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A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response
Open accessAbstract
Peroxisome proliferator-activated receptor gamma (PPAR-gamma), a member of the nuclear hormone receptor superfamily originally shown to play a critical role in adipocyte differentiation and glucose homeostasis, has recently been implicated as a regulator of cellular proliferation and inflammatory responses. Colonic epithelial cells, which express high levels of PPAR-gamma protein, have the ability to produce inflammatory cytokines that may play a role in inflammatory bowel disease (IBD). We report here that PPAR-gamma ligands dramatically attenuate cytokine gene expression in colon cancer cell lines by inhibiting the activation of nuclear factor-kappaB via an IkappaB-alpha-dependent mechanism. Moreover, thiazolidinedione ligands for PPAR-gamma markedly reduce colonic inflammation in a mouse model of IBD. These results suggest that colonic PPAR-gamma may be a therapeutic target in humans suffering from IBD.
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Metadata
- Authors
- Su, C. G., Wen, X., Bailey, S. T., Jiang, W., Rangwala, S. M., Keilbaugh, S. A., Flanigan, A., Murthy, S., Lazar, M. A., & Wu, G. D.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-08-15
- Volume
- 104
- Issue
- 4
- Pages
- 383-389
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2003115027
- Cited by
- 767
- References
- 3
- FWCI
- 15.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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