Cited by 4,769Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismDiabetes Treatment and Management

The DOI matches its Crossref record; 106 of the 106 references it cites were found in a registry or an index.

Inflammation and insulin resistance

Open access

Shoelson, S. E.·2006·Journal of Clinical Investigation

DOI 10.1172/jci29069PMC PMC1483173

Open this paper in CoChat — free account Open PDF

Abstract

Over a hundred years ago, high doses of salicylates were shown to lower glucose levels in diabetic patients. This should have been an important clue to link inflammation to the pathogenesis of type 2 diabetes (T2D), but the antihyperglycemic and antiinflammatory effects of salicylates were not connected to the pathogenesis of insulin resistance until recently. Together with the discovery of an important role for tissue macrophages, these new findings are helping to reshape thinking about how obesity increases the risk for developing T2D and the metabolic syndrome. The evolving concept of insulin resistance and T2D as having immunological components and an improving picture of how inflammation modulates metabolism provide new opportunities for using antiinflammatory strategies to correct the metabolic consequences of excess adiposity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci29069

Cites

106 of 106 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
Retracted
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Pathogen Recognition and Innate Immunity
Akira, S., Uematsu, S., & Takeuchi, O. (2006) · Cell · doi:10.1016/j.cell.2006.02.015 · Cited by 11,976
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
Dormandy, J. A., Charbonnel, B., Eckland, D. J., Erdmann, E., Massi-Benedetti, M., Moules, I. K., Skene, A. M., Tan, M. H., Lefèbvre, P. J., Murray, G. D., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67528-9 · Cited by 4,129
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

Flagged first, then by citations

Show all 106 references

Sorted by citations

Items 501–600 of 1,053

FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesity
Xiong, X., Geng, Z., Zhou, B. R., Zhang, F., Han, Y., Zhou, Y., Wang, J., Gao, X.-Y., Chen, Q., Li, Y., et al. (2018) · Metabolism · doi:10.1016/j.metabol.2018.01.013 · Cited by 165
Inflammation arising from obesity reduces taste bud abundance and inhibits renewal
Kaufman, A., Choo, E., Koh, A., & Dando, R. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2001959 · Cited by 169
Metabolic syndrome and peripheral neuropathy
Kazamel, M., Stino, A. M., & Smith, A. G. (2020) · Muscle & Nerve · doi:10.1002/mus.27086 · Cited by 174
Food Polyphenols and Type II Diabetes Mellitus: Pharmacology and Mechanisms
Naz, R., Saqib, F., Awadallah, S. M., Wahid, M., Latif, M. F., Iqbal, I., & Mubarak, M. S. (2023) · Molecules · doi:10.3390/molecules28103996 · Cited by 178
The linkage between inflammation and Type 2 diabetes mellitus
Cruz, N., Sousa, L. P., Sousa, M. O., Pietrani, N. T., Fernandes, A. P., & Gomes, K. B. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.09.003 · Cited by 161
The physiology of optimizing health with a focus on exercise as medicine
Pedersen, B. K. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114339 · Cited by 163
Osteopontin Expression in Human and Murine Obesity: Extensive Local Up-Regulation in Adipose Tissue but Minimal Systemic Alterations
Kiefer, F. W., Zeyda, M., Todoric, J., Huber, J., Geyeregger, R., Weichhart, T., Aszmann, O. C., Ludvik, B. H., Silberhumer, G. R., Prager, G., et al. (2007) · Endocrinology · doi:10.1210/en.2007-1312 · Cited by 161
Mechanisms of obesity and related pathology: linking immune responses to metabolic stress
Karalis, K. P., Giannogonas, P., Kodela, E., Koutmani, Y., Zoumakis, M., & Teli, T. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07304.x · Cited by 163
Uncoupling of Inflammation and Insulin Resistance by NF-κB in Transgenic Mice through Elevated Energy Expenditure
Tang, T., Zhang, J., Yin, J., Staszkiewicz, J., Gawrońska‐Kozak, B., Jung, D. Y., Ko, H. J., Ong, H., Kim, J. K., Mynatt, R., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.068007 · Cited by 164
Active spice-derived components can inhibit inflammatory responses of adipose tissue in obesity by suppressing inflammatory actions of macrophages and release of monocyte chemoattractant protein-1 from adipocytes
Woo, H.-M., Kang, J., Kawada, T., Yoo, H., Sung, M., & Yu, R. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.11.030 · Cited by 160
Phytochemicals in the treatment of inflammation-associated diseases: the journey from preclinical trials to clinical practice
Nisar, A., Jagtap, S., Vyavahare, S., Deshpande, M., Harsulkar, A., Ranjekar, P. K., & Prakash, O. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1177050 · Cited by 183
Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin α2β1 in Mice
Kang, L., Ayala, J. E., Lee-Young, R. S., Zhang, Z., James, F. D., Neufer, P. D., Pozzi, A., Zutter, M. M., & Wasserman, D. H. (2011) · Diabetes · doi:10.2337/db10-1116 · Cited by 159
Recent advances in biosensor technology in assessment of early diabetes biomarkers
Salek-Maghsoudi, A., Vakhshiteh, F., Torabi, R., Hassani, S., Ganjali, M. R., Norouzi, P., Hosseini, M., & Abdollahi, M. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.07.047 · Cited by 174
Macrophage-Derived AIM Is Endocytosed into Adipocytes and Decreases Lipid Droplets via Inhibition of Fatty Acid Synthase Activity
Kurokawa, J., Arai, S., Nakashima, K., Nagano, H., Nishijima, A., Miyata, K., Ose, R., Mori, M., Kubota, N., Kadowaki, T., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.04.013 · Cited by 159
Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and type 2 Diabetes
Lee, J. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0023-8 · Cited by 161
Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span
Dixit, V. D. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0108028 · Cited by 163
Adipose tissue macrophage populations and inflammation are associated with systemic inflammation and insulin resistance in obesity
Kunz, H., Hart, C. R., Gries, K. J., Parvizi, M., LAURENTI, M. C., Man, C. D., Moore, N., Zhang, X., Ryan, Z., Polley, E. C., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00070.2021 · Cited by 170
Omega-3 polyunsaturated fatty acids favourably modulate cardiometabolic biomarkers in type 2 diabetes: a meta-analysis and meta-regression of randomized controlled trials
O’Mahoney, L. L., Matu, J., Price, O. J., Birch, K. M., Ajjan, R. A., Farrar, D., Tapp, R., West, D. J., Deighton, K., & Campbell, M. D. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0740-x · Cited by 157
Microvascular Dysfunction: A Potential Mechanism in the Pathogenesis of Obesity‐associated Insulin Resistance and Hypertension
de Boer, M. P., Meijer, R. I., Wijnstok, N. J., Jonk, A. M., Houben, A. J. H. M., Stehouwer, C. D. A., Smulders, Y. M., Eringa, E. C., & Serné, E. H. (2011) · Microcirculation · doi:10.1111/j.1549-8719.2011.00130.x · Cited by 155
Adipose-Tissue and Intestinal Inflammation – Visceral Obesity and Creeping Fat
Kredel, L. I., & Siegmund, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00462 · Cited by 166
Role of Heme Oxygenase in Inflammation, Insulin-Signalling, Diabetes and Obesity
Ndisang, J. F. (2010) · Mediators of Inflammation · doi:10.1155/2010/359732 · Cited by 160
Association of Neutrophil-Lymphocyte Ratio with Glucose Intolerance: An Indicator of Systemic Inflammation in Patients with Type 2 Diabetes
Shiny, A., Subramanian, B. Y., Shanthirani, C. S., Regin, B., Anjana, R. M., Balasubramanyam, M., Jebarani, S., & Mohan, V. (2014) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0264 · Cited by 156
Toll-like receptor 4 modulates skeletal muscle substrate metabolism
Frisard, M. I., McMillan, R. P., Marchand, J., Wahlberg, K. A., Wu, Y., Voelker, K. A., Heilbronn, L. K., Haynie, K. R., Muoio, B. M., Li, L., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00307.2009 · Cited by 162
Carotenoids in the treatment of diabetes mellitus and its complications: A mechanistic review
Roohbakhsh, A., Karimi, G., & Iranshahi, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.04.057 · Cited by 156
Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice
Zhu, Y., Zhu, C., Yang, H., Deng, J., & Fan, D. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104746 · Cited by 156
Insulin Resistance, Obesity, Hypertension, and Renal Sodium Transport
Horita, S., Seki, G., Yamada, H., Suzuki, M., Koike, K., & Fujita, T. (2011) · International Journal of Hypertension · doi:10.4061/2011/391762 · Cited by 158
Genistein Suppresses LPS-Induced Inflammatory Response through Inhibiting NF-κB following AMP Kinase Activation in RAW 264.7 Macrophages
Ji, G., Zhang, Y., Yang, Q., Cheng, S., Hao, J., Zhao, X., & Jiang, Z. (2012) · PLoS ONE · doi:10.1371/journal.pone.0053101 · Cited by 159
Protein deacetylation by SIRT1: An emerging key post-translational modification in metabolic regulation
Yu, J., & Auwerx, J. H. (2009) · Pharmacological Research · doi:10.1016/j.phrs.2009.12.006 · Cited by 156
Interleukin-1 Receptor Antagonist: A New Therapy for Type 2 Diabetes Mellitus
Akash, M. S. H., Shen, Q., Rehman, K., & Chen, S. (2012) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.23057 · Cited by 158
Human Immunology of Tuberculosis
Scriba, T. J., Coussens, A. K., & Fletcher, H. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbtb2-0016-2016 · Cited by 168
Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
Kashyap, D., Sharma, A. K., Sak, K., Tuli, H. S., Buttar, H. S., & Bishayee, A. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.12.005 · Cited by 154
Adipocytokines and liver disease
Kamada, Y., Takehara, T., & Hayashi, N. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2213-6 · Cited by 155
The role of TBK1 in cancer pathogenesis and anticancer immunity
Runde, A. P., Mack, R. M., Breslin, P., & Zhang, J. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02352-y · Cited by 159
12/15‐Lipoxygenase Products Induce Inflammation and Impair Insulin Signaling in 3T3‐L1 Adipocytes
Chakrabarti, S. K., Cole, B. K., Wen, Y., Keller, S. R., & Nadler, J. L. (2009) · Obesity · doi:10.1038/oby.2009.192 · Cited by 153
Therapeutic Potential of Quercetin in the Management of Type-2 Diabetes Mellitus
Ansari, P., Choudhury, S. T., Seidel, V., Rahman, A. B., Aziz, M. A., Richi, A. E., Rahman, A., Jafrin, U. H., Hannan, J. M. A., & Abdel‐Wahab, Y. H. A. (2022) · Life · doi:10.3390/life12081146 · Cited by 174
Ionizing radiation-induced circulatory and metabolic diseases
Tapio, S., Little, M. P., Kaiser, J. C., Impens, N. R. E. N., Hamada, N., Georgakilas, A. G., Simar, D., & Salomaa, S. I. (2020) · Environment International · doi:10.1016/j.envint.2020.106235 · Cited by 153
Metformin Attenuates the Exacerbation of the Allergic Eosinophilic Inflammation in High Fat-Diet-Induced Obesity in Mice
Calixto, M. C., Lintomen, L., André, D. M., Leiria, L. O., Ferreira, D. D. S., Lellis‐Santos, C., Anhê, G. F., Bordin, S. A., Landgraf, R. G., & Antunes, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076786 · Cited by 151
Subcutaneous Adipose Tissue Macrophage Infiltration Is Associated With Hepatic and Visceral Fat Deposition, Hyperinsulinemia, and Stimulation of NF-κB Stress Pathway
Lê, K., Mahurkar‐Joshi, S., Alderete, T. L., Hasson, R. E., Adam, T. C., Kim, J. S., Beale, E., Xie, C., Greenberg, A. S., Allayee, H., et al. (2011) · Diabetes · doi:10.2337/db10-1263 · Cited by 150
Effects of coffee on type 2 diabetes mellitus
Akash, M. S. H., Rehman, K., & Chen, S. (2013) · Nutrition · doi:10.1016/j.nut.2013.11.020 · Cited by 156
Microglia and Monocyte-Derived Macrophages in Stroke
Kim, E., & Cho, S. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0463-1 · Cited by 159
The Role of Inflammasome-Dependent and Inflammasome-Independent NLRP3 in the Kidney
Kim, Y., Kim, S., Kim, K., Lee, S.-H., & Moon, J.-Y. (2019) · Cells · doi:10.3390/cells8111389 · Cited by 157
Increased Prevalence of Insulin Resistance in Patients With Differentiated Thyroid Carcinoma
Rezzónico, J., Rezzónico, M., Pusiol, E., Pitoia, F., & Nièpomniszcze, H. (2009) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2008.0062 · Cited by 153
High-Fat Diet-Induced Adiposity, Adipose Inflammation, Hepatic Steatosis and Hyperinsulinemia in Outbred CD-1 Mice
Gao, M., Ma, Y., & Liu, D. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119784 · Cited by 156
Inflammation, oxidative stress, apoptosis, and autophagy in diabetes mellitus and diabetic kidney disease: the Four Horsemen of the Apocalypse
Türkmen, K. (2016) · International Urology and Nephrology · doi:10.1007/s11255-016-1488-4 · Cited by 153
Redox Balance in the Pathogenesis of Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities
Gambino, R., Musso, G., & Cassader, M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3058 · Cited by 147
Change in Weight and Adiposity in College Students
Fedewa, M. V., Das, B. M., Evans, E. M., & Dishman, R. K. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.07.035 · Cited by 148
An intervention study in obese mice with astaxanthin, a marine carotenoid – effects on insulin signaling and pro-inflammatory cytokines
Elumalai, A., Bhuvaneswari, S., & Anuradha, C. V. (2011) · Food & Function · doi:10.1039/c1fo10161g · Cited by 149
Type‐2 diabetes: Current understanding and future perspectives
Pandey, A., Chawla, S., & Guchhait, P. (2015) · IUBMB Life · doi:10.1002/iub.1396 · Cited by 162
The Skin-Resident Immune Network
Tay, S. S., Roediger, B., Tong, P. L., Tikoo, S., & Weninger, W. (2014) · Current Dermatology Reports · doi:10.1007/s13671-013-0063-9 · Cited by 147
Obesity, metabolic syndrome and esophageal adenocarcinoma: Epidemiology, etiology and new targets
Ryan, A. M., Duong, M. T., Healy, L., Ryan, S. A., Parekh, N., Reynolds, J. V., & Power, D. G. (2011) · Cancer Epidemiology · doi:10.1016/j.canep.2011.03.001 · Cited by 151
BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK–PPARδ-dependent pathway in mice
Jung, T. W., Hwang, H.-J., Hong, H. C., Yoo, H. J., Baik, S. H., & Choi, K. M. (2015) · Diabetologia · doi:10.1007/s00125-015-3663-z · Cited by 145
Docosahexaenoic acid and eicosapentaenoic acid are converted by 3T3-L1 adipocytes to N-acyl ethanolamines with anti-inflammatory properties
Balvers, M. G. J., Verhoeckx, K. C. M., Plastina, P., Wortelboer, H. M., Meijerink, J., & Witkamp, R. F. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.06.006 · Cited by 145
Anti-obesity effect of Lactobacillus gasseri SBT2055 accompanied by inhibition of pro-inflammatory gene expression in the visceral adipose tissue in diet-induced obese mice
Miyoshi, M., Ogawa, A., Higurashi, S., & Kadooka, Y. (2013) · European Journal of Nutrition · doi:10.1007/s00394-013-0568-9 · Cited by 144
Nonalcoholic Fatty Liver Disease as a Contributor to Hypercoagulation and Thrombophilia in the Metabolic Syndrome
Targher, G., Chonchol, M., Miele, L., Zoppini, G., Pichiri, I., & Muggeo, M. (2009) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-0029-1222606 · Cited by 144
C5aR and C3aR antagonists each inhibit diet‐induced obesity, metabolic dysfunction, and adipocyte and macrophage signaling
Lim, J., Iyer, A., Suen, J. Y., Seow, V., Reid, R. C., Brown, L., & Fairlie, D. P. (2012) · The FASEB Journal · doi:10.1096/fj.12-220582 · Cited by 146
Hepatocellular Carcinoma in Obesity, Type 2 Diabetes, and NAFLD
Reeves, H. L., Zaki, M. Y. W., & Day, C. P. (2016) · Digestive Diseases and Sciences · doi:10.1007/s10620-016-4085-6 · Cited by 153
EGCG ameliorates high‐fat– and high‐fructose‐induced cognitive defects by regulating the IRS/AKT and ERK/CREB/BDNF signaling pathways in the CNS
Mi, Y., Qi, G., Fan, R., Qiao, Q., Sun, Y., Gao, Y.-Q., & Liu, X. (2017) · The FASEB Journal · doi:10.1096/fj.201700400rr · Cited by 145
The Impact of Obesity on Breast Cancer
Argolo, D. F. S. D. T. E., Hudis, C. A., & Iyengar, N. M. (2018) · Current Oncology Reports · doi:10.1007/s11912-018-0688-8 · Cited by 145
Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus
Fang, Y., Wang, X., Li, W., Han, J., Jin, J., Su, F., Zhang, J., Huang, W., Xiao, F., Pan, Q., et al. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3783 · Cited by 147
Epigenetic Mechanisms in Monocytes/Macrophages Regulate Inflammation in Cardiometabolic and Vascular Disease
Davis, F. M., & Gallagher, K. A. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.312135 · Cited by 151
Chlorogenic Acid-Induced Gut Microbiota Improves Metabolic Endotoxemia
Ye, X., Liu, Y., Hu, J., Gao, Y., Ma, Y., & Wen, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.762691 · Cited by 145
Association between triglyceride-glucose related indices with the all-cause and cause-specific mortality among the population with metabolic syndrome
Wei, X., Yu, M., Song, G., Ye, X., & Liu, L. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02215-0 · Cited by 145
Frequency and Circadian Timing of Eating May Influence Biomarkers of Inflammation and Insulin Resistance Associated with Breast Cancer Risk
Marinac, C. R., Sears, D. D., Natarajan, L., Gallo, L. C., Breen, C. I., & Patterson, R. E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0136240 · Cited by 144
COMPANION ANIMALS SYMPOSIUM: Obesity in dogs and cats: What is wrong with being fat?1
Laflamme, D. P. (2011) · Journal of Animal Science · doi:10.2527/jas.2011-4571 · Cited by 152
Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome
Wang, M.-Y., Grayburn, P. A., Chen, S., Ravazzola, M., Orci, L., & Unger, R. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801981105 · Cited by 144
Novel biochemical risk factors for type 2 diabetes: pathogenic insights or prediction possibilities?
Sattar, N., Wannamethee, S. G., & Forouhi, N. G. (2008) · Diabetologia · doi:10.1007/s00125-008-0954-7 · Cited by 143
Differential Effects of Alternate-Day Fasting Versus Daily Calorie Restriction on Insulin Resistance
Gabel, K., Kroeger, C. M., Trepanowski, J. F., Hoddy, K. K., Cienfuegos, S., Kalam, F., & Varady, K. A. (2019) · Obesity · doi:10.1002/oby.22564 · Cited by 144
Inhaled ozone (O3)-induces changes in serum metabolomic and liver transcriptomic profiles in rats
Miller, D. B., Karoly, E. D., Jones, J. C., Ward, W. O., Vallanat, B., Andrews, D. L., Schladweiler, M. C. J., Snow, S. J., Bass, V. L., Richards, J. H., et al. (2015) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2015.03.025 · Cited by 144
The many faces of PPARγ: Anti-inflammatory by any means?
Szántó, A., & Nagy, L. (2008) · Immunobiology · doi:10.1016/j.imbio.2008.07.015 · Cited by 146
A randomized, controlled trial on the effect of non-surgical periodontal therapy in patients with type 2 diabetes. Part I: effect on periodontal status and glycaemic control
Koromantzos, P. A., Makrilakis, K., Dereka, X. E., Katsilambros, N. L., Vrotsos, I. A., & Madianos, P. N. (2010) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01652.x · Cited by 149
Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation
Caprio, S., Perry, R. J., & Kursawe, R. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.12.051 · Cited by 148
Elevated plasma free fatty acids increase cardiovascular risk by inducing plasma biomarkers of endothelial activation, myeloperoxidase and PAI-1 in healthy subjects
Mathew, M., Tay, E., & Cusi, K. J. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-9 · Cited by 144
The Macrophage at the Crossroads of Insulin Resistance and Atherosclerosis
Liang, C.-P., Han, S., Senokuchi, T., & Tall, A. R. (2007) · Circulation Research · doi:10.1161/circresaha.107.152165 · Cited by 143
New insights into insulin resistance in the diabetic heart
Gray, S., & Kim, J. K. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2011.05.001 · Cited by 147
Insulin-sensitizing effects of omega-3 fatty acids: lost in translation?
Lalia, A., & Lanza, I. (2016) · Nutrients · doi:10.3390/nu8060329 · Cited by 141
Human Dedifferentiated Adipocytes Show Similar Properties to Bone Marrow‐Derived Mesenchymal Stem Cells
Poloni, A., Maurizi, G., Leoni, P., Serrani, F., Mancini, S., Frontini, A., Zingaretti, M. C., Siquini, W., Sarzani, R., & Cinti, S. (2012) · Stem Cells · doi:10.1002/stem.1067 · Cited by 138
Immuno-microbiota cross and talk: The new paradigm of metabolic diseases
Burcelin, R., Garidou, L., & Pomié, C. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2011.11.011 · Cited by 148
Role of immune responses in the development of NAFLD-associated liver cancer and prospects for therapeutic modulation
Yahoo, N., Dudek, M., Knolle, P. A., & Heikenwälder, M. F. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.02.033 · Cited by 147
Approaches to prevention of cardiovascular complications and events in diabetes mellitus
Coccheri, S. (2007) · Drugs · doi:10.2165/00003495-200767070-00005 · Cited by 139
Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes
Carstensen, M., Herder, C., Kivimäki, M., Jokela, M., Roden, M., Shipley, M. J., Witte, D. R., Brunner, E. J., & Tabák, A. G. (2010) · Diabetes · doi:10.2337/db09-1199 · Cited by 137
Mechanisms for greater insulin-stimulated glucose uptake in normal and insulin-resistant skeletal muscle after acute exercise
Cartee, G. D. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00416.2015 · Cited by 146
Evidence for the effects of yogurt on gut health and obesity
Pei, R., Martin, D., DiMarco, D. M., & Bolling, B. W. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.883356 · Cited by 145
Clodronate Liposomes Improve Metabolic Profile and Reduce Visceral Adipose Macrophage Content in Diet-Induced Obese Mice
Feng, B., Jiao, P., Nie, Y., Kim, T., Jun, D., van Rooijen, N., Yang, Z., & Xu, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024358 · Cited by 145
Apelin stimulates glucose uptake through the PI3K/Akt pathway and improves insulin resistance in 3T3-L1 adipocytes
Zhu, S., Sun, F., Li, W., Cao, Y., Wang, C., Wang, Y., Dong, L., Zhang, R., Zhang, S., Wang, H., et al. (2011) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-011-0799-0 · Cited by 140
Energy Depletion Inhibits Phosphatidylinositol 3-Kinase/Akt Signaling and Induces Apoptosis via AMP-activated Protein Kinase-dependent Phosphorylation of IRS-1 at Ser-794
Tzatsos, A., & Tsichlis, P. N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610101200 · Cited by 140
The Interactions of Obesity, Inflammation and Insulin Resistance in Breast Cancer
Rose, D. P., Gracheck, P., & Vona-Davis, L. C. (2015) · Cancers · doi:10.3390/cancers7040883 · Cited by 142
AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease
Sanjurjo, L., Aran, G., Roher, N., Valledor, A. F., & Sarrias, M. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ru0215-074r · Cited by 141
Insulin resistance in ischemic stroke: Mechanisms and therapeutic approaches
Ding, P.-F., Zhang, H., Wang, J., Gao, Y., Mao, J.-N., Hang, C., & Li, W. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1092431 · Cited by 143
Links between Thyroid Hormone Action, Oxidative Metabolism, and Diabetes Risk?
Crunkhorn, S., & Patti, M. (2008) · Thyroid · doi:10.1089/thy.2007.0249 · Cited by 141
Nut consumption in relation to cardiovascular disease risk and type 2 diabetes: a systematic review and meta-analysis of prospective studies
Zhou, D., Yu, H., He, F., Reilly, K. H., Zhang, J., Li, S., Zhang, T., Wang, B., Ding, Y., & Xi, B. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.079152 · Cited by 137
Increased intestinal permeability as a risk factor for type 2 diabetes
Cox, A. J., Zhang, P., Bowden, D. W., Devereaux, B., Davoren, P. M., Cripps, A. W., & West, N. P. (2016) · Diabetes & Metabolism · doi:10.1016/j.diabet.2016.09.004 · Cited by 138
Acarbose treatment affects the serum levels of inflammatory cytokines and the gut content of bifidobacteria in C hinese patients with type 2 diabetes mellitus
Su, B., Liu, H., Li, J., Sunli, Y., Liu, B., Liu, D., Zhang, P., & Meng, X. (2014) · Journal of Diabetes · doi:10.1111/1753-0407.12232 · Cited by 136
Vitamin D deficiency and type 2 diabetes
Ozfirat, Z., & Chowdhury, T. A. (2010) · Postgraduate Medical Journal · doi:10.1136/pgmj.2009.078626 · Cited by 139
An unbalanced monocyte polarisation in peripheral blood and bone marrow of patients with type 2 diabetes has an impact on microangiopathy
Fadini, G. P., de Kreutzenberg, S. V., Boscaro, E., Albiero, M., Cappellari, R., Kränkel, N., Landmesser, U., Toniolo, A., Bolego, C., Cignarella, A., et al. (2013) · Diabetologia · doi:10.1007/s00125-013-2918-9 · Cited by 141
Inflammatory Concepts of Obesity
Rocha, V. Z., & Folco, E. J. E. (2011) · International Journal of Inflammation · doi:10.4061/2011/529061 · Cited by 140
Getting the message across: mechanisms of physiological cross talk by adipose tissue
Lee, D.-E., Kehlenbrink, S., Lee, H., Hawkins, M. A., & Yudkin, J. S. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00015.2009 · Cited by 140
Adipose tissue in obesity and obstructive sleep apnoea
Bonsignore, M. R., McNicholas, W. T., Montserrat, J. M., & Eckel, J. (2011) · European Respiratory Journal · doi:10.1183/09031936.00047010 · Cited by 141
Adipose tissue macrophage in obesity-associated metabolic diseases
Yao, J., Wu, D., & Qiu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.977485 · Cited by 151
Complement‐mediated chronic inflammation is associated with diabetic microvascular complication
Fujita, T., Hemmi, S., Kajiwara, M., Yabuki, M., Fuke, Y., Satomura, A., & Soma, M. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2380 · Cited by 136
Circulating visfatin level is correlated with inflammation, but not with insulin resistance
Oki, K., Yamane, K., Kamei, N., Nojima, H., & Kohno, N. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02966.x · Cited by 136

Authors: Shoelson, S. E.
Affiliations: Joslin Diabetes Center (US)
Corresponding author: Shoelson, S. E.
ORCID: Shoelson, S. E.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2006-07-03
Volume: 116
Issue: 7
Pages: 1793-1801
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci29069
PMC: PMC1483173
OpenAlex: W2152377123
Cited by: 4,769
References: 106
Citations by year: 2026: 210 · 2025: 222 · 2024: 207 · 2023: 216 · 2022: 231 · 2021: 224 · 2020: 225 · 2019: 226 · 2018: 228 · 2017: 251 · 2016: 274 · 2015: 284 · 2014: 315 · 2013: 345 · 2012: 323
FWCI: 20.08
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: inflammation, insulin resistance, type 2 diabetes, salicylates, anti-inflammatory therapy, tissue macrophages, obesity, metabolic syndrome, adiposity
MeSH terms: Anti-Inflammatory Agents, Clinical Trials as Topic, Diabetes Mellitus, Type 2, Humans, Inflammation, Insulin Resistance, Liver, Obesity, Signal Transduction, Adipocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Inflammation and insulin resistance

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks