The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Neuroanatomical correlates of externally and internally generated human emotion
Open accessAbstract
OBJECTIVE: Positron emission tomography was used to investigate the neural substrates of normal human emotional and their dependence on the types of emotional stimulus. METHOD: Twelve healthy female subjects underwent 12 measurements of regional brain activity following the intravenous bolus administration of [15O]H2O as they alternated between emotion-generating and control film and recall tasks. Automated image analysis techniques were used to characterize and compare the increases in regional brain activity associated with the emotional response to complex visual (film) and cognitive (recall) stimuli. RESULTS: Film- and recall-generated emotion were each associated with significantly increased activity in the vicinity of the medial prefrontal cortex and thalamus, suggesting that these regions participate in aspects of emotion that do not depend on the nature of the emotional stimulus. Film-generated emotion was associated with significantly greater increases in activity bilaterally in the occipitotemporparietal cortex, lateral cerebellum, hypothalamus, and a region that includes the anterior temporal cortex, amygdala, and hippocampal formation, suggesting that these regions participate in the emotional response to certain exteroceptive sensory stimuli. Recall-generated sadness was associated with significantly greater increases in activity in the vicinity of the anterior insular cortex, suggesting that this region participates in the emotional response to potentially distressing cognitive or interoceptive sensory stimuli. CONCLUSIONS: While this study should be considered preliminary, it identified brain regions that participate in externally and internally generated human emotion.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Reiman et al. (1997) used either film clips or personal recall to generate emotional response and found that internal and external generation of emotion depended on subtly different brain regions.”
From Affective Cognition and its Disruption in Mood Disorders (2011) · cites this paper as Reiman et al. (1997)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199403000-00005 · Cited by 3,431
Object vision and spatial vision: Two cortical pathways
Mishkin, M., Ungerleider, L. G., & Macko, K. A. (1983) · Trends in Neurosciences · doi:10.1016/0166-2236(83)90190-x · Cited by 2,947
Circuitry and functional aspects of the insular lobe in primates including humans
AUGUSTINE, J. (1996) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00011-2 · Cited by 1,776
Comparing Functional (PET) Images: The Assessment of Significant Change
Friston, K. J., Frith, C., Liddle, P. F., & Frackowiak, R. S. J. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.122 · Cited by 1,626
Self-citationFunctional neuroanatomy of face and object processing. A positron emission tomography study.
Sergent, J., Ohta, S., & Macdonald, B. (1992) · Brain : a journal of neurology · doi:10.1093/brain/115.1.15 · Cited by 1,576
The Return of Phineas Gage: Clues About the Brain from the Skull of a Famous Patient
Damásio, H., Grabowski, T. J., Frank, R. J., Galaburda, A. M., & Damásio, A. R. (1994) · Science · doi:10.1126/science.8178168 · Cited by 1,520
(1972) · Elsevier eBooks · doi:10.1016/c2013-0-02458-9 · Cited by 1,463
Kihlstrom, J. F. (1987) · Science · doi:10.1126/science.3629249 · Cited by 1,405
Flagged first, then by citations
Research works printed but not linked: 9
- LeDoux JE, 1987, Handbook of Physiology: The Nervous System, V: Higher Cortical Functions of the Brain, 419
- Fox PT, 1989, J Nucl Med, 30, 141
- Lane RD, Davidson RJ
- Spitzer RL, 1990, Gibbon M
- Mintun MA, 1990, J Nucl Med, 31, 816
- Reiman EM, Lane RD, Ahern GL, Schwartz GE, Davidson RJ: Functional brain imaging, emotion, and consciousness, in Toward a Scientific Basis for Consciousness: The First Tucson Discussions and Debates. Edited by Hameroff SR, Kaszniak AW, Scott AC. Boston,MIT Press, 1996, pp311-320
- Goldman-Rakic PS, 1987, Handbook of Physiology: The Nervous System, V: Higher Cortical Functions of the Brain, 373
- Mesulam M-M, 1985, Principals of Behavioral Neurology
- Lang PJ, 1995, Bradley MM
Cited by
Sorted by citations
Items 401–500 of 713
Neural Correlates of Emotion Perception: From Faces to Taste
Phillips, M. L., & Heining, M. (2002) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546389.018 · Cited by 46
Emotion–Perception Interplay in the Visual Cortex: “The Eyes Follow the Heart”
Hendler, T., Rotshtein, P., & Hadar, U. (2001) · Cellular and Molecular Neurobiology · doi:10.1023/a:1015156222101 · Cited by 45
“In addition, functional brain-imaging findings in healthy subjects demonstrated both an emotional effect in visual cortex (Breiter et al., 1996; Critchley et al., 2000a; George et al., 1995; Kosslyn et al., 1996; Lane et al., 1997, 1999; Lang et al., 1996, 1998; Morris et al., 1998; Reiman et al., 1997; Taylor et al.,…”
BackgroundCerebellar activity and connectivity during the experience of disgust and happiness
Schienle, A., & Scharmüller, W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.048 · Cited by 43
“In healthy individuals, visually elicited negative and positive affect has been consistently associated with cerebellar activation (e.g., Lane et al., 1997; Paradiso et al., 1997, 2003; Reiman et al., 1997; Bermpohl et al., 2006; Moulton et al., 2011).”
BackgroundVorobyev, V., Kwon, M. S., Moe, D., Parkkola, R. K., & Hämäläinen, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129516 · Cited by 45
Affect and the Brain's Functional Organization: A Resting-State Connectivity Approach
Rohr, C. S., Okon‐Singer, H., Craddock, R. C., Villringer, A., & Margulies, D. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068015 · Cited by 42
“One potential explanation is that the mPFC may have a role in detecting emotional signals, regardless of whether they are internally or externally generated [47].”
BackgroundIsotretinoin and neuropsychiatric side effects: Continued vigilance is needed
Bremner, J. D. (2021) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2021.100230 · Cited by 50
The dynamic reorganization of the default-mode network during a visual classification task
Gao, W., Gilmore, J. H., Alcauter, S., & Lin, W. (2013) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2013.00034 · Cited by 43
“Particularly, the VER has been reported to contain axonal dopamine transporter immunoreactivity and is related to incentive-related behaviors (Anderson et al., 2006) and emotional processing (Lane et al., 1997b; Reiman et al., 1997).”
BackgroundEmotion development system by interacting with human EEG and natural scene understanding
Zhang, Q., & Lee, M. (2011) · Cognitive Systems Research · doi:10.1016/j.cogsys.2010.12.012 · Cited by 43
Yi, D., Lee, D. Y., Sohn, B. K., Choe, Y. M., Seo, E. H., Byun, M. S., & Woo, J. I. (2014) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.12.173 · Cited by 42
Neural bases of dysphoria in early Huntington's disease
Paradiso, S., Turner, B. M., Paulsen, J. S., Jorge, R. E., Ponto, L. L. B., & Robinson, R. G. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.04.001 · Cited by 46
“, 2000) and has been posited to be a neural node subserving the experiential aspects of emotion (Reiman et al., 1997).”
BackgroundSchiffer, F., Teicher, M. H., Anderson, C. M., Tomoda, A., Polcari, A. M., Navalta, C. P., & Andersen, S. L. (2007) · Behavioral and Brain Functions · doi:10.1186/1744-9081-3-13 · Cited by 43
Strazielle, C., Jazi, R., Verdier, Y., Qian, S., & Lalonde, R. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.08.005 · Cited by 43
Surguladze, S. A., Chu, E. M.-Y., Marshall, N., Evans, A., Anilkumar, A. P., Timehin, C., McDonald, C., Ecker, C., Phillips, M. L., & David, A. S. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110363316 · Cited by 38
“In the neuroimaging literature, cerebellar activation has been reported in healthy subjects during perception of emotional signals (Phan et al., 2002; Bermpohl et al., 2006), induction of feelings of sadness, anxiety (Liotti et al., 2000; Reiman et al., 1997) or happiness (Habel et al., 2005b).”
BackgroundYang, J.-C. (2004) · Korean Journal of Radiology · doi:10.3348/kjr.2004.5.2.87 · Cited by 41
“Although the exact function of this cortical area remains to be elucidated, there is some evidence that the medial prefrontal cortex is involved in the conscious experience of emotion (34).”
BackgroundKarama, S., Armony, J. L., & Beauregard, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022343 · Cited by 39
“While individual studies of emotion have generally reported the involvement of limbic and paralimbic structures, few have explicitly commented on the overlap across emotion conditions [10,13,14,15,16,17,18,19,20,21,22,23,24,25].”
BackgroundLiu, C. C., Hajra, S. G., Cheung, T., Song, X., & D’Arcy, R. C. N. (2017) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2017.00489 · Cited by 39
Functional brain imaging in neuropsychology over the past 25 years.
Roalf, D. R., & Gur, R. C. (2017) · Neuropsychology · doi:10.1037/neu0000426 · Cited by 42
“…Kaiser, & Hommer, 2000; O’Doherty, Kringelbach, Rolls, Hornak, & Andrews, 2001; Zalla et al., 2000), and viewing of emotionally provocative stimuli (Breiter et al., 1996; Canli, Zhao, Brewer, Gabrieli, & Cahill, 2000; Irwin et al., 1996; Lane et al., 1997; Morris et al., 1998; Reiman et al., 1997).”
Functional subdivisions in the anterior temporal lobes: a large scale meta-analytic investigation
Hung, J., Wang, X., Wang, X., & Bi, Y. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.05.008 · Cited by 41
Zimbardo, P. G. (1999) · Advances in experimental social psychology · doi:10.1016/s0065-2601(08)60276-2 · Cited by 39
“The amygdala has recently been shown (on PET scans) to respond more strongly to externally stimulated emotional stimuli than to memory-generated emotions (Reiman et al., 1997).”
BackgroundEmotion-based learning: insights from the Iowa Gambling Task
Turnbull, O. H., Bowman, C. H., Shanker, S., & Davies, J. L. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00162 · Cited by 47
“J., and Dudycha, M. M. (1941). Childhood memories: a review of the”
BackgroundInfluentialSchmahmann, J. D. (2000) · Elsevier eBooks · doi:10.1016/b978-012692545-6/50010-6 · Cited by 39
Yasuno, F., Kudo, T., Matsuoka, K., Yamamoto, A., Takahashi, M., Nakagawara, J., Nagatsuka, K., Iida, H., & Kishimoto, T. (2016) · BJPsych Open · doi:10.1192/bjpo.bp.116.002683 · Cited by 38
Shah, A. J., Chen, C., Campanella, C., Kasher, N., Evans, S., Reiff, C. M., Mishra, S., Hammadah, M., Lima, B. B., Wilmot, K. A., et al. (2018) · Psychophysiology · doi:10.1111/psyp.13291 · Cited by 38
“This statistic minimizes risk of both Type 1 and Type 2 error (Lane, Reiman, Ahern, Schwartz, & Davidson, 1997; Reiman et al., 1997).”
BackgroundAltered Neural Cholinergic Receptor Systems in Cocaine-Addicted Subjects
Adinoff, B. H., Devous, M. D., Williams, M. J., Best, S. E., Harris, T. S., Minhajuddin, A., Zielinski, T., & Cullum, C. M. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.18 · Cited by 38
The role of the anterior cingulate cortex in pitch variation during sad affect
Barrett, J., Pike, G. B., & Paus, T. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2003.03113.x · Cited by 37
The Neurobiology of Mindfulness
Treadway, M. T., & Lazar, S. W. (2009) · Clinical Handbook of Mindfulness · doi:10.1007/978-0-387-09593-6_4 · Cited by 64
“Studies have also highlighted the role of the insula in internally generated emotions ( Reiman, Lane, Ahern, & Scwartz, 1997 ) as well as during guilt (Shin et al., 2000).”
BackgroundThe correlation between Emotional Intelligence and gray matter volume in university students
Tan, Y., Zhang, Q., Li, W., Wei, D., Qiao, L., Qiu, J., Hitchman, G., & Liu, Y. (2014) · Brain and Cognition · doi:10.1016/j.bandc.2014.08.007 · Cited by 40
“Several studies presented evidence of the role of the insular cortex in monitoring somatic and visceral states (Craig, 2003, 2009; Critchley, Mathias, & Dolan, 2002; Critchley et al., 2005; Dunckley et al., 2005; Jabbi & Keysers, 2008; Reiman et al., 1997; Saarela et al., 2007; Singer, Critchley, & Preuschoff, 2009; T…”
BackgroundTHE RELATIONSHIP BETWEEN MAGNITUDE OF CEREBRAL ACTIVATION AND INTENSITY OF EMOTIONAL AROUSAL
FOSTER, P. S., & Harrison, D. W. (2002) · International Journal of Neuroscience · doi:10.1080/00207450290158359 · Cited by 37
“Finally, induction of sadness has resulted in increased activation within the bilateral insular (George et al., 1995; Partiot, Grafman, Sadato, Wachs, & Hallett, 1995; Reiman et al., 1997) as well as the bilateral anterior, middle, and posterior temporal cortices (Lane et al., 1997).”
BackgroundInfluentialNeural correlates of emotional recognition memory in schizophrenia: effects of valence and arousal.
Lakis, N., Jiménez, J., Mancini-Marı̈e, A., Stip, E., Lavoie, M., & Mendrek, A. (2011) · Psychiatry Research · doi:10.1016/j.pscychresns.2011.05.010 · Cited by 38
“In healthy subjects, activation in the cerebellum has been reported during the induction of feelings of sadness, anxiety (Reiman et al., 1997; Liotti et al., 2000), happiness (Habel et al.”
BackgroundStraube, T., Preißler, S., Lipka, J., Hewig, J. S., Mentzel, H., & Miltner, W. H. R. (2009) · Human Brain Mapping · doi:10.1002/hbm.20843 · Cited by 36
“…consistent with previous studies, which showed stronger activation in visual regions in response to aversive and generally emotional, as compared to neutral movie clips [Goldin et al., 2005; Lane et al., 1998; Paradiso et al., 1997; Reiman et al., 1997; Stark et al., 2005; Straube et al., 2006a,b].”
BackgroundMethodResultInfluentialThe Neurobiology of Pain, Affect and Hypnosis
Feldman, J. B. (2004) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2004.10403599 · Cited by 38
“Phan et al. (2002) point out that Reiman et al. (1997) posited that the insula may function as an "alarm center" for internally-sensed dangers or homeostatic changes.”
BackgroundAssociations between the perception of dyspnea, pain, and negative affect
Schön, D., Dahme, B., & von Leupoldt, A. (2008) · Psychophysiology · doi:10.1111/j.1469-8986.2008.00704.x · Cited by 38
“As has been suggested by Reiman, Lane, and Ahern (1997), it might, therefore, be speculated that these cortical areas are commonly involved in the processing of potentially distressing interoceptive stimuli, investing them with negative affective significance.”
BackgroundImpact of gender and genetics on emotion processing in Parkinson's disease - A multimodal study
Heller, J., Mirzazade, S., Romanzetti, S., Habel, U., Derntl, B., Freitag, N. M., Schulz, J. B., Dogan, I., & Reetz, K. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.01.034 · Cited by 37
Beking, T., Burke, S., Geuze, R. H., Staphorsius, A. S., Bakker, J., Groothuis, T. G. G., & Kreukels, B. P. C. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104461 · Cited by 33
Neural correlates of social cognition in populations at risk of psychosis: A systematic review
Kozhuharova, P., Saviola, F., Ettinger, U., & Allen, P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.010 · Cited by 36
Amigdala, corteza prefrontal y especializacion hemisferica en la experiencia y expresion emocional
Sánchez‐Navarro, J. P., & Román, F. J. (2004) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 35
Macefield, V. G., Gandevia, S. C., & Henderson, L. A. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl113 · Cited by 35
Insular volumes in first-episode schizophrenia: gender effect
Duggal, H. S., Muddasani, S., & Keshavan, M. S. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2004.08.027 · Cited by 36
“fluency, speech articulation, recall of internally generated emotions, particularly sadness, selective attention and attaching emotional valence to pleasant stimuli (Paulesu et al., 1993; Guenther, 2001; Reiman et al., 1997; Corbetta et al., 1991; CrespoFacorro et al., 2001).”
BackgroundBrain processing of tonic muscle pain induced by infusion of hypertonic saline
Thunberg, J., Lyskov, E., Korotkov, A. D., Ljubisavljević, M., Pakhomov, S. V., Катаева, Г. В., Radovanovic, S. M., Medvedev, S. V., & Johansson, H. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.05.003 · Cited by 35
Responsible AI: Gender bias assessment in emotion recognitionPreprint
Domnich, A., & Anbarjafari, G. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2103.11436 · Cited by 84
“During last decades, people were trying to justify, classify and investigate emotions [33, 34, 35, 36, 37].”
BackgroundKrauch, M., Ueltzhöffer, K. J., Brunner, R. M., Kaess, M., Hensel, S., Herpertz, S. C., & Bertsch, K. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00057 · Cited by 33
“…thalamus and hippocampus in response to descriptions of other-directed aggressive reactions speak for enhanced elevated bottom up emotion generation (Reiman et al., 1997) and may indicate deficits in the processing of contextual information (Holland and Bouton, 1999; Liberzon and Abelson, 2016).”
BackgroundBasal ganglia volumetric studies in affective disorder: what did we learn in the last 15 years?
Bonelli, R. M., Kapfhammer, H., Pillay, S. S., & Yurgelun-Todd, D. A. (2005) · Journal of Neural Transmission · doi:10.1007/s00702-005-0372-7 · Cited by 34
“It seems that while the cingulate and the prefrontal cortex activate acutely during mood challenges (Dolan et al., 1996; Maddock, 1999; Reiman et al., 1997), dysfunctions in the limbic-cortical-striatal-pallidal-thalamic circuits represent a traitlike abnormality in major depression (Neumeister et al.”
BackgroundShirao, N., Okamoto, Y., Okada, G., Ueda, K., & Yamawaki, S. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0566-x · Cited by 34
“As to the thalamus, an fMRI study revealed that the BOLD signal in the left thalamus was significantly increased during processing of high-valence facial expressions including happy and angry expressions [7], and several functional neuroimaging studies reported that the thalamus was activated when viewing films, viewi…”
BackgroundIndividual variation in neural correlates of sadness in children: A twin fMRI study
Côté, C., Beauregard, M., Girard, A., Mensour, B., Mancini-Marı̈e, A., & Pérusse, D. (2007) · Human Brain Mapping · doi:10.1002/hbm.20400 · Cited by 34
“The use of such an uncorrected threshold was motivated by the fact that we are not in the discovery phase of the neural correlates of sadness, but rather in the evaluation of individual differences in activation patterns within brain areas that have previously been identified as correlated to sadness [Beauregard et al…”
BackgroundMethodHarrington, C. R., Beswick, T. C., Graves, M., Jacobe, H. T., Harris, T. S., Kourosh, S., Devous Sr, M. D., & Adinoff, B. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00312.x · Cited by 81
“The insula, particularly the anterior insula, is preferentially involved in the evaluative, experiential or expressive aspects of internally generated emotions (Reiman et al. 1997; Craig 2003) and anterior/middle insular activation has been observed during the ingestion of chocolate in ‘chocolate lovers’ (Small et al.”
BackgroundFeel between the Lines: Implied Emotion in Sentence Comprehension
Lai, V. T., Willems, R. M., & Peter Hagoort, A. (2015) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00798 · Cited by 34
“The insula has been implicated for internally generated emotion, but not so much for externally induced emotion via pictures (Reiman et al., 1997).”
InfluentialLiu, H., Hu, Z., Peng, D., Yang, Y., & Li, K. (2009) · Brain and Language · doi:10.1016/j.bandl.2009.11.001 · Cited by 33
“…studies regarding the role of the insula in processing of unpleasant stimuli, such as the detection of disgust faces (e.g., Phillips et al., 1998), perception of pain (e.g., Treede, Apkarian, Bromm, Greenspan, & Frederich, 1999), and analysis of distressing stimuli (e.g., Reiman et al., 1997).”
BackgroundLenz, F. A., Casey, K. L., Jones, E. G., & Willis, W. D. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511770579 · Cited by 51
Raedt, R. D. (2006) · Scandinavian Journal of Psychology · doi:10.1111/j.1467-9450.2006.00511.x · Cited by 32
Paradiso, S., Robinson, R. G., Ponto, L. L. B., Watkins, G. L., & Hichwa, R. D. (2003) · Journal of Neuropsychiatry · doi:10.1176/jnp.15.1.35 · Cited by 33
Early impact of 5-HTTLPR polymorphism on the neural correlates of sadness
Fortier, É., Noreau, A., Leporé, F., Boivin, M., Pérusse, D., Rouleau, G. A., & Beauregard, M. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.09.026 · Cited by 32
The covariation of cortical electrical activity and cardiovascular responding
Foster, P. S., & Harrison, D. W. (2004) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2003.10.009 · Cited by 32
Brain Mapping: The Applications
Mayberg, H. S., & McGinnis, S. M. (2000) · Elsevier eBooks · doi:10.1016/b978-012692545-6/50018-0 · Cited by 32
The role of dysregulated amygdalic emotion in borderline personality disorder
Corrigan, F. M., Davidson, A., & Heard, H. L. (2000) · Medical Hypotheses · doi:10.1054/mehy.1999.0898 · Cited by 32
Högberg, G. (2011) · Psychology Research and Behavior Management · doi:10.2147/prbm.s10380 · Cited by 35
Constrained Spherical Deconvolution Tractography Reveals Cerebello-Mammillary Connections in Humans
Cacciola, A., Milardi, D., Calamuneri, A., Bonanno, L., Marino, S., Ciolli, P., Russo, M., Bruschetta, D., Duca, A., Trimarchi, F., et al. (2016) · The Cerebellum · doi:10.1007/s12311-016-0830-9 · Cited by 31
Paradiso, S., Ostedgaard, K. L., Vaidya, J. G., Ponto, L. L. B., & Robinson, R. (2012) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2012.05.008 · Cited by 31
“, 2001; Dum and Strick, 2003), although a number of studies have revealed increased cerebellar activity during emotion tasks (George et al., 1993; Paradiso et al., 1997, 2003; Reiman et al., 1997) while lesion studies show deficits in emotional experience (Turner et al.”
BackgroundNeuroticism associated with neural activation patterns to positive stimuli
Britton, J. C., Ho, S.-H., Taylor, S. F., & Liberzon, I. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.06.003 · Cited by 30
“Fittingly, the dMPFC has been shown to be more responsive to internally driven emotional states (Reiman et al., 1997), and it has been implicated in self-relatedness, as evidenced by increased dMPFC activation during self-referential judgments of words (Fossati et al.”
BackgroundEmotions: From neuropsychology to functional imaging
Berthoz, S., Blair, J., Clec’H, G. L., & Martinot, J. (2002) · International Journal of Psychology · doi:10.1080/00207590244000016 · Cited by 31
Matsuda, Y.-T., Fujimura, T., Katahira, K., Okada, M., Ueno, K., Cheng, K., & Okanoya, K. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00551 · Cited by 37
“…rather than the physical aspects of faces (Rotshtein et al., 2005; Fox et al., 2009b) and that the mPFC is activated when a subject perceives or attempts to regulate the effects of an emotionally evocative stimulus (Lane et al., 1997; Reiman et al., 1997; Ochsner et al., 2002; Phan et al., 2002).”
BackgroundHajszán, T., & Záborszky, L. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10279 · Cited by 31
“…interactions in processing of emotional experience and memory Functional imaging studies in humans show that several subcortical and cortical structures are engaged in encoding, expression, and recall of emotions (Rauch et al., 1996; Zald and Pardo, 1997; Reiman et al., 1997; Taylor et al., 1998).”
BackgroundFunctional MRI changes before and after onset of reported emotions
Prohovnik, I., Skudlarski, P., Fulbright, R. K., Gore, J. C., & Wexler, B. E. (2004) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2004.03.005 · Cited by 31
Kurita, S., Takei, Y., Maki, Y., Hattori, S., Uehara, T., Fukuda, M., & Mikuni, M. (2015) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12361 · Cited by 30
Alexithymia in healthy young men: A voxel-based morphometric study
Heinzel, A., Minnerop, M., Schäfer, R. B., Müller, H., Franz, M., & Hautzel, H. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.06.012 · Cited by 30
“This hypothesis fits in with functional imaging studies that support the crucial role of the ACC in emotional processing in healthy subjects and subjects with emotional disorders (Grimm et al., 2009; Lane et al., 1998; Larisch et al., 1997; Northoff et al., 2007; Reiman et al., 1997).”
ResultEmotion in voice matters: Neural correlates of emotional prosody perception
Iredale, J. M., Rushby, J. A., McDonald, S., Marco, A. D.-D., & Swift, J. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.06.025 · Cited by 30
Shen, Z., Jiang, L., Yang, S., Ye, J., Dai, N., Liu, X., Li, N., Lü, J., Liu, F., Lü, Y., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184712 · Cited by 31
van Eijndhoven, P., van Wingen, G. A., Fernández, G., Rijpkema, M., Verkes, R. J., Buitelaar, J. K., & Tendolkar, I. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.040 · Cited by 33
“The insula has been implicated before in memory formation (Kirwan et al., 2008), but is more generally known for its role in mood regulation (Reiman et al., 1997).”
Engagement of multifocal neural circuits during recall of autobiographical happy events
Cerqueira, C. T., Almeida, J., Gorenstein, C., Gentil, V., Leite, C. C., Sato, J. R., Amaro, E., & Busatto, G. F. (2008) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2008001200006 · Cited by 30
“The insula is seen as relevant to the cortical mapping of information pertaining to bodily features that accompany emotional reactions, having a specific role in the central representation of emotion-related internal visceral responses (8,29,35).”
BackgroundTseng, A., Wang, Z., Huo, Y., Goh, S., Russell, J. A., & Peterson, B. S. (2015) · Human Brain Mapping · doi:10.1002/hbm.23041 · Cited by 30
“Thus, we posit that TD participants enlisted more attentional resources when viewing low-arousal faces because they were attempting to assess and classify lowarousal, ambiguous stimuli [Petersen and Posner, 2012; Posner and Petersen, 1990; Reiman et al., 1997].”
Thermenos, H. W., Makris, N., Whitfield, S., Brown, A., Giuliano, A. J., Lee, E. H., Faraone, S. V., Tsuang, M. T., & Seidman, L. J. (2011) · Bipolar Disorders · doi:10.1111/j.1399-5618.2011.00920.x · Cited by 29
Clouard, C., Jouhanneau, M., Meunier-Salaün, M.-C., Malbert, C., & Val‐Laillet, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037968 · Cited by 29
“[68] found that the ACC was involved in the experience of unpleasant emotions, while the PHC was rather activated by pleasant taste [39].”
BackgroundLingford-Hughes, A. R., Daglish, M. R. C., Stevenson, B. J., Feeney, A., Pandit, S. A., Wilson, S. J., Myles, J. S., Grasby, P. M., & Nutt, D. (2006) · Addiction Biology · doi:10.1111/j.1369-1600.2006.00001.x · Cited by 28
“The medial prefrontal area plays a role in processing positive or negative emotions (Lane et al. 1997; Reiman et al. 1997) and is also a brain region whose metabolism is altered by drugs of abuse, e.”
BackgroundMancini-Marı̈e, A., Potvin, S., Fahim, C., Beauregard, M., Mensour, B., & Stip, É. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0302 · Cited by 28
Cerebral moderation of cardiovascular functioning: A functional cerebral systems perspective
Foster, P. S., Drago, V., Ferguson, B. J., & Harrison, D. W. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.08.021 · Cited by 28
“…following recollection of emotional memories, which is known to produce changes in both cerebral (Foster and Harrison, 2002a; Lane et al., 1997; Markowitsch et al., 2003; Reiman et al., 1997) and cardiovascular functioning (Foster and Webster, 2001; Labouvie-Vief et al., 2003; Marci et al., 2007).”
Bremner, J. D., Vythilingam, M., Vermetten, E. H. G. J. M., & Charney, D. S. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.10.028 · Cited by 29
“A p value of 0.005 has been shown to represent the best trade-off between Type I and Type II errors (Reiman et al., 1997).”
BackgroundInfluentialNK1 receptor antagonism and the neural processing of emotional information in healthy volunteers
McCabe, C., Cowen, P. J., & Harmer, C. J. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709990150 · Cited by 27
“The medial prefrontal cortex is intimately associated with this amygdala circuitry and is also often activated in tasks involving the processing of affective information (Bush et al. 2000 ; Lane et al. 1997; Reiman et al. 1997 ; Yoshimura et al. 2009), particularly those 0.”
BackgroundChaposhloo, M., Nicholson, A. A., Becker, S., McKinnon, M. C., Lanius, R. A., Shaw, S. B., & Initiative, A. D. N. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103417 · Cited by 27
“, 1997) or watching emotional movies (Lane et al., 1997; Reiman et al., 1997).”
BackgroundNeural mechanism for judging the appropriateness of facial affect
Kim, J.-W., Kim, J., Jeong, B., Ki, S. W., Im, D.-M., Lee, S. J., & Lee, H. S. (2005) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2005.08.018 · Cited by 27
Foster, P. S., & Webster, D. G. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(00)00163-x · Cited by 27
“…inŽduction Schwartz et al., 1981; Roberts and Weerts, 1982; Ekman et al., 1983; Cook et al., 1988; Stemmler, 1989; Rime et al., 1990; Sidorova et al., 1992; de Jong-Meyer et al., 1993; George et al., 1995; Partiot et al., 1995; Foster et al., 1997, .1999; Lane et al., 1997; Reiman et al., 1997 .”
Fusar‐Poli, P., Bhattacharyya, S., Allen, P., Crippa, J. A., Borgwardt, S., Martín‐Santos, R., Seal, M. L., O’Carroll, C., Atakan, Z., Zuardi, A. W., et al. (2010) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2009.06.027 · Cited by 26
Investigation of an emotion perception test using functional magnetic resonance imaging
Bae, S., Kang, K. D., Kim, S. W., Shin, Y., Nam, J. J., & Han, D. H. (2019) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2019.104994 · Cited by 26
Aberrant White Matter Microstructure in Depressed Patients with Suicidality
Zhang, H., Li, H., Yin, L., Chen, Z., Wu, B., Huang, X., Jia, Z., & Gong, Q. (2021) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27927 · Cited by 25
“The thalamus plays an important mediator role between the limbic system and the cerebral cortex, and thereby participates in the neural processing of emotional regulation and executive function.(26) Despite the mixed findings reported for the involvement of structural alterations in the thalamus in relation to suicide…”
ResultGray matter correlates of dispositional optimism: A voxel-based morphometry study
Yang, J., Wei, D., Wang, K., & Qiu, J. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.08.032 · Cited by 28
“Researchers have observed that the thalamus plays an important role in emotion regulation; for instance, it is activated when a person views films or recalls personal experiences that evoke happiness or sadness [26,36], and shows greater activity when a person imitates emotional expressions [8].”
BackgroundUecker, A., Reiman, E. M., Schacter, D. L., Polster, M. R., Cooper, L. A., Yun, L. S., & Chen, K. (1997) · Learning & Memory · doi:10.1101/lm.4.4.337 · Cited by 27
Self-citationBotellero, V. L., Skranes, J. S., Bjuland, K. J., Løhaugen, G. C. C., Haberg, A. K., Lydersen, S., Brubakk, A., Indredavik, M. S., & Martinussen, M. (2016) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-016-0093-8 · Cited by 25
“Different fMRI studies have also shown activation of the cerebellum in different emotional tasks, such us viewing pictures of deceased loved ones [81] and viewing pictures and movies evoking both negative and positive feelings [82, 83].”
BackgroundSun, J., Chen, L., He, J., Wang, Z., Guo, C., Ma, Y., Luo, Y., Gao, D.-Q., Yang, H., Fang, J., et al. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.849847 · Cited by 25
Wu, X., Wang, L., Jiang, H., Fu, Y., Wang, T., Ma, Z., Wu, X., Wang, Y., Fan, F., Song, Y., et al. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103445 · Cited by 24
Sarinopoulos, I. C., Hesson, A., Gordon, C., Lee, S. A., Wang, L., Dwamena, F. C., & Smith, R. C. (2012) · Patient Education and Counseling · doi:10.1016/j.pec.2012.10.021 · Cited by 25
“This result is consistent with the neuroimaging literature showing the anterior portion of the insular cortex to be active during emotional challenges, emotional recall, and self-generated emotions, suggesting its key role in the conscious, evaluative, experiential, and expressive aspects of internally generated emoti…”
Resultde Borst, A. W., & de Gelder, B. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw039 · Cited by 24
“The whole of the insular cortex, including posterior insula, has been suggested as a site where internally generated emotions and emotional context are evaluated and the expression of responses is initiated (Reiman et al., 1997).”
BackgroundThe brain structure and spontaneous activity baseline of the behavioral bias in trait anxiety
Yin, P., Zhang, M., Hou, X., Tan, Y., Fu, Y., & Qiu, J. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.06.036 · Cited by 25
Sebastiani, L., Simoni, A., Gemignani, A., Ghelarducci, B., & Santarcangelo, E. L. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01358-7 · Cited by 25
“The regional modifications observed in EEG [1,12,13] and neuroimaging studies [15] during emotions, in fact, could have been overwhelmed, in our experiment, by the modalities of the stimulus presentation, which are likely to have forced cognitive processes into a holistic strategy and buffered actual differences among…”
Chen, Y.-T., Huang, M.-W., Hung, I.-C., Lane, H.-Y., & Hou, C.-J. (2014) · Behavioral and Brain Functions · doi:10.1186/1744-9081-10-36 · Cited by 24
“Neuroimaging studies in healthy participants have described a large increase in amygdala activity while individuals view photos of faces with fearful expressions [7,8] and other emotionally valenced stimuli [9-12].”
BackgroundA general theory of consciousness I:Consciousness and adaptation
Peper, A. (2020) · Communicative & Integrative Biology · doi:10.1080/19420889.2020.1713967 · Cited by 26
Short-term hormone treatment modulates emotion response circuitry in postmenopausal women
Love, T., Smith, Y. R., Persad, C. C., Tkaczyk, A., & Zubieta, J. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.12.056 · Cited by 24
Parsing positive emotion in relation to agentic and affiliative components of extraversion
Morrone-Strupinsky, J. V., & Lane, R. D. (2006) · Personality and Individual Differences · doi:10.1016/j.paid.2006.10.005 · Cited by 25
Self-citationWittbrodt, M. T., Moazzami, K., Lima, B. B., Alam, Z. S., Corry, D. T., Hammadah, M., Campanella, C., Ward, L. A., Quyyumi, A. A., Shah, A. J., et al. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.05.018 · Cited by 26
“005 (uncorrected) which has been shown to minimize both Type I and Type II errors in brain imaging research (Lane et al., 1997; Reiman et al., 1997).”
BackgroundSocial Capital and the Human Psyche: Why is Social Life “Capital”?
Savage, J., & Satoshi Kanazawa, A. (2004) · Sociological Theory · doi:10.1111/j.0735-2751.2004.00231.x · Cited by 23
Phillips, M. L., & Mataix‐Cols, D. (2004) · CNS Spectrums · doi:10.1017/s1092852900009214 · Cited by 25
Reciprocal Links between Emotion and Attention
(2004) · Elsevier eBooks · doi:10.1016/b978-012264841-0/50022-6 · Cited by 27
Fear in dreams and in wakefulness: Evidence for day/night affective homeostasis
Sterpenich, V, Perogamvros, L., Tononi, G., & Schwartz, S. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/534099 · Cited by 99
Metadata
- Authors
- Reiman, E. M., Lane, R. D., Ahern, G. L., SCHWARTZ, G. E. R., Davidson, R. J., Friston, K. J., Yun, L. S., & Chen, K.
- Affiliations
- University of Arizona (US)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 1997-07-01
- Volume
- 154
- Issue
- 7
- Pages
- 918-925
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1525298240
- Semantic Scholar
- f12897c2e3c50642666b917f8c8ad7542bb93594
- Cited by
- 711
- References
- 38
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 6 · 2021: 10 · 2020: 9 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 15 · 2015: 23 · 2014: 19 · 2013: 27 · 2012: 16
- FWCI
- 18.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health (5k20mh000972-05)
- National Institute of Mental Health (MH00972, MH00875)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- emotions, neural substrates of emotion, sadness, medial prefrontal cortex, thalamus, amygdala, hippocampal formation, anterior insula, interoception, exteroception, regional brain activity
- MeSH terms
- Adult, Affective Symptoms, Arousal, Brain, Brain Mapping, Cognition, Emotions, Female, Humans, Middle Aged, Motion Pictures, Oxygen Radioisotopes, Mental Recall, Research Design, Sensation, Tomography, Emission-Computed, Visual Perception, Water
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
