The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
An epigenetically distinct breast cancer cell subpopulation promotes collective invasion
Open accessAbstract
Tumor cells can engage in a process called collective invasion, in which cohesive groups of cells invade through interstitial tissue. Here, we identified an epigenetically distinct subpopulation of breast tumor cells that have an enhanced capacity to collectively invade. Analysis of spheroid invasion in an organotypic culture system revealed that these "trailblazer" cells are capable of initiating collective invasion and promote non-trailblazer cell invasion, indicating a commensal relationship among subpopulations within heterogenous tumors. Canonical mesenchymal markers were not sufficient to distinguish trailblazer cells from non-trailblazer cells, suggesting that defining the molecular underpinnings of the trailblazer phenotype could reveal collective invasion-specific mechanisms. Functional analysis determined that DOCK10, ITGA11, DAB2, PDFGRA, VASN, PPAP2B, and LPAR1 are highly expressed in trailblazer cells and required to initiate collective invasion, with DOCK10 essential for metastasis. In patients with triple-negative breast cancer, expression of these 7 genes correlated with poor outcome. Together, our results indicate that spontaneous conversion of the epigenetic state in a subpopulation of cells can promote a transition from in situ to invasive growth through induction of a cooperative form of collective invasion and suggest that therapeutic inhibition of trailblazer cell invasion may help prevent metastasis.
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Emerging Biological Principles of Metastasis
Lambert, A. W., Pattabiraman, D. R., & Weinberg, R. A. (2017) · Cell · doi:10.1016/j.cell.2016.11.037 · Cited by 3,067
EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration
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EMT and MET : necessary or permissive for metastasis?
Jolly, M. K., Ware, K. E., Gilja, S., Somarelli, J. A., & Levine, H. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12083 · Cited by 371
Cancer-associated fibroblasts in desmoplastic tumors: emerging role of integrins
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Senescent tumor cells lead the collective invasion in thyroid cancer
Kim, Y. H., Choi, Y. W., Lee, J., Soh, E. Y., Kim, J.-H., & Park, T. J. (2017) · Nature Communications · doi:10.1038/ncomms15208 · Cited by 253
Metadata
- Authors
- Westcott, J. M., Prechtl, A. M., Maine, E. A., Dang, T. T., Esparza, M. A., Sun, H., Zhou, Y., Xie, Y., & Pearson, G. W.
- Venue
- Journal of Clinical Investigation
- Published
- 2015-04-06
- Volume
- 125
- Issue
- 5
- Pages
- 1927-1943
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2006305177
- Cited by
- 179
- References
- 6
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Westcott, J. M., Prechtl, A. M., Maine, E. A., Dang, T. T., Esparza, M. A., Sun, H., Zhou, Y., Xie, Y., & Pearson, G. W. (2015). An epigenetically distinct breast cancer cell subpopulation promotes collective invasion. Journal of Clinical Investigation. https://doi.org/10.1172/jci77767
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