing works
Comparative primate atherosclerosis
Wagner, W. D., & Clarkson, T. B. (1975) · Experimental and Molecular Pathology · doi:10.1016/0014-4800(75)90009-x · Cited by 38 · see citing works
Nitric Oxide and Peroxynitrite in Ozone-Induced Lung Injury
Laskin, D. L., Fakhrzadeh, L., & Laskin, J. D. (2001) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0667-6_24 · Cited by 34 · see citing works
Weller, B. L., Crapo, J. D., Slot, J. W., Posthuma, G., Plopper, C. G., & Pinkerton, K. E. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.17.5.2753 · Cited by 29 · see citing works
Tissue trace elements and lung superoxide dismutase activity in mice exposed to ozone
Dubick, M. A., & Keen, C. L. (1983) · Toxicology Letters · doi:10.1016/0378-4274(83)90250-3 · Cited by 21 · see citing works
Increased resting heart rate with pollutants in a population based study
Ruidavets, J., Cassadou, S., Cournot, M., Bataille, V., Meybeck, M. P., & Ferrières, J. (2005) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2004.026252 · Cited by 19 · see citing works
Toxic effects of ozone on human cells in vitro, exposed by gas diffusion through teflon film
Alink, G. M., Boer, R. M. D., Mol, J., & Temmink, J. H. M. (1980) · Toxicology · doi:10.1016/0300-483x(80)90096-7 · Cited by 19 · see citing works
Chen, C., Korshunov, V. A., Massett, M. P., Chen, Y., & Berk, B. C. (2007) · Journal of Vascular Research · doi:10.1159/000106751 · Cited by 18 · see citing works
Funabashi, H., Shima, M., Kuwaki, T., Hiroshima, K., & Kuriyama, T. (2004) · Toxicology · doi:10.1016/j.tox.2004.06.047 · Cited by 16 · see citing works
Greenwood, E. (2002) · Nature reviews. Cancer · doi:10.1038/nrc911 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ozone pollution: A Major health hazard worldwide
Zhang, J. (., Wei, Y., & Fang, Z. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02518 · Cited by 828 · see citing works
Oxidative stress and air pollution exposure
Lodovici, M., & Bigagli, E. (2011) · Journal of Toxicology · doi:10.1155/2011/487074 · Cited by 720 · see citing works
The effects of ozone on human health
Nuvolone, D., Petri, D., & Voller, F. (2018) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-9239-3 · Cited by 619 · see citing works
Integration of cellular bioenergetics with mitochondrial quality control and autophagy
Hill, B. G., Benavides, G. A., Lancaster, J. R., Ballinger, S. W., Dell’Italia, L., Zhang, J., & Darley-Usmar, V. M. (2012) · Biological Chemistry · doi:10.1515/hsz-2012-0198 · Cited by 481 · see citing works
Oxidative stress pathways of air pollution mediated toxicity: Recent insights
Gangwar, R. S., Bevan, G. H., Palanivel, R., Das, L. M., & Rajagopalan, S. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101545 · Cited by 412 · see citing works
Air particulate matter and cardiovascular disease: A narrative review
Martinelli, N., Olivieri, O., & Girelli, D. (2013) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2013.04.001 · Cited by 315 · see citing works
Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis
Araujo, J. A. (2010) · Air Quality Atmosphere & Health · doi:10.1007/s11869-010-0101-8 · Cited by 269 · see citing works
Controlled Exposure of Healthy Young Volunteers to Ozone Causes Cardiovascular Effects
Devlin, R. B., Duncan, K., Jardim, M. J., Schmitt, M. T., Rappold, A. G., & Díaz-Sánchez, D. (2012) · Circulation · doi:10.1161/circulationaha.112.094359 · Cited by 220 · see citing works
Kelly, F. J., & Fussell, J. C. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.06.019 · Cited by 169 · see citing works
Vascular and cardiac impairments in rats inhaling ozone and diesel exhaust particles
Kodavanti, U. P., Thomas, R., Ledbetter, A. D., Schladweiler, M. C., Shannahan, J. H., Wallenborn, J. G., Lund, A. K., Campen, M. J., Butler, E. O., Gottipolu, R. R., et al. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1002386 · Cited by 119 · see citing works
Mitochondrial toxicity of tobacco smoke and air pollution
Fetterman, J. L., Sammy, M. J., & Ballinger, S. W. (2017) · Toxicology · doi:10.1016/j.tox.2017.08.002 · Cited by 113 · see citing works
Möller, P., Mikkelsen, L., Vesterdal, L. K., Folkmann, J. K., Forchhammer, L., Roursgaard, M., Danielsen, P. H., & Loft, S. H. (2011) · Critical Reviews in Toxicology · doi:10.3109/10408444.2010.533152 · Cited by 108 · see citing works
Arjomandi, M., Wong, H. H., Donde, A., Frelinger, J., Dalton, S. E., Ching, W., Power, K., & Balmes, J. R. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00849.2014 · Cited by 96 · see citing works
Goodman, J. E., Prueitt, R. L., Sax, S. N., Pizzurro, D. M., Lynch, H. N., Zu, K., & Venditti, F. J. (2015) · Critical Reviews in Toxicology · doi:10.3109/10408444.2015.1031371 · Cited by 92 · see citing works
Mechanisms and Modification of Chlorine-induced Lung Injury in Animals
Yadav, A. K., Bracher, A., Doran, S. F., Leustik, M., Squadrito, G. L., Postlethwait, E. M., & Matalon, S. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201001-009sm · Cited by 91 · see citing works
Influence of weather and atmospheric pollution on physical activity in patients with COPD
Alahmari, A. D., Mackay, A. J., Patel, A. R. C., Kowlessar, B. S., Singh, R., Brill, S., Allinson, J. P., Wedzicha, J. A., & Donaldson, G. C. (2015) · Respiratory Research · doi:10.1186/s12931-015-0229-z · Cited by 89 · see citing works
Xu, M., Wang, L., Wang, M., Wang, H., Zhang, H., Chen, Y., Wang, X., Gong, J., Zhang, J. J., Adcock, I. M., et al. (2019) · Free Radical Research · doi:10.1080/10715762.2019.1630735 · Cited by 84 · see citing works
Influence of mitochondrion-toxic agents on the cardiovascular system
Finsterer, J., & Ohnsorge, P. (2013) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2013.09.002 · Cited by 83 · see citing works
CD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure
Robertson, S., Colombo, E. S., Lucas, S. N., Hall, P. R., Febbraio, M., Paffett, M. L., & Campen, M. J. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft107 · Cited by 82 · see citing works
Li, H., Wu, S., Pan, L., Xu, J., Shan, J., Yang, X., Dong, W., Deng, F., Chen, Y., Shima, M., et al. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.09.030 · Cited by 78 · see citing works
Inhaled whole exhaust and its effect on exercise performance and vascular function
Cutrufello, P. T., Rundell, K. W., Smoliga, J. M., & Stylianides, G. A. (2011) · Inhalation Toxicology · doi:10.3109/08958378.2011.604106 · Cited by 77 · see citing works
Hatch, G. E., McKee, J. M. T., Brown, J. S., McDonnell, W. F., Seal, E., Soukup, J. M., Slade, R., Crissman, K. M., & Devlin, R. B. (2013) · Biomarker Insights · doi:10.4137/bmi.s11102 · Cited by 76 · see citing works
Novel phytonutrient contributors to antioxidant protection against cardiovascular disease
Riccioni, G., Speranza, L., Pesce, M., Cusenza, S., D’Orazio, N., & Glade, M. J. (2012) · Nutrition · doi:10.1016/j.nut.2011.11.028 · Cited by 71 · see citing works
Paffett, M. L., Zychowski, K. E., Sheppard, L., Robertson, S., Weaver, J. M., Lucas, S. N., & Campen, M. J. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv093 · Cited by 67 · see citing works
Neo, E. X., Hasikin, K. B., Mokhtar, M. I., Lai, K. W., Azizan, M. M., Razak, S. A., & Hizaddin, H. F. (2022) · Frontiers in Public Health · doi:10.3389/fpubh.2022.851553 · Cited by 71 · see citing works
Arunachalam, G., Sundar, I. K., Hwang, J., Yao, H., & Rahman, I. (2010) · Journal of Inflammation · doi:10.1186/1476-9255-7-34 · Cited by 66 · see citing works
Zarogiannis, S. G., Jurkuvenaite, A., Fernandez, S., Doran, S. F., Yadav, A., Squadrito, G. L., Postlethwait, E. M., Bowen, L. E., & Matalon, S. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0432oc · Cited by 64 · see citing works
Formation of chlorinated lipids post-chlorine gas exposure
Ford, D. A., Honavar, J., Albert, C. J., Duerr, M. A., Oh, J. Y., Doran, S., Matalon, S., & Patel, R. P. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m069005 · Cited by 61 · see citing works
Mitchell, T., Chacko, B., Ballinger, S. W., Bailey, S. M., Zhang, J., & Darley-Usmar, V. (2013) · Biochemical Society Transactions · doi:10.1042/bst20120231 · Cited by 57 · see citing works
Wang, M., Sampson, P. D., Sheppard, L. E., Stein, J. H., Vedal, S., & Kaufman, J. D. (2019) · Environmental Health Perspectives · doi:10.1289/ehp3325 · Cited by 59 · see citing works
Krzywanski, D. M., Moellering, D. R., Fetterman, J. L., Dunham‐Snary, K. J., Sammy, M. J., & Ballinger, S. W. (2011) · Laboratory Investigation · doi:10.1038/labinvest.2011.95 · Cited by 60 · see citing works
Childhood Air Pollutant Exposure and Carotid Artery Intima-Media Thickness in Young Adults
Breton, C. V., Wang, X., Mack, W. J., Berhane, K. T., Lopez, M., Islam, T. S., Feng, M., Lurmann, F. W., McConnell, R., Hodis, H. N., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.096164 · Cited by 57 · see citing works
Hazari, M. S., Haykal-Coates, N., Winsett, D. W., Costa, D. L., & Farraj, A. K. (2009) · Toxicological Sciences · doi:10.1093/toxsci/kfp214 · Cited by 56 · see citing works
Zeng, X., Qian, Z. M., Vaughn, M. G., Nelson, E. J., Dharmage, S. C., Bowatte, G., Perret, J. L., Chen, D.-H., Ma, H., Lin, S., et al. (2017) · Environmental Pollution · doi:10.1016/j.envpol.2017.02.054 · Cited by 57 · see citing works
Vinikoor-Imler, L. C., Owens, E. O., Nichols, J. L., Ross, M., Brown, J. S., & Sacks, J. D. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307541 · Cited by 56 · see citing works
Jung, C., Chen, W., Lin, Y.-T., & Hwang, B. (2016) · Environmental Health Perspectives · doi:10.1289/ehp137 · Cited by 54 · see citing works
Effects of urban fine particulate matter and ozone on HDL functionality
Ramanathan, G., Yin, F., Speck, M., Tseng, C., Brook, J. R., Silverman, F., Urch, B., Brook, R. D., & Araujo, J. A. (2015) · Particle and Fibre Toxicology · doi:10.1186/s12989-016-0139-3 · Cited by 53 · see citing works
Honavar, J., Samal, A. A., Bradley, K. M., Brandon, A. P., Balanay, J. A. G., Squadrito, G. L., MohanKumar, K., Maheshwari, A., Postlethwait, E. M., Matalon, S., et al. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2010-0151oc · Cited by 50 · see citing works
Westbrook, D. G., Anderson, P. G., Pinkerton, K. E., & Ballinger, S. W. (2010) · Cardiovascular Toxicology · doi:10.1007/s12012-010-9085-8 · Cited by 49 · see citing works
Hua, Q., Meng, X., Gong, J., Qiu, X., Shang, J., Xue, T., & Zhu, T. (2024) · Fundamental Research · doi:10.1016/j.fmre.2024.02.016 · Cited by 49 · see citing works
Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction
Jiménez, M. T. B., Hahad, O., Kuntić, M., Daiber, A., & Münzel, T. F. (2023) · European Cardiology Review · doi:10.15420/ecr.2022.41 · Cited by 48 · see citing works
Ganesh, H. S., Seo, K., Fritz, H., Edgar, T. F., Novoselac, A., & Bâldea, M. (2020) · Journal of Building Engineering · doi:10.1016/j.jobe.2020.101552 · Cited by 47 · see citing works
Hahad, O., Kuntić, M., Frenis, K., Chowdhury, S., Lelieveld, J., Lieb, K., Daiber, A., & Münzel, T. F. (2021) · Antioxidants · doi:10.3390/antiox10111787 · Cited by 43 · see citing works
Farraj, A. K., Hazari, M. S., Winsett, D. W., Kulukulualani, A., Carll, A. P., Haykal-Coates, N., Lamb, C. M., Lappi, E., Terrell, D., Cascio, W. E., et al. (2011) · Environmental Health Perspectives · doi:10.1289/ehp.1104244 · Cited by 43 · see citing works
Ambient Air Pollutants and Risk of Fatal Coronary Heart Disease Among Kidney Transplant Recipients
Spencer-Hwang, R., Knutsen, S. F., Soret, S., Ghamsary, M. G., Beeson, W. L., Oda, K., Shavlik, D. J., & Jaipaul, N. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.05.017 · Cited by 41 · see citing works
Akhter, H., Ballinger, C. A., Liu, N., van Groen, T., Postlethwait, E. M., & Liu, R.-M. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv124 · Cited by 38 · see citing works
Environmental Factors Such as Noise and Air Pollution and Vascular Disease
Münzel, T. F., Steven, S., Frenis, K., Lelieveld, J., Hahad, O., & Daiber, A. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8090 · Cited by 38 · see citing works
Hernandez, M. L., Brickey, W. J., Alexis, N. E., Fry, R. C., Rager, J. E., Zhou, B., Ting, J. P. ‐., Zhou, H., & Peden, D. B. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.007 · Cited by 34 · see citing works
Clinical evidence of ozone interaction with pain mediators
Re, L., Martı́nez-Sánchez, G., & Mawsouf, N. (2010) · Saudi Medical Journal · doi:10.15537/1658-3175.5196 · Cited by 34 · see citing works
Hathaway, Q. A., Majumder, N., Goldsmith, W. T., Kunovac, A., Pinti, M. V., Harkema, J. R., Castranova, V., Hollander, J. M., & Hussain, S. (2021) · Particle and Fibre Toxicology · doi:10.1186/s12989-021-00437-8 · Cited by 33 · see citing works
Impact of air pollution on cardiovascular aging
Kuntić, M., Kuntić, I., Hahad, O., Lelieveld, J., Münzel, T. F., & Daiber, A. (2023) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2023.111857 · Cited by 33 · see citing works
França, C. M. P., Sallum, A. M. E., Braga, A. L. F., Strufaldi, F. L., Silva, C. A., & Farhat, S. C. L. (2017) · The Journal of Rheumatology · doi:10.3899/jrheum.161500 · Cited by 30 · see citing works
Miller, C. N., Dye, J. A., Ledbetter, A. D., Schladweiler, M. C. J., Richards, J. H., Snow, S. J., Wood, C. E., Henriquez, A. R., Thompson, L. C., Farraj, A. K., et al. (2017) · Environmental Health Perspectives · doi:10.1289/ehp2019 · Cited by 30 · see citing works
Kodavanti, U. P., Ledbetter, A. D., Thomas, R. F., Richards, J. H., Ward, W. O., Schladweiler, M. C. J., & Costa, D. L. (2015) · Inhalation Toxicology · doi:10.3109/08958378.2014.954169 · Cited by 29 · see citing works
Li, R., Chen, G., Liu, X., Pan, M., Kang, N., Hou, X., Liao, W., Dong, X., Yuchi, Y., Mao, Z., et al. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13500 · Cited by 29 · see citing works
Oxidative and non-oxidative DNA damage and cardiovascular disease
Malik, Q., & Herbert, K. E. (2012) · Free Radical Research · doi:10.3109/10715762.2012.663913 · Cited by 28 · see citing works
Barreno, R. X., Richards, J. B., Schneider, D. J., Cromar, K. R., Nadas, A. J., Hernandez, C. B., Hallberg, L. M., Price, R. E., Hashmi, S. S., Blackburn, M. R., et al. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00080.2013 · Cited by 28 · see citing works
Potential for Chlorine Gas–induced Injury in the Extrapulmonary Vasculature
Samal, A., Honovar, J., White, C. R., & Patel, R. P. (2010) · Proceedings of the American Thoracic Society · doi:10.1513/pats.201001-006sm · Cited by 27 · see citing works
Guo, X., Su, W., Wang, H., Li, N., Song, Q., Liang, Q., Sun, C., Liang, M., Zhou, Z., Song, E. J., et al. (2022) · International Journal of Environmental Health Research · doi:10.1080/09603123.2022.2066070 · Cited by 27 · see citing works
Bongard, R. D., Yan, K., Hoffmann, R. G., Audi, S. H., Zhang, X., Lindemer, B. J., Townsley, M. I., & Merker, M. P. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.07.040 · Cited by 26 · see citing works
Weight-of-evidence evaluation of long-term ozone exposure and cardiovascular effects
Prueitt, R. L., Lynch, H. N., Zu, K., Sax, S. N., Venditti, F. J., & Goodman, J. E. (2014) · Critical Reviews in Toxicology · doi:10.3109/10408444.2014.937855 · Cited by 26 · see citing works
The effects of air pollution and weather conditions on the incidence of acute myocardial infarction
Şen, T., Astarcıoğlu, M. A., Asarcıklı, L. D., Kılıt, C., Kafes, H., Parspur, A., Yaymacı, M., Pinar, M., Tüfekçioğlu, O., & Amasyalı, B. (2015) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2015.11.068 · Cited by 24 · see citing works
Singh, S. K., Goel, I., Tripathi, S., Ahirwar, A. K., Kumar, M., Rana, A., Dhar, R., & Karmakar, S. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-35016-9 · Cited by 25 · see citing works
Tian, L., Chu, N., Yang, H., Yan, J., Lin, B., Zhang, W., Li, K., Lai, W., Bian, L., Liu, H., et al. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.128838 · Cited by 24 · see citing works
Gordon, C. J., Jarema, K. A., Lehmann, J. R., Ledbetter, A. D., Schladweiler, M. C. J., Schmid, J. E., Ward, W. O., Kodavanti, U. P., Nyska, A., & MacPhail, R. C. (2013) · Inhalation Toxicology · doi:10.3109/08958378.2013.764946 · Cited by 23 · see citing works
Early Gestational Exposure to Inhaled Ozone Impairs Maternal Uterine Artery and Cardiac Function
Garcia, M. A., Salazar, R., Wilson, T., Lucas, S., Herbert, G., Young, T. L., Begay, J., Denson, J. L., Zychowski, K. E., Ashley, R. L., et al. (2020) · Toxicological Sciences · doi:10.1093/toxsci/kfaa164 · Cited by 23 · see citing works
Acute inhalation of ozone induces DNA methylation of apelin in lungs of Long-Evans rats
Miller, C. N., Dye, J. A., Schladweiler, M. C. J., Richards, J. H., Ledbetter, A. D., Stewart, E. J., & Kodavanti, U. P. (2018) · Inhalation Toxicology · doi:10.1080/08958378.2018.1483984 · Cited by 23 · see citing works
Su, J. G., Shahriary, E., Sage, E., Jacobsen, J., Park, K., & Mohegh, A. (2024) · Environment International · doi:10.1016/j.envint.2024.109100 · Cited by 22 · see citing works
Yu, J., Zhu, A., Liu, M., Dong, J., Chen, R., Tian, T., Liu, T., Ma, L., & Ruan, Y. (2024) · GeoHealth · doi:10.1029/2022gh000780 · Cited by 21 · see citing works
Zaky, A., Ahmad, A. M., Dell’Italia, L. J., Jahromi, L., Reisenberg, L. A., Matalon, S., & Ahmad, S. (2015) · Cardiovascular Regenerative Medicine · doi:10.14800/crm.997 · Cited by 20 · see citing works
Air Pollution and Children’s Health in Chinese
Lin, W., Chen, Z.-X., Kong, M., Xie, Y., & Zeng, X. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-5657-4_7 · Cited by 20 · see citing works
Marine Carotenoids and Oxidative Stress
Riccioni, G. (2012) · Marine Drugs · doi:10.3390/md10010116 · Cited by 20 · see citing works
Xu, H. N., Lin, Z., Gandhi, C. K., Amatya, S., Wang, Y., Li, L. Z., & Floros, J. (2020) · Antioxidants · doi:10.3390/antiox9100915 · Cited by 19 · see citing works
Promotion of cardiovascular disease by exposure to the air pollutant ozone
Cole, M. P., & Freeman, B. Α. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00187.2009 · Cited by 19 · see citing works
Effects of ozone exposure on human epithelial adenocarcinoma and normal fibroblasts cells
Poma, A. M. G., Colafarina, S., Aruffo, E., Zarivi, O., Bonfigli, A., Bucchianico, S. D., & Carlo, P. D. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184519 · Cited by 18 · see citing works
Ward, W. O., Ledbetter, A. D., Schladweiler, M. C. J., & Kodavanti, U. P. (2015) · Inhalation Toxicology · doi:10.3109/08958378.2014.954172 · Cited by 16 · see citing works
Weight-of-evidence evaluation of short-term ozone exposure and cardiovascular effects
Goodman, J. E., Prueitt, R. L., Sax, S. N., Lynch, H. N., Zu, K., Lemay, J. C., King, J. M., & Venditti, F. J. (2014) · Critical Reviews in Toxicology · doi:10.3109/10408444.2014.937854 · Cited by 16 · see citing works
Retracted Article: Ozone as U-Shaped Dose Responses Molecules (Hormetins)
Martı́nez-Sánchez, G., Pérez-Davison, G., Re, L., & Giuliani, A. (2010) · Dose-Response · doi:10.2203/dose-response.10-001.martinez-sanchez · Cited by 15 · see citing works
RetractedImpact of ozone therapy on mouse liver mitochondrial function and antioxidant system
Oliveira, M. M., Correia, S., Peirone, C., Magalhães, M., Oliveira, P. A., & Peixoto, F. (2024) · Biochimie · doi:10.1016/j.biochi.2024.03.014 · Cited by 15 · see citing works
Li, R., Chen, G., Pan, M., Hou, X., Kang, N., Chen, R., Yuchi, Y., Liao, W., Liu, X., Mao, Z., et al. (2022) · Environment International · doi:10.1016/j.envint.2022.107496 · Cited by 15 · see citing works
An ex-vivo model for evaluating bioenergetics in aortic rings
Feeley, K. P., Westbrook, D. G., Bray, A. W., & Ballinger, S. W. (2014) · Redox Biology · doi:10.1016/j.redox.2014.08.008 · Cited by 15 · see citing works
Frampton, M. W., Balmes, J. R., Bromberg, P. A., Stark, P. C., Arjomandi, M., Hazucha, M. J., Rich, D. Q., Hollenbeck-Pringle, D., Dagincourt, N., Alexis, N. E., et al. (2017) · PubMed Central · Cited by 15 · see citing works
Does Oxidative DNA Damage Cause Atherosclerosis and Metabolic Syndrome?
Madamanchi, N. R., Zhou, R.-H., Vendrov, A. E., Niu, X.-L., & Runge, M. S. (2010) · Circulation Research · doi:10.1161/circresaha.110.230904 · Cited by 15 · see citing works
Liu, M., Yu, J., Zhu, A., Ling, J., Chen, R., Zhang, Y., & Ruan, Y. (2023) · Journal of Urban Health · doi:10.1007/s11524-023-00797-w · Cited by 14 · see citing works
Jin, X., Chen, Y., Xu, B., & Tian, H. (2024) · Biology · doi:10.3390/biology13040247 · Cited by 14 · see citing works
Rahman, W., Beig, G., Barman, N., Hopke, P. K., & Hoque, R. R. (2021) · Environmental Monitoring and Assessment · doi:10.1007/s10661-021-09572-3 · Cited by 12 · see citing works
Strain differences in antioxidants in rat models of cardiovascular disease exposed to ozone
Hatch, G. E., Crissman, K. M., Schmid, J. E., Richards, J. H., Ward, W. O., Schladweiler, M. C. J., Ledbetter, A. D., & Kodavanti, U. P. (2015) · Inhalation Toxicology · doi:10.3109/08958378.2014.954170 · Cited by 12 · see citing works
Unraveling mechanisms of toxicant-induced oxidative stress in cardiovascular disease
Dugas, T. R. (2017) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.10.007 · Cited by 11 · see citing works
McIntosh-Kastrinsky, R., Díaz-Sánchez, D., Sexton, K. G., Jania, C. M., Zavala, J., Tilley, S. L., Jaspers, I., Gilmour, M. I., Devlin, R. B., Cascio, W. E., et al. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1306609 · Cited by 10 · see citing works
Appraisal of ozone as biologically active molecule and experimental tool in biomedical sciences
Mokoena, M. L., Brink, C. B., Harvey, B. H., & Oliver, D. W. (2010) · Medicinal Chemistry Research · doi:10.1007/s00044-010-9493-0 · Cited by 10 · see citing works
Rouschop, S. H., Snow, S. J., Kodavanti, U. P., Drittij-Reijnders, M.-J., Maas, L. M., Opperhuizen, A., van Schooten, F., Remels, A. H. V., & Godschalk, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147551 · Cited by 9 · see citing works
Tham, A., Lullo, D., Dalton, S. E., Zeng, S., van Koeverden, I. D., & Arjomandi, M. (2017) · Inhalation Toxicology · doi:10.1080/08958378.2017.1310333 · Cited by 9 · see citing works
Li, Y., Han, Z., Zhao, X., Liu, Y., Wu, Z., Wang, J., Li, X., Guo, X., & Tao, L. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.117755 · Cited by 8 · see citing works
Fate of Pathologically Bound Oxygen Resulting from Inhalation of Labeled Ozone in Rats
Hatch, G. E., Slade, R., & McKee, J. M. T. (2013) · Environmental Health Insights · doi:10.4137/ehi.s12673 · Cited by 8 · see citing works
Franzini, M., Valdenassi, L., Pandolfi, S., Ricevuti, G., Tirelli, U., Vaiano, F., & Chirumbolo, S. (2022) · Translational Medicine Communications · doi:10.1186/s41231-022-00132-6 · Cited by 8 · see citing works
Day, D. B., Clyde, M. A., Xiang, J., Li, F., Cui, X., Mo, J., Gong, J., Weschler, C. J., Zhang, Y., & Zhang, J. J. (2018) · Journal of Thoracic Disease · doi:10.21037/jtd.2018.06.135 · Cited by 8 · see citing works
Vascular endothelium as a target of diesel particulate matter-associated toxicants
Campen, M. J. (2012) · Archives of Toxicology · doi:10.1007/s00204-012-0806-6 · Cited by 8 · see citing works
Pulmonary transcriptional response to ozone in healthy and cardiovascular compromised rat models
Ward, W. O., & Kodavanti, U. P. (2015) · Inhalation Toxicology · doi:10.3109/08958378.2014.954173 · Cited by 7 · see citing works
Fish oil and olive oil-enriched diets alleviate acute ozone-induced cardiovascular effects in rats
Tong, H., Snow, S. J., Chen, H., Schladweiler, M. C. J., Carswell, G. K., Chorley, B. N., & Kodavanti, U. P. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115296 · Cited by 7 · see citing works
Yamei, W., Qu, S., Li, T., Chen, L., & Yang, L. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2024.1492056 · Cited by 7 · see citing works
- Authors
- Chuang, G. C., Yang, Z., Westbrook, D. G., Pompilius, M., Ballinger, C. A., White, C. R., Krzywanski, D. M., Postlethwait, E. M., & Ballinger, S. W.
- Affiliations
- University of Alabama at Birmingham (US)
- ORCID
- Venue
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Published
- 2009-08
- Volume
- 297
- Issue
- 2
- Pages
- L209-L216
- ISSN
- 1040-0605 (ISSN-L)
- 1522-1504
- PMC
- PMC2742788
- OpenAlex
- W2016752913
- Cited by
- 145
- References
- 51
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 4 · 2022: 9 · 2021: 12 · 2020: 11 · 2019: 6 · 2018: 4 · 2017: 13 · 2016: 3 · 2015: 14 · 2014: 5 · 2013: 14 · 2012: 8
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Lung Cellular and Molecular Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 77419, HL-054696, R01HL054696, R01HL077419)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK079626)
- National Institute of Environmental Health Sciences (P01-ES11617, ES11172, R01ES011172, P01ES011617)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- ozone inhalation, vascular dysfunction, mitochondrial DNA damage, oxidative stress, atherogenesis, endothelial nitric oxide synthase, nitric oxide production, vascular tone regulation, aortic plaque, ApoE-deficient mice, air pollution health effects, cardiovascular risk
- MeSH terms
- Superoxide Dismutase 2, Air Pollutants, Animals, Aorta, Blood Pressure, DNA Damage, DNA, Mitochondrial, Heart Rate, Lung Diseases, Macaca mulatta, Male, Mice, Inbred C57BL, Mitochondria, Nitrates, Nitric Oxide, Nitrites, Ozone, Superoxide Dismutase, Tyrosine, Oxidants, Oxidative Stress, Mitochondrial Diseases, Atherosclerosis, Mice, Nitric Oxide Synthase Type III
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
