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Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
Open accessAbstract
Several different neuronal populations are involved in regulating energy homeostasis. Among these, agouti-related protein (AgRP) neurons are thought to promote feeding and weight gain; however, the evidence supporting this view is incomplete. Using designer receptors exclusively activated by designer drugs (DREADD) technology to provide specific and reversible regulation of neuronal activity in mice, we have demonstrated that acute activation of AgRP neurons rapidly and dramatically induces feeding, reduces energy expenditure, and ultimately increases fat stores. All these effects returned to baseline after stimulation was withdrawn. In contrast, inhibiting AgRP neuronal activity in hungry mice reduced food intake. Together, these findings demonstrate that AgRP neuron activity is both necessary and sufficient for feeding. Of interest, activating AgRP neurons potently increased motivation for feeding and also drove intense food-seeking behavior, demonstrating that AgRP neurons engage brain sites controlling multiple levels of feeding behavior. Due to its ease of use and suitability for both acute and chronic regulation, DREADD technology is ideally suited for investigating the neural circuits hypothesized to regulate energy balance.
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In the citing paper
“Melanin-concentrating hormone (MCH) promotes food consumption by acting directly on the lateral nucleus of the hypothalamus.”
From Estrogen deficiency and the origin of obesity during menopause (2014) · cites this paper as [100]
In the citing paper
“Specifically, the agouti-related protein (AgRP) neurons in the arcuate nucleus of the hypothalamus are essential in the maintenance of energy balance, and their activity rapidly drives feeding behavior in a state of hunger173.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [173]
In the citing paper
“AgRP neurons are activated in a state of energy deficit228, and their optical stimulation can voraciously promote food consumption, but also elicits real-time place avoidance (indicative of an aversive state) in the absence of food173,227,229.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [173]
In the citing paper
“Optogenetic and chemogenetic activation of AgRP neurons can evoke feeding in fed mice and promote motivationally, food-seeking behavior [26, 27].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [27]
In the citing paper
“Conversely, inhibition of these neurons suppresses feeding [27].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [27]
In the citing paper
“A number of studies have shown that AgRP neurons in the ARC of the hypothalamus contribute to reward-driven feeding [28] and food-seeking behavior [26, 27].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [27]
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Cites
Driving fast-spiking cells induces gamma rhythm and controls sensory responses
Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Self-citationAntagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein
Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881
NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates
Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,150
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure
Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,107
Self-citationAlexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 1,019
Self-citationAgouti-related peptide–expressing neurons are mandatory for feeding
Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800
Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791
Self-citationSynaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
Tong, Q., Ye, C.-P., Jones, J. E., Elmquist, J. K., & Lowell, B. B. (2008) · Nature Neuroscience · doi:10.1038/nn.2167 · Cited by 699
Self-citation
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Sorted by citations
Items 601–700 of 1,005
Yang, M., Singh, A., de Araujo, A., McDougle, M. J., Ellis, H., Décarie-Spain, L., Kanoski, S. E., & de Lartigue, G. (2025) · Nature Metabolism · doi:10.1038/s42255-024-01194-6 · Cited by 34
A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons
Moissidis, M., Abbasova, L., Selten, M. M., Alis, R., Bernard, C., Domínguez-Canterla, Y., Oozeer, F., Qin, S., Kelly, A., Mòdol, L., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.029 · Cited by 38
Dunn, I., Wilson, P. W., Smulders, T. V., Sandilands, V., D’Eath, R. B., & Boswell, T. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12088 · Cited by 37
Üner, A. G., Gonçalves, G. H. M., Li, W., Porceban, M., Caron, N., Schönke, M., Delpire, E. J., Sakimura, K., & Bjørbæk, C. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2015.06.010 · Cited by 36
Wardman, J. H., Gomes, I., Bobeck, E. N., Stockert, J. A., Kapoor, A., Bisignano, P., Gupta, A., Mezei, M., Kumar, S., Filizola, M., et al. (2016) · Science Signaling · doi:10.1126/scisignal.aac8035 · Cited by 34
Bobeck, E. N., Gomes, I., Pena, D. A., Cummings, K. A., Clem, R. L., Mezei, M., & Devi, L. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.79 · Cited by 34
Activation of Agrp neurons modulates memory-related cognitive processes in mice
Zimmer, M. R., Schmitz, A. E., & Dietrich, M. O. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.12.024 · Cited by 36
Méquinion, M., Foldi, C. J., & Andrews, Z. B. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00190 · Cited by 34
Jiang, J., Morgan, D. A., Cui, H., & Rahmouni, K. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00411.2020 · Cited by 36
Fu, X., Teboul, E., Weiss, G. L., Antonoudiou, P., Borkar, C. D., Fadok, J. P., Maguire, J. L., & Tasker, J. G. (2022) · Nature Communications · doi:10.1038/s41467-022-28928-y · Cited by 36
Jones, E. A. A., Rao, A. T., Zilberter, M. Y., Djukic, B., Bant, J. S., Gillespie, A. K., Koutsodendris, N., Nelson, M. R., Yoon, S. Y., Huang, K., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.110159 · Cited by 36
Action of Neurotransmitter: A Key to Unlock the AgRP Neuron Feeding Circuit
Liu, T., Wang, Q., Berglund, E. D., & Tong, Q. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2012.00200 · Cited by 34
Optogenetics, physiology, and emotions
Kravitz, A. V., & Bonci, A. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00169 · Cited by 35
Bidirectional Influence of Limbic GIRK Channel Activation on Innate Avoidance Behavior
Vo, B. N., Marron Fernandez de Velasco, E., Rose, T. R., Oberle, H., Luo, H., Hopkins, C. R., & Wickman, K. (2021) · The Journal of Neuroscience · doi:10.1523/jneurosci.2787-20.2021 · Cited by 33
Developmental influences on circuits programming susceptibility to obesity
Zeltser, L. M. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.07.002 · Cited by 35
AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting
Gupta, R., Ma, Y., Wang, M., & Whim, M. D. (2017) · Endocrinology · doi:10.1210/en.2016-1268 · Cited by 33
Bae‐Gartz, I., Janoschek, R., Breuer, S., Schmitz, L., Hoffmann, T., Ferrari, N., Branik, L., Oberthuer, A., Kloppe, C.-S., Appel, S., et al. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00962 · Cited by 34
Wasinski, F., Furigo, I. C., Teixeira, P. D. S., Ramos-Lobo, A. M., Peroni, C. N., Bartolini, P., List, E. O., Kopchick, J. J., & Donato, J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.03.037 · Cited by 33
Effects of metabolic state on the regulation of melanocortin circuits
Lieu, L., Chau, D., Afrin, S., Dong, Y., Alhadeff, A. L., Betley, J. N., & Williams, K. W. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113039 · Cited by 35
A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice
Korchynska, S., Rebernik, P., Pende, M., Boi, L., Alpár, A., Tasan, R. O., Becker, K., Balueva, K., Saghafi, S., Wulff, P., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33584-3 · Cited by 33
Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network
Tang, Q., Godschall, E., Brennan, C. D., Zhang, Q., Abraham‐Fan, R., Williams, S. P., Güngül, T. B., Onoharigho, R., Buyukaksakal, A., Salinas, R., et al. (2023) · Science Advances · doi:10.1126/sciadv.adh9570 · Cited by 33
Arcuate Nucleus of the Hypothalamus: Anatomy, Physiology, and Diseases
Song, J., & Choi, S. (2023) · Experimental Neurobiology · doi:10.5607/en23040 · Cited by 34
Amygdala–liver signalling orchestrates glycaemic responses to stress
Carty, J. R. E., Devarakonda, K., O’CONNOR, R., Krek, A., Espinoza, D., Jiménez-González, M., Alvarsson, A., Hampton, R. F., Li, R., Qiu, Y., et al. (2025) · Nature · doi:10.1038/s41586-025-09420-1 · Cited by 32
Garretson, J. T., Teubner, B. J. W., Grove, K. L., Vazdarjanova, A. I., Ryu, V., & Bartness, T. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2129-14.2015 · Cited by 32
Liu, C., Lee, S., & Elmquist, J. K. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.02.008 · Cited by 33
Optogenetic and chemogenetic insights into the food addiction hypothesis
Krashes, M. J., & Kravitz, A. V. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00057 · Cited by 34
Self-citationDerous, D., Mitchell, S. E., Green, C. L., Chen, L., Han, J. J., Wang, Y., Promislow, D., Lusseau, D., Speakman, J. R., & Douglas, A. (2016) · Aging · doi:10.18632/aging.100895 · Cited by 34
Jones, E. S., Nunn, N., Chambers, A. P., Østergaard, S., Wulff, B. S., & Luckman, S. M. (2019) · Endocrinology · doi:10.1210/en.2019-00100 · Cited by 32
Sharma, P. K., Wells, L. A., Rizzo, G., Elson, J. L., Passchier, J., Rabiner, E. A., Gunn, R. N., Dexter, D. T., & Pienaar, I. S. (2020) · Neurotherapeutics · doi:10.1007/s13311-019-00830-4 · Cited by 32
Combinatorial Developmental Controls on Striatonigral Circuits
Matsushima, A., & Graybiel, A. M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107778 · Cited by 34
Orexin neurons and inhibitory Agrp→orexin circuits guide spatial exploration in mice
Garau, C., Blomeley, C. P., & Burdakov, D. (2020) · The Journal of Physiology · doi:10.1113/jp280158 · Cited by 35
Chaves, F. M., Mansano, N. D. S., Frazão, R., & Donato, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238928 · Cited by 32
Spinal cord associative plasticity improves forelimb sensorimotor function after cervical injury
Pal, A., Park, H., Ramamurthy, A., Asan, A. S., Bethea, T., Johnkutty, M., & Carmel, J. B. (2022) · Brain · doi:10.1093/brain/awac235 · Cited by 32
Lipopolysacharide Rapidly and Completely Suppresses AgRP Neuron-Mediated Food Intake in Male Mice
Liu, Y., Huang, Y., Liu, T., Wu, H., Cui, H., & Gautron, L. (2016) · Endocrinology · doi:10.1210/en.2015-2081 · Cited by 32
Beloate, L. N., Omrani, A., Adan, R. A. H., Webb, I. C., & Coolen, L. M. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0937-16.2016 · Cited by 33
Wang, Q., Shen, F.-Y., Zou, R., Zheng, J.-J., Yu, X., & Wang, Y. (2017) · Molecular Brain · doi:10.1186/s13041-017-0302-2 · Cited by 33
Shima, Y., Skibbe, H., Sasagawa, Y., Fujimori, N., Iwayama, Y., Isomura-Matoba, A., Yano, M., Ichikawa, T., Nikaido, I., Hattori, N., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113309 · Cited by 34
Li, H., Kawatake-Kuno, A., Inaba, H., Miyake, Y., Itoh, Y., Ueki, T., Oishi, N., Murai, T., Suzuki, T., & Uchida, S. (2024) · Neuron · doi:10.1016/j.neuron.2023.12.004 · Cited by 36
Yen, H.-H., & Roseberry, A. G. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3663-6 · Cited by 33
Chemical genetics: receptor–ligand pairs for rapid manipulation of neuronal activity
Wulff, P., & Arenkiel, B. R. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.008 · Cited by 33
Adenosine A2A receptors in the olfactory bulb suppress rapid eye movement sleep in rodents
Wang, Y., Li, R., Wang, D.-R., Chérasse, Y., Zhang, Z., Zhang, M.-Q., Lavielle, O., McEown, K., Schiffmann, S. N., d’Exaerde, A. D. K., et al. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1281-2 · Cited by 31
A psychological stressor conveyed by appetite-linked neurons
Lee, E. J., Hanchate, N. K., Kondoh, K., Tong, A. P., Kuang, D., Spray, A., Ye, X., & Buck, L. B. (2020) · Science Advances · doi:10.1126/sciadv.aay5366 · Cited by 31
Zhou, S., Shen, Y., Zang, S., Yin, X., & Li, P. (2021) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2021.05.014 · Cited by 31
New findings on brain actions of growth hormone and potential clinical implications
Donato, J., & Kopchick, J. J. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09861-x · Cited by 34
Shibata, M., Banno, R., Sugiyama, M., Tominaga, T., Onoue, T., Tsunekawa, T., Azuma, Y., Hagiwara, D., Lu, W., Ito, Y., et al. (2016) · Endocrinology · doi:10.1210/en.2015-1430 · Cited by 31
Agrp neuron activity is required for alcohol-induced overeating
Cains, S., Blomeley, C., Kollo, M., Rácz, R., & Burdakov, D. (2017) · Nature Communications · doi:10.1038/ncomms14014 · Cited by 30
Neuro-endocrine-immune regulation of metabolic homeostasis
Xie, C., Lin, Y., Qi, C., Wang, W., Yuan, Y., Song, D., Wang, Z., Liu, H., Feng, X., & Gao, H. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.08.001 · Cited by 31
TRPCing around the hypothalamus
Kelly, M. J., Qiu, J., & Rønnekleiv, O. K. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.05.004 · Cited by 29
Cyclin-dependent kinase 4 is a preclinical target for diet-induced obesity
Iqbal, N. J., Lu, Z., Liu, S.-M., Schwartz, G. J., Chua, S. C., & Zhu, L. (2018) · JCI Insight · doi:10.1172/jci.insight.123000 · Cited by 30
Recent Advances in Neural Circuits for Taste Perception in Hunger
Fu, O., Minokoshi, Y., & Nakajima, K. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.609824 · Cited by 30
Mini review: The relationship between energy status and adult hippocampal neurogenesis
Landry, T., & Hu, H. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.136261 · Cited by 31
CA2 inhibition reduces the precision of hippocampal assembly reactivation
He, H., Boehringer, R., Huang, A. J. Y., Overton, E. T. N., Polygalov, D., Okanoya, K., & McHugh, T. J. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.034 · Cited by 31
Kawatake-Kuno, A., Li, H., Inaba, H., Hikosaka, M., Ishimori, E., Ueki, T., Garkun, Y., Morishita, H., Narumiya, S., Oishi, N., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.01.023 · Cited by 31
Incubation of Fear Is Regulated by TIP39 Peptide Signaling in the Medial Nucleus of the Amygdala
Tsuda, M. C., Yeung, H., Kuo, J., & Usdin, T. B. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1736-15.2015 · Cited by 30
Targeting AgRP neurons to maintain energy balance: Lessons from animal models
Zagmutt, S., Mera, P., Soler‐Vázquez, M. C., Herrero, L., & Serra, D. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.07.008 · Cited by 30
Prolonged fasting induces long-lasting metabolic consequences in mice
Pedroso, J. A. B., Wasinski, F., & Donato, J. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108457 · Cited by 30
ARCGHR Neurons Regulate Muscle Glucose Uptake
de Lima, J. B. M., Debarba, L. K., Rupp, A. C., Qi, N., Ubah, C., Khan, M. M., Didyuk, O., AYYAR, I. T., Koch, M., Sandoval, D. A., et al. (2021) · Cells · doi:10.3390/cells10051093 · Cited by 30
Regulation of Thyroid Hormone Levels by Hypothalamic Thyrotropin-Releasing Hormone Neurons
Costa-e-Sousa, R. H., Rorato, R. C., Hollenberg, A. N., & Vella, K. R. (2023) · Thyroid · doi:10.1089/thy.2023.0173 · Cited by 29
Claustrum projections to the anterior cingulate modulate nociceptive and pain-associated behavior
Faig, C. A., Kim, G., Do, A. D., Dworsky-Fried, Z., Jackson, J., & Taylor, A. M. W. (2024) · Current Biology · doi:10.1016/j.cub.2024.03.044 · Cited by 31
Haigh, J., New, L. E., & Filippi, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.580879 · Cited by 30
Recent Advances in Hypertension
Oliveira, V., Kwitek, A. E., Sigmund, C. D., Morselli, L. L., & Grobe, J. L. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.14513 · Cited by 30
Scalable and modular wireless-network infrastructure for large-scale behavioural neuroscience
Qazi, R., Parker, K. E., Kim, C. Y., Rill, R., Norris, M. R., Chung, J., Bilbily, J., Kim, J. R., Walicki, M. C., Gereau, G. B., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00814-w · Cited by 29
Hypodopaminergic state of the nigrostriatal pathway drives compulsive alcohol use
Goutaudier, R., Joly, F., Mallet, D., Bartolomucci, M., Guicherd, D., Carcenac, C., Vossier, F., Dufourd, T., Boulet, S., Deransart, C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01848-5 · Cited by 31
Biddinger, J. E., & Fox, E. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1042-14.2014 · Cited by 29
McCarthy, E. A., Maqsudlu, A., Bass, M., Georghiou, S., Cherry, J. A., & Baum, M. J. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13636 · Cited by 29
Direct versus indirect actions of ghrelin on hypothalamic NPY neurons
Hashiguchi, H., Sheng, Z., Routh, V. H., Gerzanich, V., Simard, J. M., & Bryan, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184261 · Cited by 29
McIver, E. L., Atherton, J. F., Chu, H., Cosgrove, K. E., Kondapalli, J., Wokosin, D. L., Surmeier, D. J., & Bevan, M. D. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.06.076 · Cited by 29
Gruber, T., Lechner, F., Murat, C., Contreras, R. E., Sanchez-Quant, E., Miok, V., Makris, K., Thuc, O. L., González‐García, I., García-Clavé, E., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113305 · Cited by 28
A subcortical feeding circuit linking an interoceptive node to jaw movement
Kosse, C., Ivanov, J., Knight, Z. A., Pellegrino, K., & Friedman, J. M. (2024) · Nature · doi:10.1038/s41586-024-08098-1 · Cited by 28
Striosome Circuitry Stimulation Inhibits Striatal Dopamine Release and Locomotion
Okunomiya, T., Watanabe, D., Banno, H., Kondo, T., Imamura, K., Takahashi, R., & Inoue, H. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0457-24.2024 · Cited by 28
GLP-1 physiology and pharmacology along the gut-brain axis
Beutler, L. R. (2026) · Journal of Clinical Investigation · doi:10.1172/jci194744 · Cited by 28
Developmental specification of metabolic circuitry
Elson, A. E. T., & Simerly, R. B. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.09.003 · Cited by 32
A two-neuron system for adaptive goal-directed decision-making in Lymnaea
Crossley, M., Staras, K., & Kemenes, G. (2016) · Nature Communications · doi:10.1038/ncomms11793 · Cited by 28
Robins, M. T., Chiang, T., Mores, K. L., Alongkronrusmee, D., & van Rijn, R. M. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00112 · Cited by 28
Yu, X., Ma, Y., Harding, E. C., Yustos, R., Vyssotski, A. L., Franks, N. P., & Wisden, W. (2019) · SLEEP · doi:10.1093/sleep/zsz031 · Cited by 30
Ozawa, A., & Arakawa, H. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113234 · Cited by 29
AgRP neuronal activity across feeding‐related behaviours
Gouveia, A., Beleza, R. O., & Steculorum, S. M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15498 · Cited by 28
Navarro, G., Rea, W. P., Quiroz, C., Moreno, E., Gomez, D. M., Wenthur, C. J., Casadó, V., Leggio, L., Hearing, M. C., & Ferré, S. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1151-21.2021 · Cited by 28
Dunigan, A. I., & Roseberry, A. G. (2022) · Addiction Neuroscience · doi:10.1016/j.addicn.2022.100011 · Cited by 28
Freda, P. U. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.933039 · Cited by 28
Ishikawa, T., Murata, K., Okuda, H., Potapenko, I., Hori, K., Furuyama, T., Yamamoto, R., Ono, M., Kato, N., Fukazawa, Y., et al. (2022) · iScience · doi:10.1016/j.isci.2023.106332 · Cited by 28
Fetcho, R. N., Hall, B. S., Estrin, D. J., Walsh, A. P., Schuette, P. J., Kaminsky, J. C., Singh, A., Roshgodal, J., Bavley, C. C., Nadkarni, V., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37460-6 · Cited by 31
Stark, R., Reichenbach, A., & Andrews, Z. B. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.08.002 · Cited by 28
Effects of AgRP Inhibition on Energy Balance and Metabolism in Rodent Models
Dutia, R., Kim, A. J., Modes, M. E., Rothlein, R., Shen, J. M., Tian, Y., Ihbais, J., Victory, S. F., Valcarce, C., & Wardlaw, S. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065317 · Cited by 29
Denis, R., Joly‐Amado, A., Cansell, C., Castel, J., Martinez, S., Delbès, A.-S., & Luquet, S. H. (2013) · Diabetes & Metabolism · doi:10.1016/j.diabet.2013.11.002 · Cited by 33
Smith, M. A., Choudhury, A. I., Glegola, J. A., Viskaitis, P., Irvine, E. E., Silva, P. C. C. D. C., Khadayate, S. P., Zeilhofer, H. U., & Withers, D. J. (2019) · Journal of Clinical Investigation · doi:10.1172/jci130340 · Cited by 28
Pati, S., Salvi, S. S., Kallianpur, M., Vaidya, B., Banerjee, A. A., Maiti, S., Clement, J. P., & Vaidya, V. A. (2019) · eNeuro · doi:10.1523/eneuro.0124-19.2019 · Cited by 28
Chemogenetics a robust approach to pharmacology and gene therapy
Keifer, O. P., Kambara, K., Lau, A., Makinson, S., & Bertrand, D. (2020) · Biochemical Pharmacology · doi:10.1016/j.bcp.2020.113889 · Cited by 28
Chronic G q signaling in AgRP neurons does not cause obesity
Ewbank, S. N., Campos, C., Chen, J., Bowen, A. J., Padilla, S. L., Dempsey, J. L., Cui, J. Y., & Palmiter, R. D. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004941117 · Cited by 28
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Douglass, A. M., Kucukdereli, H., Madara, J. C., Wang, D., Wu, C., Lowenstein, E. D., Tao, J., & Lowell, B. B. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.11.009 · Cited by 27
Self-citationChemogenetic enhancement of functional recovery after a sciatic nerve injury
Jaiswal, P. B., & ENGLISH, A. W. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13550 · Cited by 27
Lockie, S. H., Stark, R., Méquinion, M., Ch’ng, S. S., Kong, D., Spanswick, D. C., Lawrence, A. J., & Andrews, Z. B. (2018) · Endocrinology · doi:10.1210/en.2018-00536 · Cited by 27
ARCAgRP/NPY Neuron Activity Is Required for Acute Exercise-Induced Food Intake in Un-Trained Mice
Bunner, W., Landry, T., Laing, B. T., Li, P.-X., Rao, Z., Yuan, Y., & Hu, H. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00411 · Cited by 27
Novel approaches to restore parasympathetic activity to the heart in cardiorespiratory diseases
Dyavanapalli, J. (2020) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00398.2020 · Cited by 27
Pre-locus coeruleus neurons in rat and mouse
Gasparini, S., Resch, J. M., Gore, A. M., Peltekian, L., & Geerling, J. C. (2020) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00261.2020 · Cited by 27
Gastelum, C., Perez, L., Hernandez, J., Le, N., Vahrson, I., Sayers, S., & Wagner, E. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052728 · Cited by 27
Cornejo, M. P., Denis, R., Romero, G. G., Fernández, G., Reynaldo, M., Luquet, S. H., & Perelló, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03937-0 · Cited by 27
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Grossman, C. D., & Cohen, J. Y. (2022) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-092021-125059 · Cited by 30
TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons
Xie, D., Stutz, B., Li, F., Chen, F., Lv, H., Šestan-Peša, M., Catarino, J. D. S., Gu, J., Zhao, H., Stoddard, C. E., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci162365 · Cited by 27
Du, Y.-L., Zhou, S., Ma, C., Chen, H., Du, A., Deng, G., Liu, Y., Tose, A. J., Sun, L., Liu, Y., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.06.021 · Cited by 27
Metadata
- Authors
- Krashes, M. J., Koda, S., Ye, C., Rogan, S. C., Adams, A. C., Cusher, D. S., Maratos-Flier, E., Roth, B. L., & Lowell, B. B.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Lowell, Bradford B.
- Venue
- Journal of Clinical Investigation
- Published
- 2011-04-01
- Volume
- 121
- Issue
- 4
- Pages
- 1424-1428
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3069789
- OpenAlex
- W2069072617
- Cited by
- 1,578
- References
- 22
- Citations by year
- 2026: 91 · 2025: 150 · 2024: 143 · 2023: 135 · 2022: 116 · 2021: 148 · 2020: 128 · 2019: 119 · 2018: 101 · 2017: 110 · 2016: 92 · 2015: 85 · 2014: 65 · 2013: 49 · 2012: 34
- FWCI
- 23.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Triangle Community Foundation
- National Institutes of Health (5r01dk069983-05)
- National Institute of Mental Health (U19MH082441, U19-MH82441, MH087074, R01MH061887, R01MH61887, F30MH087074)
- National Institute on Drug Abuse (R01DA017204, R01DA027120)
- National Institute of General Medical Sciences (T32GM008719, GM008719)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK075632, R01DK089044, R01DK071051, R01-DK-069983, F32DK089710, R37DK053477)
- National Institute of Neurological Disorders and Stroke (NS064882)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- AgRP neurons, agouti-related protein, feeding behavior, energy homeostasis, DREADD, designer receptors, neuronal activation, dietary intake, energy expenditure, fat stores, food-seeking behavior, food motivation
- MeSH terms
- Animals, Arcuate Nucleus of Hypothalamus, Brain, Clozapine, Eating, Energy Metabolism, Feeding Behavior, Female, Male, Mice, Transgenic, Neurons, Weight Gain, Mice, Agouti-Related Protein
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