The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
Open accessAbstract
Several different neuronal populations are involved in regulating energy homeostasis. Among these, agouti-related protein (AgRP) neurons are thought to promote feeding and weight gain; however, the evidence supporting this view is incomplete. Using designer receptors exclusively activated by designer drugs (DREADD) technology to provide specific and reversible regulation of neuronal activity in mice, we have demonstrated that acute activation of AgRP neurons rapidly and dramatically induces feeding, reduces energy expenditure, and ultimately increases fat stores. All these effects returned to baseline after stimulation was withdrawn. In contrast, inhibiting AgRP neuronal activity in hungry mice reduced food intake. Together, these findings demonstrate that AgRP neuron activity is both necessary and sufficient for feeding. Of interest, activating AgRP neurons potently increased motivation for feeding and also drove intense food-seeking behavior, demonstrating that AgRP neurons engage brain sites controlling multiple levels of feeding behavior. Due to its ease of use and suitability for both acute and chronic regulation, DREADD technology is ideally suited for investigating the neural circuits hypothesized to regulate energy balance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Melanin-concentrating hormone (MCH) promotes food consumption by acting directly on the lateral nucleus of the hypothalamus.”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [100]
In the citing paper
“Specifically, the agouti-related protein (AgRP) neurons in the arcuate nucleus of the hypothalamus are essential in the maintenance of energy balance, and their activity rapidly drives feeding behavior in a state of hunger173.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [173]
In the citing paper
“AgRP neurons are activated in a state of energy deficit228, and their optical stimulation can voraciously promote food consumption, but also elicits real-time place avoidance (indicative of an aversive state) in the absence of food173,227,229.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [173]
In the citing paper
“Optogenetic and chemogenetic activation of AgRP neurons can evoke feeding in fed mice and promote motivationally, food-seeking behavior [26, 27].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [27]
In the citing paper
“Conversely, inhibition of these neurons suppresses feeding [27].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [27]
In the citing paper
“A number of studies have shown that AgRP neurons in the ARC of the hypothalamus contribute to reward-driven feeding [28] and food-seeking behavior [26, 27].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Self-citationAntagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,150
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,107
Self-citationAlexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 1,019
Self-citationAgouti-related peptide–expressing neurons are mandatory for feeding
Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791
Self-citationSynaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
Tong, Q., Ye, C.-P., Jones, J. E., Elmquist, J. K., & Lowell, B. B. (2008) · Nature Neuroscience · doi:10.1038/nn.2167 · Cited by 699
Self-citation
Cited by
Sorted by citations
Items 901–1,000 of 1,005
Wald, H. S., Ghidewon, M. Y., Hayes, M. R., & Grill, H. J. (2023) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00232.2022 · Cited by 15
l-Ornithine is a potential acute satiety signal in the brain of neonatal chicks
Tran, P. V., Chowdhury, V. S., Do, P. H., Bahry, M. A., Yang, H., & Furuse, M. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.12.007 · Cited by 14
Devarakonda, K., & Mobbs, C. V. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.09.012 · Cited by 14
Ross, R., Mandelblat-Cerf, Y., & Verstegen, A. M. J. (2016) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000111 · Cited by 15
Barbier, M., FELLMANN, D., & Risold, P. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00688 · Cited by 15
May, M. V. L., Peris‐Sampedro, F., Stoltenborg, I., Schéle, E., Bake, T., Adan, R. A. H., & Dickson, S. L. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.633018 · Cited by 15
Fazekas, C. L., Bellardie, M., Török, B., Sipos, E., Tóth, B., Baranyi, M., Sperlágh, B., Dobos-Kovács, M., Chaillou, É., & Zelena, D. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.120037 · Cited by 14
West, K. S., Lü, C., Olson, D. P., & Roseberry, A. G. (2019) · The Journal of Physiology · doi:10.1113/jp277193 · Cited by 14
Natsubori, A., Hirai, S., Kwon, S., Ono, D., Deng, F., Wan, J., Miyazawa, M., Kojima, T., Okado, H., Karashima, A., et al. (2023) · iScience · doi:10.1016/j.isci.2022.105830 · Cited by 13
Lateral septum as a melanocortin downstream site in obesity development
Xu, Y., Jiang, Z., Li, H., Cai, J., Jiang, Y., Ortiz‐Guzman, J., Xu, Y., Arenkiel, B. R., & Tong, Q. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112502 · Cited by 13
Gao, N., Liu, Z., Wang, H., Shen, C., Dong, Z., Cui, W., Xiong, W., & Mei, L. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0247-23.2023 · Cited by 14
Advanced neurobiological tools to interrogate metabolism
Mirabella, P. N., & Fenselau, H. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00885-6 · Cited by 13
Nyema, N., McKnight, A. D., Vargas-Elvira, A. G., Schneps, H. M., Gold, E. G., Myers, K. P., & Alhadeff, A. L. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101833 · Cited by 13
GABAergic disinhibition from the BNST to PNOCARC neurons promotes HFD-induced hyperphagia
Sotelo-Hitschfeld, T., Minère, M., Klemm, P., Borgmann, D., Wnuk-Lipinski, D., Jaïs, A., Jia, X., Corneliussen, S., Kloppenburg, P., Fenselau, H., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114343 · Cited by 13
GLP-1, GIP, and Glucagon Agonists for Obesity Treatment: A Hunger Perspective
d’Ávila, M., Hall, S., & Horváth, T. L. (2024) · Endocrinology · doi:10.1210/endocr/bqae128 · Cited by 13
Mindaye, S. A., Chen, W.-H., Lin, S.-C., Chen, Y.-C., Abdelaziz, M. A., Tzeng, Y.-S., Shih, A. C.-C., Chen, S.-Y., Yang, S., & Chen, C. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114946 · Cited by 13
Holt, M. K., Valderrama, N., Polanco, M. J., Hayter, I., Badenoch, E. G., Trapp, S., & Rinaman, L. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102076 · Cited by 13
Structure-guided design of a peripherally restricted chemogenetic system
Kang, H. J., Krumm, B. E., Tassou, A., Geron, M., DiBerto, J. F., Kapolka, N. J., Gumpper, R. H., Sakamoto, K., Koçak, D. D., Olsen, R. H. J., et al. (2024) · Cell · doi:10.1016/j.cell.2024.11.001 · Cited by 14
Self-citationSharma, P., & Pienaar, I. S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.07.026 · Cited by 13
Restriction of food intake by PPP1R17-expressing neurons in the DMH
Çağlar, C., & Friedman, J. M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100194118 · Cited by 13
The relevance of adhesion G protein-coupled receptors in metabolic functions
Kaczmarek, I., Suchý, T., Prömel, S., Schöneberg, T., Liebscher, I., & Thor, D. (2021) · Biological Chemistry · doi:10.1515/hsz-2021-0146 · Cited by 14
Exercise increases NPY/AgRP and TH neuron activity in the hypothalamus of female mice
Landry, T., Shookster, D., Chaves, A., Free, K., Nguyen, T., & Hu, H. (2021) · Journal of Endocrinology · doi:10.1530/joe-21-0250 · Cited by 13
A gene–diet interaction controlling relative intake of dietary carbohydrates and fats
Nelson, N. G., Wu, L., Maier, M. T., Lam, D., Cheang, R. T., Alba, D., Huang, A., Neumann, D. A., Hill, T., Vagena, E., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101442 · Cited by 13
Ha, G. E., & Cheong, E. (2021) · Experimental Neurobiology · doi:10.5607/en21037 · Cited by 13
Delineating a serotonin 1B receptor circuit for appetite suppression in mice
Li, L., Wyler, S. C., Mercado, L. L., Xu, B., Oh, Y., SWATI, S., Chen, X., Wan, R., Arnold, A. G., Jia, L., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20212307 · Cited by 13
Borges, B. C., Elias, C. F., & Elias, L. L. K. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.005 · Cited by 13
Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK
Bellocchio, L., Ruiz-Calvo, A., Chiarlone, A., Cabanas, M., Resel, E., Cazalets, J., Blázquez, C., Cho, Y. H., Galve‐Roperh, I., & Guzmán, M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1192-16.2016 · Cited by 15
Li, L., Tang, Y., Sun, L., Rahman, K., Huang, K., Xu, W., Yu, J., Dai, J., & Cao, G. (2017) · Journal of Innovative Optical Health Sciences · doi:10.1142/s1793545817430015 · Cited by 13
He, Y., Li, Y., Pu, Z., Chen, M., Gao, Y., Chen, L., Ruan, Y., Pan, X., Zhou, Y., Ge, Y., et al. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz172 · Cited by 13
Incretin receptor agonism rapidly inhibits AgRP neurons to suppress food intake in mice
McMorrow, H. E., Cohen, A. B., Lorch, C. M., Hayes, N. W., Fleps, S. W., Frydman, J. A., Xia, J. L., Samms, R. J., & Beutler, L. R. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186652 · Cited by 12
Kostin, A., Alam, A., Saevskiy, A., McGinty, D., & Alam, M. N. (2022) · Cells · doi:10.3390/cells11142140 · Cited by 13
Balsevich, G., Petrie, G. N., Heinz, D. E., Singh, A., Aukema, R. J., Hunker, A. C., Vecchiarelli, H. A., Yau, H., Sticht, M. A., Thompson, R. J., et al. (2023) · eLife · doi:10.7554/elife.81919 · Cited by 12
Opioidergic signaling contributes to food-mediated suppression of AgRP neurons
Sayar, N., Yavuz, Y., Laule, C. F., Dong, C., Kim, H., Rysted, J., Flippo, K. H., Davis, D., Aklan, İ., Yılmaz, B., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.113630 · Cited by 12
Lavoie, O., Turmel, A., Mattoon, P., Desrosiers, W. J., Plamondon, J., Michael, N. J., & Caron, A. (2024) · Neuroendocrinology · doi:10.1159/000538716 · Cited by 12
Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation
Jung, K., Krüssel, S., Yoo, S., An, M., Burke, B., Schappaugh, N., Choi, Y., Gu, Z., Blackshaw, S., Costa, R. M., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01770-9 · Cited by 14
Functional properties of corticothalamic circuits targeting paraventricular thalamic neurons
Aquino-Miranda, G., Jalloul, D., Zhang, X. O., Li, S., Kirouac, G. J., Beierlein, M., & Monte, F. H. D. (2024) · Neuron · doi:10.1016/j.neuron.2024.10.010 · Cited by 12
From Mammals to Insects: Exploring the Genetic and Neural Basis of Eating Behavior
Mahishi, D., Agrawal, N., Jiang, W., & Yapici, N. (2024) · Annual Review of Genetics · doi:10.1146/annurev-genet-111523-102202 · Cited by 13
Amygdalo-cortical dialogue underlies memory enhancement by emotional association
Saito, Y., Osako, Y., Odagawa, M., Oisi, Y., Matsubara, C., Kato, S., Kobayashi, K., Morita, M., Johansen, J. P., & Murayama, M. (2025) · Neuron · doi:10.1016/j.neuron.2025.01.001 · Cited by 14
Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons
Li, J., Cui, Z., Gong, H., Zhang, Y., Yuan, Z., Zhang, Z.-H., Ma, Z., Zhou, N., Huang, C., Zhao, Y., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2424169122 · Cited by 12
Faour, M., Mesto, N., Martin, C., & Luquet, S. H. (2025) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-025-09990-5 · Cited by 12
Zandi, M., Shirazi, M. R. J., Tamadon, A., Akhlaghi, A., Salehi, M. S., Niazi, A., & Moghadam, A. A. (2014) · PubMed Central · Cited by 12
Hypothalamic insulin signalling as a nexus regulating mood and metabolism
Rawlinson, S., & Andrews, Z. B. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.12939 · Cited by 12
Harding, E. C., Ba, W., Zahir, R., Yu, X., Yustos, R., Hsieh, B., Lignos, L., Vyssotski, A. L., Merkle, F. T., Constandinou, T. G., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.709825 · Cited by 12
Local Drd1-neurons input to subgroups of arcuate AgRP/NPY-neurons
Chadwick, S. R., & Güler, A. D. (2022) · iScience · doi:10.1016/j.isci.2022.104605 · Cited by 12
Hypothalamic AgRP neurons exert top-down control on systemic TNF-α release during endotoxemia
Boudjadja, M. B., Culotta, I., de Paula, G. C., Harno, E., Hunter, J., Cavalcanti‐de‐Albuquerque, J. P., Luckman, S. M., Hepworth, M. R., White, A. E., Aviello, G., et al. (2022) · Current Biology · doi:10.1016/j.cub.2022.09.017 · Cited by 12
Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia
Zapata, R. C., Zhang, D., Libster, A. M., Porcu, A., Montilla‐Perez, P., Nur, A., Xu, B., Zhang, Z., Correa, S. M., Liu, C., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01981-9 · Cited by 12
Feeding neurons integrate metabolic and reproductive states in mice
Massa, M. G., Scott, R., Cara, A. L., Cortes, L. R., Vander, P. B., Sandoval, N. P., Park, J. W., Ali, S., Vélez, L. M., Wang, H. B., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107918 · Cited by 12
Repeated stress triggers seeking of a starvation-like state in anxiety-prone female mice
Kucukdereli, H., Amsalem, O., Pottala, T., Lim, M., Potgieter, L., Hasbrouck, A., Lutas, A., & Andermann, M. L. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.027 · Cited by 12
Cingulate to septal circuitry facilitates the preference to affiliate with large peer groups
Fricker, B. A., Murugan, M., Seifert, A. W., & Kelly, A. M. (2024) · Current Biology · doi:10.1016/j.cub.2024.08.019 · Cited by 12
Electrophysiological Analysis of Circuits Controlling Energy Homeostasis
Ghamari‐Langroudi, M. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8241-5 · Cited by 13
Burgdorf, C. E., Bavley, C. C., Fischer, D. K., Walsh, A. P., Martínez-Rivera, A., Hackett, J. E., Zallar, L. J., Ireton, K. E., Hofmann, F. B., Hell, J. W., et al. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-019-0597-z · Cited by 12
Long, J.-Y., Jiang, W., Xia, H.-B., Fu, J.-Y., Lu, P., Hu, F., Feng, W.-C., Sun, W.-W., Gao, M.-M., Yi, Y.-H., et al. (2020) · Neurochemistry International · doi:10.1016/j.neuint.2020.104847 · Cited by 12
Targeted Gq-GPCR activation drives ER-dependent calcium oscillations in chondrocytes
McDonough, R. C., Gilbert, R. M., Gleghorn, J. P., & Price, C. (2021) · Cell Calcium · doi:10.1016/j.ceca.2021.102363 · Cited by 12
Appetite to learn: An allostatic role for AgRP neurons in the maintenance of energy balance
Reed, F. M., Lockie, S. H., Reichenbach, A., Foldi, C. J., & Andrews, Z. B. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100337 · Cited by 12
Presence of pups suppresses hunger-induced feeding in virgin adult mice of both sexes
Han, Y., Li, X., Wang, S.-R., Wei, Y., & Xu, X. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.047 · Cited by 14
Han, Y., Xia, G., & Wu, Q. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1286-1_1 · Cited by 13
Nakatsuka, D., Kanda, T., Sato, M., Ishikawa, Y., Chérasse, Y., & Yanagisawa, M. (2024) · iScience · doi:10.1016/j.isci.2024.109289 · Cited by 11
The lateral habenula integrates age and experience to promote social transitions in developing rats
Cobb-Lewis, D. E., George, A., Hu, S., Packard, K., Song, M., Nikitah, I., Nguyen-Lopez, O., Tesone, E., Rowden, J., Wang, J., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114556 · Cited by 11
Novel neural pathways targeted by GLP-1R agonists and bariatric surgery
Hankir, M. K., & Lutz, T. A. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-03047-3 · Cited by 13
Mesolimbic dopamine neurons drive infradian rhythms in sleep-wake and heightened activity state
Markam, P. S., Bourguignon, C., Zhu, L., Ward, B., Darvas, M., Sabatini, P. V., Kokoeva, M. V., Giros, B., & Storch, K.-F. (2025) · Science Advances · doi:10.1126/sciadv.ado9965 · Cited by 11
Neurobiological mechanisms of nicotine's effects on feeding and body weight
Li, Y., Mao, J., Chai, G., Zheng, R., Liu, X., & Xie, J. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106021 · Cited by 12
Boyle, L. M., Sheng, W., Villegas, A., Sahai, R., Irfan, S., Lee, H., Young, W. S., Leroy, F., & Siegelbaum, S. A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115714 · Cited by 15
FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons
Kohno, D., Kawabata‐Iwakawa, R., Ichinose, S., Suyama, S., Ohashi, K., Ariyani, W., Sadakata, T., Yokota‐Hashimoto, H., Kobayashi, R., Horii, T., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00503-3 · Cited by 11
Lac-Phe induces hypophagia by inhibiting AgRP neurons in mice
Liu, H., Li, V. L., Liu, Q., Liu, Y., Su, C., Wong, H.-X. K., Yin, N., Liu, H., Fang, X., McDermott, K. M., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01377-9 · Cited by 11
Dymecki, S. M., Ray, R., Brust, R. D., Corcoran, A. E., Kim, J. C., Richerson, G. B., & Nattie, E. (2012) · Science · doi:10.1126/science.1222519 · Cited by 11
Odor blocking of stress hormone responses
Lee, E. J., Saraiva, L. R., Hanchate, N. K., Ye, X., Asher, G. D., Ho, J. C., & Buck, L. B. (2022) · Scientific Reports · doi:10.1038/s41598-022-12663-x · Cited by 11
Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors
Piper, N. B. C., Whitfield, E. A., Stewart, G. D., Xu, X., & Furness, S. G. B. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115115 · Cited by 11
TRIM67 Deficiency Exacerbates Hypothalamic Inflammation and Fat Accumulation in Obese Mice
Jia, L., Chen, Z., Pan, T. S., Xia, Y., He, J., Jahangir, A., Wei, X., Liu, W., Shi, R., Huang, C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169438 · Cited by 12
Sensory regulation of absence seizures in a mouse model of Gnb1 encephalopathy
Teng, S., Zhen, F., McRae, B. R., Zhu, E., Frankel, W. N., & Peng, Y. (2022) · iScience · doi:10.1016/j.isci.2022.105488 · Cited by 11
Haspula, D., & Cui, Z. (2023) · Cells · doi:10.3390/cells12131801 · Cited by 12
Paraventricular ThalamicMC3RCircuits Link Energy Homeostasis with Anxiety-Related Behavior
Cho, D., O'Berry, K., Possa‐Paranhos, I. C., Butts, J., Palanikumar, N., & Sweeney, P. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0704-23.2023 · Cited by 11
Canonical transient receptor potential channels and hypothalamic control of homeostatic functions
Kelly, M. J., & Wagner, E. J. (2024) · Journal of Neuroendocrinology · doi:10.1111/jne.13392 · Cited by 11
Neuroscience: Dissecting appetite
Trivedi, B. P. (2014) · Nature · doi:10.1038/508s64a · Cited by 13
Dissecting inhibitory brain circuits with genetically-targeted technologies
Murphey, D. K., Herman, A. M., & Arenkiel, B. R. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00124 · Cited by 11
Is Smaller Better? A Proposal to Use Bacteria For Neuroscientific Modeling
Ram, A., & Lo, A. W. (2018) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2018.00007 · Cited by 11
Inhibition of Itch by Hunger and AgRP Neuron Activity
Alhadeff, A. L., Park, O., Hernandez, E., & Betley, J. N. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.06.005 · Cited by 11
Hypothalamic-Extended Amygdala Circuit Regulates Temporal Discounting
Li, H. E., Rossi, M. A., Watson, G. D. R., Moore, H. G., Cai, M. T., Kim, N., Vokt, K. A., Lu, D., Bartholomew, R. A., Hughes, R. N., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1836-20.2020 · Cited by 13
Qiu, B., Bell, R. L., Cao, Y., Zhang, L., Stewart, R. B., Graves, T. J., Lumeng, L., Yong, W., & Liang, T. (2016) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2016.04.010 · Cited by 11
Behavioral dissection of hunger states in Drosophila
Weaver, K. J., Raju, S., Rucker, R. A., Chakraborty, T., Holt, R. A., & Pletcher, S. D. (2023) · eLife · doi:10.7554/elife.84537.3 · Cited by 13
Soto, B. A., Ma, Y., Nollet, M., Wong, S., Miracca, G., Rastinejad, D., Yustos, R., Vyssotski, A. L., Franks, N. P., & Wisden, W. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2422878122 · Cited by 10
Ährlund‐Richter, S., Osako, Y., Jenks, K. R., Odom, E., Huang, H., Arnold, D. B., & Sur, M. (2025) · Neuron · doi:10.1016/j.neuron.2025.10.037 · Cited by 12
Ogg, M. C., Lansdell, B., Franks, H. T., Hughes, A. C., Lee, J., Nolen, H. G., Shirinifard, A., & Schwarz, L. A. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116687 · Cited by 10
Cui, Z., & Smith, A. S. (2019) · Journal of Biological Methods · doi:10.14440/jbm.2019.288 · Cited by 10
Province, H. S., Xiao, C., Mogul, A. S., Sahoo, A., Jacobson, K. A., Piñol, R. A., Gavrilova, O., & Reitman, M. L. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243986 · Cited by 10
Le, N., Sayers, S., Mata‐Pacheco, V., & Wagner, E. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.877647 · Cited by 10
Patra, P. H., Tench, B., Hitrec, T., Holmes, F. E., Drake, R. A., Cerritelli, S., Spanswick, D. C., & Pickering, A. E. (2022) · Pain · doi:10.1097/j.pain.0000000000002802 · Cited by 10
The gut signals to AGRP-expressing cells of the pituitary to control glucose homeostasis
Liu, S.-M., Ifebi, B., Johnson, F., Xu, A., Ho, J., Yang, Y., Schwartz, G. J., Jo, Y., & Chua, S. C. (2023) · Journal of Clinical Investigation · doi:10.1172/jci164185 · Cited by 10
Kawano, T., Zhou, J., Anwar, S., Salah, H., Dayal, A. H., Ishikawa, Y., Boetel, K., Takahashi, T., Sharma, K., & Inoue, M. (2023) · Nature Communications · doi:10.1038/s41467-023-39518-x · Cited by 10
Coordinated Regulation of Hepatic Energy Stores by Leptin and Hypothalamic Agouti-Related Protein
Warne, J. P., Varonin, J. M., Nielsen, S. S., Olofsson, L. E., Kaelin, C. B., Chua, S. C., Barsh, G. S., Koliwad, S. K., & Xu, A. W. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0830-13.2013 · Cited by 10
RetractedPharmacosynthetic Deconstruction of Sleep-Wake Circuits in the Brain
Varin, C., & Bonnavion, P. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_183 · Cited by 10
Gan, L., Sun, J., Yang, S., Zhang, X., Wu, C., Sun, Y., Wu, X., Cheng, C., Yuan, J. T., Li, A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.085 · Cited by 10
Singha, A. K., Palavicini, J. P., Pan, M., Farmer, S., Sandoval, D. A., Han, X., & Fujikawa, T. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.588447 · Cited by 10
Elwyn, R., Mitchell, J., Kohn, M. R., Driver, C., Hay, P., Lagopoulos, J., & Hermens, D. F. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105122 · Cited by 10
Kakava-Georgiadou, N., Zwartkruis, M. M., Bullich‐Vilarrubias, C., Luijendijk, M. C. M., Garner, K. M., van der Plasse, G., & Adan, R. A. H. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00049 · Cited by 10
Korgan, A. C., Wei, W., Martin, S. L. A., Kaczorowski, C. C., & O’Connell, K. M. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.31.446473 · Cited by 10
Metabolic sensing in AgRP regulates sucrose preference and dopamine release in the nucleus accumbens
Reichenbach, A., Dempsey, H., & Andrews, Z. B. (2024) · Journal of Neuroendocrinology · doi:10.1111/jne.13389 · Cited by 9
Hartley, N. D., Krol, A., Choi, S., Rome, N., Levandowski, K. M., Pasqualoni, S., Jones, C., Tian, J., Lee, S., Lee, H., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115037 · Cited by 9
An intra-brainstem circuitry for pain-induced inhibition of itch
Prajapati, J. N., Shah, D. P., & Barik, A. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.008 · Cited by 9
Kumaraguru, S., Morgan, J., & Wong, F. K. (2025) · Science Advances · doi:10.1126/sciadv.adq5842 · Cited by 10
Velica, A., Henriksson, K., Malfatti, T., Ciralli, B., Nogueira, I., Asimakidou, E., & Kullander, K. (2025) · European Journal of Neuroscience · doi:10.1111/ejn.70086 · Cited by 9
Metadata
- Authors
- Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Lowell, Bradford B.
- Venue
- Journal of Clinical Investigation
- Published
- 2011-04-01
- Volume
- 121
- Issue
- 4
- Pages
- 1424-1428
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3069789
- OpenAlex
- W2069072617
- Cited by
- 1,578
- References
- 22
- Citations by year
- 2026: 91 · 2025: 150 · 2024: 143 · 2023: 135 · 2022: 116 · 2021: 148 · 2020: 128 · 2019: 119 · 2018: 101 · 2017: 110 · 2016: 92 · 2015: 85 · 2014: 65 · 2013: 49 · 2012: 34
- FWCI
- 23.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Triangle Community Foundation
- National Institutes of Health (5r01dk069983-05)
- National Institute of Mental Health (U19MH082441, U19-MH82441, MH087074, R01MH061887, R01MH61887, F30MH087074)
- National Institute on Drug Abuse (R01DA017204, R01DA027120)
- National Institute of General Medical Sciences (T32GM008719, GM008719)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK075632, R01DK089044, R01DK071051, R01-DK-069983, F32DK089710, R37DK053477)
- National Institute of Neurological Disorders and Stroke (NS064882)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- AgRP neurons, agouti-related protein, feeding behavior, energy homeostasis, DREADD, designer receptors, neuronal activation, dietary intake, energy expenditure, fat stores, food-seeking behavior, food motivation
- MeSH terms
- Animals, Arcuate Nucleus of Hypothalamus, Brain, Clozapine, Eating, Energy Metabolism, Feeding Behavior, Female, Male, Mice, Transgenic, Neurons, Weight Gain, Mice, Agouti-Related Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review