Cited by 4,769Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismDiabetes Treatment and Management

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Inflammation and insulin resistance

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Shoelson, S. E.·2006·Journal of Clinical Investigation

DOI 10.1172/jci29069PMC PMC1483173

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Abstract

Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance until recently. Together with the discovery of an important role for tissue macrophages, these new findings are helping to reshape thinking about how obesity increases the risk for developing T2D and the metabolic syndrome. The evolving concept of insulin resistance and T2D as having immunological components and an improving picture of how inflammation modulates metabolism provide new opportunities for using antiinflammatory strategies to correct the metabolic consequences of excess adiposity.

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Authors: Shoelson, S. E.
Affiliations: Joslin Diabetes Center (US)
Corresponding author: Shoelson, S. E.
ORCID: Shoelson, S. E.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2006-07-03
Volume: 116
Issue: 7
Pages: 1793-1801
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci29069
PMC: PMC1483173
OpenAlex: W2152377123
Cited by: 4,769
References: 106
Citations by year: 2026: 210 · 2025: 222 · 2024: 207 · 2023: 216 · 2022: 231 · 2021: 224 · 2020: 225 · 2019: 226 · 2018: 228 · 2017: 251 · 2016: 274 · 2015: 284 · 2014: 315 · 2013: 345 · 2012: 323
FWCI: 20.08
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: inflammation, insulin resistance, type 2 diabetes, salicylates, anti-inflammatory therapy, tissue macrophages, obesity, metabolic syndrome, adiposity
MeSH terms: Anti-Inflammatory Agents, Clinical Trials as Topic, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin Resistance, Liver, Obesity, Signal Transduction, Adipocytes

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