Cited by 4,769Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismDiabetes Treatment and Management

The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.

Inflammation and insulin resistance

Open access

Shoelson, S. E.·2006·Journal of Clinical Investigation

DOI 10.1172/jci29069PMC PMC1483173

Open this paper in CoChat — free account Open PDF

Abstract

Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance until recently. Together with the discovery of an important role for tissue macrophages, these new findings are helping to reshape thinking about how obesity increases the risk for developing T2D and the metabolic syndrome. The evolving concept of insulin resistance and T2D as having immunological components and an improving picture of how inflammation modulates metabolism provide new opportunities for using antiinflammatory strategies to correct the metabolic consequences of excess adiposity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci29069

Cites

106 of 106 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
Retracted
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 12,401
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
Dormandy, J. A., Charbonnel, B., Eckland, D. J., Erdmann, E., Massi-Benedetti, M., Moules, I. K., Skene, A. M., Tan, M. H., Lefèbvre, P. J., Murray, G. D., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67528-9 · Cited by 4,129
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

Show all 106 references

Sorted by citations

Items 601–700 of 1,053

Molecular Therapy for Obesity and Diabetes Based on a Long-Term Increase in Hepatic Fatty-Acid Oxidation §Δ
Orellana-Gavaldà, J. M., Herrero, L., Malandrino, M. I., Pañeda, A., Sol Rodríguez-Peña, M., Petry, H., Asins, G., Van Deventer, S., Hegardt, F. G., & Serra, D. (2011) · Hepatology · doi:10.1002/hep.24140 · Cited by 135
Visceral adiposity syndrome
Lopes, H. F., Corrêa‐Giannella, M. L., Consolim‐Colombo, F. M., & Egan, B. M. (2016) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-016-0156-2 · Cited by 147
Weight loss is a critical factor to reduce inflammation
Bianchi, V. E. (2018) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2018.08.007 · Cited by 142
Targeting gut microbiota as a possible therapy for diabetes
He, C., Shan, Y., & Song, W. (2015) · Nutrition Research · doi:10.1016/j.nutres.2015.03.002 · Cited by 139
Metabolic syndrome, autoimmunity and rheumatic diseases
Medina, G., Lastra, O. L. V., Peralta-Amaro, A. L., Jiménez-Arellano, M. P., Saavedra, M. Á., Cruz-Domínguez, M. P., & Jara, L. J. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.01.009 · Cited by 135
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
Aryal, B., Singh, A. K., Zhang, X., Varela, L., Rotllan, N., Goedeke, L., Chaube, B., Camporez, J.-P., Vatner, D. F., Horvath, T. L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.97918 · Cited by 127
The impact of vitamin D deficiency on diabetes and cardiovascular risk
Baz-Hecht, M., & Goldfine, A. B. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3283372859 · Cited by 137
Hyaluronan Accumulates With High-Fat Feeding and Contributes to Insulin Resistance
Kang, L., Lantier, L., Kennedy, A., Bonner, J. S., Mayes, W. H., Bracy, D. P., Bookbinder, L. H., Hasty, A. H., Thompson, C. B., & Wasserman, D. H. (2013) · Diabetes · doi:10.2337/db12-1502 · Cited by 133
Inflammation, heat shock proteins, and type 2 diabetes
Hooper, P. L., & Hooper, P. L. (2008) · Cell Stress and Chaperones · doi:10.1007/s12192-008-0073-x · Cited by 133
Effects of chronic exercise on gut microbiota and intestinal barrier in human with type 2 diabetes
Pasini, E., Corsetti, G., Assanelli, D., Testa, C., Romano, C., Dioguardi, F. S., & Aquilani, R. (2019) · Minerva Medica · doi:10.23736/s0026-4806.18.05589-1 · Cited by 137
Endothelial dysfunction in obesity: etiological role in atherosclerosis
Meyers, M. R., & Gokce, N. (2007) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e3282be90a8 · Cited by 134
Interleukin-17A inhibits adipocyte differentiation in human mesenchymal stem cells and regulates pro-inflammatory responses in adipocytes
Shin, J. H., Shin, D. W., & Noh, M. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.03.008 · Cited by 140
Effects of sitagliptin therapy on markers of low-grade inflammation and cell adhesion molecules in patients with type 2 diabetes
Tremblay, A. J., Lamarche, B., Deacon, C. F., Weisnagel, S. J., & Couture, P. (2014) · Metabolism · doi:10.1016/j.metabol.2014.06.004 · Cited by 132
Role of interleukins in obesity: implications for metabolic disease
Febbraio, M. A. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.02.004 · Cited by 134
Obesity, low testosterone levels and erectile dysfunction
Diaz‐Arjonilla, M., Schwarcz, M. G., Swerdloff, R. S., & Wang, C. (2008) · International Journal of Impotence Research · doi:10.1038/ijir.2008.42 · Cited by 134
Long-term oral exposure to bisphenol A induces glucose intolerance and insulin resistance
Moon, M. K., Jeong, I.-K., Oh, T. J., Ahn, H. Y., Kim, H. H., Park, Y. J., Jang, H. C., & Park, K. S. (2015) · Journal of Endocrinology · doi:10.1530/joe-14-0714 · Cited by 138
Insulin resistance is associated with specific gut microbiota in appendix samples from morbidly obese patients.
Moreno‐Indias, I., Sánchez‐Alcoholado, L., García‐Fuentes, E., Cardona, F., Queipo‐Ortuño, M. I., & Tinahones, F. J. (2016) · PubMed · Cited by 136
Metabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation
Johnson, A. R., Qin, Y., Cozzo, A. J., Freemerman, A. J., Huang, M. J., Zhao, L., Sampey, B. P., Milner, J. J., Beck, M. A., Damania, B., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.04.005 · Cited by 130
The atypical PKCs in inflammation: NF‐κB and beyond
Díaz-Meco, M. T., & Moscat, J. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01093.x · Cited by 132
Increased serum visfatin in patients with metabolic syndrome and carotid atherosclerosis
Zhong, M., Tan, H., Gong, H., Wang, S., Zhang, Y., & Zhang, W. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03248.x · Cited by 131
Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases
Choi, A. J. S., & Ryter, S. W. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0104 · Cited by 132
Pathological parainflammation and endoplasmic reticulum stress in depression: potential translational targets through the CNS insulin, klotho and PPAR-γ systems
Gold, P. W., Licinio, J., & Pavlatou, M. G. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.167 · Cited by 132
Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease
Mendoza, J. M., Isakova, T., Cai, X., Bayes, L. Y., Faul, C., Scialla, J. J., Lash, J. P., Chen, J., He, J., Navaneethan, S. D., et al. (2016) · Kidney International · doi:10.1016/j.kint.2016.10.021 · Cited by 138
Diabetes and Sepsis: Risk, Recurrence, and Ruination
Frydrych, L. M., Fattahi, F., He, K., Ward, P. A., & Delano, M. J. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00271 · Cited by 141
Effect of Dietary Sugar Intake on Biomarkers of Subclinical Inflammation: A Systematic Review and Meta-Analysis of Intervention Studies
Corte, K. W. D., Perrar, I., Penczynski, K. J., Schwingshackl, L., Herder, C., & Buyken, A. E. (2018) · Nutrients · doi:10.3390/nu10050606 · Cited by 138
Epicardial Adipose Tissue as a Source of Nuclear Factor-κB and c-Jun N-Terminal Kinase Mediated Inflammation in Patients with Coronary Artery Disease
Baker, A. R., Harte, A. L., Howell, N., Pritlove, D. C., Ranasinghe, A. M., da Silva, N. F., Youssef, E. M., Khunti, K., Davies, M. J., Bonser, R. S., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2579 · Cited by 131
Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids
Bhaswant, M., Poudyal, H., & Brown, L. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.02.001 · Cited by 133
A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells
Huh, J. Y., Kim, J. I., Park, Y. J., Hwang, I., Lee, Y. S., Sohn, J. H., Lee, S. K., Alfadda, A. A., Kim, S. S., Choi, S. H., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00552-12 · Cited by 137
Relationship of Abdominal Visceral and Subcutaneous Adipose Tissue With Lipoprotein Particle Number and Size in Type 2 Diabetes
Sam, S., Haffner, S. M., Davidson, M. H., D’Agostino, R. B., Feinstein, S. B., Kondos, G. T., Pérez, A., & Mazzone, T. (2008) · Diabetes · doi:10.2337/db08-0157 · Cited by 130
Hypoglycemic agents and potential anti-inflammatory activity
Mathews, S. T., Kothari, V. M., & Galdo, J. A. (2016) · Journal of Inflammation Research · doi:10.2147/jir.s86917 · Cited by 133
Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus
Shim, K., Begum, R., Yang, C. F., & Wang, H. (2019) · World Journal of Diabetes · doi:10.4239/wjd.v11.i1.1 · Cited by 128
Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes
Bowker, N., Shah, R. L., Sharp, S. J., Luan, J., Stewart, I. D., Wheeler, E., Ferreira, M. A. R., Baras, A., Wareham, N. J., Langenberg, C., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103062 · Cited by 134
Lipophilic Micronutrients and Adipose Tissue Biology
Landrier, J., Marcotorchino, J., & Tourniaire, F. (2012) · Nutrients · doi:10.3390/nu4111622 · Cited by 129
A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance
Goldfine, A. B., Conlin, P. R., Halperin, F., Koška, J., Permana, P. A., Schwenke, D. C., Shoelson, S. E., & Reaven, P. D. (2013) · Diabetologia · doi:10.1007/s00125-012-2819-3 · Cited by 127
Self-citation
Interferon Regulatory Factor 4 Regulates Obesity-Induced Inflammation Through Regulation of Adipose Tissue Macrophage Polarization
Eguchi, J., Kong, X., Tenta, M., Wang, X., Kang, S., & Rosen, E. D. (2013) · Diabetes · doi:10.2337/db12-1327 · Cited by 134
Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease
Xu, A., & Vanhoutte, P. M. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00765.2011 · Cited by 130
Mutual regulation of metabolic processes and proinflammatory NF-κB signaling
Kracht, M., Müller‐Ladner, U., & Schmitz, M. L. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.07.027 · Cited by 129
Age-related changes in muscle architecture and metabolism in humans: The likely contribution of physical inactivity to age-related functional decline
Shur, N. F., Creedon, L., Skirrow, S., Atherton, P. J., Macdonald, I. A., Lund, J. N., & Greenhaff, P. L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101344 · Cited by 148
Acute and sustained inflammation and metabolic dysfunction induced by high refined carbohydrate‐containing diet in mice
Oliveira, M. C., Garcia, Z. M., Henriques, M. C., Soriani, F. M., Pinho, V., Faria, A. M. C., Santiago, A. F., Cara, D. C., Souza, D. G., Teixeira, M. M., et al. (2013) · Obesity · doi:10.1002/oby.20230 · Cited by 129
Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high‐fat diet
Lanthier, N., Molendi‐Coste, O., Cani, P. D., van Rooijen, N., Horsmans, Y., & Leclercq, I. A. (2011) · The FASEB Journal · doi:10.1096/fj.11-189472 · Cited by 138
Potential Role of Tumor Necrosis Factor-α in Downregulating Sex Hormone–Binding Globulin
Simó, R., Barbosa-Desongles, A., Lecube, A., Hernández, C., & Selva, D. M. (2011) · Diabetes · doi:10.2337/db11-0727 · Cited by 127
The Role of Chronic Inflammation in Obesity-Associated Cancers
Ramos‐Niño, M. E. (2013) · ISRN Oncology · doi:10.1155/2013/697521 · Cited by 137
Gut-liver interaction in triglyceride-rich lipoprotein metabolism
Xiao, C., Hsieh, J., Adeli, K., & Lewis, G. F. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00178.2011 · Cited by 131
Nuclear Factor-Kappa B and Alzheimer Disease, Unifying Genetic and Environmental Risk Factors from Cell to Humans
Jones, S. V., & Kounatidis, I. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01805 · Cited by 131
Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin
Miyashita, K., Beppu, F., Hosokawa, M., Liu, X., & Wang, S. (2020) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2020.108364 · Cited by 134
Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta‐analysis
Engebretson, S. P., & Kocher, T. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.1340017 · Cited by 133
Inflammation is associated with a decrease of lipogenic factors in omental fat in women
Poulain‐Godefroy, O., Lecœur, C., Pattou, F. N., Frühbeck, G., & Froguel, P. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00926.2007 · Cited by 128
Clinical problems caused by obesity
Kyrou, I., Randeva, H. S., Barber, T., Tsigos, C., Kaltsas, G. A., & Weickert, M. O. (2022) · Warwick Research Archive Portal (University of Warwick) · doi:10.82444/warw.33841351 · Cited by 127
Diabetes mellitus and oral health
Kudiyirickal, M. G., & Pappachan, J. M. (2014) · Endocrine · doi:10.1007/s12020-014-0496-3 · Cited by 134
Tissular Tregs: A unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism
Cipolletta, D., Kolodin, D., Benoist, C. O., & Mathis, D. J. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.06.002 · Cited by 127
Aiding and Abetting Anhedonia: Impact of Inflammation on the Brain and Pharmacological Implications
Lucido, M. J., Bekhbat, M., Goldsmith, D. R., Treadway, M. T., Haroon, E., Felger, J. C., & Miller, A. H. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000043 · Cited by 133
Higher systemic immune-inflammation index and systemic inflammation response index levels are associated with stroke prevalence in the asthmatic population: a cross-sectional analysis of the NHANES 1999-2018
Cheng, W., Bu, X., Xu, C., Wen, G., Kong, F., Pan, H., Yang, S., & Chen, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1191130 · Cited by 125
The metabolic syndrome and neuropathy: Therapeutic challenges and opportunities
Callaghan, B. C., & Feldman, E. L. (2013) · Annals of Neurology · doi:10.1002/ana.23986 · Cited by 126
Apoptosis and Cytokines in Non-Alcoholic Steatohepatitis
Syn, W., Choi, S. S., & Diehl, A. M. (2009) · Clinics in Liver Disease · doi:10.1016/j.cld.2009.07.003 · Cited by 124
Macrophage Polarization and Insulin Resistance: PPARγ in Control
Charo, I. F. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.07.006 · Cited by 129
Type 2 diabetes mellitus—an autoimmune disease?
Velloso, L. A., Eizirik, D. L., & Cnop, M. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.131 · Cited by 124
Metagenome and metabolism: the tissue microbiota hypothesis
Burcelin, R., Sérino, M., Chabo, C., Garidou, L., Pomié, C., Courtney, M., Amar, J., & Bouloumié, A. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12157 · Cited by 130
Clinical and laboratory diagnosis of the metabolic syndrome
Olufadi, R., & Byrne, C. D. (2008) · Journal of Clinical Pathology · doi:10.1136/jcp.2007.048363 · Cited by 123
Ceramides and mitochondrial fatty acid oxidation in obesity
Fucho, R., Casals, N., Serra, D., & Herrero, L. (2016) · The FASEB Journal · doi:10.1096/fj.201601156r · Cited by 128
Effect of Exercise on Markers of Inflammation in Breast Cancer Survivors: The Yale Exercise and Survivorship Study
Jones, S. B., Thomas, G. A., Hesselsweet, S. D., Alvarez-Reeves, M., Yu, H., & Irwin, M. L. (2012) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-12-0278 · Cited by 132
Macrophage Glucose-6-Phosphate Dehydrogenase Stimulates Proinflammatory Responses with Oxidative Stress
Ham, M., Lee, J., Choi, A. H., Jang, H., Choi, G., Park, J., Kozuka, C., Sears, D. D., Masuzaki, H., & Kim, J. B. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01260-12 · Cited by 129
Cytokines and fatty liver diseases
Niederreiter, L., & Tilg, H. (2018) · Liver Research · doi:10.1016/j.livres.2018.03.003 · Cited by 127
Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions
Siddiqui, J. A., Pothuraju, R., Jain, M., Batra, S. K., & Nasser, M. W. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188359 · Cited by 126
Obesity and Metabolic Syndrome: An Inflammatory Condition
Scarpellini, E., & Tack, J. F. (2012) · Digestive Diseases · doi:10.1159/000336664 · Cited by 124
Weight Loss and the Prevention and Treatment of Type 2 Diabetes Using Lifestyle Therapy, Pharmacotherapy, and Bariatric Surgery: Mechanisms of Action
Grams, J. M., & Garvey, W. T. (2015) · Current Obesity Reports · doi:10.1007/s13679-015-0155-x · Cited by 127
Activation of Peroxisome Proliferator–Activated Receptor β/δ Inhibits Lipopolysaccharide-Induced Cytokine Production in Adipocytes by Lowering Nuclear Factor-κB Activity via Extracellular Signal–Related Kinase 1/2
Rodríguez‐Calvo, R., Serrano, L., Coll, T., Moullan, N., Sánchez, R. M., Merlos, M., Palomer, X., Laguna, J. C., Michalik, L., Wahli, W., et al. (2008) · Diabetes · doi:10.2337/db08-0176 · Cited by 121
Dietary Phytochemicals: Natural Swords Combating Inflammation and Oxidation‐Mediated Degenerative Diseases
Islam, M. A., Alam, F., Solayman, M., Khalil, M. I., Kamal, M. A., & Gan, S. H. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5137431 · Cited by 127
The association of neutrophil to lymphocyte ratio, mean platelet volume, and platelet distribution width with diabetic retinopathy and nephropathy: a meta-analysis
Liu, J., Liu, X., Li, Y., Quan, J., Wei, S., An, S., Yang, R., & Liu, J. (2018) · Bioscience Reports · doi:10.1042/bsr20180172 · Cited by 128
Association between insulin resistance and uncontrolled hypertension and arterial stiffness among US adults: a population-based study
Tan, L., Liu, Y., Liu, J., Zhang, G., Liu, Z., & Shi, R. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-02038-5 · Cited by 122
Inflammatory Genes in Epicardial Fat Contiguous With Coronary Atherosclerosis in the Metabolic Syndrome and Type 2 Diabetes
Sacks, H. S., Fain, J. N., Cheema, P., Bahouth, S. W., Garrett, E., Wolf, R. Y., Wolford, D., & Samaha, J. (2011) · Diabetes Care · doi:10.2337/dc10-2083 · Cited by 121
Whole and Refined Grain Intakes Are Related to Inflammatory Protein Concentrations in Human Plasma
Masters, R. C., Liese, A. D., Haffner, S. M., Wagenknecht, L. E., & Hanley, A. J. (2010) · The Journal of Nutrition · doi:10.3945/jn.109.116640 · Cited by 121
Systemic impact of intestinal helminth infections
Mishra, P. K., Palma, M., Bleich, D., Loke, P., & Gause, W. C. (2014) · Mucosal Immunology · doi:10.1038/mi.2014.23 · Cited by 122
Antidiabetic Effect of Brain-Derived Neurotrophic Factor and Its Association with Inflammation in Type 2 Diabetes Mellitus
Eyileten, C., Kapłon‐Cieślicka, A., Mirowska-Guzel, D. M., Małek, Ł. A., & Postula, M. A. (2017) · Journal of Diabetes Research · doi:10.1155/2017/2823671 · Cited by 124
Adiponectin Limits IFN-γ and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis
Surendar, J., Frohberger, S. J., Indulekha, K., Schmitt, V., Stamminger, W., Neumann, A., Wilhelm, C., Hoerauf, A. M., & Hübner, M. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02555 · Cited by 123
The Role of Catechins in Regulating Diabetes: An Update Review
Wen, L., Wu, D., Tan, X., Zhong, M., Xing, J., Li, W., Li, D., & Cao, F. (2022) · Nutrients · doi:10.3390/nu14214681 · Cited by 132
The Interplay between Obesity and Inflammation
Săvulescu-Fiedler, I., Mihalcea, R., Dragosloveanu, Ş., Scheau, C., Baz, R. O., Căruntu, A., Scheau, A.-E., Căruntu, C., & Benea, S. N. (2024) · Life · doi:10.3390/life14070856 · Cited by 138
Tissue Inhibitor of Metalloproteinase 3 Deficiency Causes Hepatic Steatosis and Adipose Tissue Inflammation in Mice
Menghini, R., Menini, S., Amoruso, R., Fiorentino, L., Casagrande, V., Marzano, V., Tornei, F., Bertucci, P., Iacobini, C., Sérino, M., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.10.079 · Cited by 127
Metabolic consequences of hyperglycemia and insulin resistance
Jellinger, P. S. (2007) · Clinical cornerstone · doi:10.1016/s1098-3597(07)80019-6 · Cited by 121
Transcriptional regulation of the GLUT4 gene: from PPAR-γ and FOXO1 to FFA and inflammation
Armoni, M., Harel, C., & Karnieli, E. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.02.001 · Cited by 125
Adipose tissue‐resident regulatory T cells: phenotypic specialization, functions and therapeutic potential
Cipolletta, D. (2014) · Immunology · doi:10.1111/imm.12262 · Cited by 125
Impact of body mass index on neoadjuvant treatment outcome: a pooled analysis of eight prospective neoadjuvant breast cancer trials
Fontanella, C., Lederer, B., Gade, S., Vanoppen, M., Blohmer, J., Costa, S. D., Denkert, C., Eidtmann, H., Gerber, B., Hanusch, C. A., et al. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3287-5 · Cited by 127
Update on the metabolic syndrome in children
Saland, J. M. (2007) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3280208519 · Cited by 120
Mitogen-Activated Protein Kinases, Inhibitory-κB Kinase, and Insulin Signaling in Human Omental Versus Subcutaneous Adipose Tissue in Obesity
Bashan, N., Dorfman, K., Tarnovscki, T., Harman‐Boehm, I., Liberty, I. F., Blüher, M., Ovadia, S., Maymon-Zilberstein, T., Potashnik, R., Stümvoll, M., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1369 · Cited by 123
Inflammatory Mechanisms of Diabetes and Its Vascular Complications
Nedosugova, L. V., Markina, Y. V., Бочкарева, Л. А., Кузина, И. А., Petunina, N. A., Yudina, I. Y., & Kirichenko, T. V. (2022) · Biomedicines · doi:10.3390/biomedicines10051168 · Cited by 135
Inflammatory Mediators and Insulin Resistance in Obesity: Role of Nuclear Receptor Signaling in Macrophages
Fuentes, L., Rőszer, T., & Ricote, M. (2010) · Mediators of Inflammation · doi:10.1155/2010/219583 · Cited by 122
Relation of depot-specific adipose inflammation to insulin resistance in human obesity
Bigornia, S., Farb, M. G., Mott, M. M., Hess, D. T., Carmine, B. J., Fiscale, A. J., Joseph, L., Apovian, C. M., & Gokce, N. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.3 · Cited by 127
The effect of salsalate on insulin action and glucose tolerance in obese non-diabetic patients: results of a randomised double-blind placebo-controlled study
Koška, J., Ortega, E., Bunt, J. C., Gasser, A., Impson, J., Hanson, R. L., Forbes, J. M., de Courten, B. V., & Krakoff, J. A. (2008) · Diabetologia · doi:10.1007/s00125-008-1239-x · Cited by 122
Systemic inflammation and the metabolic syndrome among middle-aged community volunteers
Marsland, A. L., McCaffery, J. M., Muldoon, M. F., & Manuck, S. B. (2010) · Metabolism · doi:10.1016/j.metabol.2010.05.015 · Cited by 124
Early Life Exposure to Maternal Insulin Resistance Has Persistent Effects on Hepatic NAFLD in Juvenile Nonhuman Primates
Wesolowski, S. R., Baquero, K. C., Newsom, S. A., Kasmi, K. C. E., Bergman, B. C., Shulman, G. I., Grove, K. L., & Friedman, J. E. (2014) · Diabetes · doi:10.2337/db14-0276 · Cited by 119
Allogeneic Mesenchymal Precursor Cells in Type 2 Diabetes: A Randomized, Placebo-Controlled, Dose-Escalation Safety and Tolerability Pilot Study
Skyler, J. S., Fonseca, V. A., Segal, K. R., & Rosenstock, J. (2015) · Diabetes Care · doi:10.2337/dc14-2830 · Cited by 126
Relationship between Non-Alcoholic Fatty Liver Disease and Psoriasis: A Novel Hepato-Dermal Axis?
Mantovani, A., Gisondi, P., Lonardo, A., & Targher, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020217 · Cited by 124
Daidzein, its effects on impaired glucose and lipid metabolism and vascular inflammation associated with type 2 diabetes
Das, D., Sarkar, S., Bordoloi, J., Wann, S. B., Kalita, J., & Manna, P. (2018) · BioFactors · doi:10.1002/biof.1439 · Cited by 119
The proinflammatory effects of chronic excessive exercise
da Rocha, A. L., Pinto, A. P., Kohama, E. B., Pauli, J. R., de Moura, L. P., Cintra, D. E., Ropelle, E. R., & da Silva, A. S. R. (2019) · Cytokine · doi:10.1016/j.cyto.2019.02.016 · Cited by 119
Insulin Resistance Postburn: Underlying Mechanisms and Current Therapeutic Strategies
Gauglitz, G. G., Herndon, D. N., & Jeschke, M. G. (2008) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e31818481ce · Cited by 120
Hypothalamic resistin induces hepatic insulin resistance
Muse, E. D., Lam, T. K. T., Scherer, P. E., & Rossetti, L. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30440 · Cited by 124
Inflammation and thrombosis in diabetes
Hess, K., & Grant, P. J. (2011) · Thrombosis and Haemostasis · doi:10.1160/ths10-11-0739 · Cited by 117
Effects of Initiating Insulin and Metformin on Glycemic Control and Inflammatory Biomarkers Among Patients With Type 2 Diabetes: The LANCET Randomized Trial
Pradhan, A. D., Everett, B. M., Cook, N. R., Rifai, N., & Ridker, P. M. (2009) · JAMA · doi:10.1001/jama.2009.1347 · Cited by 117
Helicobacter pyloriinfection and diabetes: Is it a myth or fact
He, C. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i16.4607 · Cited by 128
Multiple intravenous infusions of bone marrow mesenchymal stem cells reverse hyperglycemia in experimental type 2 diabetes rats
Hao, H., Liu, J., Shen, J., Zhao, Y., Liu, H., Hou, Q., Tong, C., Ti, D., Dong, L., Cheng, Y., et al. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.117 · Cited by 117
Dietary Capsaicin Attenuates Metabolic Dysregulation in Genetically Obese Diabetic Mice
Kang, J., Goto, T., Ngoc, H. L., Kim, H., Tu, T. H., Noh, H.-J., Kim, C.-S., Choe, S.-Y., Kawada, T., Yoo, H., et al. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1367 · Cited by 122

Authors: Shoelson, S. E.
Affiliations: Joslin Diabetes Center (US)
Corresponding author: Shoelson, S. E.
ORCID: Shoelson, S. E.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2006-07-03
Volume: 116
Issue: 7
Pages: 1793-1801
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci29069
PMC: PMC1483173
OpenAlex: W2152377123
Cited by: 4,769
References: 106
Citations by year: 2026: 210 · 2025: 222 · 2024: 207 · 2023: 216 · 2022: 231 · 2021: 224 · 2020: 225 · 2019: 226 · 2018: 228 · 2017: 251 · 2016: 274 · 2015: 284 · 2014: 315 · 2013: 345 · 2012: 323
FWCI: 20.08
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: inflammation, insulin resistance, type 2 diabetes, salicylates, anti-inflammatory therapy, tissue macrophages, obesity, metabolic syndrome, adiposity
MeSH terms: Anti-Inflammatory Agents, Clinical Trials as Topic, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin Resistance, Liver, Obesity, Signal Transduction, Adipocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation and insulin resistance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks