Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth

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Items 101–189 of 189

1. PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis
   Kallesh Danappa Jayappa, Brian Tran, Vicki L. Gordon, Christopher G. Morris, Shekhar Saha, Caroline C. Farrington, Caitlin M. O’Connor, Kaitlin P. Zawacki, Krista M. Isaac, MARK A. KESTER et al. · 2023 · Journal of Clinical Investigation
2. New high-throughput endstation to accelerate the experimental optimization pipeline for synchrotron X-ray footprinting
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3. PP2A as the Main Node of Therapeutic Strategies and Resistance Reversal in Triple-Negative Breast Cancer
   Henan Zhao, Duojiao Li, Baojing Zhang, Yan Qi, Yun-Peng Diao, Yuhong Zhen, Xiaohong H. Shu · 2017 · Molecules
4. Protein Phosphatases—A Touchy Enemy in the Battle Against Glioblastomas: A Review
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5. Protein phosphatase 2A controls ongoing DNA replication by binding to and regulating cell division cycle 45 (CDC45)
   Abbey L. Perl, Caitlin M. O’Connor, Pengyan Fa, Franklin Mayca Pozo, Junran Zhang, Youwei Zhang, Goutham Narla · 2019 · Journal of Biological Chemistry
6. Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis
   Hiroyuki Kato, Keisuke Tateishi, Hiroaki Fujiwara, Hideaki Ijichi, Keisuke Yamamoto, Takuma Nakatsuka, Miwako Kakiuchi, Makoto Sano, Yotaro Kudo, Yoku Hayakawa et al. · 2020 · Cancer Genomics & Proteomics
7. From Tyrosine Kinases to Tyrosine Phosphatases: New Therapeutic Targets in Cancers and Beyond
   Yu Zhou, Zhimeng Yao, Yusheng Lin, Hao Zhang · 2024 · Pharmaceutics
8. Biology of the adenovirus E4orf4 protein: from virus infection to cancer cell death
   Tamar Kleinberger · 2019 · FEBS Letters
9. Rationale for MYC imaging and targeting in pancreatic cancer
   Günter Schneider, Matthias Wirth, Ulrich Bernd Keller, Dieter Saur · 2021 · EJNMMI Research
10. Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines
    Sylvestre P. J. T. Bachollet, Vito Vece, Alison N. McCracken, Brendan T. Finicle, Elizabeth M. Selwan, Nadine Ben Romdhane, Amogha Dahal, Cuauhtemoc B. Ramirez, Aimee L. Edinger, Stephen Hanessian · 2020 · ACS Medicinal Chemistry Letters
11. A Cancer-Associated Missense Mutation in PP2A-Aα Increases Centrosome Clustering during Mitosis
    Noelle V. Antao, Marina Marcet-Ortega, Paolo Cifani, Alex Kentsis, Emily A. Foley · 2019 · iScience
12. PP2A alleviates oxidized LDL-induced endothelial dysfunction by regulating LOX-1/ROS/MAPK axis
    Kaicheng Xu, Xiwen Liu, Dexin Yin, Guanghao Ren, Yue Zhao · 2020 · Life Sciences
13. PPP2R4 dysfunction promotes KRAS-mutant lung adenocarcinoma development and mediates opposite responses to MEK and mTOR inhibition
    Bob Meeusen, Emanuela Elsa Cortesi, Judit Domènech Omella, Anna A. Sablina, Juan‐José Ventura, Veerle Janssens · 2021 · Cancer Letters
14. Sensitization of FOLFOX-Resistant Colorectal Cancer Cells via the Modulation of a Novel Pathway Involving Protein Phosphatase 2A
    Satya Narayan, Asif Raza, Iqbal Mahmud, Nayeong Koo, Timothy J. Garrett, Mary E. Law, Brian Keith Law, Arun Kumar Sharma · 2021 · iScience
15. Dephosphorylation of Girdin by PP2A inhibits breast cancer metastasis
    Jiang Li, Atsushi Enomoto, Liang Weng, Lun‐Quan Sun, Masahide Takahashi · 2019 · Biochemical and Biophysical Research Communications
16. LCK‐Mediated RIPK3 Activation Controls Double‐Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A‐ERK Axis
    Sung‐Min Hwang, Yu‐Jin Ha, Gi‐Bang Koo, Hyun‐Jin Noh, A‐Yeon Lee, Byeong‐Ju Kim, Sun Mi Hong, Michael J. Morgan, Seong‐il Eyun, Dakeun Lee et al. · 2022 · Advanced Science
17. PP2A ‐based triple‐strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells
    Oxana V. Denisova, Joni Merisaari, Riikka Huhtaniemi, Xi Qiao, Laxman Yetukuri, Mikael Jumppanen, Amanpreet Kaur, Mirva Pääkkönen, Сarina von Schantz‐Fant, Michael H. J. Ohlmeyer et al. · 2023 · Molecular Oncology
18. Inhibiting PP2Acα Promotes the Malignant Phenotype of Gastric Cancer Cells through the ATM/METTL3 Axis
    Zhaoxiang Cheng, Shan Gao, Xiaojie Liang, Chao Lian, Jianquan Chen, Chao Fang · 2021 · BioMed Research International
19. Discovery of Novel Small-Molecule Scaffolds for the Inhibition and Activation of WIP1 Phosphatase from a RapidFire Mass Spectrometry High-Throughput Screen
    Victor Clausse, Yuhong Fang, Dingyin Tao, Harichandra D. Tagad, Hongmao Sun, Yuhong Wang, Karavadhi Surendra, Kelly C. Lane, Zhendan Shi, Olga V. Vasalatiy et al. · 2022 · ACS Pharmacology & Translational Science
20. The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush
    Mingxing Teng, Damian W. Young, Zhi Tan · 2022 · Journal of Medicinal Chemistry
21. BRG1 promotes progression of B-cell acute lymphoblastic leukemia by disrupting PPP2R1A transcription
    Qian Kang, Dan Ma, Peng Zhao, Xiao Chai, Yi Huang, Rui Gao, Tianzhuo Zhang, Ping Liu, Bo Deng, Cheng Feng et al. · 2024 · Cell Death and Disease
22. Unraveling the CDK9/PP2A/ERK Network in Transcriptional Pause Release and Complement Activation in KRAS‐mutant Cancers
    Yafang Wang, Lansong Xu, Lijun Ling, Mingyue Yao, Shangxuan Shi, Chengcheng Yu, Yingnian Li, Jie Shen, Hualiang Jiang, Chengying Xie · 2024 · Advanced Science
23. Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality
    Jos F. van Pelt, Bob Meeusen, Rita Derua, Liesbeth Guffens, Eric Van Cutsem, Veerle Janssens, Chris Verslype · 2023 · Journal of Translational Medicine
24. RAS and PP2A activities converge on epigenetic gene regulation
    Anna Aakula, Mukund Sharma, Francesco Tabaro, Reetta Nätkin, Jesse Kamila, Henrik Honkanen, Matthieu Schapira, C.H. Arrowsmith, Matti Nykter, Jukka K. Westermarck · 2023 · Life Science Alliance
25. Emerging Roles of B56 Phosphorylation and Binding Motif in PP2A-B56 Holoenzyme Biological Function
    Yanqiao Zhang, Haonan Jiang, Haimeng Yin, Xinyuan Zhao, Yali Zhang · 2024 · International Journal of Molecular Sciences
26. Select Stabilization of a Tumor-Suppressive PP2A Heterotrimer
    Vidhi M. Shah, Isabel A. English, Rosalie C. Sears · 2020 · Trends in Pharmacological Sciences
27. SWATH-MS proteomics of PANC-1 and MIA PaCa-2 pancreatic cancer cells allows identification of drug targets alternative to MEK and PI3K inhibition
    Alain Aguilar‐Valdés, Lilia Guadalupe Noriega, Armando Roberto Tovar, Marı́a de Jesús Ibarra-Sánchez, Víctor A. Sosa‐Hernández, José Luis Maravillas‐Montero, Juan Martínez‐Aguilar · 2021 · Biochemical and Biophysical Research Communications
28. Allosteric activation of PP2A inhibits experimental abdominal aortic aneurysm
    Xianming Zhou, Chao Zhang, Fei Xie, Wei Wei, Rui Li, Qian Xu, Yu Wang, Philip A. Klenotic, Goutham Narla, Nianguo Dong et al. · 2021 · Clinical Science
29. Tonic ATP-mediated growth suppression in peripheral nerve glia requires arrestin-PP2 and is evaded in NF1
    Robert A. Coover, Tabitha E. Healy, Guo Li, Katherine E. Chaney, Robert F. Hennigan, Craig S. Thomson, Lindsey Aschbacher‐Smith, Michael P. Jankowski, Nancy Ratner · 2018 · Acta Neuropathologica Communications
30. PP2A promotes apoptosis and facilitates docetaxel sensitivity via the PP2A/p‑eIF4B/XIAP signaling pathway in prostate cancer
    Siwen Yin, Yong Chen, Hang Tong, Tinghao Li, Zijia Qin, Junlong Zhu, Weiyang He · 2022 · Oncology Letters
31. A SMAP in the face for cancer
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32. KRAS-mediated upregulation of CIP2A promotes suppression of PP2A-B56α to initiate pancreatic cancer development
    Samantha L. Tinsley, Ella Rose D. Chianis, Rebecca A. Shelley, Gaganpreet K. Mall, Alisha Dhiman, Garima Baral, Harish Kothandaraman, Mary C. Thoma, Isabel A. English, Colin J. Daniel et al. · 2024 · Oncogene
33. Direct observation of small molecule activator binding to single PR65 protein
    Annie Yang-Schulz, Maria Zacharopoulou, Sema Zeynep Yilmaz, Anupam Banerjee, Satyaki Saha, Daniel Nietlispach, Michael H. J. Ohlmeyer, Mert Gür, Laura S. Itzhaki, İvet Bahar et al. · 2025 · npj Biosensing
34. MYC at the tumor–immune interface: mechanisms of immune escape and immunotherapy resistance
    Íñigo González-Larreategui, M. C. Martin, Sílvia Casacuberta‐Serra, Laura Soucek · 2026 · Frontiers in Immunology
35. An okadaic acid fragment analogue prevents nicotine-induced resistance to cisplatin by recovering PP2A activity in non-small cell lung cancer cells
    Raquel L. Arribas, Anna Bordas, Judit Domènech Omella, José Luis Cedillo, Veerle Janssens, Carmen Montiel, Cristóbal de los Rı́os · 2020 · Bioorganic Chemistry
36. Protein Phosphatase 2a Inhibits Gastric Cancer Cell Glycolysis by Reducing MYC Signaling
    Wei Zhang, Zhenhua Cai, Ruiqing Zhou, Xiaohui Liu, Yunzhang Feng, Yunzhang Feng · 2022 · Cell Biochemistry and Biophysics
37. Targeting protein synthesis pathways in MYC-amplified medulloblastoma
    Devendra Kumar, Ranjana Kumari Kanchan, Nagendra K. Chaturvedi · 2025 · Discover Oncology
38. GSK3β is a critical, druggable component of the network regulating the active NOTCH1 protein and cell viability in CLL
    Filomena De Falco, Chiara Rompietti, Daniele Sorcini, Angela Espósito, Annarita Scialdone, Stefano Baldoni, Beatrice Del Papa, Francesco Maria Adamo, Estevão Carlos Silva Barcelos, Erica Dorillo et al. · 2022 · Cell Death and Disease
39. The Effects of Protein Phosphatase 2A Activation with Novel Tricyclic Sulfonamides on Hepatoblastoma
    Laura V. Bownes, Janet Rae Julson, Colin H. Quinn, Sara Claire Hutchins, Michael H. Erwin, Hooper R. Markert, Jerry E. Stewart, Elizabeth Mroczek‐Musulman, Jamie M. Aye, Karina Jin Yoon et al. · 2023 · Journal of Pediatric Surgery
40. Rules for PP2A-controlled phosphosignalling and drug responses
    Otto Kauko, Susumu Y. Imanishi, Evgeny Kulesskiy, Teemu D. Laajala, Laxman Yetukuri, Anni Laine, Mikael Jumppanen, Pekka Haapaniemi, Luyao Ruan, Bhagwan Yadav et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
41. Small-Molecule Activation of Protein Phosphatase 2A Counters Bleomycin-Induced Fibrosis in Mice
    Meshach Pillai, P. Lafortune, Abdoulaye Jules Dabo, Howard K.Y. Yu, Sangmi S. Park, H. Taluru, Huma Ahmed, Dylan Bobrow, Zeeshan Sattar, Bakr Jundi et al. · 2023 · ACS Pharmacology & Translational Science
42. Small-molecule modulators of B56-PP2A restore 4E-BP function to suppress eIF4E-dependent translation in cancer cells
    Michelle A. Lum, Kayla A. Jonas, Shreya Parmar, Adrian R. Black, Caitlin M. O’Connor, Stephanie Dobersch, Naomi Yamamoto, Tess M. Robertson, Aidan Schutter, Miranda Giambi et al. · 2025 · Journal of Clinical Investigation
43. Targeting T-type channels in cancer: What is on and what is off?
    Anna Visa, Lía Alza, Adrián Casas-Benito, Judit Herreros, Carles Cantı́ · 2021 · Drug Discovery Today
44. Phosphatase Dysregulation in Cancer: Signaling Pathways and Therapeutic Opportunities
    Maryam Jama, Michael Overduin, Khaled Barakat · 2025 · MedComm – Oncology
45. Splice of Life for Cancer: Missplicing of PPP2R5A by Mutant SF3B1 Leads to MYC Stabilization and Tumorigenesis
    Caitlin M. O’Connor, Goutham Narla · 2020 · Cancer Discovery
46. C-glycosides analogues of the okadaic acid central fragment exert neuroprotection via restoration of PP2A-phosphatase activity: A rational design of potential drugs for Alzheimer's disease targeting tauopathies
    Raquel L. Arribas, Lucía Viejo, Isaac Bravo, Minerva Martinez-Castillo, Eva Ramos, Alejandro Romero, Eva M. García‐Frutos, Veerle Janssens, Carmen Montiel, Cristóbal de los Rı́os · 2023 · European Journal of Medicinal Chemistry
47. Novel PP2A-Activating Compounds in Neuroblastoma
    Nazia Nazam, Laura V. Bownes, Janet Rae Julson, Colin H. Quinn, Michael H. Erwin, Raoud Marayati, Hooper R. Markert, Sorina Shirley, Jerry E. Stewart, Karina Jin Yoon et al. · 2024 · Cancers
48. Cancer stem cell phosphatases
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49. Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Emphysema
    Brian Soto, Huma Ahmed, Meshach Pillai, Sangmi S. Park, Magdalena A. Ploszaj, Joshua Reece, H. Taluru, Dylan Bobrow, Howard K.Y. Yu, P. Lafortune et al. · 2023 · American Journal of Respiratory Cell and Molecular Biology
50. Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases
    Howard K.Y. Yu, Sahil Zaveri, Zeeshan Sattar, Michael Schaible, Brais Perez Gandara, Anwar Uddin, Lucas R. McGarvey, Michael H. J. Ohlmeyer, Patrick M. Geraghty · 2023 · Medicina
51. PP2A as a New Player in Chronic Obstructive Pulmonary Disease
    Xiuying Li, Toru Nyunoya · 2018 · American Journal of Respiratory Cell and Molecular Biology
52. Protein Phosphatase 2A Activation Promotes Heart Transplant Acceptance in Mice
    Xianming Zhou, Qian Xu, Wangzi Li, Nianguo Dong, Colin T. Stomberski, Goutham Narla, Zhiyong Lin · 2023 · Transplantation
53. Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells
    Oxana V. Denisova, Joni Merisaari, Amanpreet Kaur, Laxman Yetukuri, Mikael Jumppanen, Carina von Schantz, Michael H. J. Ohlmeyer, Krister Wennerberg, Tero A. Aittokallio, Mikko Taipale et al. · 2022 · Scientific Reports
54. Identification of a Novel Protein Phosphatase 2A Activator, PPA24, as a Potential Therapeutic for FOLFOX-Resistant Colorectal Cancer
    Hannah Johnson, Amandeep Singh, Asif Raza, Congzhou Mike Sha, Jian Wang, Krishne Gowda, Zhihang Shen, Nair Hariprasad Haritha, Chenglong Li, Nikolay V. Dokholyan et al. · 2024 · Journal of Medicinal Chemistry
55. PP2A activation targets MYCN in neuroblastoma
    Nazia Nazam, Shamza Manzoor, Maryam G. Shaikh, Morgan L. Brown, Janet Rae Julson, Colin H. Quinn, Swatika P. Butey, Sorina N. Shirley, Jamie M. Aye, Karina Jin Yoon et al. · 2026 · Cell Death and Disease
56. Design, Synthesis, and Bioevaluation of Adamantane‐1‐Carboxamide N‐Acylthioureas for Airway Antiallergic Therapy
    Rahimeh Eshaghi Malekshah, Amir Karim, Chi‐Xin Guo, Yu‐Ting Chu, Feng‐Ming Yang, Sung‐Po Hsu, S. C. Hsu · 2026 · ChemBioChem
57. Protein phosphatase 2A regulates senescence and immunogenicity in medulloblastoma models
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58. PP2A Attenuates Thoracic Aneurysm and Dissection in Mouse Models of Marfan Syndrome
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59. The pro-apoptotic peptide PEP-010 triggers apoptosis in pancreatic tumor models in monotherapy and in combination with gemcitabine independently of the KRAS status
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60. Small Molecule Activator of Phosphatase PP2A Remodels Scaffold PR65 Structural Dynamics To Promote Holoenzyme Assembly
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61. Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilizing Effects on the Scaffold PR65
    Mohsin M. Naqvi, Maria Zacharopoulou, Satyaki Saha, Anupam Banerjee, Sema Zeynep Yilmaz, Vanda Šunderlíková, Christopher M. Johnson, Janet R. Kumita, Shang-Hua Yang, Reuven Gordon et al. · 2026 · JACS Au
62. Activation of PP2A-B56a leads to aberrant EGFR signaling and proliferative phenotypes in PDAC
    Claire M. Pfeffer, Sydney J. Clifford, Saadia A. Karim, Ella Rose D. Chianis, . Heil Brittany N, Lauren E. Gartenhaus, Emma F. Kay, Garima Baral, Elizabeth G. Hoffman, Sagar M. Utturkar et al. · 2026 · Molecular Cancer Therapeutics
63. The use of protein phosphatase 2A activators in combination therapies for pancreas cancer
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64. GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis
    Xiaoni Shi, Shaoqi Yang, Wei Luo, Sha Wang, Jie Huang, Meng‐Ling Chen, Jing Wang, Yusi Cheng, Xinxin Zhang, Jie Chao · 2022 · Research Square
65. Reply: Relevance of the PP2A Pathway in the Molecular Mechanisms of Chronic Obstructive Pulmonary Disease
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66. Study on the Differentially Expressed Genes and Signaling Pathways in Systemic Lupus Erythematosus Using Integrated Bioinformatics Method
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67. PPP2R3A Affects the Function and Mechanism of Heterogeneous Fibroblasts in Pulmonary Fibrosis
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68. Faculty Opinions recommendation of Selective PP2A Enhancement through Biased Heterotrimer Stabilization.
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69. Supplementary Tables and Figures from PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition–Dependent GSK-3β–Mediated c-Myc and Pim-1 Proteasomal Degradation
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70. Data from PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition–Dependent GSK-3β–Mediated c-Myc and Pim-1 Proteasomal Degradation
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71. Data from Small-Molecule–Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death
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72. eLife Assessment: Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16
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73. Protein phosphatase 2A activators under investigation for smoking-related chronic obstructive pulmonary disease and related disorders
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74. Phosphatases: An undervalued class of antitumor drug targets
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75. Additional file 1 of GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis
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76. Additional file 1 of Human pancreatic cancer patients with Epithelial-to-Mesenchymal Transition and an aggressive phenotype show a disturbed balance in Protein Phosphatase Type 2A expression and functionality
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77. The protein phosphatase 2A-B56α complex regulates N-Myc degradation in neuroblastoma
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79. Cell penetrating and interfering peptides as new cancer therapy
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80. Développement d'antiviraux à large spectre contre le virus de la rage et les autres virus à ARN négatif
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83. Corynoxine Inhibits Tumor Growth via Targeting NQO1 and Modulating the PTPA–NQO1/PP2A Switch to Activate PP2A
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84. Quantitative SAR of Oleanolic Acid Derivatives at the Kinase–Phosphatase Interface: PTP1B Selectivity and RTK Pharmacology in Cancer
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85. PP2A targeting: balancing anticancer potential and neurological risk
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86. “Locking” CDK9 inhibition by activating integrator function in HIV transcription
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87. BindingDB Entry 50017445: The Pursuit of Enzyme Activation: A Snapshot of the Gold Rush.
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88. BindingDB Entry 50018255: Strategies for Targeting Serine/Threonine Protein Phosphatases with Small Molecules in Cancer.
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89. BindingDB Entry 50020539: The evolution of small molecule enzyme activators.
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