Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

Cardin, J. A., Carlén, M., Meletis, K., Knoblich, U., Zhang, F., Deisseroth, K., Tsai, L.-H., & Moore, C. I. (2009) · Nature · doi:10.1038/nature08002 · Cited by 2,603

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881

NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in Neonates

Luquet, S. H., Perez, F. A., Hnasko, T. S., & Palmiter, R. D. (2005) · Science · doi:10.1126/science.1115524 · Cited by 1,150

The Need to Feed

Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120

Divergence of Melanocortin Pathways in the Control of Food Intake and Energy Expenditure

Balthasar, N., Dalgaard, L. T., Lee, C. E., Yu, J. H., Funahashi, H., Williams, T. B., Ferreira, M. A. R., Tang, V., McGovern, R. A., Kenny, C. D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.035 · Cited by 1,107

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

Alexander, G. M., Rogan, S. C., Abbas, A. I., Armbruster, B. N., Pei, Y., Allen, J., Nonneman, R. J., Hartmann, J. F., Moy, S. S., Nicolelis, M. A. L., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.014 · Cited by 1,019

Agouti-related peptide–expressing neurons are mandatory for feeding

Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800

Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis

Dhillon, H., Zigman, J. M., Ye, C., Lee, C. E., McGovern, R. A., Tang, V., Kenny, C. D., Christiansen, L. M., White, R. D., Edelstein, E. A., et al. (2006) · Neuron · doi:10.1016/j.neuron.2005.12.021 · Cited by 791

Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance

Tong, Q., Ye, C.-P., Jones, J. E., Elmquist, J. K., & Lowell, B. B. (2008) · Nature Neuroscience · doi:10.1038/nn.2167 · Cited by 699

Ninjin-yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia

Goswami, C., Dezaki, K., Wang, L., Inui, A., Seino, Y., & Yada, T. (2019) · Neuropeptides · doi:10.1016/j.npep.2019.03.001 · Cited by 45

AAV9-Retro mediates efficient transduction with axon terminal absorption and blood–brain barrier transportation

Lin, K., Zhong, X., Li, L., Ying, M., Yang, T., Zhang, Z., He, X., & Xu, F. (2020) · Molecular Brain · doi:10.1186/s13041-020-00679-1 · Cited by 45

Understanding the interplay between food structure, intestinal bacterial fermentation and appetite control

Dagbasi, A., Lett, A. M., Murphy, K., & Frost, G. (2020) · Proceedings of the Nutrition Society · doi:10.1017/s0029665120006941 · Cited by 44

An mPOA-ARCAgRP pathway modulates cold-evoked eating behavior

Yang, S., Tan, Y. L., Wu, X., Wang, J., Sun, J., Liu, A., Gan, L., Shen, B., Zhang, X., Fu, Y., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109502 · Cited by 44

Chemogenetics—A Transformational and Translational Platform

English, J. G., & Roth, B. L. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1921 · Cited by 46

DREADDs in Drosophila: A Pharmacogenetic Approach for Controlling Behavior, Neuronal Signaling, and Physiology in the Fly

Becnel, J., Johnson, O., Majeed, Z. R., Tran, V., Yu, B., Roth, B. L., Cooper, R. L., Kerut, E. K., & Nichols, C. D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.003 · Cited by 46

Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in mice

Aitta‐aho, T., Pappa, E., Burdakov, D., & Apergis‐Schoute, J. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.10.005 · Cited by 44

Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons

Uygun, D. S., Ye, Z., Zecharia, A. Y., Harding, E. C., Yu, X., Yustos, R., Vyssotski, A. L., Brickley, S. G., Franks, N. P., & Wisden, W. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.3714-15.2016 · Cited by 48

Modulation of Feeding and Associated Behaviors by Lateral Hypothalamic Circuits

Qualls‐Creekmore, E., & Münzberg, H. (2018) · Endocrinology · doi:10.1210/en.2018-00449 · Cited by 45

Fasting induces remodeling of the orexigenic projections from the arcuate nucleus to the hypothalamic paraventricular nucleus, in a growth hormone secretagogue receptor–dependent manner

Cabral, A., Fernández, G., Tolosa, M. J., Moggia, Á. R., Calfa, G. D., Francesco, P. N. D., & Perelló, M. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.11.014 · Cited by 44

Brain Circuit of Claustrophobia-like Behavior in Mice Identified by Upstream Tracing of Sighing

Li, P., Li, S., Wang, X., Phillips, C. D., Schwarz, L. A., Luo, L., de Lecea, L., & Krasnow, M. A. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107779 · Cited by 45

Chronic neuronal activation increases dynamic microtubules to enhance functional axon regeneration after dorsal root crush injury

Wu, D., Jin, Y., Shapiro, T. M., Hinduja, A., Baas, P. W., & Tom, V. J. (2020) · Nature Communications · doi:10.1038/s41467-020-19914-3 · Cited by 46

Platform introducing individually tailored variability in nerve stimulations and dietary regimen to prevent weight regain following weight loss in patients with obesity

Khoury, T., & Ilan, Y. (2021) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2021.02.003 · Cited by 46

Functional Heterogeneity of Arcuate Nucleus Pro-Opiomelanocortin Neurons: Implications for Diverging Melanocortin Pathways

Sohn, J., & Williams, K. W. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8240-6 · Cited by 46

Neuropeptide Y-expressing dorsal horn inhibitory interneurons gate spinal pain and itch signalling

Boyle, K. A., Polgár, E., Gutièrrez‐Mecinas, M., Dickie, A. C., Cooper, A. H., Bell, A. M., Jumolea, E., Casas-Benito, A., Watanabe, M., Hughes, D. I., et al. (2023) · eLife · doi:10.7554/elife.86633 · Cited by 45

The role of epigenetics in hypothalamic energy balance control: implications for obesity

Obri, A., & Claret, M. (2019) · Cell Stress · doi:10.15698/cst2019.07.191 · Cited by 46

Retinoid X Receptor α Regulates DHA-Dependent Spinogenesis and Functional Synapse Formation In Vivo

Cao, H., Li, M.-Y., Li, G., Li, S.-J., Wen, B., Lü, Y., & Yu, X. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107649 · Cited by 47

THE INTRIGUING LIGAND-DEPENDENT AND LIGAND-INDEPENDENT ACTIONS OF THE GROWTH HORMONE SECRETAGOGUE RECEPTOR ON REWARD-RELATED BEHAVIORS

Cornejo, M. P., Mustafá, E. R., Barrile, F., Cassano, D., Francesco, P. N. D., Raingo, J., & Perelló, M. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.10.017 · Cited by 46

Hunger‐driven adaptive prioritization of behavior

Smith, N. K., & Grueter, B. A. (2021) · FEBS Journal · doi:10.1111/febs.15791 · Cited by 43

Leptin, the brain and energy homeostasis: From an apparently simple to a highly complex neuronal system

Maffei, M., & Giordano, A. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09636-2 · Cited by 46

Hypothalamic Non-AgRP, Non-POMC GABAergic Neurons Are Required for Postweaning Feeding and NPY Hyperphagia

Kim, E. R., Wu, Z., Sun, H., Xu, Y., Mangieri, L. R., Xu, Y., & Tong, Q. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1110-15.2015 · Cited by 44

Pleiotropic effects of proopiomelanocortin and VGF nerve growth factor inducible neuropeptides for the long-term regulation of energy balance

Helfer, G., & Stevenson, T. J. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110876 · Cited by 43

An inhibitory circuit from central amygdala to zona incerta drives pain-related behaviors in mice

Singh, S., Wilson, T. D., Valdivia, S., Benowitz, B., Chaudhry, S., Ma, J., Adke, A. P., Soler‐Cedeño, O., Velásquez, D., Penzo, M. A., et al. (2022) · eLife · doi:10.7554/elife.68760 · Cited by 42

Zona incerta dopamine neurons encode motivational vigor in food seeking

Ye, Q., Nunez, J., & Zhang, X. (2023) · Science Advances · doi:10.1126/sciadv.adi5326 · Cited by 42

Circuit mechanism for suppression of frontal cortical ignition during NREM sleep

Li, B., Ma, C., Huang, Y., Ding, X., Silverman, D., Chen, C., Darmohray, D. M., Lu, L., Liu, S., Montaldo, G., et al. (2023) · Cell · doi:10.1016/j.cell.2023.11.012 · Cited by 42

Plasticity of the Melanocortin System: Determinants and Possible Consequences on Food Intake

Nuzzaci, D., Laderrière, A., Lemoine, A., Nédélec, E., Pénicaud, L., Rigault, C., & Bénani, A. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00143 · Cited by 44

Probabilistic, spinally-gated control of bladder pressure and autonomous micturition by Barrington’s nucleus CRH neurons

Ito, H., Sales, A. C., Fry, C. H., Kanai, A., Drake, M. J., & Pickering, A. E. (2020) · eLife · doi:10.7554/elife.56605 · Cited by 42

The role of gut hormones in appetite regulation (review)

Maric, G. D., Gazibara, T. M., Zaletel, I. V., Labudović‐Borović, M., Tomanović, N., Ćirić, M., & Puškaš, N. (2014) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.101.2014.4.1 · Cited by 42

Activation of Pyramidal Neurons in Mouse Medial Prefrontal Cortex Enhances Food-Seeking Behavior While Reducing Impulsivity in the Absence of an Effect on Food Intake

Warthen, D. M., Lambeth, P. S., Ottolini, M., Shi, Y., Barker, B. S., Gaykema, R. P. A., Newmyer, B. A., Joy-Gaba, J., Ohmura, Y., Perez‐Reyes, E., et al. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00063 · Cited by 41

Nicotine excites VIP interneurons to disinhibit pyramidal neurons in auditory cortex

Askew, C. E., López, A. J., Wood, M. A., & Metherate, R. (2019) · Synapse · doi:10.1002/syn.22116 · Cited by 45

ROCK1 in AgRP Neurons Regulates Energy Expenditure and Locomotor Activity in Male Mice

Hu, H., Lee, S., Ye, C., Sousa‐Lima, I., Oh, B., Lowell, B. B., Zabolotny, J. M., & Kim, Y. (2013) · Endocrinology · doi:10.1210/en.2013-1343 · Cited by 41

Inhibitory top-down projections from zona incerta mediate neocortical memory

Schroeder, A., Pardi, M. B., Keijser, J., Dalmay, T., Groisman, A. I., Schuman, E. M., Sprekeler, H., & Letzkus, J. J. (2023) · Neuron · doi:10.1016/j.neuron.2022.12.010 · Cited by 41

New insights in the mechanisms of weight‐loss maintenance: Summary from a Pennington symposium

Flanagan, E. W., Spann, R. A., Berry, S. E., Berthoud, H., Broyles, S. T., Foster, G. D., Krakoff, J. A., Loos, R. J. F., Lowe, M. R., Ostendorf, D. M., et al. (2023) · Obesity · doi:10.1002/oby.23905 · Cited by 42

A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice

Gannot, N., Li, X., Phillips, C. D., Ozel, A. B., Koecklin, K. H. U., Lloyd, J. P., Zhang, L., Emery, K., Stern, T., Li, J. Z., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01712-5 · Cited by 40

Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors

Gong, S., Fayette, N., Heinsbroek, J. A., & Ford, C. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.012 · Cited by 42

A critical update on the l eptin‐melanocortin system

Lavoie, O., Michael, N. J., & Caron, A. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15765 · Cited by 43

Somatostatin interneurons restrict cell recruitment to retinally driven spontaneous activity in the developing cortex

Leighton, A. H., Cheyne, J. E., Houwen, G. J., Maldonado, P. P., de Winter, F., Levelt, C. N., & Löhmann, C. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109316 · Cited by 37

Brain regulation of hunger and motivation: The case for integrating homeostatic and hedonic concepts and its implications for obesity and addiction

Morales, I. (2022) · Appetite · doi:10.1016/j.appet.2022.106146 · Cited by 39

Understanding the role of growth hormone in situations of metabolic stress

Tavares, M. R., Frazão, R., & Donato, J. (2022) · Journal of Endocrinology · doi:10.1530/joe-22-0159 · Cited by 41

Interactions of Circadian Rhythmicity, Stress and Orexigenic Neuropeptide Systems: Implications for Food Intake Control

Błasiak, A., Gundlach, A. L., Hess, G., & Lewandowski, M. H. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00127 · Cited by 40

Neuronal cAMP/PKA Signaling and Energy Homeostasis

Yang, L. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1286-1_3 · Cited by 39

Medial Amygdala Kiss1 Neurons Mediate Female Pheromone Stimulation of Luteinizing Hormone in Male Mice

Aggarwal, S., Tang, C., Sing, K., Kim, H. W., Millar, R. P., & Tello, J. A. (2018) · Neuroendocrinology · doi:10.1159/000496106 · Cited by 41

POMC Neurons Dysfunction in Diet-induced Metabolic Disease: Hallmark or Mechanism of Disease?

Quarta, C., Fioramonti, X., & Cota, D. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.031 · Cited by 41

Complementary Genetic Targeting and Monosynaptic Input Mapping Reveal Recruitment and Refinement of Distributed Corticostriatal Ensembles by Cocaine

Wall, N. R., Neumann, P. A., Beier, K. T., Mokhtari, A. K., Luo, L., & Malenka, R. C. (2019) · Neuron · doi:10.1016/j.neuron.2019.10.032 · Cited by 43

AgRP neurons trigger long-term potentiation and facilitate food seeking

Wang, C., Zhou, W., He, Y., Yang, T., Xu, P., Yang, Y., Cai, X., Wang, J., Liu, H., Yu, M., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-020-01161-1 · Cited by 40

Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance

Dodd, G. T., Kim, S. J., Méquinion, M., Xirouchaki, C. E., Brüning, J. C., Andrews, Z. B., & Tiganis, T. (2021) · Science Advances · doi:10.1126/sciadv.abf4100 · Cited by 39

Parabrachial Calca neurons drive nociplasticity

Condon, L. F., Yu, Y., Park, S., Cao, F., Pauli, J. L., Nelson, T. S., & Palmiter, R. D. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114057 · Cited by 41

Loss of GPR75 protects against non-alcoholic fatty liver disease and body fat accumulation

Leeson-Payne, A. T. S., Iyinikkel, J., Malcolm, C., Lam, B., Sommer, N., Dowsett, G. K. C., de Morentin, P. B. M., Thompson, D., MacKenzie, A., Chianese, R., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.016 · Cited by 40

Semaglutide effects on energy balance are mediated by Adcyap1+ neurons in the dorsal vagal complex

Teixidor-Deulofeu, J., Sköldheden, S. B., Font‐Gironès, F., Feješ, A., Ruud, J., & Engström, L. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.04.018 · Cited by 37

Understanding how discrete populations of hypothalamic neurons orchestrate complicated behavioral states

Graebner, A. K., Iyer, M., & Carter, M. E. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00111 · Cited by 37

Contemporary approaches to neural circuit manipulation and mapping: focus on reward and addiction

Saunders, B. T., Richard, J. M., & Janak, P. H. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0210 · Cited by 40

Nucleus incertus corticotrophin‐releasing factor 1 receptor signalling regulates alcohol seeking in rats

Walker, L. C., Kastman, H. E., Koeleman, J. A., Smith, C. M., Perry, C. J., Krstew, E., Gundlach, A. L., & Lawrence, A. J. (2016) · Addiction Biology · doi:10.1111/adb.12426 · Cited by 38

Resolving Behavioral Output via Chemogenetic Designer Receptors Exclusively Activated by Designer Drugs

Burnett, C. J., & Krashes, M. J. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1333-16.2016 · Cited by 40

Chemogenetic silencing of GABAergic dorsal horn interneurons induces morphine-resistant spontaneous nocifensive behaviours

Koga, K., Kanehisa, K., Kohro, Y., Shiratori‐Hayashi, M., Tozaki‐Saitoh, H., Inoue, K., Furue, H., & Tsuda, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-04972-3 · Cited by 38

Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity

Shi, X., Chacko, S. K., Li, F., Li, D., Burrin, D. G., Chan, L., & Guan, X. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.08.009 · Cited by 38

Activation of a lateral hypothalamic-ventral tegmental circuit gates motivation

Schiffino, F. L., Siemian, J. N., Petrella, M., Laing, B. T., Sarsfield, S., Borja, C. B., Gajendiran, A., Zuccoli, M. L., & Aponte, Y. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219522 · Cited by 38

Neural circuit control of innate behaviors

Wei, X., Jiao, Z., Senol, E., Yao, J., Zhao, M., Zhao, Z., Chen, X., Cao, P., Fu, Y., Gao, Z., et al. (2021) · Science China Life Sciences · doi:10.1007/s11427-021-2043-2 · Cited by 40

SCORHE: A novel and practical approach to video monitoring of laboratory mice housed in vivarium cage racks

Salem, G. H., Dennis, J. U., Krynitsky, J., Garmendia‐Cedillos, M., Swaroop, K., Malley, J. D., Pajevic, S., Abuhatzira, L., Bustin, M., Gillet, J., et al. (2014) · Behavior Research Methods · doi:10.3758/s13428-014-0451-5 · Cited by 38

Somato-Dendritic Localization and Signaling by Leptin Receptors in Hypothalamic POMC and AgRP Neurons

Ha, S., Baver, S. B., Huo, L., Gata, A., Hairston, J. E., Huntoon, N., Li, W., Zhang, T., Benecchi, E. J., Ericsson, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077622 · Cited by 38

Increased intrinsic and synaptic excitability of hypothalamic POMC neurons underlies chronic stress-induced behavioral deficits

Fang, X., Chen, Y., Wang, J., Zhang, Z., Bai, Y., Denney, K., Gan, L., Guo, M., Weintraub, N. L., Lei, Y., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01872-5 · Cited by 37

Hypothalamic redox balance and leptin signaling - Emerging role of selenoproteins

Gong, T., Torres, D. J., Berry, M. J., & Pitts, M. W. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.02.038 · Cited by 38

Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior

Salesse, C., Charest, J., Doucet-Beaupré, H., Castonguay, A.-M., Labrecque, S., Koninck, P. D., & Lévesque, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.084 · Cited by 37

A neural circuit for excessive feeding driven by environmental context in mice

Mohammad, H., Senol, E., Graf, M. R., Lee, C.-Y., Li, Q., Liu, Q., Yeo, X. Y., Wang, M., Laskaratos, A., Xu, F., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00875-9 · Cited by 37

Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing

Meier, D. T., Rachid, L., Wiedemann, S. J., Traub, S., TRIMIGLIOZZI, K. A., Stawiski, M., Sauteur, L., Winter, D. V., Foll, C. L., Brégère, C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32509-4 · Cited by 40

The gut microbiota modulate locomotion via vagus-dependent glucagon-like peptide-1 signaling

Lai, T.-T., Tsai, Y.-H., Liou, C.-W., Fan, C., Hou, Y.-T., Yao, T.-H., Chuang, H.-L., & Wu, W. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00477-w · Cited by 40

A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding

de Morentin, P. B. M., González, J. A., Dowsett, G. K. C., Martynova, Y. V., Yeo, G. S. H., Sylantyev, S., & Heisler, L. K. (2024) · Current Biology · doi:10.1016/j.cub.2024.02.074 · Cited by 39

The Role of BDNF and TrkB in the Central Control of Energy and Glucose Balance: An Update

Harvey, T. L., & Rios, M. (2024) · Biomolecules · doi:10.3390/biom14040424 · Cited by 37

History and future of leptin: Discovery, regulation and signaling

Münzberg, H., Heymsfield, S. B., Berthoud, H., & Morrison, C. D. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156026 · Cited by 37

A hypothalamic circuit that modulates feeding and parenting behaviours

Alcantara, I. C., Li, C., Gao, C., Rodriguez-Gonzalez, S., Mickelsen, L. E., Papas, B. N., Goldschmidt, A. I., Cohen, I. M., Mazzone, C. M., Salgado, I. D. A., et al. (2025) · Nature · doi:10.1038/s41586-025-09268-5 · Cited by 36

Intestinal interoceptive dysfunction drives age-associated cognitive decline

Cox, T. O., Devason, A. S., de Araujo, A., Mason, S., Subramanian, M., Salvador, A. F. M., Descamps, H. C., Kim, J., Zhu, Y., Litichevskiy, L., et al. (2026) · Nature · doi:10.1038/s41586-026-10191-6 · Cited by 39

Optogenetics and pharmacogenetics: principles and applications

Jiang, J., Cui, H., & Rahmouni, K. (2017) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00091.2017 · Cited by 39

Unified Classification of Molecular, Network, and Endocrine Features of Hypothalamic Neurons

Romanov, R. A., Alpár, A., Hökfelt, T. G. M., & Harkany, T. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050414 · Cited by 36

A Novel Next-Generation Sequencing and Analysis Platform to Assess the Identity of Recombinant Adeno-Associated Viral Preparations from Viral DNA Extracts

Guerin, K. I., Rego, M. A., Bourges, D., Ersing, I., Haery, L., DeMaio, K. H., Sanders, E., Tasissa, M., Kostman, M. P., Tillgren, M. L., et al. (2020) · Human Gene Therapy · doi:10.1089/hum.2019.277 · Cited by 36

Use of DREADD Technology to Identify Novel Targets for Antidiabetic Drugs

Wang, L., Zhu, L., Meister, J., Bone, D. B. J., Pydi, S. P., Rossi, M., & Wess, J. (2020) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-030220-121042 · Cited by 36

Astrocyte Gliotransmission in the Regulation of Systemic Metabolism

Murat, C. D. B., & García‐Cáceres, C. (2021) · Metabolites · doi:10.3390/metabo11110732 · Cited by 38

Hypothalamic Grb10 enhances leptin signalling and promotes weight loss

Liu, H., He, Y., Bai, J., Zhang, C., Zhang, F., Yang, Y., Luo, H., Yu, M., Liu, H., Tu, L., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-022-00701-x · Cited by 37

Narrative review of ferroptosis in obesity

He, L., Zhou, Z., & Li, C. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17701 · Cited by 36

Reactivation of Early-Life Stress-Sensitive Neuronal Ensembles Contributes to Lifelong Stress Hypersensitivity

Rodier, J.-A., Mclain, C., Minerva, A. R., Rashford, R. L., Bennett, S. N., Rogers, F. D., & Peña, C. J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0016-23.2023 · Cited by 40

Chemogenetic activation of an infralimbic cortex to basolateral amygdala projection promotes resistance to acute social defeat stress

Dulka, B. N., Bagatelas, E. D., Bress, K. S., Grizzell, J. A., Cannon, M. K., Whitten, C. J., & Cooper, M. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-63879-8 · Cited by 38

Activation of locus coeruleus to rostromedial tegmental nucleus (RMTg) noradrenergic pathway blunts binge-like ethanol drinking and induces aversive responses in mice

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Food-induced dopamine signaling in AgRP neurons promotes feeding

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Endocannabinoid release at ventral hippocampal-amygdala synapses regulates stress-induced behavioral adaptation

Kondev, V., Najeed, M., Yasmin, F., Morgan, A., Loomba, N., Johnson, K., Adank, D. N., Dong, A., Delpire, E. J., Li, Y., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113027 · Cited by 35

Translational potential of mouse models of human metabolic disease

Farooqi, I. S., & Xu, Y. (2024) · Cell · doi:10.1016/j.cell.2024.07.011 · Cited by 37

A parabrachial hub for need-state control of enduring pain

Goldstein, N., Maes, A., Allen, H. N., Nelson, T. S., Kruger, K. A., Kindel, M., Yeung, A. T. M., Smith, N. K., Carty, J. R. E., Boccia, L., et al. (2025) · Nature · doi:10.1038/s41586-025-09602-x · Cited by 35

Minireview: Central Sirt1 Regulates Energy Balance via the Melanocortin System and Alternate Pathways

Toorie, A. M., & Nillni, E. A. (2014) · Molecular Endocrinology · doi:10.1210/me.2014-1115 · Cited by 35

A Life without Hunger: The Ups (and Downs) to Modulating Melanocortin-3 Receptor Signaling

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Phosphoinositide 3-Kinase Is Integral for the Acute Activity of Leptin and Insulin in Male Arcuate NPY/AgRP Neurons

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Emerging roles for hypothalamic microglia as regulators of physiological homeostasis

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PPG neurons in the nucleus of the solitary tract modulate heart rate but do not mediate GLP-1 receptor agonist-induced tachycardia in mice

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Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex

Wang, B., Sarria, M. S. B., An, X., He, M., Alam, N. M., Prusky, G. T., Crair, M. C., & Huang, Z. J. (2019) · Neuron · doi:10.1016/j.neuron.2020.11.004 · Cited by 36

Regulation of Brain Primary Cilia Length by MCH Signaling: Evidence from Pharmacological, Genetic, Optogenetic, and Chemogenic Manipulations

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The melanocortin action is biased toward protection from weight loss in mice

Li, H., Xu, Y., Jiang, Y., Jiang, Z., Ortiz‐Guzman, J., Morrill, J., Cai, J., Mao, Z., Xu, Y., Arenkiel, B. R., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37912-z · Cited by 38

Molecular and neural control of social hierarchy by a forebrain-thalamocortical circuit

Nelson, A. C., Kapoor, V., Vaughn, E., Gnanasegaram, J. A., Rubinstein, N. D., Talay, M., Murthy, V. N., & Dulac, C. G. (2025) · Cell · doi:10.1016/j.cell.2025.07.024 · Cited by 35

Corticospinal circuit remodeling after central nervous system injury is dependent on neuronal activity

Bradley, P. M., Denecke, C. K., Aljović, A., Schmalz, A., Kerschensteiner, M., & Bareyre, F. M. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20181406 · Cited by 35

A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism

He, Y., Shu, G., Yang, Y., Xu, P., Xia, Y., Wang, C., Saito, K., Hinton, A., Yan, X., Liu, C., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.044 · Cited by 34

AgRP neurons coordinate the mitigation of activity-based anorexia

Hickey, A. K. S., Duane, S. C., Mickelsen, L. E., Karolczak, E. O., Shamma, A. M., Skillings, A., Li, C., & Krashes, M. J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01932-w · Cited by 34

Exercise-induced hypothalamic neuroplasticity: Implications for energy and glucose metabolism

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Negative feedback control of hypothalamic feeding circuits by the taste of food

Aitken, T. J., Liu, Z., Ly, T., Shehata, S., Sivakumar, N., Medina, N. L. S., Gray, L. A., Zhang, J., Dundar, N., Barnes, C., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.07.017 · Cited by 34

Regulation of energy balance by leptin as an adiposity signal and modulator of the reward system

Asgari, R., Caceres-Valdiviezo, M., Wu, S., Hamel, L., Humber, B. E., Agarwal, S. M., Fletcher, P. J., Fulton, S., Hahn, M., & Pereira, S. (2024) · Molecular Metabolism · doi:10.1016/j.molmet.2024.102078 · Cited by 35

Neuronal Regulation of Feeding and Energy Metabolism: A Focus on the Hypothalamus and Brainstem

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AgRP neuronal activity across feeding‐related behaviours

Gouveia, A., Beleza, R. O., & Steculorum, S. M. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15498 · Cited by 28

Dynamic Control Of Behavior By Hypothalamic Hunger Neurons

Goldstein, N. (2022) · ScholarlyCommons (University of Pennsylvania)

314-OR: Mechanisms of AgRP Neuron-Induced Hunger

Knight, Z. A. (2019) · Diabetes · doi:10.2337/db19-314-or

AgRP neurons: Regulators of feeding, energy expenditure, and behavior

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Hypothalamic AgRP neurons and the regulation of appetite and body weight: A review

Wang, P., & Zhang, G. (2018) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/n972018-00413 · Cited by 2