Cited by 1,578Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorHypothalamic control of reproductive hormones

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Open access
Krashes, Michael J., Koda, Shuichi, Ye, ChianPing, Rogan, Sarah C., Adams, Andrew C., Cusher, Daniel S., Maratos-Flier, Eleftheria, Roth, Bryan L., Lowell, Bradford B.·2011·Journal of Clinical Investigation

Abstract

Several different neuronal populations are involved in regulating energy homeostasis. Among these, agouti-related protein (AgRP) neurons are thought to promote feeding and weight gain; however, the evidence supporting this view is incomplete. Using designer receptors exclusively activated by designer drugs (DREADD) technology to provide specific and reversible regulation of neuronal activity in mice, we have demonstrated that acute activation of AgRP neurons rapidly and dramatically induces feeding, reduces energy expenditure, and ultimately increases fat stores. All these effects returned to baseline after stimulation was withdrawn. In contrast, inhibiting AgRP neuronal activity in hungry mice reduced food intake. Together, these findings demonstrate that AgRP neuron activity is both necessary and sufficient for feeding. Of interest, activating AgRP neurons potently increased motivation for feeding and also drove intense food-seeking behavior, demonstrating that AgRP neurons engage brain sites controlling multiple levels of feeding behavior. Due to its ease of use and suitability for both acute and chronic regulation, DREADD technology is ideally suited for investigating the neural circuits hypothesized to regulate energy balance.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci46229

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 22 references

Cited by

Sorted by citations

Items 301–400 of 1,005

Metadata

Authors
Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B.
Affiliations
  • Beth Israel Deaconess Medical Center (US)
  • University of North Carolina at Chapel Hill (US)
Corresponding author
Lowell, Bradford B.
Venue
Journal of Clinical Investigation
Published
2011-04-01
Volume
121
Issue
4
Pages
1424-1428
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2069072617
Cited by
1,578
References
22
Citations by year
2026: 91 · 2025: 150 · 2024: 143 · 2023: 135 · 2022: 116 · 2021: 148 · 2020: 128 · 2019: 119 · 2018: 101 · 2017: 110 · 2016: 92 · 2015: 85 · 2014: 65 · 2013: 49 · 2012: 34
FWCI
23.49
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
  • UNC Libraries
Funders
  • Triangle Community Foundation
  • National Institutes of Health (5r01dk069983-05)
  • National Institute of Mental Health (U19MH082441, U19-MH82441, MH087074, R01MH061887, R01MH61887, F30MH087074)
  • National Institute on Drug Abuse (R01DA017204, R01DA027120)
  • National Institute of General Medical Sciences (T32GM008719, GM008719)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK075632, R01DK089044, R01DK071051, R01-DK-069983, F32DK089710, R37DK053477)
  • National Institute of Neurological Disorders and Stroke (NS064882)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
AgRP neurons, agouti-related protein, feeding behavior, energy homeostasis, DREADD, designer receptors, neuronal activation, dietary intake, energy expenditure, fat stores, food-seeking behavior, food motivation
MeSH terms
Animals, Arcuate Nucleus of Hypothalamus, Brain, Clozapine, Eating, Energy Metabolism, Feeding Behavior, Female, Male, Mice, Transgenic, Neurons, Weight Gain, Mice, Agouti-Related Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review