The DOI matches its Crossref record; 128 of the 128 references it cites were found in a registry or an index.
A cytokine-mediated link between innate immunity, inflammation, and cancer
Open accessAbstract
It has been established that cancer can be promoted and/or exacerbated by inflammation and infections. Indeed, chronic inflammation orchestrates a tumor-supporting microenvironment that is an indispensable participant in the neoplastic process. The mechanisms that link infection, innate immunity, inflammation, and cancer are being unraveled at a fast pace. Important components in this linkage are the cytokines produced by activated innate immune cells that stimulate tumor growth and progression. In addition, soluble mediators produced by cancer cells recruit and activate inflammatory cells, which further stimulate tumor progression. However, inflammatory cells also produce cytokines that can limit tumor growth. Here we provide an overview of the current understanding of the role of inflammation-induced cytokines in tumor initiation, promotion, and progression.
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“After chronic stress breaks this balance through a long-term pro-inflammatory response, these cells and cytokines can act on all stages of tumor development, including initiation, promotion, malignant transformation, invasion, and metastasis through mutation, epigenetic modification, and regulation of the tumor microenvironment [(50, 51); Figure 3].”
From Chronic Stress Promotes Cancer Development (2020) · cites this paper as [51]
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Cited by
Sorted by citations
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755
Self-citationOxidative stress, inflammation, and cancer: How are they linked?
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Macrophage Diversity Enhances Tumor Progression and Metastasis
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Metadata
- Authors
- Lin, W.-W., & Karin, M.
- Affiliations
- National Taiwan University (TW)
- University of California San Diego (US)
- Corresponding author
- Karin, Michael
- Venue
- Journal of Clinical Investigation
- Published
- 2007-05-01
- Volume
- 117
- Issue
- 5
- Pages
- 1175-1183
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1857251
- OpenAlex
- W2133439754
- Cited by
- 1,940
- References
- 128
- Citations by year
- 2026: 18 · 2025: 39 · 2024: 60 · 2023: 92 · 2022: 93 · 2021: 117 · 2020: 117 · 2019: 102 · 2018: 93 · 2017: 123 · 2016: 104 · 2015: 127 · 2014: 134 · 2013: 130 · 2012: 124
- FWCI
- 8.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- cytokines, innate immunity, inflammation, cancer, chronic inflammation, tumor microenvironment, tumor promotion, tumor progression, infection and cancer, tumor initiation, inflammatory cells
- MeSH terms
- Animals, Humans, Immunity, Innate, Inflammation, Neoplasms, Cytokines
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